Hormonal regulation of appetite and food intake

References

• Xavier Pi-Sunyer F. Obesity research and clinical management. Lean times ahead. Odyssey 1997; 3(1)26–33
   Google Scholar
• Nattiv A, Agostini R, Drinkwater B, Yeager K K. The female athlete triad. The inter-relatedness of disordered eating, amenorrhea, and osteoporosis. Clin Sports Med 1994; 13: 405–18
   PubMed Web of Science ®Google Scholar
• Oomura Y, Shimizu N, Miyahara S, Hattori K. Chemo-sensitive neurons in the hypothalamus: do they relate to feeding behavior?. Neural Basis of Feeding and Reward, B Hoebel, D Novin. Haer Institute, Brunswick, ME 1982; 551–66
   Google Scholar
• Brobeck J R, Tepperman J, Long C NH. Experimental hypothalamic hyperphagia in the albino rat. Yale J Biol Med 1943; 15: 831–53
   PubMedGoogle Scholar
• Anand B K, Brobeck J R. Hypothalamic control of food intake in rats and cats. Yale J Biol Med 1951; 24: 123–40
   PubMed Web of Science ®Google Scholar
• Richard D. Involvement of corticotropin-releasing factor in the control of food intake and energy expenditure. Attn N Y Acad Sci 1993; 697: 155–72
   PubMed Web of Science ®Google Scholar
• Burden V R, White B D, Dean R G, Martin R J. Activity of the hypothalamic-pituitary-adrenal axix is elevated in rats with activity-based anorexia. J Nutr 1993; 123: 1217–25
   PubMed Web of Science ®Google Scholar
• Hotta M, Shibasaki T, Masuda A, et al. The response of plasma adrenocorticotropin and Cortisol to corticotropin-releasing hormone (CRH) and cerebrospinal fluid immuno-reactive CRH in anorexia nervosa patients. J Clin Endocrinol Metab 1986; 62: 319–24
   PubMed Web of Science ®Google Scholar
• Doerr P, Fichter M, Pirke K M, Lund R. Relationship between weight gain and hypothalamic pituitary adrenal function in patients with anorexia nervosa. J Steroid Biocbem 1980; 13: 529–37
   PubMedGoogle Scholar
• Villanueva A L, Schlosser C, Hopper B, Liu J H, Hoffman D I, Rebar R W. Increased Cortisol production in women runners. J Clin Endocrinol Metab 1986; 63: 133–6
   PubMed Web of Science ®Google Scholar
• Gibbs J, Smith G P. Satiety: the roles of peptides from the stomach and the intestine. Fed Proc 1986; 45: 1391–5
   PubMedGoogle Scholar
• Ballinger A, McLoughlin L, Medbak S, Clark M. Cholecystokinin is a satiety hormone in humans at physiological post-prandial plasma concentrations. Clin Sci 1995; 89: 375–81
   Web of Science ®Google Scholar
• Geracioti T D, Jr, Liddlc R A. Impaired cholecystokinin secretion in bulimia nervosa. N Engl J Med 1988; 319: 683–8
   PubMed Web of Science ®Google Scholar
• Linden Hirschberg A, Lindholm C, Carlstrom K, von Schoultz B. Reduced serum cholecystokinin response to food intake in female athletes. Metabolism 1994; 43: 217–22
   PubMed Web of Science ®Google Scholar
• Wolkowitz O M, Gertz B, Weingartner H, Beccaria L, Thompson K, Liddle R A. Hunger in humans induced by MK-329, a specific peripheral-type cholecystokinin receptor antagonist. Biol Psychiatry 1990; 28: 169–73
   PubMed Web of Science ®Google Scholar
• Miesncr J, Smith G P, Gibbs J, Tyrka A. Intravenous infusion of CCK -receptor antagonist increases food intake in rats. Am J Physiol 1992; 262: R216–9
   Google Scholar
• Dourish C T, Rycroft W, Iversen S D. Postponement of satiety by blockade of brain cholecystokinin (CCK) receptors. Science 1989; 245: 1509–11
   PubMed Web of Science ®Google Scholar
• Kamilaris T C, Johnson E O, Calogero A E, et al. Cholecystokinin-octapeptide stimulates hypothalamic-pituitary-adrenal function in rats: role of corticotropin-releasing hormone. Endocrinology 1992; 130: 1764–74
   PubMed Web of Science ®Google Scholar
• White J D., Neuropeptide Y. a central regulator of energy homeostasis. Regul Pept 1993; 49: 93–107
