Circadian clock disruptions and the risk of cancer

References

• Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002;418:935–41.
   PubMed Web of Science ®Google Scholar
• Le Minh N, Damiola F, Tronche F, Schutz G, Schibler U. Glucocorticoid hormones inhibit food-induced phase- shifting of peripheral circadian oscillators. EMBO J. 2001; 20:7128–36.
   PubMed Web of Science ®Google Scholar
• Duffield GE, Best JD, Meurers BH, Bittner A, Loros JJ, Dunlap JC. Circadian programs of transcriptional activation, signaling, and protein turnover revealed by microarray analysis of mammalian cells. Curr Biol. 2002;12:551–7.
   PubMed Web of Science ®Google Scholar
• Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH, . Extensive and divergent circadian gene expression in liver and heart. Nature. 2002;417:78–83.
   PubMed Web of Science ®Google Scholar
• Schernhammer ES, Laden F, Speizer FE, Willett WC, Hunter DJ, Kawachi I, . Night-shift work and risk of colorectal cancer in the Nurses’ Health Study. J Natl Cancer Inst. 2003;95:825–8.
   PubMed Web of Science ®Google Scholar
• Kubo T, Ozasa K, Mikami K, Wakai K, Fujino Y, Watanabe Y, . Prospective cohort study of the risk of prostate cancer among rotating-shift workers: findings from the Japan collaborative cohort study. Am J Epidemiol. 2006;164: 549–55.
   PubMed Web of Science ®Google Scholar
• Conlon M, Lightfoot N, Kreiger N. Rotating shift work and risk of prostate cancer. Epidemiology. 2007;18:182–3.
   PubMed Web of Science ®Google Scholar
• Viswanathan AN, Hankinson SE, Schernhammer ES. Night shift work and the risk of endometrial cancer. Cancer Res. 2007;67:10618–22.
   PubMed Web of Science ®Google Scholar
• Lahti TA, Partonen T, Kyyrönen P, Kauppinen T, Pukkala E. Night-time work predisposes to non-Hodgkin lymphoma. Int J Cancer. 2008;123:2148–51.
   PubMed Web of Science ®Google Scholar
• Stevens RG. Working against our endogenous circadian clock: breast cancer and electric lighting in the modern world. Mutat Res. 2009;680:106–8.
   PubMed Web of Science ®Google Scholar
• Blask DE, Hill SM, Dauchy RT, Xiang S, Yuan L, Duplessis T, . Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night. J Pineal Res. 2011;51:259–69.
   PubMed Web of Science ®Google Scholar
• Hansen J, Stevens RG. Case-control study of shift-work and breast cancer risk in Danish nurses: impact of shift systems. Eur J Cancer. 2012;48:1722–9.
   PubMed Web of Science ®Google Scholar
• Stevens RG, Hansen J, Costa G, Haus E, Kauppinen T, Aronson KJ, . Considerations of circadian impact for defining ‘shift work’ in cancer studies: IARC Working Group Report. Occup Environ Med. 2011;68:154–62.
   PubMed Web of Science ®Google Scholar
• Logan RW, Zhang C, Murugan S, O’Connell S, Levitt D, Rosenwasser AM, . Chronic shift-lag alters the circadian clock of NK cells and promotes lung cancer growth in rats. J Immunol. 2012;188:2583–91.
   PubMed Web of Science ®Google Scholar
• Wu M, Zeng J, Chen Y, Zeng Z, Zhang J, Cai Y, . Experimental chronic jet lag promotes growth and lung metastasis of Lewis lung carcinoma in C57BL/6 mice. Oncol Rep. 2012;27:1417–28.
   PubMed Web of Science ®Google Scholar
• Sutela H. Working time in the European Union: Finland. Helsinki: Statistics Finland; 2009.
   Google Scholar
• Vinogradova IA, Anisimov VN, Bukalev AV, Ilyukha VA, Khizhkin EA, Lotosh TA, . Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats. Aging (Albany NY). 2010;2:82–92.
   PubMedGoogle Scholar
• Kloog I, Portnov BA, Rennert HS, Haim A. Does the modern urbanized sleeping habitat pose a breast cancer risk?Chronobiol Int. 2011;28:76–80.
   PubMed Web of Science ®Google Scholar
• Cao Q, Gery S, Dashti A, Yin D, Zhou Y, Gu J, . A role for the clock gene per1 in prostate cancer. Cancer Res. 2009;69:7619–25.
