Nitric Oxide in Inflammation and Immune Response

References

• Moncada S, Palmer R MJ, Higgs E A. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991; 43: 109–42
   PubMed Web of Science ®Google Scholar
• Snyder S H, Bredt D. Biological roles of nitric oxide. Sci Am, 266: 68–77
   Google Scholar
• Moncada S. The L-arginine-nitric oxide pathway. Acta Physiol Scand 1992; 145: 201–27
   PubMedGoogle Scholar
• Stefanovic-Racic M, Stadler J, Evans C H. Nitric oxide and arthritis. Arthritis Rheum 1993; 36: 1036–43
   PubMed Web of Science ®Google Scholar
• Nussler A K, Billiar T R. Inflammation, immunoregulation, and inducible nitric oxide synthase. J Leukoc Biol 1993; 54: 171–8
   PubMed Web of Science ®Google Scholar
• Änggård E. Nitric oxide: mediator, murderer, and medicine. Lancet 1994; 343: 1199–206
   PubMed Web of Science ®Google Scholar
• Palmer R MJ, Ferrige A G, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524–6
   PubMed Web of Science ®Google Scholar
• Palmer R MJ, Ashton D S, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988; 333: 664–6
   PubMed Web of Science ®Google Scholar
• Ignarro L J, Burns R E, Buga G M, Wood K S. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ Res 1987; 61: 866–79
   PubMed Web of Science ®Google Scholar
• Furchgott R F. Studies on relaxation of rabbit aorta by sodium nitrite: the basis for the proposal that the acid-activatable inhibitory factors from retractor penis is inorganic nitrite and the endothelium-derived relaxing factor is nitric oxide. Mechanisms of Vasodilatation, P M Vanhoutte. Raven Press, New York 1988; 401–4
   Google Scholar
• Koshland D E. The molecule of the year (Editorial). Science 1992; 258: 1861
   PubMed Web of Science ®Google Scholar
• Knowles R G, Moncada S. Nitric oxide synthases in mammals. Biochem J 1994; 298: 249–58
   PubMed Web of Science ®Google Scholar
• Förstermann U, Schmidt H HW, Pollock J S, et al. Isoforms of nitric oxide synthase: characterization and purification from different cell types. Biochem Pharmacol 1991; 42: 1849–57
   PubMed Web of Science ®Google Scholar
• Marsden P A, Heng H HQ, Scherer S W, et al. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem 1993; 268: 17478–88
   PubMed Web of Science ®Google Scholar
• Doyle A G, Herbein G, Montaner U, et al. lnterleukin-13 alters the activation state of murine macrophages in vitro: comparison with interleukin-4 and interferon-gamma. Eur J Immunol 1994; 24: 1441–5
   PubMed Web of Science ®Google Scholar
• Palmer R MJ, Rees D D, Ashton D S, Moncada S. L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun 1988; 153: 1251–6
   PubMed Web of Science ®Google Scholar
• Rogers N E, Ignarro L T. Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine. Biochem Biophys Res Commun 1992; 189: 242–9
   PubMed Web of Science ®Google Scholar
• Assreuy J, Cunha F Q, Liew F Y, Moncada S. Feedback inhibition of nitric oxide synthase activity by nitric oxide. Br J Pharmacol 1993; 108: 833–7
   PubMed Web of Science ®Google Scholar
• Knowles R G, Salter M, Brooks S L, Moncada S. Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat. Biochem Biophys Res Commun 1990; 172: 1042–8
   PubMed Web of Science ®Google Scholar
• Palmer R MJ, Andrews T, Foxwell N A, Moncada S. Glucocorticoids do not affect the induction of a novel calcium-dependent nitric oxide synthase in rabbit chondrocytes. Biochem Biophys Res Commun 1992; 188: 209–15
   Google Scholar
• Ignarro L J, Fukuto J M, Griscavage J M, Rogers N E, Byrns R E. Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci USA 1993; 90: 8103–7
   PubMed Web of Science ®Google Scholar
• Wennmalm Å, Benthin G, Petersson A-S. Dependence of the metabolism of nitric oxide (NO) in healthy human whole blood on the oxygenation of its red cell haemoglobin. Br J Pharmacol 1992; 106: 507–8
   PubMed Web of Science ®Google Scholar
