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Research Article

Factors associated with the course of symptoms in bipolar disorder during a 1-year follow-up: Depression vs. sub-threshold mixed state

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Pages 419-426 | Accepted 27 May 2011, Published online: 05 Jul 2011

References

  • Murray C, Lopez A. The global burden of disease. A comprehensive assessment of morbidity and disability from diseases, injuries and risk factors in 1990 and projected to 2020. Cambridge, MA: Harvard University Press; 1996.
  • Goodwin FK, Jamison KR. Manic-depressive illness: Bipolar disorders and recurrent depression. New York: Oxford University Press; 2007.
  • Turvey CL, Coryell WH, Solomon DA, Leon AC, Endicott J, Keller MB, . Long-term prognosis of bipolar I disorder. Acta Psychiatr Scand 1999;99:110–9.
  • Joffe RT, MacQueen GM, Marriott M, Trevor Young L. A prospective, longitudinal study of percentage of time spent ill in patients with bipolar I or bipolar II disorders. Bipolar Disord 2004;6:62–6.
  • Huxley N, Baldessarini RJ. Disability and its treatment in bipolar disorder patients. Bipolar Disord 2007;9:183–96.
  • Goetz I, Tohen M, Reed C, Lorenzo M, Vieta E. Functional impairment in patients with mania: Baseline results of the EMBLEM study. Bipolar Disord 2007;9:45–52.
  • Rosa AR, Franco C, Martinez-Aran A, Sanchez-Moreno J, Reinares M, Salamero M, . Functional impairment in patients with remitted bipolar disorder. Psychother Psychosom 2008;77:390–2.
  • Judd LL, Akiskal HS, Schettler PJ, Endicott J, Maser J, Solomon DA, . The long-term natural history of the weekly symptomatic status of bipolar I disorder. Archiv Gen Psy 2002;59:530–7.
  • Judd LL, Akiskal HS, Schettler PJ, Coryell W, Endicott J, Maser JD, . A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder. Archiv Gen Psy 2003;60:261–9.
  • Kupka RW, Altshuler LL, Nolen WA, Suppes T, Luckenbaugh DA, Leverich GS, . Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder. Bipolar Disord 2007;9:531–5.
  • Leverich GS, Altshuler LL, Frye MA, Suppes T, McElroy SL, Keck PE, Jr., . Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers. Am J Psychiatry 2006;163:232–9.
  • Bauer MS, Kirk GF, Gavin C, Williford WO. Determinants of functional outcome and healthcare costs in bipolar disorder: A high-intensity follow-up study. J Affect Dis 2001;65:231–41.
  • Bryant-Comstock L, Stender M, Devercelli G. Health care utilization and costs among privately insured patients with bipolar I disorder. Bipolar Disord 2002;4:398–405.
  • Altshuler LL, Gitlin MJ, Mintz J, Leight KL, Frye MA. Subsyndromal depression is associated with functional impairment in patients with bipolar disorder. J Clin Psychiatry 2002;63:807–11.
  • Judd LL, Akiskal HS, Schettler PJ, Endicott J, Leon AC, Solomon DA, . Psychosocial disability in the course of bipolar I and II disorders: A prospective, comparative, longitudinal study. Arch Gen Psychiatry 2005;62:1322–30.
  • Altshuler LL, Post RM, Black DO, Keck PE, Jr., Nolen WA, Frye MA, . Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: Results of a large, multisite study. J Clin Psychiatry 2006;67:1551–60.
  • Goodwin GM, Anderson I, Arango C, Bowden CL, Henry C, Mitchell PB, . ECNP consensus meeting. Bipolar depression. Nice, March 2007. Eur Neuropsychopharmacol 2008;18:535–49.
  • Kasper S, Calabrese JR, Johnson G, Tajima O, Vieta E, Viguera A, Yatham LN, Young AH. International Consensus Group on the evidence-based pharmacologic treatment of bipolar I and II depression. J Clin Psychiatry 2008;69:1632–46.
  • Akiskal HS. The prevalent clinical spectrum of bipolar disorders: Beyond DSM-IV. J Clin Psychopharmacol 1996;16 (2 Suppl 1): 4S–14S.
  • Angst J, Cassano G. The mood spectrum: Improving the diagnosis of bipolar disorder. Bipolar Disord 2005;7 Suppl 4:4–12.
  • Angst J. The bipolar spectrum. Br J Psychiatry 2007;190:189–91.
  • Angst J. Bipolar disorder—Methodological problems and future perspectives. Dialog Clin Neurosci 2008;10:129–39.
  • Benazzi F. The continuum hypothesis of mood disorders. J Clin Psychiatry 2008;69:1187–8.
