Exploring Pathogenetic Mechanisms Using Transgenic Animals

References

• Connelly C S, Fahl W E, Iannaccone P M. The role of transgenic animals in the analysis of various biological aspects of normal and pathologic states. Exp Cell Res 1989; 183: 257–76
   PubMed Web of Science ®Google Scholar
• Brinster R L, Chen H Y, Messing A, van Dyke T, Levfne A J, Palmiter R D. Transgenic mice harboring SV 40 T-antigen genes develop characteristic brain tumors. Cell 1984; 37: 367–79
   PubMed Web of Science ®Google Scholar
• Iannaccone P M, Weinberg W C, Deamant F D. On the clonal origin of tumors: a review of experimental models. Int J Cancer 1987; 39: 778–84
   PubMedGoogle Scholar
• Suda Y, Aizawa S, Furuta Y, et al. Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene (Val659-Glu659). EMBO J 1990; 9: 181–90
   PubMed Web of Science ®Google Scholar
• Dunsford H A, Sell S, Chisari F V. Mepatocarcinogenesis due to chronic liver injury in hepatitis B virus transgenic mice. Cancer Res 1990; 50: 3400–7
   PubMed Web of Science ®Google Scholar
• Yang J T, Liu C Z, Iannaccone P M. HPV-16 genomic sequences cause carcinoma formation in transgenic mice. Proc AACR 1992; 33: 182
   Google Scholar
• Quaife C J, Pinkert C A, Ornitz D M, Palmiter R D, Brinster R L. Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice. Cell 1987; 48: 1023–34
   PubMed Web of Science ®Google Scholar
• Moriyama T, Guilhot S, Klopchin K, et al. Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science 1990; 248: 361–4
   PubMed Web of Science ®Google Scholar
• Chisari F V, Klopchin K, Moriyama T, et al. Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 1989; 59: 1145–56
   PubMed Web of Science ®Google Scholar
• Jhappan C, Stable C, Harkins R H, Fausto N, Smith G H, Mertino G T. TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 1990; 61: 1137–46
   PubMed Web of Science ®Google Scholar
• Matsui A P, Halter S A, Holt J T, Hogan B L, Coffey R J. Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. Cell 1990; 61: 1147–55
   PubMed Web of Science ®Google Scholar
• Sandgren E P, Luetteke N C, Palmiter R D, Brinster R L, Lee D C. Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell 1990; 61: 1121–35
   PubMed Web of Science ®Google Scholar
• Dyer K R, Messing A. A metal-inducible pathology in the liver, pancreas, and kidney of transgenic mice expressing SV 40 early region genes. Am J Pathol 1989; 135: 401–10
   PubMedGoogle Scholar
• Ceci J D, Kovatch R M, Swing D A, et al. Transgenic mice carrying a murine amylase 2.2/SV 40 T antigen fusion gene develop pancreatic acinar cell and stomach carcinomas. Oncogene 1991; 6: 323–32
   PubMedGoogle Scholar
• Levine D S, Sanchez C A, Rabinovitch P S, Reid B J. Formation of the tertraploid intermediate is associated with the development of cells with more than four centrioles in the elastase-simian virus 40 tumor antigen transgenic mouse model of pancreatic cancer. Proc Natl Acad Sci USA 1991; 88: 6427–31
   PubMed Web of Science ®Google Scholar
• Barbacid M. ras Genes. Annu Rev Biochem 1987; 56: 779–827
   PubMed Web of Science ®Google Scholar
• Ng Y K, Radosevich J, Bauer K, Iannaccone P M. Spatio-temporal changes in H-ras p21 expression through the hepatocyte cell cycle during liver regeneration. Dev Biol 1992; 150: 352–62
   PubMedGoogle Scholar
• Wilkinson W O, Sandgren E P, Palmiter R D, Brinster R L, Bell R M. Elevation of 1,2-diacylglycerol in ras-transformed neonatal liver and pancreas of transgenic mice. Oncogene 1989; 4: 625–8
   PubMedGoogle Scholar
• Yang J T, Liu C Z, Kim J Y, Wolinsky S M, Iannaccone P M. HPV 16 genes are sufficient for carcinogenesis in transgenic mice. J Cell Biol 1991; 115: 226a
   Google Scholar
• Pfister H. Papillomaviruses and Human Cancer. CRC Press, Boca Raton 1990
   Google Scholar
• Choo K B, Chang K Y, Liew L N, Hsu H C, Cheng W T. Unregulated and basal transcriptional activities of the regulatory sequence of the type 18 human papillomavirus genome in transgenic mice. Virology 1992; 188: 378–83
   PubMedGoogle Scholar
• Cardiff R D, Sinn E, Muller W, Leder P. Transgenic oncogene mice. Tumor phenotype predicts genotype. Am J Pathol 1991; 139: 495–501