• Wagner D A, Young V R, Tannenbaum S R. Mammalian nitrate biosynthesis: incorporation of 15-NH3 into nitrate is enhanced by endotoxin treatment. Proc Natl Acad Sci USA 1983; 80: 4518–21
   PubMedGoogle Scholar
• Hibbs J B, Westenfelder C, Taintor R, et al. Evidence for cytokine-induced nitric oxide synthesis from L-arginine in patients receiving interleukin-1 therapy. J Clin Invest 1992; 89: 867–77
   PubMed Web of Science ®Google Scholar
• Ochoa J B, Curti B, Peltzman A B, et al. Increased circulating nitrogen oxides after human tumor immunotherapy: correlation with toxic hemodynamic changes. J Natl Cancer Inst 1992; 84: 864–7
   PubMed Web of Science ®Google Scholar
• Ochoa J B, Udekwu A O, Billiar T R, et al. Nitrogen oxide levels in patients following trauma and during sepsis. Ann Surg 1991; 214: 621–6
   PubMed Web of Science ®Google Scholar
• Petros A, Bennett D, Vallance P. Effects of nitric oxide synthase inhibitors on hypertension in patients with septic shock. Lancet 1991; 338: 1557–8
   PubMed Web of Science ®Google Scholar
• Petros A, Lamb G, Leone A, Moncada S, Bennett D, Vallance P. Effects of nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc Res 1994; 28: 34–9
   PubMed Web of Science ®Google Scholar
• Farrell A J, Blake D R, Palmer R MJ, Moncada S. Elevated synovial and serum nitrite suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 1992; 51: 1219–22
   PubMed Web of Science ®Google Scholar
• Stamler J S, Jaraki O, Osborne J, et al. Nitric oxide circulates in mammalian plasma primarily as a S-nitroso adduct of serumalbumin. Proc Natl Acad Sci USA 1992; 89: 7674–7
   PubMed Web of Science ®Google Scholar
• Ignarro L J. Signal transduction mechanisms involving nitric oxide. Biochem Pharmacol 1991; 41: 485–90
   PubMed Web of Science ®Google Scholar
• Lepoivre M, Chanais B, Yapo A, Lemaire G, Thelander L, Tenu J P. Alteration of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells. J Biol Chem 1990; 265: 14143–9
   PubMed Web of Science ®Google Scholar
• Kwon N S, Stuehr D J, Nathan C F. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J Exp Med 1991; 174: 761–7
   PubMed Web of Science ®Google Scholar
• Drapier J-C, Hibbs J B. Differentation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulphur enzymes in the macrophage effector cells. J Immunol 1988; 140: 2829–38
   PubMed Web of Science ®Google Scholar
• Wink D A, Osawa Y, Darbyshire J F, Jones C R, Eshenaus S C, Nims R W. Inhibition of cytochromes P-450 by nitric oxide and a nitric oxide-releasing agent. Arch Biochem Biophys, 300: 115–23
   Google Scholar
• Kanner J, Harel S, Granit R. Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin. Lipids 1992; 27: 46–9
   PubMed Web of Science ®Google Scholar
• Clancy R M, Leszczynska-Piziak J, Abramson S B. Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase. J Clin Invest 1992; 90: 1116–21
   PubMed Web of Science ®Google Scholar
• Molina y Vedia L, McDonald B, Reep B, et al. Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J Biol Chem 1992; 267: 24929–32
   PubMed Web of Science ®Google Scholar
• Dimmeler S, Ankarcrona M, Nicotera P, Brune B. Exogenous nitric oxide (NO) generation or IL-1a-induced intracellular NO production stimulates inhibitory auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase in RINm5F cells. J Immunol 1993; 150: 2964–71
   PubMed Web of Science ®Google Scholar
• Salvemini D, Misko T P, Masferrer J L, Seibert K, Currie M G, Needleman P. Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci USA 1993; 90: 7240–4
   PubMed Web of Science ®Google Scholar
• Inoue T, Fukuo K, Morimoto S, Koh E, Ogihara T. Nitric oxide mediates interleukin-1-induced prostaglandin E2 production by vascular smooth muscle cells. Biochem Biophys Res Commun 1993; 194: 420–4
   PubMed Web of Science ®Google Scholar
• Corbett J A, Kwon G, Turk J, McDaniel L. IL-1β induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: Activation of cyclooxygenase by nitric oxide. Biochem J 1993; 32: 13767–70
