Immunotherapy Against Invasive Fungal Diseases in Stem Cell Transplant Recipients

REFERENCES

• Bacci, A., Montagnoli, C., (2002). Dendritic cells pulsed with fungal RNA induce protective immunity to Candida albicans in hematopoietic transplantation. J. Immunol. 168(6):2904–2913.
   PubMed Web of Science ®Google Scholar
• Beck, O., Koehl, U., (2008). Enumeration of functionally active anti-Aspergillus T-cells in human peripheral blood. J. Immunol. Meth. 335(1–2):41–45.
   PubMed Web of Science ®Google Scholar
• Beck, O., Topp, M. S., (2006). Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus. Blood 107(6):2562–2569.
   PubMed Web of Science ®Google Scholar
• Bonifazi, P., Zelante, T., (2009). Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans. Mucosal Immunol. 2(4):362–374.
   PubMed Web of Science ®Google Scholar
• Bow, E. J. (2009). Invasive fungal infection in haematopoietic stem cell transplant recipients: epidemiology from the transplant physician’s viewpoint.” Mycopathologia 168(6):283–297.
   PubMed Web of Science ®Google Scholar
• Bow, E. J., Meddings, J. B. (2006). Intestinal mucosal dysfunction and infection during remission-induction therapy for acute myeloid leukaemia. Leukemia 20(12):2087–2092.
   PubMed Web of Science ®Google Scholar
• Bozza, S., Clavaud, C., (2009). Immune sensing of Aspergillus fumigatus proteins, glycolipids, and polysaccharides and the impact on Th immunity and vaccination. J. Immunol. 183(4): 2407–2414.
   PubMed Web of Science ®Google Scholar
• Bozza, S., Perruccio, K., (2003). A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation. Blood 102(10):3807–3814.
   PubMed Web of Science ®Google Scholar
• Camps, I. R. (2008). Risk factors for invasive fungal infections in haematopoietic stem cell transplantation. Int. J. Antimicrob. Agents 32 (Suppl 2): S119–123.
   PubMed Web of Science ®Google Scholar
• Casadevall, A., Pirofski, L. A. (2007). Antibody-mediated protection through cross-reactivity introduces a fungal heresy into immunological dogma. Infect. Immun. 75(11): 5074–5078.
   PubMed Web of Science ®Google Scholar
• Cenci, E., Mencacci, A., (2000). T cell vaccination in mice with invasive pulmonary aspergillosis. J. Immunol. 165(1):381–388.
   PubMed Web of Science ®Google Scholar
• Cenci, E., Mencacci, A., (1999). Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses. J. Infect. Dis. 180(6):1957–1968.
   PubMed Web of Science ®Google Scholar
• Chaturvedi, A. K., Kavishwar, A., (2005). Monoclonal immunoglobulin G1 directed against Aspergillus fumigatus cell wall glycoprotein protects against experimental murine aspergillosis. Clin. Diagn. Lab. Immunol. 12(9):1063–1068.
   PubMedGoogle Scholar
• Denning, D. W. (1998). Invasive aspergillosis. Clin. Infect. Dis. 26(4): 781–803; quiz 804–5.
   PubMed Web of Science ®Google Scholar
• d’Ostiani, C. F., Del Sero, G., (2000). Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J. Exp. Med. 191(10):1661–1674.
   PubMed Web of Science ®Google Scholar
• Dvorak, C. C., Steinbach, W. J., (2005). Risks and outcomes of invasive fungal infections in pediatric patients undergoing allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 36(7): 621–629.
   PubMed Web of Science ®Google Scholar
• Grigull, L., Pulver, N., (2006). G-CSF mobilised granulocyte transfusions in 32 paediatric patients with neutropenic sepsis. Support Care Cancer 14(9):910–916.
   PubMed Web of Science ®Google Scholar
• Hamadani, M., Hofmeister, C. C., (2008). Addition of infliximab to standard acute graft-versus-host disease prophylaxis following allogeneic peripheral blood cell transplantation. Biol. Blood Marrow Transpl. 14(7):783–789.
