29
Views
38
CrossRef citations to date
0
Altmetric
Miscellaneous Article

Nitric Oxide in Cardiovascular Diseases

, &
Pages 343-351 | Published online: 08 Jul 2009

References

  • Moncada S. The L-arginine: nitric oxide pathway. Acta Physiol Scand 1992; 145: 201–27
  • Furchgott R F, Zawadzki J V. The obligatory role of endothelial cells in the relaxation o1 arterial smooth muscle by acetylcholine. Nature 1980; 288: 373–6
  • Furchgott R F. Studies on relaxation of rabbit aorta by sodium nitrite: the basis for the proposal that the acid activatable factor from bovine retractor penis is inorganic nitrite and the endothelium-derived relaxing factor is nitric oxide. Mechanisms of Vasodilatation, P M Vanhoutte. Raven, New York 1988; 401–14
  • Ignarro L J, Byrns R E, Wood K S. Biochemical and pharmacological properties of endothelium-derived relaxing factor and its similarity to nitric oxide radical. Mechanisms of Vasodilatation, P M Vanhoutte. Raven, New York 1988; 427–35
  • Palmer R MJ, Ferrige A G, Moncada S. Nitric oxide accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524–6
  • Sessa W C, Pritchard K, Seyedi N, Wang J, Hintze T H. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res 1994; 74: 349–53
  • Schmidt H HHW, Zernikow B, Baeblich S, Böhme E. Basal and stimulated formation and release of L-arginine-derived nitrogen oxides from cultured endothelial cells. J Pharmacol Exp Ther 1990; 254: 591–7
  • Weiner C P, Lizasoain I, Baylis S A, Knowles R G, Charles I C, Moncada S. Induction of calcium-dependent nitric oxide synthase by sex hormones. Proc Natl Acad Sci USA 1994; 91: 5212–6
  • Rees D D, Palmer R MJ, Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Nail Acad Sci USA 1989; 86: 3375–8
  • Vallance P, Collier J, Moncada S. Effects of endothelium derived nitric oxide on peripheral arteriolar tone in man. Lancet 1989; ii: 997–1000
  • Radomski M W, Palmer R MJ, Moncada S. An L-arginine to nitric oxide pathway in human platelets regulates aggregation. Proc Natl Acad Sci USA 1990; 87: 5193–7
  • Rees D D, Palmer R MJ, Hodson H, Moncada S. A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation. Br J Pharmacol 1989; 96: 418–24
  • Palmer R MJ, Bridge L, Foxwell N A, Moncada S. The role of nitric oxide in endothelial damage and its inhibition by glucocorticoids. Br J Pharmacol 1992; 105: 11–12
  • Blot S, Arnal J F, Xu Y, Gray F, Michel J-B. Spinal cord infarcts during long-term inhibition of nitric oxide synthase in rats. Stroke 1994; 25: 1666–73
  • Dubey R K, Lüscher T F. Nitric oxide inhibits angiotensin II-induced migration of vascular smooth muscle cells. Hypertension 1993; 22: 412
  • Lüscher T F, Vanhoutte P M. Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension 1986; 8: 344–8
  • Dohi Y, Thiel M A, Buhler F R, Lüscher T F. Activation of the endothelial L-arginine pathway in pressurized mesenteric resistance arteries: effect of age and hypertension. Hypertension 1990; 15: 170–9
  • Lüscher T F. Endothelium-derived nitric oxide: the endogenous nitrovasodilator in the human cardiovascular system. Eur Heart J 1991; 12(Suppl E)2–11
  • Tschudi M R, Crisclone L, Lüscher T F. Effect of aging and hypertension on endothelial function of rat coronary arteries. J Hypertension 1991; 9: 164–5
  • Kelm M, Feelisch M, Krebber T, Motz W, Strauer B E. The role of nitric oxide in the regulation of coronary vascular resistance in arterial hypertension: comparison of normotensive and spontaneously hypertensive rats. J Cardio-vasc Pharmacol 1992; 20: 183–6
  • Nava E, Noll G, Lüscher T F. Increased activity of constitutive nitric oxide synthase in cardiac endothelium in spontaneous hypertension. Circulation 1995, (in press)
  • Nava E, Noll G, Lüscher T F. Increased activity of constitutive nitric oxide synthase in hearts from spontaneously hypertensive rats. Circulation 1994; 90: 1–299
  • Nava E, Leone A M, Wiklund N P, Moncada S. Detection of release of nitric oxide by vasoactive substances in the anaesthesized rat. The Biology of Nitric Oxide, M Feelisch, R Busse, S Moncada. Portland Press, London 1994; 179–80
  • Nava E, Moreau P, Lüscher T F. Basal production of nitric oxide is increased, but inefficacious in spontaneous hypertension. Circ Res 1995, (in press)
  • Nakazono K, Watanabe N, Matsuno K, Sasaki J, Sato T. Does superoxide underlie the pathogenesis of hypertension?. Proc Natl Acad Sci USA 1991; 88: 10045–8
