Interleukin-18 gene polymorphism and markers of subclinical atherosclerosis. The Cardiovascular Risk in Young Finns Study

References

• Ross R. Atherosclerosis—an inflammatory disease. N Engl J Med. 1999;340:115–26.
   PubMed Web of Science ®Google Scholar
• Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–95.
   PubMed Web of Science ®Google Scholar
• Okamura H, Tsutsui H, Kashiwamura S, Yoshimoto T, Nakanishi K. Interleukin-18: a novel cytokine that augments both innate and acquired immunity. Adv Immunol. 1998; 70:281–312.
   PubMed Web of Science ®Google Scholar
• Mallat Z, Corbaz A, Scoazec A, Graber P, Alouani S, Esposito B, . Interleukin-18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability. Circ Res. 2001;89:E41–5.
   PubMed Web of Science ®Google Scholar
• Mallat Z, Corbaz A, Scoazec A, Besnard S, Leseche G, Chvatchko Y, . Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability. Circulation. 2001;104:1598–603.
   PubMed Web of Science ®Google Scholar
• Mallat Z, Henry P, Fressonnet R, Alouani S, Scoazec A, Beaufils P, . Increased plasma concentrations of interleukin-18 in acute coronary syndromes. Heart. 2002;88: 467–9.
   PubMed Web of Science ®Google Scholar
• Nakamura K, Okamura H, Wada M, Nagata K, Tamura T. Endotoxin-induced serum factor that stimulates gamma interferon production. Infect Immun. 1989;57:590–5.
   PubMed Web of Science ®Google Scholar
• Sanchez E, Palomino-Morales RJ, Ortego-Centeno N, Jimenez-Alonso J, Gonzalez-Gay MA, Lopez-Nevot MA, . Identification of a new putative functional IL18 gene variant through an association study in systemic lupus erythematosus. Hum Mol Genet. 2009;18:3739–48.
   PubMedGoogle Scholar
• Giedraitis V, He B, Huang WX, Hillert J. Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J Neuroimmunol. 2001;112:146–52.
   PubMed Web of Science ®Google Scholar
• Liang XH, Cheung W, Heng CK, Wang DY. Reduced transcriptional activity in individuals with IL-18 gene variants detected from functional but not association study. Biochem Biophys Res Commun. 2005;338:736–41.
   PubMed Web of Science ®Google Scholar
• Arimitsu J, Hirano T, Higa S, Kawai M, Naka T, Ogata A, . IL-18 gene polymorphisms affect IL-18 production capability by monocytes. Biochem Biophys Res Commun. 2006;342:1413–6.
   PubMed Web of Science ®Google Scholar
• Tiret L, Godefroy T, Lubos E, Nicaud V, Tregouet DA, Barbaux S, . Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease. Circulation. 2005;112:643–50.
   PubMed Web of Science ®Google Scholar
• Barbaux S, Poirier O, Godefroy T, Kleinert H, Blankenberg S, Cambien F, . Differential haplotypic expression of the interleukin-18 gene. Eur J Hum Genet. 2007;15:856–63.
   Google Scholar
• Thompson SR, McCaskie PA, Beilby JP, Hung J, Jennens M, Chapman C, . IL18 haplotypes are associated with serum IL-18 concentrations in a population-based study and a cohort of individuals with premature coronary heart disease. Clin Chem. 2007;53:2078–85.
   PubMed Web of Science ®Google Scholar
• Thompson SR, Novick D, Stock CJ, Sanders J, Brull D, Cooper J, . Free interleukin (IL)-18 levels, and the impact of IL18 and IL18BP genetic variation, in CHD patients and healthy men. Arterioscler Thromb Vasc Biol. 2007;27:2743–9.
   PubMed Web of Science ®Google Scholar
• Chen MC, Chen CJ, Yang CH, Wu CJ, Fang CY, Hsieh YK, . Interleukin-18: a strong predictor of the extent of coronary artery disease in patients with unstable angina. Heart Vessels. 2007;22:371–5.
   Google Scholar
• Hulthe J, McPheat W, Samnegard A, Tornvall P, Hamsten A, Eriksson P. Plasma interleukin (IL)-18 concentrations is elevated in patients with previous myocardial infarction and related to severity of coronary atherosclerosis independently of C-reactive protein and IL-6. Atherosclerosis. 2006;188: 450–4.
   PubMedGoogle Scholar
• Blankenberg S, Tiret L, Bickel C, Peetz D, Cambien F, Meyer J, . Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina. Circulation. 2002;106:24–30.
   PubMed Web of Science ®Google Scholar
• Espinola-Klein C, Rupprecht HJ, Bickel C, Lackner K, Schnabel R, Munzel T, . Inflammation, atherosclerotic burden and cardiovascular prognosis. Atherosclerosis. 2007; 195:e126–34.
   Google Scholar
• Bis JC, Heckbert SR, Smith NL, Reiner AP, Rice K, Lumley T, . Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke. Atherosclerosis. 2008;198:166–73.
   PubMed Web of Science ®Google Scholar
• Lorenz MW, von Kegler S, Steinmetz H, Markus HS, Sitzer M. Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke. 2006;37:87–92.
   PubMed Web of Science ®Google Scholar
• Simons PC, Algra A, Bots ML, Grobbee DE, van der Graaf Y. Common carotid intima-media thickness and arterial stiffness: indicators of cardiovascular risk in high-risk patients. The SMART Study (Second Manifestations of ARTerial disease). Circulation. 1999;100:951–7.
