The influence of therapeutic alliance and insight on medication adherence in schizophrenia

References

• Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005;353:487–97.
   PubMed Web of Science ®Google Scholar
• Llorca PM. Partial compliance in schizophrenia and the impact on patient outcomes. Psychiatry Res 2008;161:235–47.
   PubMed Web of Science ®Google Scholar
• Novick D, Haro JM, Suarez D, Perez V, Dittmann RW, Haddad PM. Predictors and clinical consequences of non-adherence with antipsychotic medication in the outpatient treatment of schizophrenia. Psychiatry Res 2010;176:109–13.
   PubMed Web of Science ®Google Scholar
• Velligan DI, Weiden PJ, Sajatovic M, Scott J, Carpenter D, Ross R, . The expert consensus guideline series: Adherence problems in patients with serious and persistent mental illness. J Clin Psychiatry 2009;70 Suppl 4:1–46.
   Web of Science ®Google Scholar
• Weiden PJ, Kozma C, Grogg A, Locklear J. Partial compliance and risk of rehospitalization among California Medicaid patients with schizophrenia. Psychiatr Serv 2004;55:886–91.
   PubMed Web of Science ®Google Scholar
• Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, . Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005;353:1209–23.
   PubMed Web of Science ®Google Scholar
• Ascher-Svanum H, Zhu B, Faries DE, Salkever D, Slade EP, Peng X, . The cost of relapse and the predictors of relapse in the treatment of schizophrenia. BMC Psychiatry 2010;10:2.
   PubMed Web of Science ®Google Scholar
• Fleischhacker WW, Oehl MA, Hummer M. Factors influencing compliance in schizophrenia patients. J Clin Psychiatry 2003;64 Suppl 16:10–3.
   PubMed Web of Science ®Google Scholar
• Lacro JP, Dunn LB, Dolder CR, Leckband SG, Jeste DV. Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: A comprehensive review of recent literature. J Clin Psychiatry 2002;63:892–909.
   PubMed Web of Science ®Google Scholar
• Rocca P, Crivelli B, Marino F, Mongini T, Portaleone F, Bogetto F. Correlations of attitudes toward antipsychotic drugs with insight and objective psychopathology in schizophrenia. Compr Psychiatry 2008;49:170–6.
   PubMed Web of Science ®Google Scholar
• Mohamed S, Rosenheck R, McEvoy J, Swartz M, Stroup S, Lieberman JA. Cross-sectional and longitudinal relationships between insight and attitudes toward medication and clinical outcomes in chronic schizophrenia. Schizophr Bull 2009;35:336–46.
   PubMed Web of Science ®Google Scholar
• Adewuya AO, Ola BA, Mosaku SK, Fatoye FO, Eegunranti AB. Attitude towards antipsychotics among out-patients with schizophrenia in Nigeria. Acta Psychiatr Scand 2006;113:207–11.
   PubMed Web of Science ®Google Scholar
• Day JC, Bentall RP, Roberts C, Randall F, Rogers A, Cattell D, . Attitudes toward antipsychotic medication: The impact of clinical variables and relationships with health professionals. Arch Gen Psychiatry 2005;62:717–24.
   PubMed Web of Science ®Google Scholar
• Hunt GE, Bergen J, Bashir M. Medication compliance and comorbid substance abuse in schizophrenia: Impact on community survival 4 years after a relapse. Schizophr Res 2002;54:253–64.
   PubMed Web of Science ®Google Scholar
• Owen RR, Fischer EP, Booth BM, Cuffel BJ. Medication noncompliance and substance abuse among patients with schizophrenia. Psychiatr Serv 1996;47:853–8.
   PubMed Web of Science ®Google Scholar
• Compton MT, Rudisch BE, Weiss PS, West JC, Kaslow NJ. Predictors of psychiatrist-reported treatment-compliance problems among patients in routine U.S. psychiatric care. Psychiatry Res 2005;137: 29–36.
   PubMed Web of Science ®Google Scholar
• Neale MS, Rosenheck RA. Therapeutic alliance and outcome in a VA intensive case management program. Psychiatr Serv 1995;46: 719–21.