   PubMedGoogle Scholar
• Shibasaki T, Oda T, Imaki T, Ling N, Demura H. Injection of anti-neuropeptide Y gamma-globulin into the hypothalamic paraventricular nucleus decreases food intake in rats. Brain Res 1993; 601: 313–6
   PubMed Web of Science ®Google Scholar
• Heinrichs S C, Menzaghi F, Merlo Pich E, Hauger R L, Koob G F. Corticotropin releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y. Brain Res 1993; 611: 18–24
   PubMed Web of Science ®Google Scholar
• Billington C J, Briggs J E, Harker S, Grace M, Levine A S. Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism. Am J Physiol 1994; 266: R1765–70
   PubMed Web of Science ®Google Scholar
• Moltz J H, McDonald J K. Neuropeptide Y: direct and indirect action on insulin secretion in the rat. Peptides 1985; 6: 1155–9
   PubMed Web of Science ®Google Scholar
• Albers H E, Ottenweller J E, Liou S Y, Lumpkin M D, Anderson E R. Neuropeptide Y in the hypothalamus: effect on corticosterone and single-unit activity. Am J Physiol 1990; 258: R376–82
   PubMedGoogle Scholar
• Johnson R D. Opioid involvement in feeding behaviour and the pathogenesis of certain eating disorders. Med Hypotheses 1995; 45: 491–7
   PubMed Web of Science ®Google Scholar
• Drewnowski A, Krahn D D, Demitrack M A, Nairn K, Gosnell B A. Taste responses and preferences for sweet high-fat foods: evidence for opioid involvement. Physiol Behau 1992; 51: 371–9
   PubMed Web of Science ®Google Scholar
• Carr K, Simon E, Papadouka V. The role of multiple opioid receptors in the potentation of reward by food restriction. Brain Res 1994; 639: 253–60
   PubMed Web of Science ®Google Scholar
• Morely J E, Levine A S. Stress-induced eating is mediated through endogenous opiates. Science 1980; 209: 1259–61
   PubMed Web of Science ®Google Scholar
• Lonnqvist E. The obese (oh) gene and its product leptin - a new route toward obesity treatment in man?. Q J Med 1996; 89: 327–32
   Google Scholar
• Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman J M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425–32
   PubMed Web of Science ®Google Scholar
• Halaas J L, Gajiwala K S, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543–6
   PubMed Web of Science ®Google Scholar
• Pelleymounter A M, Cullen M J, Baker M B, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540–3
   PubMed Web of Science ®Google Scholar
• Tartaglia L, Dembski L, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83: 1263–71
   PubMed Web of Science ®Google Scholar
• Stephens T W, Basinski M, Bristow P K, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995; 377: 530–2
   PubMed Web of Science ®Google Scholar
• Schwartz M W, Seeley R J, Campfield L A, Burns P, Baskin D G. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996; 98: 1101–6
   PubMed Web of Science ®Google Scholar
• Costa A, Poma A, Martignoni E, Nappi G, Ur E, Grossman A. Stimulation of corticotrophin-releasing hormone release by the obese (ob) gene product, leptin, from hypothalamic explants. Neuroreport 1997; 8: 1131–4
   PubMed Web of Science ®Google Scholar
• Lee G, Proenca R, Montez J M, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632–5
   PubMed Web of Science ®Google Scholar
• Considine R V, Considine E L, Williams C J, Hyde T M, Caro J F. The hypothalamic leptin receptor in humans. Identification of incidental sequence polymorphisms and the absence of the db/db mouse and the fa/fa rat mutations. Diabetes 1996; 19: 992–4
   Web of Science ®Google Scholar
• Mutt V. Secretin and cholecystokinin. Advances in Metabolic Disorders. II. Gastrointestinal Hormones, V Mutt. Academic Press, San Diego, CA 1988; 11: 270–320
   Google Scholar
• Linden A. Role of cholecystokinin in feeding and lactation. Acta Physiol Scand 1989; 137(Suppl)585