   Google Scholar
• Franchi A M, Chaud M, Rettori V, Suburo A, McCann S M, Gimeno M. Role of nitric oxide in eicosanoid synthesis and uterine motility in estrogen-treated rat uteri. Proc Natl Acad Sci USA 1994; 91: 539–43
   PubMed Web of Science ®Google Scholar
• Alanko J, Sievi E, Lähteenmäki T, Mucha I, Riutta A, Vapaatalo H. Effects of NO donors, SIN-1 and GEA 3175 on prostacyclin and cGMP synthesis in cultured rat endothelial cells. Agents Actions 1995; 45: 195–9
   Google Scholar
• Beckman J S, Beckman T W, Chen J, Marshall P A, Freeman P A. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990; 87: 1620–4
   PubMed Web of Science ®Google Scholar
• Laszio F, Whittle B JR, Moncada S. Time-dependent enhancement of inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors. Br J Pharmacol 1994; 111: 1309–15
   Google Scholar
• Ialenti A, Ianaro A, Moncada S, Di Rosa M. Modulation of acute inflammation by endogenous nitric oxide. Eur J Pharmacol 1992; 211: 177–82
   PubMed Web of Science ®Google Scholar
• Teixeira M M, Williams T J, Hellewell P G. Role of prostaglandins and nitric oxide in acute inflammatory reactions in guinea-pig skin. Br J Pharmacol 1993; 110: 1515–21
   PubMed Web of Science ®Google Scholar
• Warren J G. Nitric oxide and human skin blood flow responses to acetylcholine and ultraviolet light. FASEB J 1994; 8: 247–51
   PubMed Web of Science ®Google Scholar
• Nathan C, Hibbs J B. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 1991; 3: 65–70
   PubMed Web of Science ®Google Scholar
• Langrehr J M, Hoffman R A, Lancaster J R, Simmons R L. Nitric oxide—a new endogenous immunomodulator. Transplantation 1993; 55: 1205–12
   PubMed Web of Science ®Google Scholar
• Karupiah G, Xie Q W, Buller R M, Nathan C, Duarte C, Mac Micking J D. Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science 1993; 261: 1445–8
   PubMed Web of Science ®Google Scholar
• Malawista S E, Montgomery R R, van Blaricom G. Evidence of reactive nitrogen mediates in killing of staphylococci by human neutrophil cytoblasts: a new microbicidal pathway for human polymorphonuclear leukocytes. J Clin Invest 1992; 90: 631–6
   PubMed Web of Science ®Google Scholar
• Feng H M, Popov V L, Walker D H. Depletion of gamma interferon and tumor necrosis factor alpha in mice with Rickettsia conorii-infected endothelium: impairment of rickettsicidal nitric oxide production resulting in fatal, overwhelming rickettsial disease. Infect Immunol 1994; 62: 1952–60
   PubMed Web of Science ®Google Scholar
• Seguin M C, Klotz F W, Schneider I, et al. Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interferon gamma and CD8+ T cells. J Exp Med 1994; 180: 353–8
   PubMed Web of Science ®Google Scholar
• Gregory S H, Wing E J, Hoffman R A, Simmons R L. Reactive nitrogen intermediates suppress the primary immunologic response to Listeria. J Immunol 1993; 150: 2901–9
   Google Scholar
• Corbett J A, Lancaster J R, Jr, Sweetland M A, McDaniel M L. Interleukin-1 α-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans: role of nitric oxide in interleukin-1α-induced inhibition of insulin secretion. J Biol Chem 1991; 266: 21351–4
   PubMed Web of Science ®Google Scholar
• Corbett J A, Wang J L, Hughes J H, et al. Nitric oxide and cGMP formation induced by interleukin-1α in islets of Langerhans: Evidence for an effector role of nitric oxide in islet dysfunction. Biochem J 1992; 287: 229–35
   PubMed Web of Science ®Google Scholar
• Weinberg J B, Granger D L, Pisetsky D S, et al. The role of nitric oxide in the pathogenesis of spontaneuos murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice and reduction of spontaneous glomerulonephritis and arthritis by orally administered N-monomethyl-L-arginine. J Exp Med 1994; 179: 651–60
   PubMed Web of Science ®Google Scholar
• Langrehr J M, Murase N, Markus P M, et al. Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat. J Clin Invest 1992; 90: 679–83
