Meta-analysis of three observational studies of amlodipine/valsartan in hypertensive patients with additional risk factors

References

• Whitworth JA. 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens. 2003;21: 1983–1992.
   PubMed Web of Science ®Google Scholar
• Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, et al. Obesity and cardiovascular disease: Pathophysiology, evaluation, and effect of weight loss. Arterioscler Thromb Vasc Biol. 2006;26:968–976.
   PubMed Web of Science ®Google Scholar
• Brown CD, Higgins M, Donato KA, Rohde FC, Garrison R, Obarzanek E, et al. Body mass index and the prevalence of hypertension and dyslipidemia. Obes Res. 2000;8:605–619.
   PubMedGoogle Scholar
• Ernst ND, Obarzanek E, Clark MB, Briefel RR, Brown CD, Donato K. Cardiovascular health risks related to overweight. J Am Diet Assoc. 1997;97:S47–S51.
   Google Scholar
• Krauss RM, Winston M, Fletcher BJ, Grundy SM. Obesity: Impact on cardiovascular disease. Circulation. 1998;98: 1472–1476.
   Google Scholar
• Pimenta E, Oparil S. Management of hypertension in the elderly. Nat Rev Cardiol. 2012;9:286–296. doi:10.1038/nrcardio.2012.27.
   PubMed Web of Science ®Google Scholar
• Banach M, Aronow WS. Should we have any doubts about hypertension therapy in elderly patients? ACCF/AHA 2011 expert consensus document on hypertension in the elderly. Pol Arch Med Wewn. 2011;121:253–258.
   PubMed Web of Science ®Google Scholar
• Gil-Extremera B, Cia-Gomez P. Hypertension in the elderly. Int J Hypertens. 2012;859176. Epub 2011 Aug 16.
   Google Scholar
• Virdis A, Bruno RM, Neves MF, Taddei S, Ghiadoni L. Hypertension in the elderly: An evidence-based review. Curr Pharm Des. 2011;17:3020–2031.
   PubMed Web of Science ®Google Scholar
• Mitka M. New guidance covers ways to prevent and treat hypertension in elderly patients. JAMA. 2011;305:2394–2398.
   PubMed Web of Science ®Google Scholar
• Schall P, Wehling M. Treatment of arterial hypertension in the very elderly: A meta-analysis of clinical trials. Arzneimittelforschung. 2011;61:221–228.
   PubMed Web of Science ®Google Scholar
• Beckett NS, Peters R, Fletcher AE, Staessen JA, Liu L, Dumitrascu D, et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358: 1887–1898.
   PubMed Web of Science ®Google Scholar
• Bulpitt CJ, Beckett NS, Cooke J, Dumitrascu DL, Gil-Extremera B, Nachev C, et al. Results of the pilot study for the Hypertension in the Very Elderly Trial. J Hypertens. 2003;21:2409–2417.
   PubMed Web of Science ®Google Scholar
• Gueyffier F, Bulpitt C, Boissel JP, Schron E, Ekbom T, Fagard, R et al. Antihypertensive drugs in very old people: A subgroup meta-analysis of randomised controlled trials. INDANA Group. Lancet. 1999;353:793–796.
   PubMed Web of Science ®Google Scholar
• SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA. 1991;265: 3255–3264.
   PubMed Web of Science ®Google Scholar
• Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, Birkenhager WH, et al. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet. 1997;350: 757–764.
   PubMed Web of Science ®Google Scholar
• Mancia G, De BG, Dominiczak A, Cifkova R, Fagard R, Germano G, et al. 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007;25:1105–1187.
   PubMed Web of Science ®Google Scholar
• da Silva PM. Efficacy of fixed-dose combination therapy in the treatment of patients with hypertension: Focus on amlodipine/valsartan. Clin Drug Investig. 2010;30: 625–641.
   PubMed Web of Science ®Google Scholar
• Flack JM, Hilkert R. Single-pill combination of amlodipine and valsartan in the management of hypertension. Expert Opin Pharmacother. 2009;10:1979–1994.
