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REVIEW ARTICLE

Brain-derived neurotrophic factor and suicide pathogenesis

Pages 87-96 | Received 27 Jul 2009, Accepted 11 Nov 2009, Published online: 18 Feb 2010

References

  • Goldsmith SK, Pellmar TC, Kleinman AM, Bunney WE. Committee on Pathophysiology and Prevention of Adolescent and Adult Suicide, Board on Neuroscience and Behavioral Health, Institute of Medicine of the National Academies. Reducing suicide, a national imperative. Washington DC: The National Academies Press; 2002.
  • Minino AM, Smith BL. Deaths: preliminary data for 2000. Natl Vital Stat Rep. 2002;49:1–40.
  • Greydanus DE, Bacopoulou F, Tsalamanios E. Suicide in adolescents: a worldwide preventable tragedy. Keio J Med. 2009;58:95–102.
  • Wasserman D. Negative life events (losses, changes, traumas and narcissistic injury) and suicide. Wasserman D. Suicide: an unnecessary death. London: Dunitz; 2001. 111–7.
  • Ahrens B, Linden M. Is there a suicidality syndrome independent of specific major psychiatric disorders? Result of a split half multiple regression analysis. Acta Psychiatr Scand. 1996;94:79–86.
  • Mann JJ, Waternaux C, Haas GL, Malone KM. Toward a clinical model of suicidal behavior in psychiatric patients. Am J Psychiatry. 1999;156:181–9.
  • Garcia R. Stress, synaptic plasticity, and psychopathology. Rev Neurosci. 2002;13:195–208.
  • Duman RS, Malberg J, Nakagawa S, D’Sa C. Neuronal plasticity and survival in mood disorders. Biol Psychiatry. 2000;48:732–9.
  • Fossati P, Radtchenko A, Boyer P. Neuroplasticity: from MRI to depressive symptoms. Eur Neuropsychopharmacol. 2004;14 (Suppl 5):S503–10.
  • Altshuler LL, Casanova MF, Goldberg TE, Kleinman JE. The hippocampus and parahippocampus in schizophrenia, suicide, and control brains. Arch Gen Psychiatry. 1990;47:1029–34.
  • Rajkowska G. Morphometric methods for studying the pre-frontal cortex in suicide victims and psychiatric patients. Ann N Y Acad Sci. 1997;836:253–68.
  • Rajkowska G. Cell pathology in mood disorders. Semin Clin Neuropsychiatry. 2002;7:281–92.
  • Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS. Hippocampal volume reduction in major depression. Am J Psychiatry. 2000;157:115–8.
  • Rosoklija G, Toomayan G, Ellis SP, Keilp J, Mann JJ, Latov N, . Structural abnormalities of subicular dendrites in subjects with schizophrenia and mood disorders: preliminary findings. Arch Gen Psychiatry. 2000;57:349–56.
  • Cotter D, Mackay D, Chana G, Beasley C, Landau S, Everall IP. Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder. Cereb Cortex. 2002;12:386–94.
  • Aganova EA, Uranova NA. Morphometric analysis of synaptic contacts in the anterior limbic cortex in the endogenous psychoses. Neurosci Behav Physiol. 1992;22:59–65.
  • Hajszan T, MacLusky NJ, Leranth C. Short-term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampus. Eur J Neurosci. 2005;21:1299–303.
  • Honer WG. Assessing the machinery of mind: synapses in neuropsychiatric disorders. J Psychiatry Neurosci. 1999;24:116–21.
  • McEwen BS. Effects of adverse experiences for brain structure and function. Biol Psychiatry. 2000;48:721–31.
  • Sheline YI. 3D MRI studies of neuroanatomic changes in unipolar depression: the role of stress and medical comorbidity. Biol Psychiatry. 2000;48:791–800.
  • Cerqueira JJ, Mailliet F, Almeida OF, Jay TM, Sousa N. The prefrontal cortex as a key target of the maladaptive response to stress. J Neurosci. 2007;27:2781–7.