   PubMed Web of Science ®Google Scholar
• Schroeder S, Enderle MD, Ossen R, Meisner C, Baumbach A, Pfohl M, . Noninvasive determination of endothelium-mediated vasodilation as a screening test for coronary artery disease: pilot study to assess the predictive value in comparison with angina pectoris, exercise electrocardiography, and myocardial perfusion imaging. Am Heart J. 1999;138(4 Pt 1):731–9.
   Google Scholar
• Boutouyrie P, Tropeano AI, Asmar R, Gautier I, Benetos A, Lacolley P, . Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension. 2002;39:10–5.
   PubMed Web of Science ®Google Scholar
• Blacher J, Pannier B, Guerin AP, Marchais SJ, Safar ME, London GM. Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease. Hypertension. 1998;32:570–4.
   PubMed Web of Science ®Google Scholar
• Hijmering ML, Stroes ES, Pasterkamp G, Sierevogel M, Banga JD, Rabelink TJ. Variability of flow mediated dilation: consequences for clinical application. Atherosclerosis. 2001;157:369–73.
   PubMed Web of Science ®Google Scholar
• Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, . Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340:1111–5.
   PubMed Web of Science ®Google Scholar
• Yamagami H, Kitagawa K, Hoshi T, Furukado S, Hougaku H, Nagai Y, . Associations of serum IL-18 levels with carotid intima-media thickness. Arterioscler Thromb Vasc Biol. 2005;25:1458–62.
   PubMed Web of Science ®Google Scholar
• Chapman CM, McQuillan BM, Beilby JP, Thompson PL, Hung J. Interleukin-18 levels are not associated with subclinical carotid atherosclerosis in a community population. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS). Atherosclerosis. 2006;189:414–9.
   PubMed Web of Science ®Google Scholar
• Åkerblom HK, Viikari J, Uhari M, Räsänen L, Byckling T, Louhivuori K, . Atherosclerosis precursors in Finnish children and adolescents. I. General description of the cross-sectional study of 1980, and an account of the children's and families' state of health. Acta Paediatr Scand Suppl. 1985; 318:49–63.
   PubMedGoogle Scholar
• Juonala M, Viikari JS, Hutri-Kähönen N, Pietikäinen M, Jokinen E, Taittonen L, . The 21-year follow-up of the Cardiovascular Risk in Young Finns Study: risk factor levels, secular trends and east-west difference. J Intern Med. 2004;255:457–68.
   PubMed Web of Science ®Google Scholar
• Raitakari OT, Juonala M, Kähönen M, Taittonen L, Laitinen T, Mäki-Torkko N, . Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA. 2003;290:2277–83.
   PubMed Web of Science ®Google Scholar
• Hernesniemi JA, Raitakari OT, Kähönen M, Juonala M, Hutri-Kähönen N, Marniemi J, . Toll-like receptor 4 gene (Asp299Gly) polymorphism associates with carotid artery elasticity. The cardiovascular risk in young Finns study. Atherosclerosis. 2008;198:152–9.
   Google Scholar
• Juonala M, Viikari JS, Kähönen M, Taittonen L, Rönnemaa T, Laitinen T, . Geographic origin as a determinant of carotid artery intima-media thickness and brachial artery flow-mediated dilation: the Cardiovascular Risk in Young Finns study. Arterioscler Thromb Vasc Biol. 2005;25:392–8.
   PubMed Web of Science ®Google Scholar
• Livak KJ. Allelic discrimination using fluorogenic probes and the 5′ nuclease assay. Genet Anal. 1999;14:143–9.
   PubMedGoogle Scholar
• Ida A, Tsuji Y, Muranaka J, Kanazawa R, Nakata Y, Adachi S, . IL-18 in pregnancy; the elevation of IL-18 in maternal peripheral blood during labour and complicated pregnancies. J Reprod Immunol. 2000;47:65–74.
   PubMed Web of Science ®Google Scholar
• Kashef MA, Dehaghani AS, Naeimi S, Fattahi MJ, Ghaderi A. Interleukin-18 gene promoter polymorphisms in women with gestational trophoblastic diseases. J Reprod Med. 2008; 53:853–9.
   PubMedGoogle Scholar
• Li J, Ji L. Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity. 2005; 95:221–7.
   PubMed Web of Science ®Google Scholar
• Nyholt DR. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet. 2004;74:765–9.
   PubMed Web of Science ®Google Scholar
• Stephens M, Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet. 2003;73:1162–9.
   PubMed Web of Science ®Google Scholar
• Hernesniemi JA, Karhunen PJ, Oksala N, Kähönen M, Levula M, Rontu R, . Interleukin 18 gene promoter polymorphism: a link between hypertension and pre-hospital sudden cardiac death: the Helsinki Sudden Death Study. Eur Heart J. 2009;30:2939–46.
   PubMed Web of Science ®Google Scholar
• Shaw LJ, Bairey Merz CN, Pepine CJ, Reis SE, Bittner V, Kelsey SF, . Insights from the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part I: gender differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategies. J Am Coll Cardiol. 2006;47(3 Suppl):S4–20.
   Google Scholar
• Juonala M, Järvisalo MJ, Mäki-Torkko N, Kähönen M, Viikari JS, Raitakari OT. Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the Cardiovascular Risk in Young Finns Study. Circulation. 2005; 112:1486–93.
   PubMed Web of Science ®Google Scholar