   PubMed Web of Science ®Google Scholar
• Hamza, N. S., Lisgaris, M., (2004). Kinetics of myeloid and lymphocyte recovery and infectious complications after unrelated umbilical cord blood versus HLA-matched unrelated donor allogeneic transplantation in adults. Br. J. Haematol. 124(4):488–498.
   PubMed Web of Science ®Google Scholar
• Hebart, H., Bollinger, C., (2002). Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies. Blood 100(13):4521–4528.
   PubMed Web of Science ®Google Scholar
• Jantunen, E., Salonen, J., (2004). Invasive fungal infections in autologous stem cell transplant recipients: A nation-wide study of 1188 transplanted patients. Eur. J. Haematol. 73(3):174–178.
   PubMed Web of Science ®Google Scholar
• Kondori, N, Edebo, L., (2004). Circulating beta (1–3) glucan and immunoglobulin G subclass antibodies to Candida albicans cell wall antigens in patients with systemic candidiasis. Clin. Diagn. Lab. Immunol. 11(2): 344–350.
   PubMedGoogle Scholar
• Kontoyiannis, D. P., Marr, K. A., (2010). Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001–2006: Overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database. Clin. Infect. Dis. 50(8):1091–1100.
   PubMed Web of Science ®Google Scholar
• Langner, S., Staber, P., (2008). Palifermin reduces incidence and severity of oral mucositis in allogeneic stem-cell transplant recipients. Bone Marrow Transplant 42(4): 275–279.
   PubMed Web of Science ®Google Scholar
• Lehrnbecher, T., Chanock, S. J. (2001). Myeloid growth factors in supportive care of cancer and marrow transplant therapies. Cytokine therapeutics in infectious diseases. S. M. Holland. Philadelphia, PA, Lippincott Williams & Williams: 251–293.
   Google Scholar
• Lehrnbecher, T., Koehl, U., (2008). Changes in host defence induced by malignancies and antineoplastic treatment: Implication for immunotherapeutic strategies. Lancet Oncol. 9(3):269–278.
   PubMed Web of Science ®Google Scholar
• Lehrnbecher, T. Welte, K. (2002). Haematopoietic growth factors in children with neutropenia. Br. J. Haematol. 116(1):28–56.
   PubMed Web of Science ®Google Scholar
• Lehrnbecher, T., Zimmermann, M., (2007). Prophylactic human granulocyte colony-stimulating factor after induction therapy in pediatric acute myeloid leukemia. Blood 109:936–943.
   PubMed Web of Science ®Google Scholar
• Levine, J. E., Blazar, B. R., (2008). Long-term follow-up of a phase I/II randomized, placebo-controlled trial of palifermin to prevent graft-versus-host disease (GVHD) after related donor allogeneic hematopoietic cell transplantation (HCT). Biol. Blood Marrow Transplant 14(9):1017–1021.
   PubMed Web of Science ®Google Scholar
• Maitta, R. W., Datta, K., (2004). Protective and nonprotective human immunoglobulin M monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan manifest different specificities and gene use profiles. Infect. Immun. 72(8):4810–4818.
   PubMed Web of Science ®Google Scholar
• Mikulska, M., Raiola, A. M., (2009). Risk factors for invasive aspergillosis and related mortality in recipients of allogeneic SCT from alternative donors: An analysis of 306 patients. Bone Marrow Transplant 44(6):361–370.
   PubMed Web of Science ®Google Scholar
• Montagnoli, C., Perruccio, K., (2008). Provision of antifungal immunity and concomitant alloantigen tolerization by conditioned dendritic cells in experimental hematopoietic transplantation. Blood Cells Mol. Dis. 40(1):55–62.