   Google Scholar
• Smith G P, Jerome C, Cushin B J, Eterno R, Simansky K J. Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat. Science 1981; 213: 1036–7
   PubMed Web of Science ®Google Scholar
• Moran T H, Ameglio P J, Schwartz G J, McHugh P R. Blockade of type A, but not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK. Am J Physiol 1992; 262: R46–50
   PubMed Web of Science ®Google Scholar
• Linden A, Uvnas-Moberg K, Forsberg G, Bednar I, Sodersten P. Involvement of cholecystokinin in food intake. I. Concentrations of cholecystokinin-like immunoreactivity in the cerebrospinal fluid of male rats. J Neuroendocrinal 1990; 2: 783–9
   PubMed Web of Science ®Google Scholar
• Levine A S, Morley J E. Peripherally administered somatostatin reduces feeding by a vagal mediated mechanism. Pharmacol Biochem Behav 1982; 16: 897–902
   PubMed Web of Science ®Google Scholar
• Pirke K M, Friess E, Kellner M B, Krieg J -C, Fichter M M. Somatostatin in eating disorders. Int J Eat Disord 1994; 15: 99–102
   PubMed Web of Science ®Google Scholar
• Ritter S, Weatherford S C, Stone S L. Glucagon-induced inhibition of feedings is impaired by hepatic portal alloxan injection. Am J Physiol 1986; 250: R682–90
   Google Scholar
• Geary N, Smith G P. Selective hepatic vagotomy blocks pancreatic glucagon's satiety effect. Physiol Behav 1983; 31: 391–4
   PubMed Web of Science ®Google Scholar
• Bray G A. Peptides affect the intake of specific nutrients and the sympathetic nervous system. Am J Clin Nutr 1992; 55: 265S–71S
   PubMed Web of Science ®Google Scholar
• Billington C J, Briggs J E, Link J G, Levine A S. Glucagon in physiological concentrations stimulates brown fat thermogenesis in vivo. Am J Physiol 1991; 261: R501–7
   PubMedGoogle Scholar
• Grossman S P. The role of glucose, insulin and glucagon in the regulation of food intake and body weight. Neurosct Biobehav Rev 1986; 10: 295–315
   PubMed Web of Science ®Google Scholar
• Janowitz H D, Ivy A C. Role of blood sugar levels in spontaneous and insulin-induced hunger in man. Appl Physiol 1948; 1: 643–5
   Web of Science ®Google Scholar
• Vanderweele D A, Xavier Pi-Sunyer F, Novin D, Bush M J. Chronic insulin infusion suppresses food ingestion and body weight gain in rats. Brain Res Bull 1980; 5: 5–11
   Web of Science ®Google Scholar
• Woods S C, Porte D, Jr, Bobbioni E, et al. Insulin: its relationship to the central nervous system and to the control of food intake and body weight. Am J Clin Nutr 1985; 42: 1063–71
   PubMed Web of Science ®Google Scholar
• Erlanson -A, Ibertsson C. Enterostatin - a peptide regulating fat intake. Scand J Nutr 1994; 38: 11–4
   Google Scholar
• Okada S, Lin L, York D A, Bray G A. Chronic effects of intracerebral ventricular enterostatin in Osborne-Mendel rats fed a high-fat diet. Physiol Behav 1993; 54: 325–9
   PubMed Web of Science ®Google Scholar
• Rössner S, Barkeling B, Erlanson-AIbertsson C, Larsson P, Wåhlin-Boll E. Intravenous enterostatin does not affect single meal food intake in man. Appetite 1995; 24: 37–42
   PubMed Web of Science ®Google Scholar
• Greenberg D, Smith G P, Gibbs J. Intraduodenal infusions of fats elicit satiety in sham-feeding rats. Am J Physiol 1990; 259: R110–8
   Google Scholar
• Philipp E, Pirke K -M, Kellner M B, Krieg J -C. Disturbed cholecystokinin secretion in patients with eating disorders. Life Sci 1991; 48: 2443–50
   PubMed Web of Science ®Google Scholar
• Crawley J N, Beinfeld M C. Rapid development of tolerance to the behavioural actions of cholecystokinin. Nature 1983; 302: 703–6
   PubMed Web of Science ®Google Scholar
• West D B, Fey D, Woods S C. Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am J Physiol 1984; 246: R776–87