   PubMed Web of Science ®Google Scholar
• Gery S, Virk RK, Chumakov K, Yu A, Koeffler HP. The clock gene Per2 links the circadian system to the estrogen receptor. Oncogene. 2007;26:7916–20.
   PubMed Web of Science ®Google Scholar
• Shav-Tal Y, Zipori D. PSF and p54nrb/NonO – multi- functional nuclear proteins. FEBS Lett. 2002;531:109–14.
   PubMed Web of Science ®Google Scholar
• Amelio AL, Miraglia LJ, Conkright JJ, Mercer BA, Batalov S, Cavett V, . A coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway. Proc Natl Acad Sci USA. 2007;104:20314–9.
   PubMed Web of Science ®Google Scholar
• O’Neill JS, Maywood ES, Chesham JE, Takahashi JS, Hastings MH. cAMP-dependent signaling as a core component of the mammalian circadian pacemaker. Science. 2008;320:949–53.
   PubMed Web of Science ®Google Scholar
• Uchida Y, Hirayama J, Nishina H. A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses. Biol Pharm Bull. 2010;33: 535–44.
   Google Scholar
• Geyfman M, Kumar V, Liu Q, Ruiz R, Gordon W, Espitia F, . Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis. Proc Natl Acad Sci USA. 2012;109:11758–63.
   PubMed Web of Science ®Google Scholar
• Lie JA, Kjuus H, Zienolddiny S, Haugen A, Stevens RG, Kjærheim K. Night work and breast cancer risk among Norwegian nurses: assessment by different exposure metrics. Am J Epidemiol. 2011;173:1272–79.
   PubMed Web of Science ®Google Scholar
• Lewy AJ, Wehr TA, Goodwin FK, Newsome DA, Markey SP. Light suppresses melatonin secretion in humans. Science. 1980;210:1267–9.
   PubMed Web of Science ®Google Scholar
• Hill SM, Blask DE, Xiang S, Yuan L, Mao L, Dauchy RT, . Melatonin and associated signaling pathways that control normal breast epithelium and breast cancer. J Mammary Gland Biol Neoplasia. 2011;16:235–45.
   PubMed Web of Science ®Google Scholar
• Johnston JD, Tournier BB, Andersson H, Masson-Pévet M, Lincoln GA, Hazlerigg DG. Multiple effects of melatonin on rhythmic clock gene expression in the mammalian pars tuberalis. Endocrinology. 2006;147:959–65.
   PubMed Web of Science ®Google Scholar
• Wagner GC, Johnston JD, Tournier BB, Ebling FJ, Hazlerigg DG. Melatonin induces gene-specific effects on rhythmic mRNA expression in the pars tuberalis of the Siberian hamster (Phodopus sungorus). Eur J Neurosci. 2007;25: 485–90.
   PubMed Web of Science ®Google Scholar
• Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, . Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010;16:1152–6.
   PubMed Web of Science ®Google Scholar
• Nguyen J, Wright KPJr.Influence of weeks of circadian misalignment on leptin levels. Nat Sci Sleep. 2009;2010: 9–18.
   Google Scholar
• Zhu Y, Leaderer D, Guss C, Brown HN, Zhang Y, Boyle P, . Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma. Int J Cancer. 2007;120:432–5.
   PubMed Web of Science ®Google Scholar
• Hoffman AE, Zheng T, Stevens RG, Ba Y, Zhang Y, Leaderer D, . Clock-cancer connection in non-Hodgkin's lymphoma: a genetic association study and pathway analysis of the circadian gene cryptochrome 2. Cancer Res. 2009;69: 3605–13.
   PubMed Web of Science ®Google Scholar
• Fu L, Pelicano H, Liu J, Huang P, Lee C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell. 2002;111:41–50.
   PubMed Web of Science ®Google Scholar
• Abolhassani M, Aloulou N, Chaumette MT, Aparicio T, Martin-Garcia N, Mansour H, . Leptin receptor-related immune response in colorectal tumors: the role of colonocytes and interleukin-8. Cancer Res. 2008;68:9423–32.
