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Research Article

Identification and confirmation of haptoglobin as a potential serum biomarker in hypertrophic cardiomyopathy using proteomic approaches

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Pages 341-347 | Received 31 May 2012, Accepted 02 Apr 2013, Published online: 23 May 2013

References

  • Ommen SR, Nishimura RA. Hypertrophic cardiomyopathy. Curr Probl Cardiol. 2004;29:239–91.
  • Tsybouleva N, Zhang L, Chen S, Patel R, Lutucuta S, Nemoto S, et al. Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy. Circulation. 2004;109:1284–91.
  • Elliott P, McKenna WJ. Hypertrophic cardiomyopathy. Lancet. 2004;36:1881–91.
  • Maron BJ, Niimura H, Casey SA, Soper MK, Wright GB, Seidman JG, et al. Development of left ventricular hypertrophy in adults in hypertrophic cardiomyopathy caused by cardiac myosin-binding protein C gene mutations. J Am Coll Cardiol. 2001;38:315–21.
  • Ho CY, Seidman CE. A contemporary approach to hypertrophic cardiomyopathy. Circulation. 2006;113:858–62.
  • Marian AJ. Hypertrophic cardiomyopathy: from genetics to treatment. Eur J Clin Invest. 2010;40:360–9.
  • Watkins H, Thierfelder L, Anan R, Jarcho J, Matsumori A, McKenna W, et al. Independent origin of identical beta cardiac myosin heavy-chain mutations in hypertrophic cardiomyopathy. Am J Hum Genet. 1993;53:1180–5.
  • Kenyon GL, DeMarini DM, Fuchs E, Galas DJ, Kirsch JF, Leyh TS, et al. Defining the mandate of proteomics in the post-genomics era: workshop report. Mol Cell Proteomics. 2002;1:763–80.
  • Orenes-Piñero E, Cortón M, González-Peramato P, Algaba F, Casal I, Serrano A, et al. Searching urinary tumor markers for bladder cancer using a two-dimensional differential gel electrophoresis (2D-DIGE) approach. J Proteome Res. 2007;6:4440–8.
  • Ares-Carrasco S, Picatoste B, Camafeita E, Carrasco-Navarro S, Zubiri I, Ortiz A, et al. Proteome changes in the myocardium of experimental chronic diabetes and hypertension: role of PPARα in the associated hypertrophy. J Proteomics. 2012;75:1816–29.
  • Wei BR, Simpson RM, Johann DJ, Dwyer JE, Prieto DA, Kumar M, et al. Proteomic profiling of H-Ras-G12V induced hypertrophic cardiomyopathy in transgenic mice using comparative LC-MS analysis of thin fresh-frozen tissue sections. J Proteome Res. 2012;11:1561–70.
  • Roldán V, Marín F, Gimeno JR, Ruiz-Espejo F, González J, Feliu E, et al. Matrix metalloproteinases and tissue remodeling in hypertrophic cardiomyopathy. Am Heart J. 2008;156:85–91.
  • Cambronero F, Marín F, Roldán V, Hernández-Romero D, Valdés M, Lip GY. Biomarkers of pathophysiology in hypertrophic cardiomyopathy: implications for clinical management and prognosis. Eur Heart J. 2009; 30:139–51.
  • Moreno V, Hernández-Romero D, Vilchez JA, García-Honrubia A, Cambronero F, Casas T, et al. Serum levels of high-sensitivity troponin T: a novel marker for cardiac remodeling in hypertrophic cardiomyopathy. J Card Fail. 2010;16:950–6.
  • Karp NA, Lilley KS. Investigating sample pooling strategies for DIGE experiments to address biological variability. Proteomics. 2009;9:388–97.
  • Zhang SD, Gant TW. Effect of pooling samples on the efficiency of comparative studies using microarrays. Bioinformatics. 2005;21:4378–83.
  • Karp NA, McCormick PS, Russell MR, Lilley KS. Experimental and statistical considerations to avoid false conclusions in proteomics studies using differential in-gel electrophoresis. Mol Cell Proteomics. 2007;6:1354–64.
  • Shevchenko A, Tomas H, Havlis J, Olsen JV, Mann M. In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc. 2006;1:2856–60.
  • Zezulka A, Shapiro L, Singh S. Chronic haemolytic anaemia in hypertrophic cardiomyopathy. Br Heart J. 1984;52:474–6.
  • Lambert M, Bosly E, Boland B, Hainaut P, Vanoverschelde JL. Intravascular haemolysis in hypertrophic cardiomyopathy. Eur Heart J. 1996;17:1601–2.
  • Heilmann C, Geisen U, Benk C, Berchtold-Herz M, Trummer G, Schlensak C, et al. Haemolysis in patients with ventricular assist devices: major differences between systems. Eur J Cardiothorac Surg. 2009;36:580–4.
  • Kubo T, Kitaoka H, Terauchi Y, Tamura S, Okawa M, Yamasaki N, et al. Hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy. J Cardiol. 2010;55:125–9.
  • Jacobson RJ, Rath CE, Perloff JK. Intravascular haemolysis and thrombocytopenia in left ventricular out-flow obstruction. Br Heart J. 1973;35:849–54.
  • Tolosano E, Fagoonee S, Hirsch E, Berger FG, Baumann H, Silengo L, et al. Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis. Blood. 2002;100:4201–8.
  • Watanabe J, Grijalva V, Hama S, Barbour K, Berger FG, Navab M, et al. Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein. J Biol Chem. 2009;284: 18292–301.
  • Balla J, Jacob HS, Balla G, Nath K, Eaton JW, Vercellotti GM. Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc Natl Acad Sci U S A 1993;90:9285–9.
  • Wagener FA, Eggert A, Boerman OC, Oyen WJ, Verhofstad A, Abraham NG, et al. Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase. Blood. 2001;98:1802–11.
  • Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, et al. Identification of the haemoglobin scavenger receptor. Nature. 2001;409:198–201.

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