  • Lüscher T F, Vanhoutte P M. Mechanisms of altered endothelium-dependent responses in hypertensive blood vessels. Relaxing and Contracting Factors, P M Vanhoutte. Humana Press, Clifton, NJ 1988; 495–509
  • Lüscher T F, Raij L, Vanhoutte P M. Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats. Hypertension 1987; 9: 157–63
  • Calver A, Collier J, Moncada S, Vallance P. Effect of local intra-arterial NQ-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal. J Hypertens 1992; 10: 1025–31
  • Under L, Kiowski W, Bühler F R, Lüscher T F. Indirect evidence for the release of endothelium-derived relaxing factor in human forearm circulation in vivo: blunted response in essential hypertension. Circulation 1990; 81: 1762–7
  • Panza J A, Casino P R, Kilcoyne C M, Quyyumi A A. Role of endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation 1993; 87: 1468–74
  • Taddei S, Virdis A, Mattel P, Salvetti A. Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension 1993; 21: 929–33
  • Cockcroft J R, Chowlenczyk P J, Benjamin N, Ritter J M. Preserved endothelium-dependent vasodilation in patients with essential hypertension. N Engl J Med 1994; 330: 1036–40
  • Salazar F J, Alberola A, Pinilla J M, Romero J C, Quesada T. Salt-induced increase in arterial pressure during nitric oxide synthesis inhibition. Hypertension 1993; 22: 49–55
  • Lahera V, Salom M G, Miranda Guardiola F, Moncada S, Romero J C. Effects of N-nitro-L-arginine methyl ester on renal function and blood pressure. Am J Physiol 1991; 261: F1033–7
  • Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992; 329: 572–5
  • Gustafsson S SE, Leone A M, Persson M G, Wiklund N P, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun 1991; 181: 852–7
  • Leone A M, Gustafsson S E, Francis P L, Persson M G, Wiklund N P, Moncada S. Nitric oxide is present in exhaled breath in humans: direct GC-MS confirmation. Biochem Biophys Res Commun 1994; 201: 883–7
  • Wiklund N P, Persson M G, Gustafsson L E, Moncada S, Hedqvist P. Modulatory role of endogenous nitric oxide in pulmonary circulation in vivo. Eur J Pharmacol 1990; 185: 123–4
  • Roberts J D, Polanger D M, Lang P, Zapol W M. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lance 1992; 340: 818–9
  • Kinsella J P, Nelsh S R, Shaffer E, Arman S H. Low dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992; 340: 819–20
  • Roberts J D, Lang P, Bigatello L M, Viahakes G J, Zapol W M. Inhaled nitric oxide in congenital heart disease. Circulation 1993; 87: 447–53
  • Pepke-Zaba J, Higenbottam T X, TuanDinh-Xuan A, Stone D, Wallwork J. Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Lancet 1991; 338: 1173–4
  • Blomqvist H, Wickerts C J, Andreen M, Ullberg U, Ortqvist A, Frostell C. Enhanced pneumonia resolution by inhalation of nitric oxide. Acta Anaesthesiol Scand 1993; 37: 110–4
  • Adatia I, Thomson J, Landzberg M, Wessel D. Inhaled nitric oxide in chronic obstructive lung disease. Lancet 1993; 341: 307–8
  • Bierman E L. Atherosclerosis and other forms of atherosclerosis. Harrison's Principles of Internal Medicine, 12th edn., Wilson, et al. McGraw-Hill, New York 1991; 992–1001
  • Woolf N. Pathology of atherosclerosis. Br Med Bull 1990; 46: 960–85
  • Clozel M, Kuhn H, Hefti F. Effects of angiotensin converting enzyme inhibitors and of hydralazine in hypertensive rats. Hypertension 1990; 16: 532–40
  • Lüscher T F. The endothelium as a target and mediator of cardiovascular disease. Eur J Clin Invest 1993; 23: 670–85
  • Osborne J A, Siegman M J, Sedar A W, Mooers S U, Lefer A M. Lack of endothelium-dependent relaxation in coronary arteries of cholesterol-fed rabbits. Am J Physiol 1989; 256: C591–7
  • Chester A H, O'Nell G S, Moncada S, Tadjkarimi S, Yacoub M H. Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries. Lancet 1990; 336: 897–900
  • Verbeuren T J, Jordaens F H, Van Hove C E, Herman A G. Release and vascular activity of endothelium-derived relaxing factor in atherosclerotic rabbit aorta. Eur J Pharmacol 1990; 191: 173–84
  • Guerra R, Jr, Brotherton A F, Goodwin P J, Clark C R, Armstrong M L, Harrison D G. Mechanisms of abnormal endothelium-dependent vascular relaxation in atherosclerosis: implications for altered autocrine and paracrine functions of EDRF. Blood Vessels 1989; 26: 300–14
  • Ylä-Hertuala S, Paliuski W, Rosenfeld M E, et al. Evidence for the presence of oxidatively modified low-density lipoproteins in atherosclerotic lesions of rabbit and man. J Clin Invest 1989; 84: 1086
  • Tanner F C, Noll G, Boulanger C M, Lüscher T F. Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide. Circulation 1991; 83: 2112–20