   PubMed Web of Science ®Google Scholar
• Aloulou N, Bastuji-Garin S, Le Gouvello S, Abolhassani M, Chaumette MT, Charachon A, . Involvement of the leptin receptor in the immune response in intestinal cancer. Cancer Res. 2008;68:9413–22.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Brown HN, Zhang Y, Stevens RG, Zheng T. Period3 structural variation: a circadian biomarker associated with breast cancer in young women. Cancer Epidemiol Biomarkers Prev. 2005;14:268–70.
   PubMed Web of Science ®Google Scholar
• Chu LW, Zhu Y, Yu K, Zheng T, Yu H, Zhang Y, . Variants in circadian genes and prostate cancer risk: a population-based study in China. Prostate Cancer Prostatic Dis. 2008;11:342–8.
   Google Scholar
• Zhu Y, Stevens RG, Leaderer D, Hoffman A, Holford T, Zhang Y, . Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk. Breast Cancer Res Treat. 2008;107:421–5.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Stevens RG, Hoffman AE, Fitzgerald LM, Kwon EM, Ostrander EA, . Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. Cancer Res. 2009;69:9315–22.
   PubMed Web of Science ®Google Scholar
• Hoffman AE, Yi CH, Zheng T, Stevens RG, Leaderer D, Zhang Y, . CLOCK in breast tumorigenesis: genetic, epigenetic, and transcriptional profiling analyses. Cancer Res. 2010;70:1459–68.
   PubMed Web of Science ®Google Scholar
• Hoffman AE, Zheng T, Yi CH, Stevens RG, Ba Y, Zhang Y, . The core circadian gene Cryptochrome 2 influences breast cancer risk, possibly by mediating hormone signaling. Cancer Prev Res (Phila). 2010;3:539–48.
   PubMed Web of Science ®Google Scholar
• Yi C, Mu L, de la Longrais IA, Sochirca O, Arisio R, Yu H, . The circadian gene NPAS2 is a novel prognostic biomarker for breast cancer. Breast Cancer Res Treat. 2010;120:663–9.
   PubMed Web of Science ®Google Scholar
• Dai H, Zhang L, Cao M, Song F, Zheng H, Zhu X, . The role of polymorphisms in circadian pathway genes in breast tumorigenesis. Breast Cancer Res Treat. 2011;127: 531–40.
   PubMed Web of Science ®Google Scholar
• Bunger MK, Wilsbacher LD, Moran SM, Clendenin C, Radcliffe LA, Hogenesch JB, . Mop3 is an essential component of the master circadian pacemaker in mammals. Cell. 2000;103:1009–17.
   PubMed Web of Science ®Google Scholar
• Zeng ZL, Wu MW, Sun J, Sun YL, Cai YC, Huang YJ, . Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity. J Biochem. 2010;148: 319–26.
   PubMed Web of Science ®Google Scholar
• Sahar S, Sassone-Corsi P. Metabolism and cancer: the circadian clock connection. Nat Rev Cancer. 2009;9:886–96.
   PubMed Web of Science ®Google Scholar
• Reddy AB, O’Neill JS. Healthy clocks, healthy body, healthy mind. Trends Cell Biol. 2010;20:36–44.
   PubMed Web of Science ®Google Scholar
• Gery S, Komatsu N, Kawamata N, Miller CW, Desmond J, Virk RK, . Epigenetic silencing of the candidate tumor suppressor gene Per1 in non-small cell lung cancer. Clin Cancer Res. 2007;13:1399–404.
   PubMed Web of Science ®Google Scholar
• Tokunaga H, Takebayashi Y, Utsunomiya H, Akahira J, Higashimoto M, Mashiko M, . Clinicopathological significance of circadian rhythm-related gene expression levels in patients with epithelial ovarian cancer. Acta Obstet Gynecol Scand. 2008;87:1060–70.
   PubMed Web of Science ®Google Scholar
• Oshima T, Takenoshita S, Akaike M, Kunisaki C, Fujii S, Nozaki A, . Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer. Oncol Rep. 2011;25:1439–46.
   PubMed Web of Science ®Google Scholar
• Sun Y, Yang Z, Niu Z, Peng J, Li Q, Xiong W, . MOP3, a component of the molecular clock, regulates the development of B cells. Immunology. 2006;119:451–60.
   PubMed Web of Science ®Google Scholar
• Taniguchi H, Fernández AF, Setién F, Ropero S, Ballestar E, Villanueva A, . Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies. Cancer Res. 2009;69:8447–54.
   PubMed Web of Science ®Google Scholar
• Gery S, Komatsu N, Baldjyan L, Yu A, Koo D, Koeffler HP. The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol Cell. 2006;22:375–82.