  • Thoenen H. Neurotrophins and activity-dependent plasticity. Prog Brain Res. 2000;128:183–91.
  • Cooper JD, Skepper JN, Berzaghi MD, Lindholm D, Sofroniew MV. Delayed death of septal cholinergic neurons after excitotoxic ablation of hippocampal neurons during early postnatal development in the rat. Exp Neurol. 1996;139:143–55.
  • Huang E, Reichardt LF. Neurotrophins: Roles in neuronal development and function. Annu Rev Neurosci. 2001;24:677–736.
  • Seidah NG, Benjannet S, Pareek S, Chrétien M, Murphy RA. Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases. FEBS Lett. 1996;379:247–50.
  • Lu B, Pang PT, Woo NH. The yin and yang of neurotrophin action. Nat Rev Neurosci. 2005;6:603–14.
  • Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, . The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003;112:257–69.
  • Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, Zhen S, . Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science. 2004;306:487–91.
  • Reichardt LF. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 2006;361:1545–64.
  • Hasegawa Y, Yamagishi S, Fujitani M, Yamashita T. p75 neurotrophin receptor signaling in the nervous system. Biotechnol Annu Rev. 2004;10:123–49.
  • Thoenen H. Neurotrophins and neuronal plasticity. Science. 1995;270:593–8.
  • Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry. 2006;59:1116–27.
  • Brunoni AR, Lopes M, Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol. 2008;11:1169–80.
  • Castrén, E. Is mood chemistry? Nat Rev Neurosci. 2005;6:241–6.
  • Mann JJ. A current perspective of suicide and attempted suicide. Ann Intern Med. 2002;136:302–11.
  • Lopez JF, Palkovits M, Arato M, Mansour A, Akil H, Watson SJ. Localization and quantification of proopiomelanocortin mRNA and glucocorticoid receptor mRNA in pituitaries of suicide victims. Neuroendocrinology. 1992;56:491–501.
  • Szigethy E, Conwell Y, Forbes NT, Cox C, Caine ED. Adrenal weight and morphology in victims of completed suicide. Biol Psychiatry. 1994;36:374–80.
  • Dumser T, Barocka A, Schubert E. Weight of adrenal glands may be increased in persons who commit suicide. Am J Forensic Med Pathol. 1998;19:72–6.
  • Nemeroff CB, Owens MJ, Bissette G, Andorn AC, Stanley M. Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Arch Gen Psychiatry. 1988;45:577–9.
  • McGowan PO, Sasaki A, D’Alessio AC, Dymov S, Labonté B, Szyf M, . Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci. 2009;12:342–8.
  • Coryell W, Schlesser M. The dexamethasone suppression test and suicide prediction. Am J Psychiatry. 2001;158:748–53.
  • Jokinen J, Carlborg A, Mårtensson B, Forslund K, Nordström AL, Nordström P. DST non-suppression predicts suicide after attempted suicide. Psychiatry Res. 2007;150:297–303.
  • Jokinen J, Nordström AL, Nordström P. CSF 5-HIAA and DST non-suppression–-orthogonal biologic risk factors for suicide in male mood disorder inpatients. Psychiatry Res. 2009;165:96–102.
  • Smith MA, Makino S, Kvetnansky R, Post RM. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci. 1995;15:1768–77.
  • Ueyama T, Kawai Y, Nemoto K, Sekimoto M, Toné S, Senba E. Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain. Neurosci Res. 1997;28:103–10.
  • Fuchikami M, Morinobu S, Kurata A, Yamamoto S, Yamawaki S. Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampus. Int J Neuropsychopharmacol. 2009;12:73–82.
  • Rasmusson AM, Shi L, Duman R. Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock. Neuropsychopharmacology. 2002;27:133–42.
  • Pizarro JM, Lumley LA, Medina W, Robison CL, Chang WE, Alagappan A, . Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice. Brain Res. 2004;1025:10–20.
  • Schaaf MJM, de Jong J, de Kloet ER, Vreugdenhil E. Down-regulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain Res. 1998;813:112–20.