  • Dunner DL, Gershon ES, Goodwin FK. Heritable factors in the severity of affective illness. Sci Pro Amer Psychiatric Assn 1970;123:187–8.
  • Klerman GL. The spectrum of mania. Compr Psy 1981;22:11–20.
  • Benazzi F. Depressive mixed state: Testing different definitions. Psychiatry Clin Neurosci 2001;55:647–52.
  • Goldberg JF, Perlis RH, Ghaemi SN, Calabrese JR, Bowden CL, Wisniewski S, . Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: Findings from the STEP-BD. Am J Psychiatry 2007;164:1348–55.
  • Perlis RH, Ostacher MJ, Patel JK, Marangell LB, Zhang H, Wisniewski SR, . Predictors of recurrence in bipolar disorder: Primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry 2006;163:217–24.
  • Goldberg JF, Garno JL, Leon AC, Kocsis JH, Portera L. Association of recurrent suicidal ideation with nonremission from acute mixed mania. Am J Psychiatry 1998;155:1753–5.
  • Suppes T, Mintz J, McElroy SL, Altshuler LL, Kupka RW, Frye MA. Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: A sex-specific phenomenon. Arch Gen Psychiatry 2005;62:1089–96.
  • Hantouche EG, Akiskal HS, Azorin JM, Chatenet-Duchene L, Lancrenon S. Clinical and psychometric characterization of depression in mixed mania: A report from the French National Cohort of 1090 manic patients. J Affect Dis 2006;96:225–32.
  • Dilsaver SC, Chen YW, Swann AC, Shoaib AM, Krajewski KJ. Suicidality in patients with pure and depressive mania. Am J Psychiatry 1994;151:1312–5.
  • Khalsa HM, Salvatore P, Hennen J, Baethge C, Tohen M, Baldessarini RJ. Suicidal events and accidents in 216 first-episode bipolar I disorder patients: Predictive factors. J Affect Dis 2008;106:179–84.
  • Minnai GP, Tondo L, Salis P, Ghiani C, Manfredi A, Paluello MM, . Secular trends in first hospitalizations for major mood disorders with comorbid substance use. Int J Neuropsychopharmacol 2006;9:319–26.
  • Perugi G, Akiskal HS, Micheli C, Toni C, Madaro D. Clinical characterization of depressive mixed state in bipolar-I patients: Pisa-San Diego collaboration. J Affect Dis 2001;67:105–14.
  • Dodd S, Kulkarni J, Berk L, Ng F, Fitzgerald PB, de Castella AR, . A prospective study of the impact of subthreshold mixed states on the 24-month clinical outcomes of bipolar I disorder or schizoaffective disorder. J Affect Dis 2010;124:22–8.
  • Mazza M, Mandelli L, Di Nicola M, Harnic D, Catalano V, Tedeschi D, . Clinical features, response to treatment and functional outcome of bipolar disorder patients with and without co-occurring substance use disorder: 1-year follow-up. J Affect Dis 2009;115:27–35.
  • First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition (SCID-I/P, Version 2.0). New York: Biometrics Research Department, New York State Psychiatric Institute; 1995.
  • First MB, Spitzer RL, Gibbon M, Williams BW, Benjamin L. Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II). New York: Biometrics Research Department, New York State Psychiatric Institute; 1990.
  • Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62.
  • Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol 1959;32:50–5.
  • Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: Reliability, validity and sensitivity. Br J Psychiatry 1978;133:429–35.
  • Endicott J, Spitzer RL, Fleiss JL, Cohen J. The Global Assessment Scale. A procedure for measuring overall severity of psychiatric disturbance. Arch Gen Psychiatry 1976;33:766–71.
  • Weissman MM, Bothwell S. Assessment of social adjustment by patient self-report. Arch Gen Psychiatry 1976;33:1111–5.
  • Burckhardt CS, Woods SL, Schultz AA, Ziebarth DM. Quality of life of adults with chronic illness: A psychometric study. Res Nurs Health 1989;12:347–54.
  • American Psychiatric Association, 2000. Diagnostic and statistical manual of mental disorders, 4th, text revision (DSM-IV-TR). Washington, DC: American Psychiatric Press, Inc.
  • StatSoft I. STATISTICA per Windows, 1995.
  • Sackeim HA. The definition and meaning of treatment-resistant depression. J Clin Psychiatry 2001;62 Suppl 16:10–7.
  • Himmelhoch JM, Garfinkel ME. Sources of lithium resistance in mixed mania. Psychopharmacol Bull 1986;22:613–20.