   PubMed Web of Science ®Google Scholar
• Sancar A, Lindsey-Boltz LA, Kang TH, Reardon JT, Lee JH, Ozturk N. Circadian clock control of the cellular response to DNA damage. FEBS Lett. 2010;584:2618–25.
   PubMed Web of Science ®Google Scholar
• Yang MY, Yang WC, Lin PM, Hsu JF, Hsiao HH, Liu YC, . Altered expression of circadian clock genes in human chronic myeloid leukemia. J Biol Rhythms. 2011;26: 136–48.
   PubMedGoogle Scholar
• Miyazaki K, Wakabayashi M, Hara Y, Ishida N. Tumor growth suppression in vivo by overexpression of the circadian component, PER2. Genes Cells. 2010;15:351–8.
   PubMed Web of Science ®Google Scholar
• Alhopuro P, Björklund M, Sammalkorpi H, Turunen M, Tuupanen S, Biström M, . Mutations in the circadian gene CLOCK in colorectal cancer. Mol Cancer Res. 2010;8:952–60.
   PubMed Web of Science ®Google Scholar
• Saharinen P, Eklund L, Pulkki K, Bono P, Alitalo K. VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol Med. 2011;17:347–62.
   PubMed Web of Science ®Google Scholar
• Weis SM, Cheresh DA. Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med. 2011;17: 1359–70.
   PubMed Web of Science ®Google Scholar
• Wood PA, Du-Quiton J, You S, Hrushesky WJ. Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index. Mol Cancer Ther. 2006;5:2023–33.
   PubMed Web of Science ®Google Scholar
• Guess J, Burch JB, Ogoussan K, Armstead CA, Zhang H, Wagner S, . Circadian disruption, Per3, and human cytokine secretion. Integr Cancer Ther. 2009;8:329–36.
   PubMed Web of Science ®Google Scholar
• Sato F, Bhawal UK, Kawamoto T, Fujimoto K, Imaizumi T, Imanaka T, . Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression. Genes Cells. 2008;13:131–44.
   PubMed Web of Science ®Google Scholar
• Hamaguchi H, Fujimoto K, Kawamoto T, Noshiro M, Maemura K, Takeda N, . Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Biochem J. 2004;382:43–50.
   PubMed Web of Science ®Google Scholar
• Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller- Hermelink HK, Vardiman J, . The World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. Report of the Clinical Advisory Committee meeting, Airlie House, Virginia, November, 1997. Ann Oncol. 1999;10:1419–32.
   PubMed Web of Science ®Google Scholar
• Khapre RV, Samsa WE, Kondratov RV. Circadian regulation of cell cycle: molecular connections between aging and the circadian clock. Ann Med. 2010;42:404–15.
   PubMed Web of Science ®Google Scholar
• Yu EA, Weaver DR. Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes. Aging (Albany NY). 2011;3:479–93.
   PubMedGoogle Scholar
• Innominato PF, Lévi FA, Bjarnason GA. Chronotherapy and the molecular clock: clinical implications in oncology. Adv Drug Deliv Rev. 2010;62:979–1001.
   PubMed Web of Science ®Google Scholar
• Minami Y, Kasukawa T, Kakazu Y, Iigo M, Sugimoto M, Ikeda S, . Measurement of internal body time by blood metabolomics. Proc Natl Acad Sci U S A. 2009;106:9890–5.
   PubMed Web of Science ®Google Scholar
• Ueda HR, Chen W, Minami Y, Honma S, Honma K, Iino M, . Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles. Proc Natl Acad Sci U S A. 2004;101:11227–32.
   PubMedGoogle Scholar
• Gorbacheva VY, Kondratov RV, Zhang R, Cherukuri S, Gudkov AV, Takahashi JS, . Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc Natl Acad Sci U S A. 2005;102:3407–12.
   PubMed Web of Science ®Google Scholar
• Bernard S, Čajavec Bernard B, Lévi F, Herzel H. Tumor growth rate determines the timing of optimal chronomodulated treatment schedules. PLoS Comput Biol. 2010;6: e1000712.
   PubMed Web of Science ®Google Scholar
• Ballesta A, Dulong S, Abbara C, Cohen B, Okyar A, Clairambault J, . A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery. PLoS Comput Biol. 2011;7:e1002143.
   Google Scholar