   PubMed Web of Science ®Google Scholar
• Boden G, Chen X, Mozzoli M, Ryan I. Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab 1996; 81: 3419–23
   PubMed Web of Science ®Google Scholar
• Saad M F, Damani S, Gingerich R L, et al. Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab 1997; 82: 579–84
   PubMed Web of Science ®Google Scholar
• Saladin R, De Vos P, Guerre-Millo M, et al. Transient increase in obese gene expression after food intake or insulin administration. Nature 1995; 377: 527–9
   PubMed Web of Science ®Google Scholar
• De Vos P, Saladin R, Auwerx J, Staels B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 1995; 270: 15958–61
   PubMed Web of Science ®Google Scholar
• Kolaczynski J W, Nyce M R, Considine R V, et al. Acute and chronic effect of insulin on leptin production in humans. Studies in vivo and in vitro. Diabetes 1996; 45: 699–701
   PubMed Web of Science ®Google Scholar
• Masuzaki H, Ogawa Y, Hosoda K, et al. Glucocorticoid regulation of leptin synthesis and secretion in humans -elevated plasma leptin levels in Cushing-syndrome. J Clin Endocrinol Metab 1997; 82: 2542–7
   PubMed Web of Science ®Google Scholar
• Wade G N, Gray J M. Gonadal effects on food intake and adiposity: a metabolic hypothesis. Physiol Behav 1979; 22: 583–93
   PubMed Web of Science ®Google Scholar
• Castonguay T W. Glucocorticoids as modulators in the control feeding. Brain Res Bull 1991; 27: 423–8
   PubMed Web of Science ®Google Scholar
• Bohler H CL, Zoeller R T, King J C, Rubin B S, Weber R, Merriam G R. Corticotropin releasing hormone messenger RNA is elevated on the afternoon of proestrus in the parvocellular paraventricular nucleus of the female rat. Mol Brain Res 1990; 8: 259–62
   PubMedGoogle Scholar
• Bonavera J J, Dube M G, Kalra P S, Kalra S P. Anorectic effects of estrogen may be mediated by decreased neuropeptide-Y release in the hypothalamic paraventricular nucleus. Endocrinology 1994; 134: 2367–70
   PubMed Web of Science ®Google Scholar
• Leibowitz S F. Brain monoamines and peptides: role in the control of eating behavior. Fed Proc 1986; 45: 1396–403
   PubMedGoogle Scholar
• Baxter J D, Rousseau G G. Glucocorticoid hormone action: an overview. Glucocorticoid Hormone Action. Monogr Endocrinol, J D Baxter, G G Rosseau. Springer Verlag, Berlin 1979; Vol 12.: 1–24
   Google Scholar
• Rebuffe-Scrive M, Brönnegård M, Nilsson A, Eldh J, Gustafsson J -Å, Björntorp P. Steroid hormone receptors in human adipose tissues. J Clin Endocrinol Metab 1990; 71: 1215–9
   PubMed Web of Science ®Google Scholar
• Xu X, Björntorp P. Effects of dexamethasone on multiplication and differentiation of rat adipose precursor cells. Exp Cell Res 1990; 189: 247–52
   PubMed Web of Science ®Google Scholar
• Rebuffe-Scrive M, Mårin P, Björntorp P. Effect of testosterone on abdominal adipose tissue in men. Int J Obes 1991; 15: 791–5
   PubMed Web of Science ®Google Scholar
• Seidell J C, Björntorp P, Sjöström L, Kvist H, Sannerstedt R. Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels but negatively with testosterone levels. Metabolism 1990; 39: 897–901
   PubMed Web of Science ®Google Scholar
• Evand P, Hoffman R, Kalkhoff R, Kissebah A. Relationship of androgenic activity to body fat topography, fat cell morphology and metabolic abberations in menopausal women. J Clin Endocrinol Metab 1983; 57: 304–10
   PubMed Web of Science ®Google Scholar
• Laatikainen T J, Apter D L, Paavonen J A, Wahlström T R. Steroids in ovarian and peripheral venous blood in polycystic ovarian disease. Clin Endocrinol 1980; 13: 125–34
   PubMed Web of Science ®Google Scholar
• Rebuffe-Scrive M, Enk L, Crona N, et al. Fat cell metabolism in different regions in women. Effect of menstrual cycle, pregnancy, and lactation. J Clin Invest 1985; 75: 1973–6