   PubMed Web of Science ®Google Scholar
• Frank AF, Gunderson JG. The role of the therapeutic alliance in the treatment of schizophrenia. Relationship to course and outcome. Arch Gen Psychiatry 1990;47:228–36.
   PubMed Web of Science ®Google Scholar
• Solomon P, Draine J, Delaney MA. The working alliance and consumer case management. J Ment Health Adm 1995;22:126–34.
   PubMedGoogle Scholar
• Svensson B, Hansson L. Therapeutic alliance in cognitive therapy for schizophrenic and other long-term mentally ill patients: Development and relationship to outcome in an in-patient treatment programme. Acta Psychiatr Scand 1999;99:281–7.
   PubMed Web of Science ®Google Scholar
• Barrowclough C, Meier P, Beardmore R, Emsley R. Predicting therapeutic alliance in clients with psychosis and substance misuse. J Nerv Ment Dis 2010;198:373–7.
   PubMed Web of Science ®Google Scholar
• Wittorf A, Jakobi U, Bechdolf A, Muller B, Sartory G, Wagner M, . The influence of baseline symptoms and insight on the therapeutic alliance early in the treatment of schizophrenia. Eur Psychiatry 2009;24:259–67.
   PubMed Web of Science ®Google Scholar
• Lecomte T, Spidel A, Leclerc C, MacEwan GW, Greaves C, Bentall RP. Predictors and profiles of treatment non-adherence and engagement in services problems in early psychosis. Schizophr Res 2008; 102:295–302.
   PubMed Web of Science ®Google Scholar
• Weiss KA, Smith TE, Hull JW, Piper AC, Huppert JD. Predictors of risk of nonadherence in outpatients with schizophrenia and other psychotic disorders. Schizophr Bull 2002;28:341–9.
   PubMed Web of Science ®Google Scholar
• Catty J, Winfield H, Clement S. The therapeutic relationship in secondary mental health care: A conceptual review of measures. Acta Psychiatr Scand 2007;116:238–52.
   PubMed Web of Science ®Google Scholar
• Misdrahi D, Verdoux H, Lancon C, Bayle F. The 4-Point ordinal Alliance Self-report: A self-report questionnaire for assessing therapeutic relationships in routine mental health. Compr Psychiatry 2009; 50:181–5.
   PubMed Web of Science ®Google Scholar
• Luborsky L, Crits-Christoph P, Alexander L, Margolis M, Cohen M. Two helping alliance methods for predicting outcomes of psychotherapy. A counting signs vs. a global rating method. J Nerv Ment Dis 1983;171:480–91.
   PubMed Web of Science ®Google Scholar
• Thompson K, Kulkarni J, Sergejew AA. Reliability and validity of a new Medication Adherence Rating Scale (MARS) for the psychoses. Schizophr Res 2000;42:241–7.
   PubMed Web of Science ®Google Scholar
• Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care 1986;24:67–74.
   PubMed Web of Science ®Google Scholar
• Hogan TP, Awad AG, Eastwood R. A self-report scale predictive of drug compliance in schizophrenics: Reliability and discriminative validity. Psychol Med 1983;13:177–83.
   PubMed Web of Science ®Google Scholar
• Misdrahi D, Verdoux H, Llorca PM, Bayle FJ. Therapeutic adherence and schizophrenia: The interest of the validation of the French translation of Medication Adherence Rating Scale (MARS). Encephale 2004;30:409–10.
   PubMed Web of Science ®Google Scholar
• Amador XF, Strauss DH, Yale SA, Flaum MM, Endicott J, Gorman JM. Assessment of insight in psychosis. Am J Psychiatry 1993;150: 873–9.
   PubMed Web of Science ®Google Scholar
• Lecrubier Y, Sheehan D, Weiller E, Amorim P, Bonora I, Sheehan K, . The MINI International Neuropsychiatric Interview (M.I.N.I.). A short diagnostic structured interview: Reliability and validity according to the CDI. European Psychiatry 1997;12:224–31.