   PubMed Web of Science ®Google Scholar
• Garside P, Hutton A K, Severn A, Liew F Y, Mowat A M. Nitric oxide mediates intestinal pathology in graft-vs.-host disease. Eur J Immunol 1992; 22: 2141–5
   PubMed Web of Science ®Google Scholar
• Hoffman R A, Langrehr J M, Dull K E, Simmons R L. Nitric oxide production by mouse sponge matrix allograft-infiltrating cells. Comparison with the rat species. Transplantation 1993; 55: 591–6
   Google Scholar
• Bermudez L E. Differential mechanisms of intracellular killing of mycobacterium avium and listeria monocytogenes by activated human and murine macrophages. The role of nitric oxide. Clin Exp Immunol 1993; 91: 277–81
   PubMed Web of Science ®Google Scholar
• Schneemann M, Schoedon G, Hofer S, Blau N, Guerrero L, Schaffner A. Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes. J Infect Dis 1993; 167: 1358–63
   PubMedGoogle Scholar
• Mossalayi M D, Paul-Eugene N, Ouaaz F, et al. Involvement of FceRII/CD23 and L-arginine-dependent pathway in IgE-mediated stimulation of human monocyte functions. Int Immunol 1994; 6: 931–4
   PubMed Web of Science ®Google Scholar
• McCall T B, Boughton-Smith N K, Palmer R MJ, Whittle B JR, Moncada S. Synthesis of nitric oxide from L-arginine by neutrophils. Biochem J 1989; 261: 293–6
   PubMed Web of Science ®Google Scholar
• Kolls J, Xie J, LeBlanc R, et al. Rapid induction of messenger RNA for nitric oxide synthase II in rat neutrophils in vivo by endotoxin and its suppression by prednisolone. Proc Soc Exp Biol Med 1994; 205: 220–5
   PubMed Web of Science ®Google Scholar
• McCall T B, Palmer R MJ, Moncada S. Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone. Eur J Immunol 1991; 21: 2523–7
   PubMed Web of Science ®Google Scholar
• Salvemini D, de Nucci G, Gryglewski R J, Vane J R. Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor. Proc Natl Acad Sci USA 1989; 86: 6328–32
   PubMed Web of Science ®Google Scholar
• Nicolini F A, Wilson A C, Mehta P, Mehta J L. Comparative platelet inhibitory effects of human neutrophils and lymphocytes. J Lab Clin Med 1990; 116: 147–52
   PubMed Web of Science ®Google Scholar
• Faint R W, Mackie I J, Machin S J. Platelet aggregation is inhibited by a nitric oxide-like factor released from human neutrophils in vitro. Br J Haematol 1991; 77: 539–45
   PubMed Web of Science ®Google Scholar
• Schmidt H HW, Seifert R, Bohme E. Formation and release of nitric oxide from human neutrophils and HL-60 cells induced by a chemotactic peptide, platelet-activating factor and leukotriene B4. FEBS Lett 1989; 244: 357–60
   PubMed Web of Science ®Google Scholar
• Wright C D, Milsch A, Busse R, Osswald H. Generation of nitric oxide by human neutrophils. Biochem Biophys Res Commun 1989; 160: 813–9
   PubMed Web of Science ®Google Scholar
• Goode H F, Webster N R, Howdle P D, Walker B E. Nitric oxide production by human peripheral blood polymorphonuclear leucocytes. Clin Sci (Colch) 1994; 86: 411–5
   Google Scholar
• Wyatt T A, Lincoln T M, Pryzwansky K B. Vimentin is transiently co-localized with and phosphorylated by cyclic GMP-dependent protein kinase in formyl-peptide-stimulated neutrophils. J Biol Chem 1991; 266: 21274–80
   PubMedGoogle Scholar
• Bryant J L, Mehta P, Von der Porten A, Mehta J L. Co-purification of 130 kD nitric oxide synthase and a 22 kD link protein from human neutrophils. Biochem Biophys Res Commun 1992; 189: 558–64
   PubMed Web of Science ®Google Scholar
• Keller R, Keist R, Erb P, et al. Expression of cellular effector functions and production of reactive nitrogen intermediates: a comparative study including T lymphocytes, T-like cells, neutrophil granulocytes and mononuclear phagocytes. Cell Immunol 1990; 131: 398–403
   PubMedGoogle Scholar
• Van Dervort A L, Yan L, Madara P J, et al. Nitric oxide regulates endotoxin-induced TNFα production by human neutrophils. J Immunol 1994; 152: 4102–9
