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Research Article

Cerebral blood flow, sympathetic nerve activity and stroke risk in obstructive sleep apnoea. Is there a direct link?

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Pages 27-33 | Received 29 Feb 2012, Accepted 21 May 2012, Published online: 25 Sep 2012

References

  • Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005;353:2034–2041.
  • Munoz R, Duran-Cantolla J, Martínez-Vila E, Gallego J, Rubio R, Aizpuru F, . Severe sleep apnea and risk of ischemic stroke in the elderly. Stroke. 2006;37:2317–2321.
  • Redline S, Yenokyan G, Gottlieb DJ, Shahar E, O’Connor GT, Resnick HE, . Obstructive sleep apnea–hypopnea and incident stroke: The sleep heart health study. Am J Respir Crit Care Med. 2010;182:269–277.
  • Urbano F, Roux F, Schindler J, Mohsenin V. Impaired cerebral autoregulation in obstructive sleep apnea. J Appl Physiol. 2008;105:1852–1857.
  • Bålfors EM, Franklin KA. Impairment of cerebral perfusion during obstructive sleep apneas. Am J Respir Crit Care Med. 1994;150:1587–1591.
  • Klingelhöfer J, Hajak G, Sander D, Schulz-Varszegi M, Rüther E, Conrad B. Assessment of intracranial hemodynamics in sleep apnea syndrome. Stroke. 1992;23:1427–1433.
  • Narkiewicz K, Somers VK. The sympathetic nervous system and obstructive sleep apnea: Implications for hypertension. J Hypertens. 1997;15:1613–1619.
  • Narkiewicz K, van de Borne PJ, Montano N, Dyken ME, Phillips BG, Somers VK. Contribution of tonic chemoreflex activation to sympathetic activity and blood pressure in patients with obstructive sleep apnea. Circulation. 1998;97: 943–945.
  • Ogoh S. Comments on Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Autonomic nervous system influences dynamic cerebral blood flow. J Appl Physiol. 2008;105:1370.
  • Ogoh S, Ainslie PN. Cerebral blood flow during exercise: Mechanisms of regulation. J Appl Physiol. 2009;107:1370–1380.
  • Van Lieshout JJ, Secher NH. Point: Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Point: Sympathetic activity does influence cerebral blood flow. J Appl Physiol. 2008;105:1364–1366.
  • Heistad DD, Marcus ML. Effect of sympathetic stimulation on permeability of the blood–brain barrier to albumin during acute hypertension in cats. Circ Res1979;45:331–338.
  • Cassaglia PA, Griffiths RI, Walker AM. Sympathetic nerve activity in the superior cervical ganglia increases in response to imposed increases in arterial pressure. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1255–R1261.
  • Loos N, Grant DA, Wild J, Paul S, Barfield C, Zoccoli G, . Sympathetic nervous control of the cerebral circulation in sleep. J Sleep Res. 2005;14:275–283.
  • Cassaglia PA, Griffiths RI, Walker AM. Cerebral sympathetic nerve activity has a major regulatory role in the cerebral circulation in REM sleep. J Appl Physiol. 2009;106:1050–1056.
  • Bhambhani Y, Maikala R, Farag M, Rowland G. Reliability of near-infrared spectroscopy measures of cerebral oxygenation and blood volume during handgrip exercise in nondisabled and traumatic brain-injured subjects. J Rehabil Res Dev. 2006;43: 845–856.
  • Ogoh S, Sato K, Fisher JP, Seifert T, Overgaard M, Secher NH. The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects. Clin Physiol Funct Imaging. 2011;31:445–451.
  • Wszedybyl-Winklewska M, Frydrychowski AF, Winklewski PJ. Assessing changes in pial artery resistance and subarachnoid space width using a non-invasive method in healthy humans during the handgrip test. Acta Neurobiol Exp. 2012;72: 80–88.
  • Edvinsson L, McCulloch J, Uddman R. Feline cerebral veins and arteries: Comparison of autonomic innervation and vasomotor responses. J Physiol. 1982;325:161–173.
  • Gulbenkian S, Uddman R, Edvinsson L. Neuronal messengers in the human cerebral circulation. Peptides. 2001;22: 995–1007.