   Web of Science ®Google Scholar
• Ecdeu GW. Assessment manual for psychopharmacology National Institute of Mental Health. 1976.
   Google Scholar
• DSMIV. American Psychiatric Association. Washington DC; 1995.
   Google Scholar
• SAS II. SAS/STAT User's Guide, Version 9.2. Cary, NC: SAS Institute; 2008.
   Google Scholar
• Sajatovic M, Davies M, Bauer MS, McBride L, Hays RW, Safavi R, . Attitudes regarding the collaborative practice model and treatment adherence among individuals with bipolar disorder. Compr Psychiatry 2005;46:272–7.
   PubMed Web of Science ®Google Scholar
• Zeber JE, Copeland LA, Good CB, Fine MJ, Bauer MS, Kilbourne AM. Therapeutic alliance perceptions and medication adherence in patients with bipolar disorder. J Affect Disord 2008; 107:53–62.
   PubMed Web of Science ®Google Scholar
• Staring AB, Van der Gaag M, Van den Berge M, Duivenvoorden HJ, Mulder CL. Stigma moderates the associations of insight with depressed mood, low self-esteem, and low quality of life in patients with schizophrenia spectrum disorders. Schizophr Res 2009;115: 363–9.
   PubMed Web of Science ®Google Scholar
• Acosta FJ, Bosch E, Sarmiento G, Juanes N, Caballero-Hidalgo A, Mayans T. Evaluation of noncompliance in schizophrenia patients using electronic monitoring (MEMS(R)) and its relationship to sociodemographic, clinical and psychopathological variables. Schizophr Res 2008.
   Web of Science ®Google Scholar
• Sajatovic M, Ignacio RV, West JA, Cassidy KA, Safavi R, Kilbourne AM, . Predictors of nonadherence among individuals with bipolar disorder receiving treatment in a community mental health clinic. Compr Psychiatry 2009;50:100–7.
   PubMed Web of Science ®Google Scholar
• Mutsatsa SH, Joyce EM, Hutton SB, Webb E, Gibbins H, Paul S, . Clinical correlates of early medication adherence: West London first episode schizophrenia study. Acta Psychiatr Scand 2003;108:439–46.
   PubMed Web of Science ®Google Scholar
• Weiden PJ, Mackell JA, McDonnell DD. Obesity as a risk factor for antipsychotic noncompliance. Schizophr Res 2004;66:51–7.
   PubMed Web of Science ®Google Scholar
• Hudson TJ, Owen RR, Thrush CR, Han X, Pyne JM, Thapa P, . A pilot study of barriers to medication adherence in schizophrenia. J Clin Psychiatry 2004;65:211–6.
   PubMed Web of Science ®Google Scholar
• Awad AG, Voruganti LN. New antipsychotics, compliance, quality of life, and subjective tolerability—Are patients better off? Can J Psychiatry 2004;49:297–302.
   PubMed Web of Science ®Google Scholar
• Keith SJ, Kane JM. Partial compliance and patient consequences in schizophrenia: Our patients can do better. J Clin Psychiatry 2003; 64:1308–15.
   PubMed Web of Science ®Google Scholar
• Olfson M, Mechanic D, Hansell S, Boyer CA, Walkup J, Weiden PJ. Predicting medication noncompliance after hospital discharge among patients with schizophrenia. Psychiatr Serv 2000;51: 216–22.
   PubMed Web of Science ®Google Scholar
• Kikkert MJ, Barbui C, Koeter MW, David AS, Leese M, Tansella M, . Assessment of medication adherence in patients with schizophrenia: The Achilles heel of adherence research. J Nerv Ment Dis 2008;196:274–81.
   PubMed Web of Science ®Google Scholar
• Velligan DI, Lam YW, Glahn DC, Barrett JA, Maples NJ, Ereshefsky L, . Defining and assessing adherence to oral antipsychotics: A review of the literature. Schizophr Bull 2006;32: 724–42.
   PubMed Web of Science ®Google Scholar