  • McElroy SL, Keck PE, Jr., Pope HG, Jr., Hudson JI, Faedda GL, Swann AC. Clinical and research implications of the diagnosis of dysphoric or mixed mania or hypomania. Am J Psychiatry 1992;149:1633–44.
  • Clothier J, Swann AC, Freeman T. Dysphoric mania. J Clin Psychopharmacol 1992;12 (1 Suppl):13S–6S.
  • Goldberg JF, Perlis RH, Bowden CL, Thase ME, Miklowitz DJ, Marangell LB, . Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: Findings from the STEP-BD. Am J Psychiatry 2009;166:173–81.
  • Benazzi F. Major depressive episodes with hypomanic symptoms are common among depressed outpatients. Compr Psychiatry 2001;42:139–43.
  • Akiskal HS, Benazzi F. Delineating depressive mixed states: Therapeutic significance. Clin Approaches Bipolar Disord 2003;2:41–7.
  • Ghaemi SN, Ko JY, Goodwin FK. “Cade's disease” and beyond: Misdiagnosis, antidepressant use, and a proposed definition for bipolar spectrum disorder. Can J Psychiatry 2002;47:125–34.
  • El-Mallakh RS, Ghaemi SN. Antidepressants in bipolar depression. Bipolar Depression. Washington, DC: American Psychiatric Publishing; 2006.
  • Sharma V, Khan M, Smith A. A closer look at treatment resistant depression: Is it due to a bipolar diathesis? J Affect Dis 2005;84:251–7.
  • Goldberg JF, Truman CJ. Antidepressant-induced mania: An overview of current controversies. Bipolar Disord 2003;5:407–20.
  • Wehr TA, Sack DA, Rosenthal NE, Cowdry RW. Rapid cycling affective disorder: Contributing factors and treatment responses in 51 patients. Am J Psychiatry 1988;145:179–84.
  • Chun BJ, Dunner DL. A review of antidepressant-induced hypomania in major depression: Suggestions for DSM-V. Bipolar Disord 2004;6:32–42.
  • Akiskal HS, Benazzi F, Perugi G, Rihmer Z. Agitated “unipolar” depression re-conceptualized as a depressive mixed state: Implications for the antidepressant–suicide controversy. J Affect Dis 2005;85:245–58.
  • Coryell W, Scheftner W, Keller M, Endicott J, Maser J, Klerman GL. The enduring psychosocial consequences of mania and depression. Am J Psychiatry 1993;150:720–7.
  • De Lisio G, Maremmani I, Perugi G, Cassano GB, Deltito J, Akiskal HS. Impairment of work and leisure in depressed outpatients. A preliminary communication. J Affect Dis 1986;10:79–84.
  • Depp CA, Davis CE, Mittal D, Patterson TL, Jeste DV. Health-related quality of life and functioning of middle-aged and elderly adults with bipolar disorder. J Clin Psychiatry 2006;67:215–21.
  • Conus P, Cotton S, Abdel-Baki A, Lambert M, Berk M, McGorry PD. Symptomatic and functional outcome 12 months after a first episode of psychotic mania: Barriers to recovery in a catchment area sample. Bipolar Dis 2006;8:221–31.
  • Serretti A, Cavallini MC, Macciardi F, Namia C, Franchini L, Souery D. Social adjustment and self-esteem in remitted patients with mood disorders. Eur Psychiatry 1999;14:137–42.
  • MacQueen GM, Young LT, Robb JC, Marriott M, Cooke RG, Joffe RT. Effect of number of episodes on wellbeing and functioning of patients with bipolar disorder. Acta Psychiatr Scand 2000;101:374–81.
  • Robb JC, Cooke RG, Devins GM, Young LT, Joffe RT. Quality of life and lifestyle disruption in euthymic bipolar disorder. J Psychiat Res 1997;31:509–17.
  • DelBello MP, Hanseman D, Adler CM, Fleck DE, Strakowski SM. Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode. Am J Psychiatry 2007;164:582–90.
  • Kupfer DJ, Frank E, Grochocinski VJ, Cluss PA, Houck PR, Stapf DA. Demographic and clinical characteristics of individuals in a bipolar disorder case registry. J Clin Psychiatry 2002;63:120–5.
  • Henry C, M'Bailara K, Desage A, Gard S, Misdrahi D, Vieta E. Towards a reconceptualization of mixed states, based on an emotional-reactivity dimensional model. J Affect Dis 2007; 101:35–41.
  • Cassidy F, Ahearn E, Murry E, Forest K, Carroll BJ. Diagnostic depressive symptoms of the mixed bipolar episode. Psychol Med 2000;30:403–11.
  • Benazzi F. Bipolar II depressive mixed state: Finding a useful definition. Compr Psy 2003;44:21–7.

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