   PubMed Web of Science ®Google Scholar
• Xu X, Hoebeke J, Björntorp P. Progestin binds to the glucocorticoid receptor and mediates antiglucocorticoid effect in rat adipose precursor cells. J Steroid Biochem 1991; 36: 465–71
   Google Scholar
• Wade G N, Gray J M. Cytoplasmic 17-β (3H) estradiol binding in rat adipose tissues. Endocrinology 1978; 103: 1695–701
   PubMed Web of Science ®Google Scholar
• Brown J E, Kaye S A, Folsom A R. Parity-related weight change in women. Int J Obes 1992; 16: 627–31
   Web of Science ®Google Scholar
• Tonkelaar I, Seidell J C, Noord P AH, et al. Fat distribution in relation to age, degree of obesity, smoking habits, parity and estrogen use: a cross-sectional study of 11, 825 Dutch women participating in the DOM project. Int J Obes 1990; 14: 753–61
   PubMed Web of Science ®Google Scholar
• Collins V A, Dowse G K, Zimmet P Z. Evidence against association between pariaty and NIDDM from five population groups. Diabetes Care 1991; 14: 975–81
   PubMed Web of Science ®Google Scholar
• Dalvit S P. The effect of the menstrual cycle on patterns of food intake. Am J Clin Nutr 1981; 34: 1811–5
   PubMed Web of Science ®Google Scholar
• Pasquali R, Casimirri F, Morselli Labate A M, et al. Body weight, fat distribution and the menopausal status in women. Int J Obes 1994; 18: 614–21
   PubMed Web of Science ®Google Scholar
• Wing R R, Matthews K A, Kuller L H, Meilahn E N, Plantinga P L. Weight gain at the time of the menopause. Arch Intern Med 1991; 151: 583–91
   Google Scholar
• Rebuffe-Scrive M, Eldh J, Hafstrom L O, Bjorntorp P. Metabolism of mammary, abdominal and femoral adipocytes in women before and after menopause. Metabolism 1986; 35: 792–7
   PubMed Web of Science ®Google Scholar
• Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U. Impact of obesity on metabolism in men and women. Clin Invest 1983; 72: 1150–62
   Google Scholar
• Cripps A W, Williams V J. The effect of pregnancy and lactation on food intake, gastrointestinal anatomy and the absorptive capacity of the small intestine in the albino rat. Br J Nutr 1975; 33: 17–32
   PubMed Web of Science ®Google Scholar
• Forsum E, Kabir N, Sadurskis A, Westerterp K. Total energy expenditure of healthy Swedish women during pregnancy and lactation. Am J Clin Nutr 1992; 56: 334–42
   PubMed Web of Science ®Google Scholar
• Landau R L. The appetite of pregnant women. JAMA 1983; 250: 3323
   PubMed Web of Science ®Google Scholar
• Rosso P. Regulation of food intake during pregnancy and lactation. Ann N Y Acad Sci 1987; 499: 191–6
   PubMed Web of Science ®Google Scholar
• Pope J F, Skinner J D, Carruth B R. Cravings and aversions of pregnant adolescents. J Am Diet Assoc 1992; 29: 1479–82
   Google Scholar
• Linden A, Eriksson M, Carlqvist M, Uvnas-Moberg K. Plasma levels of gastrin, somatostatin, and cholecystokinin immunoreactivity during pregnancy and lactation in dogs. Gastroenterology 1987; 92: 578–84
   PubMed Web of Science ®Google Scholar
• Kramer F M, Stunkard A J, Marshall K A, McKinney S, Liebschutz J. Breast-feeding reduced maternal lower-body fat. J Am Diet Assoc 1993; 93: 429–33
   PubMed Web of Science ®Google Scholar
• Fleming A S. Control of food intake in the lactating rat: role of suckling and hormones. Physiol Behav 1976; 17: 841–8
   PubMed Web of Science ®Google Scholar
• Lindén A, Uvnás-Moberg K, Forsberg G, Bcdnar I, Encroth P, Sodersten P. Involvement of cholecystokinin in food intake. II. Lactational hyperphagia in the rat. J Neuroendocrinal 1990; 2: 791–6
   PubMed Web of Science ®Google Scholar
• Daly S EJ, Hartmann P E. Infant demand and milk supply. Part 1, Infant demand and milk production in lactating women. J Hum Eact 1995; 11: 21–6