  • Dwivedi Y, Rizavi HS, Pandey GN. Antidepressants reverse corticosterone-mediated decrease in BDNF expression: Dissociation in regulation of specific exons by antidepressants and corticosterone. Neuroscience. 2006;139:1017–29.
  • Barbany G, Persson H. Regulation of neurotrophin mRNA expression in the rat brain by glucocorticoids. Eur J Neurosci. 1992;4:396–403.
  • Chao HM, Sakai RR, Ma LY, McEwen BS. Adrenal steroid regulation of neurotrophic factor expression in the rat hippocampus. Endocrinology. 1998;139:3112–8.
  • Nakayama M, Gahara Y, Kitamura T, Ohara O. Distinctive four promoters collectively direct expression of brain-derived neurotrophic factor gene. Mol Brain Res. 1994;21:206–18.
  • Marmigere F, Givalois L, Rage F, Arancibia S, Tapia-Arancibia L. Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats. Hippocampus. 2003;13:646–55.
  • Rage F, Givalois L, Marmigere F, Tapia-Arancibia L, Arancibia S. Immobilization stress rapidly modulates BDNF mRNA expression in the hypothalamus of adult male rats. Neuroscience. 2002;112:309–18.
  • Karege F, Schwald M, Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett. 2002;328:261–64.
  • Kim YK, Lee HP, Won SD, Park EY, Lee HY, Lee BH, . Low plasma BDNF is associated with suicidal behavior in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:578–9.
  • Lee BH, Kim H, Park SH, Kim YK. Decreased plasma BDNF level in depressive patients. J Affect Disord. 2007: 101:239–44.
  • Dawood T, Anderson J, Barton D, Lambert E, Esler M, Hotchkin E, . Reduced overflow of BDNF from the brain is linked with suicide risk in depressive illness. Mol Psychiatry. 2007;12:981–3.
  • Deveci A, Aydemir O, Taskin O, Taneli F, Esen-Danaci A. Serum BDNF levels in suicide attempters related to psychosocial stressors: a comparative study with depression. Neuropsychobiology. 2007;56:93–7.
  • Lee BH, Kim YK. Reduced platelet BDNF level in patients with depression. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:849–53.
  • Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry. 2003;60:804–15.
  • Karege F, Vaudan G, Schwald M, Perroud N, La Harpe R. Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Brain Res Mol Brain Res. 2005;136:29–37.
  • Kozicz T, Tilburg-Ouwens D, Faludi G, Palkovits M, Roubos E. Gender-related urocortin 1 and brain-derived neurotrophic factor expression in the adult human midbrain of suicide victims with depression. Neuroscience. 2008;152:1015–23.
  • Pandey GN, Ren X, Rizavi HS, Conley RR, Roberts RC, Dwivedi Y. Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims. Int J Neuropsychopharmacol. 2008;11:1047–61.
  • Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL, . Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci. 2004;24:4401–11.
  • Toro R, Chupin M, Garnero L, Leonard G, Perron M, Pike B, . Brain volumes and Val66Met polymorphism of the BDNF gene: local or global effects? Brain Struct Funct. 2009;213:501–9.
  • Cheeran B, Talelli P, Mori F, Koch G, Suppa A, Edwards M, . A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS. J Physiol. 2008;586:5717–25.
  • Hong CJ, Huo SJ, Yen FC, Tung CL, Pan GM, Tsai SJ. Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology. 2003;48:186–9.
  • Kim B, Kim CY, Hong JP, Kim SY, Lee C, Joo YH. Brain-derived neurotrophic factor Val/Met polymorphism and bipolar disorder. Association of the Met allele with suicidal behavior of bipolar patients. Neuropsychobiology. 2008;582:97–103.
  • Iga J, Ueno S, Yamauchi K, Numata S, Tayoshi-Shibuya S, Kinouchi S, . The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:1003–6.
  • Sarchiapone M, Carli V, Roy A, Iacoviello L, Cuomo C, Latella MC, . Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients. Neuropsychobiology. 2008;57:139–45.