  • Arbab MA, Wiklund L, Svendgaard NA. Origin and distribution of cerebral vascular innervation from superior cervical, trigeminal and spinal ganglia investigated with retrograde and anterograde WGA-HRP tracing in the rat. Neuroscience. 1986;19:695–708.
  • Cuevas P, Gutierrez-Diaz JA, Reimers D, Dujovny M, Diaz FG, Ausman JI. Adrenergic innervation of human middle cerebral artery. Ultrastructural observations. Surg Neurol. 1987;27:113–116.
  • Edvinsson L, Owman C. Pharmacological characterization of adrenergic alpha and beta receptors mediating the vasomotor responses of cerebral arteries in vitro. Circ Res. 1974; 35:835–849.
  • Frydrychowski AF, Wszedybyl-Winklewska M, Guminski W, Przyborska A, Kaczmarek J, Winklewski PJ. Use of near infrared transillumination/back scattering sounding (NIR-T/BSS) to assess effects of elevated intracranial pressure on width of subarachnoid space and cerebrovascular pulsation in animals. Acta Neurobiol Exp. 2011;71:313–321.
  • Lee TJ, Su C, Bevan JA. Neurogenic sympathetic vasoconstriction of the rabbit basilar artery. Circ Res. 1976;39: 120–126.
  • Roatta S, Canova D, Bosone D, Micieli G, Passatore M. Noradrenergic constriction of cerebral arteries as detected by transcranial Doppler (TCD) in the rabbit. Ultrasound Med Biol. 2003;29:1397–1404.
  • Visocchi M, Chiappini F, Cioni B, Meglio M. Cerebral blood flow velocities and trigeminal ganglion stimulation. A transcranial Doppler study. Stereotact Funct Neurosurg. 1996; 66:184–192.
  • Giller CA. The Emperor has no clothes: Velocity, flow, and the use of TCD. J Neuroimaging. 2003;13:97–98.
  • Lunt MJ, Ragab S, Birch AA, Schley D, Jenkinson DF. Comparison of caffeine-induced changes in cerebral blood flow and middle cerebral artery blood velocity shows that caffeine reduces middle cerebral artery diameter. Physiol Meas. 2004;25:467–474.
  • Wilson MH, Eds ell ME, Davagnanam I, Hirani SP, Martin DS, Levett DZ, .; Caudwell Xtreme Everest Research Group. Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia – An ultrasound and MRI study. J Cereb Blood Flow Metab. 2011; 31:2019–2029.
  • Brassard P, Seifert T, Secher NH. Is cerebral oxygenation negatively affected by infusion of norepinephrine in healthy subjects?Br J Anaesth. 2009;102:800–805.
  • Brassard P, Seifert T, Wissenberg M, Jensen PM, Hansen CK, Secher NH. Phenylephrine decreases frontal lobe oxygenation at rest but not during moderately intense exercise. J Appl Physiol. 2010;108:1472–1478.
  • Nissen P, Brassard P, Jørgensen TB, Secher NH. Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension. Neurocrit Care. 2010;12:17–23.
  • Lucas SJ, Tzeng YC, Galvin SD, Thomas KN, Ogoh S, Ainslie PN. Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension. 2010;55: 698–705.
  • Sato K, Sadamoto T. Different blood flow responses to dynamic exercise between internal carotid and vertebral arteries in women. J Appl Physiol. 2010;109:864–869.
  • Ainslie PN, Ashmead JC, Ide K, Morgan BJ, Poulin MJ. Differential responses to CO2 and sympathetic stimulation in the cerebral and femoral circulations in humans. J Physiol. 2005;566:613–624.
  • Ikemura T, Someya N, Hayashi N. Autoregulation in the ocular and cerebral arteries during the cold pressor test. and handgrip exercise. Eur J Appl Physiol. 2011; DOI: 10.1007/s00421-011-2016-y.
  • Sohn YH. Cerebral hemodynamic changes induced by sympathetic stimulation tests. Yonsei Med J. 1998;39:322–327.