   Google Scholar
• Amatayakui K, Sivasomboon B, Thanangkul O. A study of the mechanism of weight gain in medroxyprogesterone acetate users. Contraception 1980; 22: 605–22
   PubMed Web of Science ®Google Scholar
• Gillmer M DG. Metabolic effects of combined oral contraceptives. Contraception: Science and Practice, M Filshie, J Guillebaud. Butterworths, London 1989; 11–38
   Google Scholar
• American College of Obstetricians and Gynecologists. Safety of oral contraceptives for teenagers. J Adolesc Health 1992; 13: 333–6
   PubMed Web of Science ®Google Scholar
• Karlsson R, Lindén A, von Schoultz B. Suppression of 24-hour cholecystokinin secretion by oral contraceptives. Am J Obstet Gynecol 1992; 167: 58–9
   PubMed Web of Science ®Google Scholar
• Lindén Hirchberg A, Byström B, Carlström K, von Schoultz B. Reduced serum cholecystokinin and increase in body fat during oral contraception. Contraception 1996; 52: 109–13
   Google Scholar
• Barrett-Connor E, Brown W V, Turner J, Austin M, Criqui M H. Heart disease risk factors and hormone use in postmenopausal women. JAMA 1979; 241: 2167–9
   PubMed Web of Science ®Google Scholar
• Brzezinski A, Reubinoff B, Wurtman J, et al. Effects of the menopause and HRT on body composition, fat distribution and food intake. Gynecol Endocrinol 1995; 9(Suppl 1)FC35
   Google Scholar
• Glucocortioid Hormone Action. Monogr Endocrinol Vol 12, J D Baxter, G G Rousseau. Springer Verlag, Berlin 1979
   Google Scholar
• Krotkiewski M, Blohme B, Lindholm N, Bjorntorp P. The effects of adrenal corticosteroids on regional adipocyte size in man. J Clin Endocrinol Metal 1976; 42: 91–7
   PubMed Web of Science ®Google Scholar
• Lukert B P, Johnsen B E, Robinson R G. Estrogen and progesterone replacement therapy reduces glucocorticoid-induced bone loss. J Bone Miner Res 1992; 7: 1063–9
   PubMed Web of Science ®Google Scholar
• Berger M, Cuppers H J, Hegner H, Jorgens V, Berchtold P. Absorption kinetics and biologic effects of subcutaneously injected insulin preparations. Diabetes Care 1982; 5: 77–1
   PubMed Web of Science ®Google Scholar
• Bjorntorp P. The associations between obesity, adipose tissue distribution and disease. Acta Med Scand Suppl 1988; 723: 121–34
   PubMedGoogle Scholar
• Bjorntorp P. “Portal” adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 1990; 10: 493–6
   PubMedGoogle Scholar
• Marin P, Darin Amemiya N. T, Andersson B, Bjorntorp Jem S. Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 1992; 41: 882–6
   PubMed Web of Science ®Google Scholar
• Brunani A, Invitti C, Dubini A, et al. Cerebrospinal fluid and plasma concentrations of SR1H, beta-cudorphin, CRH, NPY and CHRH in obese and normal weight subjects. Int J Obes 1995; 19: 17–21
   Web of Science ®Google Scholar
• Strombom U, Krotkiewski M, Blennow K, Mansson J -E, Ekman R, Bjorntorp P. The concentrations of monoamine metabolites and neuropeptides in the cerebrospinal fluid of obese women with different body fat distribution. Int J Obes 1996; 20: 351–68
   Web of Science ®Google Scholar
• Pasquali R, Cantobelli S, Casimirri F, et al. The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab 1993; 77: 341–6
   PubMed Web of Science ®Google Scholar
• Beck P. Contraceptive steroids: modification of carbohydrate and lipid metabolism. Metabolism 1973; 22: 841–5
   PubMed Web of Science ®Google Scholar
• Berg C, Carlsson B, Olsson J -H, Selleskog U, Hillensjö T. Regulation of androgen production in cultured human thecal cells by insulin-like growth factor I and insulin. Fcrtil Steril 1993; 59: 323–31
   PubMed Web of Science ®Google Scholar
• Rebuffé-Scrive M, Cullberg G, Lundberg P -A, Lindstedt G, Björntorp P. Anthropometric variables and metabolism in polycystic ovarian disease. Harm Metab Res 1989; 21: 391–7