  • Minor R L, Jr, Myers P R, Guerra R, Jr, Bates J N, Harrison D G. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest 1990; 86: 2109–16
  • Mügge A, Elwell J H, Peterson T E, Harrison D G. Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity. Am J Physiol 1991; 260: 219–25
  • Ohara Y, Peterson T E, Harrison D G. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993; 91: 2546–51
  • Mügge A, Elwell J H, Peterson T E, Hofmeyer T G, Helstad D D, Harrison D G. Chronic treatment with polethylene glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits. Circ Res 1991; 69: 1293–300
  • Girerd X J, Hirsch A T, Cooke J P, Dzau V J, Creager M A. L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. Circ Res 1990; 67: 1301–8
  • Drexler H, Zelher A M, Meinzer K, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolemic patients by L-arginine. Lancet 1991; 338: 1546–50
  • Panza J A, Casino P R, Badar D M, Quyyumi A A. Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension. Circulation 1993; 87: 1475–81
  • Amezcua J L, Palmer R MJ, Souza B M, Moncada S. Nitric oxide synthesized from L-arginine regulates vascular tone in the coronary circulation of the rabbit. Br J Pharmacol 1989; 97: 1119–24
  • Schulz R, Smith J A, Lewis M J, Moncada S. Nitric oxide synthase in cultured endocardial cells of the pig. Br J Pharmacol 1991; 104: 21–4
  • Schulz R, Nava E, Moncada S. Induction and potential biological relevance of a Ca2+-independent nitric oxide synthase in the myocardium. Br J Pharmacol 1992; 105: 575–80
  • Belder A J, Radomski M W, Why H JF, et al. Nitric oxide synthase activities in human myocardium. Lancet 1993; 341: 84–5
  • Grocott-Mason R, Fort S, Lewis M J, Shah A M. Myocardial relaxant effect of exogenous nitric oxide in isolated ejecting hearts. Am J Physiol 1994; 266: 1699–705
  • Balligand J L, Kelly R A, Marsden P A, Smith T W, Michel T. Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc Natl Acad Sci USA 1993; 90: 347–51
  • Smith J A, Radomski M W, Schulz R, Moncada S, Lewis M J. Porcine ventricular endocardial cells in culture express the inducible form of nitric oxide synthase. Br J Pharmacol 1993; 108: 1107–10
  • Hosenpud J D, Campbell S M, Mendelson D J. Interleukin-1-induced myocardial depression in isolated beating heart preparations. J Heart Transplant 1989; 8: 460–4
  • Sobotka P A, McMannis J, Fisher R I, Stein D G, Thomas J Z, Jr. Effects of interleukin-2 on cardiac function in the isolated rat heart. J Clin Invest 1990; 86: 845–50
  • Hibbs J B, Jr, Westenfelder C, Taintor R, et al. Evidence for cytokine-inducible nitric oxide synthase from L-arginine in patients receiving interleukin-2 therapy. J Clin Invest 1992; 89: 867–77
  • Nora R, Abrams J S, Tait S, Hiponia D J, Silverman H J. Myocardial toxic effects during recombinant interleukin-2 treatment. J Natl Cancer Inst 1989; 81: 59–63
  • Root R K, Jacobs R. Septicemia and septic shock. Harrison's Principles of Internal Medicine, 12th edn., J D Wilson, et al. McGraw Hill, New York 1991; 502–7
  • Bilifau A, Vandekerchjove F. Cytokines and their interactions with other inflammatory mediators in the pathogenesis of sepsis and septic shock. Eur J Clin Invest 1991; 21: 559–73
  • Nava E, Palmer R MJ, Moncada S. Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?. Lancet 1991; 338: 1555–7
  • Nava E, Palmer R MJ, Moncada S. The role of nitric oxide in endotoxin shock; effects of NG-monomethyl-L-arginine. J Cardiovasc Pharmacol 1992; 20(Suppl 12)S132–4
  • Kilboum R G, Gross S S, Jubran A, et al. NG-methyl-L-arginine inhibits tumour necrosis factor-induced hypotension: implications for the involvement of nitric oxide. Proc Natl Acad Sci USA 1990; 87: 3629–32
  • Wright C E, Rees D D, Moncada S. The protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc Res 1992; 26: 48–57
  • Perren Cobb J, Natanson C, Hoffman W D, et al. Nω-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin. J Exp Med 1992; 176: 1175–82
  • Mulder M F, Van Lambalgen A A, Huisman E, Visser J J, Van den Bos G C, Thijs L G. Protective role of NO in the regional hemodynamic changes during acute endotoxemia in rats. Am J Physiol 1994; 266: H1558–64
  • Petros A, Bennett D, Vallance P. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 1991; 338: 1557–8
  • Petros A, Lamb G, Leone A M, Moncada S, Bennet D, Moncada S. Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc Res 1994; 28: 34–9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.