   PubMed Web of Science ®Google Scholar
• Fogari R, Zoppi A, Derosa G, Mugellini A, Lazzari P, Rinaldi A, et al. Effect of valsartan addition to amlodipine on ankle oedema and subcutaneous tissue pressure in hypertensive patients. J Hum Hypertens. 2007;21:220–224.
   PubMed Web of Science ®Google Scholar
• Lemmer B, Middeke M, Schaaf B, Eckes L. Prescribing practices and morning blood pressure control: Results of a large-scale, primary-care study conducted in Germany. J Hum Hypertens. 2008;22:295–297. Epub 2008 Jan 17.
   PubMed Web of Science ®Google Scholar
• Wolf-Maier K, Cooper RS, Banegas JR, Giampaoli S, Hense HW, Joffres M, et al. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA. 2003;289:2363–2369.
   PubMed Web of Science ®Google Scholar
• Wolf-Maier K, Cooper RS, Kramer H, Banegas JR, Giampaoli S, Joffres MR, et al. Hypertension treatment and control in five European countries, Canada, and the United States. Hypertension. 2004;43:10–17.
   PubMed Web of Science ®Google Scholar
• Guidelines Subcommittee. World Health Organization– International Society of Hypertension guidelines for the management of hypertension. J Hypertens. 1999;17:151–183.
   PubMed Web of Science ®Google Scholar
• Deutsche Hochdruckliga e.V. DHL® – Deutsche Hypertonie Gesellschaft: Leitlinien zur Behandlung der arteriellen Hypertonie, status of 1 June 2008.
   Google Scholar
• Frampton JE, Scott LJ. Amlodipine/valsartan single-pill combination: A review of its use in the management of hypertension. Am J Cardiovasc Drugs. 2009;9:309–330.
   PubMed Web of Science ®Google Scholar
• Philipp T, Smith TR, Glazer R, Wernsing M, Yen J, Jin J, et al. Two multicenter, 8-week, randomized, double-blind, placebo-controlled, parallel-group studies evaluating the efficacy and tolerability of amlodipine and valsartan in combination and as monotherapy in adult patients with mild to moderate essential hypertension. Clin Ther. 2007;29:563–580.
   PubMed Web of Science ®Google Scholar
• Hansson L, Lindholm LH, Ekbom T, Dahlof B, Lanke J, Schersten B, et al. Randomised trial of old and new antihypertensive drugs in elderly patients: Cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study. Lancet. 1999;354:1751–1756.
   PubMed Web of Science ®Google Scholar
• Deutsche Hochdruckliga e.V. DHL® – Deutsche Hypertonie Gesellschaft: Neue Entwicklungen in der Hochdrucktherapie; 2011.
   Google Scholar
• Bangalore S, Shahane A, Parkar S, Messerli FH. Compliance and fixed-dose combination therapy. Curr Hypertens Rep. 2007;9:184–189.
   PubMed Web of Science ®Google Scholar
• Dickson M, Plauschinat CA. Compliance with antihypertensive therapy in the elderly: A comparison of fixed-dose combination amlodipine/benazepril versus component-based free-combination therapy. Am J Cardiovasc Drugs. 2008;8: 45–50.
   PubMed Web of Science ®Google Scholar
• Lavie CJ, Milani RV, Ventura HO. Obesity and cardiovascular disease: Risk factor, paradox, and impact of weight loss. J Am Coll Cardiol. 2009;53:1925–1932.
   PubMed Web of Science ®Google Scholar
• Thomas M C, Atkins RC. Blood pressure lowering for the prevention and treatment of diabetic kidney disease. Drugs. 2006;66:2213–2234.
   PubMed Web of Science ®Google Scholar
• Thomas MC, Atkins R. Assessment and management of hypertension in patients with type 2 diabetes. Intern Med J. 2009;39:143–149.
   PubMed Web of Science ®Google Scholar