   PubMed Web of Science ®Google Scholar
• Liu J J, Chen J R, Wiley J, Johnston C C, Buxton B F. Inhibition by a stable factor derived from neutrophils of endothelium-dependent relaxation in rat aorta. Am J Physiol 1993; 265: H1454–9
   PubMed Web of Science ®Google Scholar
• Pieper G M, Clarke G A, Gross G J. Stimulatory and inhibitory action of nitric oxide donor agents vs. nitrovasodilators on reactive oxygen production by isolated polymorphonuclear leukocytes. J Pharm Exp Ther 1994; 269: 451–6
   PubMed Web of Science ®Google Scholar
• Belenky S N, Robbins R A, Rennard S I, Gossman G L, Nelson K J, Rubinstein I. Inhibitors of nitric oxide synthase attenuate human neutrophil chemotaxis in vitro. J Lab Clin Med 1993; 122: 388–94
   Google Scholar
• Wyatt T A, Lincoln T M, Pryzwansky K B. Regulation of human neutrophil degranulation by LY-83583 and arginine: role of cGMP-dependent protein kinase. Am J Physiol 1993; 265: C201–11
   Google Scholar
• Ney P, Schröder H, Schrör K. Nitrovasodilator-induced inhibition of LTB4 release from human PMN may be mediated by cyclic GMP. Eicosanoids 1990; 3: 243–5
   Google Scholar
• Schröder H, Ney P, Woditsch I, Schrör K. Cyclic GMP mediates SIN-1-induced inhibition of human polymorphonuclear leukocytes. Eur J Pharmacol 1990; 182: 211–8
   Google Scholar
• Darius H, Grodzinska L, Meyer J. The effects of nitric oxide donors molsidomine and SIN-1 on human polymorphonuclear leukocyte function in vitro and ex vivo. Eur J Clin Pharmacol 1992; 43: 629–33
   Google Scholar
• Siminiak T, Zozulinska D, Wysocki H. Inhibition of polymorphonuclear neutrophil function by nitric oxide donor SIN-1 in vitro; relationship to the presence of platelets. Pharmacol Commun 1992; 2: 217–24
   Google Scholar
• Moilanen E, Vuorinen P, Kankaanranta H, Metsä-Ketelä T, Vapaatalo H. Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions. Br J Pharmacol 1993; 109: 852–8
   PubMed Web of Science ®Google Scholar
• Clancy R M, Leszczynska-Piziak J, Abramson S B. Nitric oxide stimulates the ADP-ribosylation of actin in human neutrophils. Biochem Biophys Res Commun 1993; 191: 847–52
   Google Scholar
• Cooke J P, Tsao P S. Cytoprotective effects of nitric oxide. Circulation 1993; 88: 2451–4
   PubMed Web of Science ®Google Scholar
• Pohl U, Busse R. EDRF increases cyclic GMP in platelets during passage through the coronary vascular bed. Circ Res 1989; 65: 1798–803
   PubMed Web of Science ®Google Scholar
• Radomski M W, Palmer R MJ, Moncada S. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 1990; 87: 5293–7
   Google Scholar
• Bath P MW, Hassall D G, Gladwin A-M, Palmer R MJ, Martin J F. Nitric oxide and prostacyclin: divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro. Arterioscler Thromb 1991; 11: 254–60
   PubMed Web of Science ®Google Scholar
• Kubes P S, Suzuki M, Granger D N. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991; 88: 4651–5
   PubMed Web of Science ®Google Scholar
• Tsao P S, Lefer A M. Time course and mechanism of endothelial dysfunction in isolated ischemic and hypoxic perfused rat hearts. Am J Physiol 1990; 259: H1660–6
   PubMedGoogle Scholar
• Moilanen E, Arola O, Malo-Ranta U, . Nitric oxide-donors inhibit neutrophil adhesion to endothelial cells. The Biology of Nitric Oxide, S Moncada, M Feelish, R Busse, E A Higgs, et al, 1994; Vol 4: 271–5
   Google Scholar
• Ma X-I, Weyrich A S, Lefer D J, Lefer A M. Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium. Circ Res 1993; 72: 403–12
   PubMed Web of Science ®Google Scholar
• Lefer D J, Nakanishi K, Johnston W E, Vinten-Johansen J. Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion in dogs. Circulation 1993; 88: 2337–50
   PubMed Web of Science ®Google Scholar
• Albina J E, Abate J A, Henry W L. Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation: role of IFN-gamma in the induction of nitric oxide synthesizing pathway. J Immunol 1991; 147: 1441–8
   Google Scholar