  • Rasmussen P, Plomgaard P, Krogh-Madsen R, Kim YS, van Lieshout JJ, Secher NH, . MCA Vmean and the arterial lactate-to-pyruvate ratio correlate during rhythmic handgrip. J Appl Physiol. 2006;101:1406–1411.
  • Seifert T, Fisher JP, Young CN, Hartwich D, Ogoh S, Raven PB, . Glycopyrrolate abolishes the exercise-induced increase in cerebral perfusion in humans. Exp Physiol. 2010; 95:1016–1025.
  • Johansson B, Li CL, Olsson Y, Klatzo I. The effect of acute arterial hypertension on the blood–brain barrier to protein tracers. Acta Neuropathol. 1970;16:117–124.
  • Somers VK, Dyken ME, Mark AL, Abboud FM. Sympathetic-nerve activity during sleep in normal subjects. N Engl J Med. 1993;328:303–307.
  • Somers VK, Dyken ME, Clary MP, Abboud FM. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest. 1995;96:1897–1904.
  • LeMarbre G, Stauber S, Khayat RN, Puleo DS, Skatrud JB, Morgan BJ. Baroreflex-induced sympathetic activation does not alter cerebrovascular CO2 responsiveness in humans. J Physiol. 2003;551:609–616.
  • Wilson TD, Shoemaker JK, Kozak R, Lee TY, Gelb AW. Reflex-mediated reduction in human cerebral blood volume. J Cereb Blood Flow Metab. 2005;25:136–143.
  • Traystman RJ, Rapela CE. Effect of sympathetic nerve stimulation on cerebral and cephalic blood flow in dogs. Circ Res. 1975;36:620–630.
  • Ulrich K, Kuschinsky W. In vivo effects of alpha-adrenoceptor agonists and antagonists on pial veins of cats. Stroke. 1985; 16:880–884.
  • Brown WR, Moody DM, Thore CR, Anstrom JA, Challa VR. Microvascular changes in the white mater in dementia. J Neurol Sci. 2009;283:28–31.
  • Nation DA, Hong S, Jak AJ, Delano-Wood L, Mills PJ, Bondi MW, . Stress, exercise, and Alzheimer's disease: A neurovascular pathway. Med Hypotheses. 2011;76:847–854.
  • Kontos HA, Wei EP, Navari RM, Levasseur JE, Rosenblum WI, Patterson JL Jr.Responses of cerebral arteries and arterioles to acute hypotension and hypertension. Am J Physiol. 1978;234:H371–H383.
  • Narayanan N, Leffler CW, Daley ML. Influence of hypercapnic vasodilation on cerebrovascular autoregulation and pial arteriolar bed resistance in piglets. J Appl Physiol. 2008; 105:152–157.
  • Kagstrom E, Smith ML, Siesjo BK. Cerebral circulatory responses to hypercapnia and hypoxia in the recovery period following complete and incomplete cerebral ischemia in the rat. Acta Physiol Scand. 1983;118:281–291.
  • Vorstrup S, Henriksen L, Paulson OB. Effect of acetazolamide on cerebral blood flow and cerebral metabolic rate for oxygen. J Clin Invest. 1984;74:1634–1639.
  • Brian JE Jr.Carbon dioxide and the cerebral circulation. Anesthesiology. 1998;88:1365–1386.
  • Domoki F, Zimmermann A, Tóth-Szuki V, Busija DW, Bari F. Acetazolamide induces indomethacin and ischaemia-sensitive pial arteriolar vasodilation in the piglet. Acta Paediatr. 2008;97:280–284.
  • Frydrychowski AF, Rojewski M, Guminski W, Kaczmarek J, Juzwa W. Technical foundation for non-invasive assessment of changes in the width of the subarachnoid space with near-infrared transillumination-back scattering sounding (NIR-TBSS). IEEE Trans Biomed Eng. 2002;49: 887–904.
  • Frydrychowski AF, Wszedybyl-Winklewska M, Bandurski T, Winklewski PJ. Flow-induced changes in pial artery compliance registered with a non-invasive method in rabbits. Microvasc Res. 2011;82:156–162.
  • Frydrychowski AF, Wszedybyl-Winklewska M, Guminski W, Lass P, Bandurski T, Winklewski PJ. Effects of acute hypercapnia on the amplitude of cerebrovascular pulsation in humans registered with a non-invasive method. Microvasc Res. 2012;83:229–236.