  • Zarrilli F, Angiolillo A, Castaldo G, Chiariotti L, Keller S, Sacchetti S, . Brain derived neurotrophic factor (BDNF) genetic polymorphism (Val66Met) in suicide: A study of 512 cases. Am J Med Genet B Neuropsychiatr Genet. 2008;150B:599–600.
  • Vincze I, Perroud N, Buresi C, Baud P, Bellivier F, Etain B, . Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene. Bipolar Disord. 2008;10:580–7.
  • Perroud N, Courtet P, Vincze I, Jaussent I, Jollant F, Bellivier F, . Interaction between BDNF Val66Met and childhood trauma on adult's violent suicide attempt. Genes Brain Behav. 2008;7:314–22.
  • Middlemas DS, Lindberg RA, Hunter T. trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol Cell Biol. 1991;11:143–53.
  • Armanini MP, McMahon SB, Sutherland J, Shelton DL, Philips HS. Truncated and catalytic isoforms of TrkB are co-expressed in neurons of rat and mouse CNS. Eur J Neurosci. 1995;7:1403–9.
  • Eide EF, Vining ER, Eide BL, Zang K, Wang X-Y, Reichardt LF. Naturally occurring truncated TrkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling. J Neurosci. 1996;16:3123–9.
  • Fryer RH, Kaplan DR, Feinstein SC, Radeke MJ, Grayson DR, Kromer LF. Developmental and mature expression of full-length and truncated TrkB receptors in the rat forebrain. J Comp Neurol. 1996;374:21–40.
  • Dwivedi Y, Rizavi H, Zhang H, Mondal AC, Roberts RC, Conley RR, . Neurotrophin receptor activation and expression in human postmortem brain: effect of suicide. Biol Psychiatry. 2009;65:319–28.
  • Ernst C, Deleva V, Deng X, Sequeira A, Pomarenski A, Klempan T, . Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Arch Gen Psychiatry. 2009;66:22–32.
  • Ernst C, Chen ES, Turecki G. Histone methylation and decreased expression of TrkB.T1 in orbital frontal cortex of suicide completers. Mol Psychiatry. 2009;14:830–2.
  • Esposito D, Patel P, Stephens RM, Perez P, Chao MV, Kaplan DR, . The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factor. J Biol Chem. 2001;276:32687–95.
  • Meldolesi J, Sciorati C, Clementi E. The p75 receptor: first insights into the transduction mechanisms leading to either cell death or survival. Trends Pharmacol Sci. 2000;21:242–3.
  • Roux PP, Colicos MA, Barker PA, Kennedy TE. p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure. J Neurosci. 1999;19:6887–96.
  • Whitfield J, Neame SJ, Paquet L, Bernard O, Ham J. Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron. 2001;29:629–43.
  • Zhou H, Summers SA, Birnbaum MJ, Pittman RN. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. J Biol Chem. 1998;273:16568–75.
  • Dwivedi Y, Rizavi HS, Roberts RC, Conley RC, Tamminga CA, Pandey GN. Reduced activation and expression of ERK1/2 MAP kinase in the postmortem brain of depressed suicide subjects. J Neurochem. 2001;77:916–28.
  • Dwivedi Y, Rizavi HS, Conley RR, Pandey GN. ERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf. Mol Psychiatry. 2006;11:86–98.
  • Dwivedi Y, Rizavi HS, Teppen T, Zhang H, Mondal A, Roberts RC, . Lower phosphoinositide 3-kinase (PI 3-kinase) activity and differential expression levels of selective catalytic and regulatory PI 3-kinase subunit isoforms in prefrontal cortex and hippocampus of suicide subjects. Neuropsychopharmacology. 2008;33:2324–40.
  • Hempstead BL. The many faces of p75NTR. Curr Opin Neurobiol. 2002;12:260–7.
  • McGregor S, Strauss J, Bulgin N, De Luca V, George CJ, Kovacs M, . p75(NTR) gene and suicide attempts in young adults with a history of childhood-onset mood disorder. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:696–700.
  • Schratt GM, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M, . A brain-specific microRNA regulates dendritic spine development. Nature. 2006;439:283–9.

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