   PubMedGoogle Scholar
• Kwan H, Pecenka V, Tsukamoto A, et al. Transgenes expressing the wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Mol Cell Biol 1991; 12: 147–54
   Google Scholar
• Oldstone M B, Nerenberg M, Southern P, Proce J, Lewicki H. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune responses. Cell 1991; 65: 319–31
   PubMed Web of Science ®Google Scholar
• Ohashi P S, Oehen S, Buerki K, et al. Ablation of 'tolerance' and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 1991; 65: 305–17
   PubMed Web of Science ®Google Scholar
• Bohme J, Haskins K, Stecha P, et al. Transgenic mice with I-A on islet cells are normaglycemic but immunologically intolerant. Science 1989; 244: 1179–83
   PubMed Web of Science ®Google Scholar
• Bohme J, Schuhbaur B, Kanagawa O, Benoist C, Mathis D. MHC-linked protection from diabetes dissociated from clonal deletion of T cells. Science 1990; 249: 293–5
   PubMed Web of Science ®Google Scholar
• Reich E P, Sherwln R S, Kanagawa O, Janeway C A, Jr. An explanation of the protective effect of the MHC class II I-E molecule in murine diabetes. Nature 1989; 341: 326–8
   PubMed Web of Science ®Google Scholar
• Sarvetnick N, Shizuru J, Liggitt D, et al. Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma. Nature 1990; 346: 844–7
   PubMed Web of Science ®Google Scholar
• Hofmann S L, Russell D W, Brown M S, Goldstein J L, Hammer R E. Overexpression of low density lipoprotein (LDL) receptors eliminates LDL from plasma in transgenic mice. Science 1988; 239: 1277–81
   PubMed Web of Science ®Google Scholar
• Hofmann S L, Eaton D L, Brown M S, McConathy W J, Goldstein J L, Hammer R E. Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice. J Clin Invest 1990; 85: 1542–7
   PubMed Web of Science ®Google Scholar
• Pathak R K, Yokode M, Hammer R E, et al. Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice. J Cell Biol 1990; 111: 347–59
   PubMedGoogle Scholar
• Yokode M, Hammer R E, Ishibashi S, Brown M S, Goldstein J L. Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors. Science 1990; 250: 1273–5
   PubMed Web of Science ®Google Scholar
• Rubin E M, Krauss R M, Spangler E A, Verstuyft J G, Clift S M. Inhibition of early atherogenesis in transgenic mice by human apoliprotein Al. Nature 1991; 353: 265–7
   PubMed Web of Science ®Google Scholar
• Kuehn M R, Bradley A, Robertson E J, Evans M J. A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature 1987; 326: 295–8
   PubMed Web of Science ®Google Scholar
• Dunnett S B, Sirinathsinghji D J, Heavens R, Rogers D C, Kuehn M R. Monoamine deficiency in a transgenic (Hprt-) mouse model of Lesch-Nyhan syndrome. Brain Res 1989; 501: 401–6
   PubMedGoogle Scholar
• Tsukamoto A S, Grosscheid R, Guzman R C, Parslow T, Varmus H E. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 1988; 55: 619–25
   PubMed Web of Science ®Google Scholar
• McMahon A P, Bradley A. The wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 1990; 62: 1073–85
   PubMed Web of Science ®Google Scholar
• Thomas K R, Capecchi M R. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 1990; 346: 847–50
   PubMed Web of Science ®Google Scholar
• Joyner A L, Skarnes W C, Rossant J. Production of a mutation in mouse en-2 gene by homologous recombination in embryonic stem cells. Nature 1989; 338: 153–5
   PubMedGoogle Scholar
• Joyner A, Herrup K, Auerbach B A, Davis C A, Rossant J. Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the en-2 homeobox. Science 1991; 251: 1239–43
   PubMed Web of Science ®Google Scholar
• Orenic T V, Slusarski D C, Kroll K L, Holmgren R A. Cloning and characterization of the segment polarity gene cubitus interruptus dominant of Drosophila. Genes Dev 1990; 4: 1053–67
   PubMedGoogle Scholar
• Ruppert J M, Vogelstein B, Kinzier K W. The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A. Mol Cell Biol 1991; 11: 1724–8
   PubMedGoogle Scholar
• Walterhouse D, Ahmed M, Slusarski D, et al, gli, a putative zinc finger transcription factor, is expressed in a segmental pattern during normal mouse development Devel Dynamics.