  • Aaslid R, Lindegaard KF, Sorteberg W, Nornes H. Cerebral autoregulation dynamics in humans. Stroke. 1989;20: 45–52.
  • Birch AA, Dirnhuber MJ, Hartley-Davies R, Iannotti F, Neil-Dwyer G. Assessment of autoregulation by means of periodic changes in blood pressure. Stroke. 1995;26: 834–837.
  • Panerai RB. Assessment of cerebral pressure autoregulation in humans – A review of measurement methods. Physiol Meas. 1998;19:305–338.
  • Zhang R, Zuckerman JH, Giller CA, Levine BD. Transfer function analysis of dynamic cerebral autoregulation in humans. Am J Physiol. 1998;274:H233–H241.
  • Ainslie PN, Celi L, McGrattan K, Peebles K, Ogoh S. Dynamic cerebral autoregulation and baroreflex sensitivity during modest and severe step changes in arterial PCO2. Brain Res. 2008;1230:115–124.
  • Jordan J, Shannon JR, Diedrich A, Black B, Costa F, Robertson D, . Interaction of carbon dioxide and sympathetic nervous system activity in the regulation of cerebral perfusion in humans. Hypertension. 2000;36: 383–388.
  • Przybyłowski T, Bangash MF, Reichmuth K, Morgan BJ, Skatrud JB, Dempsey JA. Mechanisms of the cerebrovascular response to apnoea in humans. J Physiol. 2003;548: 323–332.
  • Dujic Z, Uglesic L, Breskovic T, Valic Z, Heusser K, Marinovic J, . Involuntary breathing movements improve cerebral oxygenation during apnea struggle phase in elite divers. J Appl Physiol. 2009;107:1840–1846.
  • Cassaglia PA, Griffiths RI, Walker AM. Sympathetic withdrawal augments cerebral blood flow during acute hypercapnia in sleeping lambs. Sleep. 2008;31:1729–1734.
  • Hayakawa T, Terashima M, Kayukawa Y, Ohta T, Okada T. Changes in cerebral oxygenation and hemodynamics during obstructive sleep apneas. Chest. 1996;109:916–921.
  • Valipour A, McGown AD, Makker H, O’Sullivan C, Spiro SG. Some factors affecting cerebral tissue saturation during obstructive sleep apnoea. Eur Respir J. 2002;20: 444–450.
  • Placidi F, Diomedi M, Cupini LM, Bernardi G, Silvestrini M. Impairment of daytime cerebrovascular reactivity in patients with obstructive sleep apnoea syndrome. J Sleep Res. 1998;7:288–292.
  • Reichmuth KJ, Dopp JM, Barczi SR, Skatrud JB, Wojdyla P, Hayes D Jr, . Impaired vascular regulation in patients with obstructive sleep apnea: Effects of continuous positive airway pressure treatment. Am J Respir Crit Care Med. 2009;180: 1143–1150.
  • Morgan BJ, Reichmuth KJ, Peppard PE, Finn L, Barczi SR, Young T, . Effects of sleep-disordered breathing on cerebrovascular regulation: A population-based study. Am J Respir Crit Care Med. 2010;182:1445–1452.
  • Sugita Y, Iijima S, Teshima Y, Shimizu T, Nishimura N, Tsutsumi T, . Marked episodic elevation of cerebrospinal fluid pressure during nocturnal sleep in patients with sleep apnea hypersomnia syndrome. Electroencephalogr Clin Neurophysiol. 1985;60:214–219.
  • Jennum P, Børgesen SE. Intracranial pressure and obstructive sleep apnea. Chest. 1989;95:279–283.
  • Parati G, Lombardi C, Hedner J, Bonsignore MR, Grote L, Tkacova R, .; European Respiratory Society; EU COST ACTION B26 members. Position paper on the management of patients with obstructive sleep apnea and hypertension: Joint recommendations by the European Society of Hypertension, by the European Respiratory Society and by the members of European COST (CO-operation in Scientific and Technological research) ACTION B26 on obstructive sleep apnea. J Hypertens. 2012;30:633–646.

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