   PubMed Web of Science ®Google Scholar
• Lindstedt G, Lundberg P -A, Lapidus L, Lundgren H, Bengtsson C, Björntorp P. Low sex-hormone-binding globulin concentration as independent risk factor for development of NIDDM. 12-yr follow-up of a population study of women in Gothenburg, Sweden. Diabetes 1991; 40: 123–8
   PubMed Web of Science ®Google Scholar
• Giugliano D. Opioid peptides and obesity. Eur J Med 1992; 1: 90–6
   PubMedGoogle Scholar
• Pasquali R, Cantobelli S, Casimirri F, et al. The role of the opioid peptides in the development of hyperinsulinemia in obese women with abdominal body fat distribution. Metabolism 1992; 41: 763–7
   PubMed Web of Science ®Google Scholar
• Atkinson R L, Berke L K, Drake C R, Bibbs M L, Williams F L, Kaiser D L. Effects of long-term therapy with naltrexone on body weight in obesity. Clin Pharmacol Tber 1985; 38: 419–25
   PubMed Web of Science ®Google Scholar
• Recant L, Voyles N R, Luciano M, Pert C. Naltrexone reduced weight gain, alters ‘β-endorphin’, and reduces insulin output from pancreatic islets of genetically obese mice. Peptides 1980; 1: 309–13
   PubMed Web of Science ®Google Scholar
• Guigliano D, Cozzolino D, Salvatore T, et al. Physiological elevations of plasma β-endorphin alter glucose metabolism in obese, but not normal-weight, subjects. Metabolism 1992; 41: 184–90
   PubMed Web of Science ®Google Scholar
• Fulghesu A M, Lanzone A, Cucinelli F, Caruso A, Mancuso S. Long-term naltrexone treatment reduces the exaggerated insulin secretion in patients with polycystic ovary disease. Obstet Gynecol 1993; 82: 191–7
   PubMed Web of Science ®Google Scholar
• Cozzolino D, Sessa G, Salvatore T, et al. The involvement of the opioid system in human obesity: a study in normal weight relatives of obese people. J Clin Endocrinol Metab 1996; 81: 713–8
   PubMed Web of Science ®Google Scholar
• Piazza P V, Deroche V, Deminiére J -M, Maccari S, Lc Moal M, Simon H. Corticosterone in the range of stress-induced levels possesses reinforcing properties: implications for sensation-seeking behaviors. Proc Natl Acad Sci U S A 1993; 90: 11738–42
   PubMed Web of Science ®Google Scholar
• Loucks A B, Mortola J F, Girton L, Yen S SC. Alterations in the hypothalamic-pituitary-ovanan and the hypothalamic-pituitary-adrenal axes in athletic women. J Clin Endocrinol Metab 1989; 68: 402–11
   PubMed Web of Science ®Google Scholar
• Robinson P H. Perceptivity and paraceptivity during measurement of gastric emptying in anorexia and bulimia nervosa. Br J Psychiatry 1989; 154: 400–5
   PubMed Web of Science ®Google Scholar
• Mitchell J E, Lainc D E, Morley J E, Levine A S. Naloxone but not CCK-8 may attenuate binge-eating behavior in patients with the bulimia syndrome. Bio! Psychiatry 1986; 21: 1399–406
   PubMed Web of Science ®Google Scholar
• Ferron F, Considine R V, Peino R, Lado I G, Dieguez C, Casanueva F F. Serum leptin concentrations in patients with anorexia nervosa, bulimia nervosa and non-specific eating disorders correlate with the body mass index but are independent of the respective disease. Clin Endocrinol 1997; 46: 289–93
   PubMed Web of Science ®Google Scholar
• Jahanfar S, Eden J A, Nguyent T V. Bulimia nervosa and polycystic ovary syndrome. Gynecol Endocrinol 1995; 9: 113–7
   PubMed Web of Science ®Google Scholar
• Fitcher M M, Noegel R. Concordance for bulimia nervosa in twins. Int J Fat Disord 1990; 9: 255–63
   Web of Science ®Google Scholar
• Bergman L, Eriksson E. Marked symptom reduction in two women with bulimia nervosa treated with the testosterone receptor antagonist flutamide. Acta Psychiatr Scand 1996; 94: 137–9
   PubMed Web of Science ®Google Scholar