   Google Scholar
• Walterhouse D, Ahmed M, Kalamaras J, et al. The oncogene gli is expressed during normal embryonic development in the mouse. Proc AACR 1992; 33: 371
   Google Scholar
• Ahmed W, Walterhouse D, Kalamaras J, et al. Expression of the putative oncogene Gli during mouse embryogenesis. J Cell Biol 1991; 115: 146a
   Google Scholar
• Vortkamp A, Gessler M, Grzeschik K-H. GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families. Nature 1991; 352: 539–40
   PubMed Web of Science ®Google Scholar
• Shine H D, Readhead C, Popko B, Hood L, Sidman R L. Morphometric analysis of normal, mutant, and transgenic CNS: correlation of myelin basic protein expression to myelogenesis. J Neurochem 1991; 58: 342–9
   Google Scholar
• Weinberg W C, Deamant F D, Lannaccone P M. Patterns of expression of class I antigens in the tissues of congenic strains of rat. Hybridoma 1985; 4: 27–36
   PubMedGoogle Scholar
• Turniey A M, Morahan G, Okano H, et al. Dysmyelination in transgenic mice resulting from expression of class I histocompatibility molecules in oligodendrocytes. Nature 1991; 353: 503–5
   PubMedGoogle Scholar
• Readhead C, Hood L. The demyelinating mouse mutations shiverer (shi) and myelin deficiency (shimld). Behav Genet 1990; 20: 213–34
   PubMed Web of Science ®Google Scholar
• Kimura M, Sato M, Akatsuka A, et al. Restoration of myelin formation by single type of myelin basic protein in transgenic shiverer mice. Proc Natl Acad Sci USA 1989; 86: 5661–5
   PubMedGoogle Scholar
• Scarpelli D G, Iannaccone P M. Cell injury and genetic diseases. Anderson's Pathology, J M Kissane. C.V. Mosby, St Louis 1990; 1–65
   Google Scholar
• Kyle J W, Birkenmeier E H, Gwynn B, et al. Correction of murine mucopolysaccharidosis VII by a human betaglucuronidase transgene. Proc Natl Acad Sci USA 1990; 87: 3914–8
   PubMed Web of Science ®Google Scholar
• Behringer R R, Mathews L S, Palmiter R D, Brinster R L. Dwarf mice produced by genetic ablation of growth hormone-expressing cells. Genes Dev 1988; 2: 453–61
   PubMed Web of Science ®Google Scholar
• Behringer R R, Lewin T M, Quaife C J, Palmiter R D, Brinster R L, D'Ercole A J. Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic mice. Endocrinology 1990; 127: 1033–40
   PubMed Web of Science ®Google Scholar
• Shea B T, Hammer R E, Brinster R L. Growth allometry of the organs in giant transgenic mice. Endocrinology 1987; 121: 1924–30
   PubMedGoogle Scholar
• Vize P D, Michalska A E, Ashman R, et al. Introduction of a porcine growth hormone fusion gene into transgenic pigs promotes growth. J Cell Sci 1988; 90: 295–300
   PubMed Web of Science ®Google Scholar
• Bartke A, Steger R W, Hodges S L, et al. Infertility in transgenic female mice with human growth hormone expression: evidence for luteal failure. J Exp Zool 1988; 248: 121–4
   PubMedGoogle Scholar