• Mills C D. Molecular basis of 'suppressor' macrophages: arginine metabolism via the nitric oxide synthase pathway. J Immunol 1991; 146: 2719–23
   PubMed Web of Science ®Google Scholar
• Lejeune P, Lagadec P, Onier N, Pinard D, Ohshima H, Jeannin J F. Nitric oxide involvement in tumor-induced immunosuppression. J Immunol, 152: 5077–83
   Google Scholar
• Merryman P F, Clancy R M, He X Y, Abramson S B. Modulation of human T cell responses by nitric oxide and its derivative, S-nitrosoglutathone. Arthritis Rheum 1993; 36: 1414–22
   PubMedGoogle Scholar
• Vuorinen P. Exogenous modification of nitrovasodilator-induced cyclic GMP formation in human lymphocytes. Pharmacol Toxicol 1992; 70: 463–7
   Google Scholar
• Lander H M, Sehajpal P, Levine D M, Novogrodsky A. Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds. J Immunol 1993; 150: 1509–16
   PubMedGoogle Scholar
• Lander H M, Sehajpal P K, Novogrodsky A. Nitric oxide signalling: a possible role for G proteins. J Immunol 1993; 151: 7182–7
   PubMed Web of Science ®Google Scholar
• Taylor-Robinson A W, Philips R S, Severn A, Moncada S, Liew F Y. The role of TH1 and TH2 cells in a rodent malaria infection. Science 1931–4; 260
   Google Scholar
• Taylor-Robinson A W, Liew F Y, Severn A, et al. Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. Eur J Immunol 1994; 24: 980–4
   PubMed Web of Science ®Google Scholar
• Isobe K, Nakashima I. Feedback suppression of staphylococcal enterotoxin-stimulated T-lymphocyte proliferation by macrophages through inductive nitric oxide synthesis. Infect Immun 1992; 60: 4832–7
   Google Scholar
• Florquin S, Amraoui Z, Dubois C, Decuyper J, Goldman M. The protective role of endogenously synthesized nitric oxide in staphylococcal enterotoxin B-induced shock in mice. J Exp Med 1994; 180: 1153–8
   PubMed Web of Science ®Google Scholar
• Stefanovic-Racic M, Meyers K, Meschter C, Coffey J W, Hoffman R A, Evans C H. N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats. Arthritis Rheum 1994; 37: 1062–9
   PubMed Web of Science ®Google Scholar
• Stadler J, Stefanovic-Racic M, Billiar T R, et al. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol 1991; 147: 3915–20
   PubMed Web of Science ®Google Scholar
• Charles I G, Palmer R MJ, Hickery M S, et al. Cloning, characterization and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc Natl Acad Sci USA 1993; 90: 11419–23
   PubMed Web of Science ®Google Scholar
• Kondo S, Ishiguro N, Iwata H, Nakashima I, Isobe K. The effects of nitric oxide on chondrocytes and lymphocytes. Biochem Biophys Res Commun 1993; 197: 1431–7
   Google Scholar
• Palmer R MJ, Hickery M S, Charles I G, Moncada S, Bayliss M T. Induction of nitric oxide synthase in human chondrocytes. Biochem Biophys Res Commun 1993; 193: 398–405
   PubMed Web of Science ®Google Scholar
• Järvinen T AH, Moilanen T, Järvinen T LN, Moilanen E. Nitric oxide mediates interleukin-1 induced inhibition of glycosaminoglycan synthesis in rat articular cartilage. Med Inflammation 1995, (in press)
   Google Scholar
• Rediske J J, Koehne C F, Zhang B, Lotz M. The inducible production of nitric oxide by articular cell types. Osteoarthritis Cartilage 1994; 2: 199–206
   Google Scholar
• McCartney-Francis N, Allen J B, Mizel D E, et al. Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med 1993; 178: 749–54
   PubMed Web of Science ®Google Scholar
• Taskiran D, Stefanovic-Racic M, Georgescu H, Evans C. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Commun 1994; 200: 142–8
   PubMed Web of Science ®Google Scholar
• Ialenti A, Moncada S, Di Rosa M. Modulation of adjuvant arthritis by endogenous nitric oxide. Br J Pharmacol 1993; 110: 701–6
   PubMed Web of Science ®Google Scholar
• Oyanagui Y. Nitric oxide and superoxide radical are involved in both initiation and development of adjuvant arthritis in rats. Life Sci 1994; 54: PL285–9
   PubMed Web of Science ®Google Scholar