   PubMed Web of Science ®Google Scholar
• Moragues, M. D., Omaetxebarria, M. J., (2003). A monoclonal antibody directed against a Candida albicans cell wall mannoprotein exerts three anti-C. albicans activities. Infect. Immun. 71(9):5273–5279.
   PubMed Web of Science ®Google Scholar
• Morgan, J., Wannemuehler, K. A., (2005). Incidence of invasive aspergillosis following hematopoietic stem cell and solid organ transplantation: interim results of a prospective multicenter surveillance program. Med. Mycol. 43 Suppl 1:S49–58.
   PubMed Web of Science ®Google Scholar
• Morrison, B. E., Park, S. J., (2003). Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis. J. Clin. Invest. 112(12):1862–1870.
   PubMed Web of Science ®Google Scholar
• Mousset, S., Hermann, S., (2005). Prophylactic and interventional granulocyte transfusions in patients with haematological malignancies and life-threatening infections during neutropenia. Ann. Hematol. 84(11):734–741.
   PubMed Web of Science ®Google Scholar
• Neofytos, D., Horn, D., (2009). Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry. Clin. Infect. Dis. 48(3):265–273.
   PubMed Web of Science ®Google Scholar
• Nosanchuk, J. D., Steenbergen, J. N., (2003). Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum. J. Clin. Invest. 112(8):1164–75.
   PubMed Web of Science ®Google Scholar
• Pagano, L., Caira, M, (2007). Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study–Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne. Clin. Infect. Dis. 45(9):1161–1170.
   PubMed Web of Science ®Google Scholar
• Panoskaltsis-Mortari, A., Lacey, D. L., (1998). Keratinocyte growth factor administered before conditioning ameliorates graft-versus-host disease after allogeneic bone marrow transplantation in mice. Blood 92(10):3960–3967.
   PubMed Web of Science ®Google Scholar
• Park, S. J., Hughes, M. A., (2009). Early NK cell-derived IFN-{gamma} is essential to host defense in neutropenic invasive aspergillosis. J. Immunol. 182(7):4306–4312.
   PubMed Web of Science ®Google Scholar
• Passweg, J. R., Koehl, U., (2006). Natural-killer-cell-based treatment in haematopoietic stem-cell transplantation. Best Pract. Res. Clin. Haematol. 19(4):811–824.
   PubMed Web of Science ®Google Scholar
• Perruccio, K., Tosti, A., (2005). Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation. Blood 106:4397–4406.
   PubMed Web of Science ®Google Scholar
• Ringden, O., Labopin, M., (2004). Treatment with granulocyte colony-stimulating factor after allogeneic bone marrow transplantation for acute leukemia increases the risk of graft-versus-host disease and death: a study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. J. Clin. Oncol. 22(3):416–423.
   PubMed Web of Science ®Google Scholar
• Roilides, E., Lyman, C. A., (1996). Ex vivo effects of macrophage colony-stimulating factor on human monocyte activity against fungal and bacterial pathogens. Cytokine 8(1):42–48.
   PubMed Web of Science ®Google Scholar
• Roilides, E., Tsaparidou, S., (1999). Interleukin-12 enhances antifungal activity of human mononuclear phagocytes against Aspergillus fumigatus: implications for a gamma interferon-independent pathway. Infect. Immun. 67(6):3047–3050.
   PubMed Web of Science ®Google Scholar
• Romani, L. (2004). Immunity to fungal infections. Nat. Rev. Immunol. 4(1):1–23.
   PubMed Web of Science ®Google Scholar
• Romani, L. Puccetti, P. (2007). Controlling pathogenic inflammation to fungi. Expert Rev. Anti. Infect. Ther. 5(6):1007–1017.
   PubMed Web of Science ®Google Scholar
• Romani, L., Puccetti, P., (1997). Interleukin-12 in infectious diseases. Clin. Microbiol. Rev. 10(4):611–636.
   PubMed Web of Science ®Google Scholar
• Rotstein, C., Bow, E. J., (1999). Randomized placebo-controlled trial of fluconazole prophylaxis for neutropenic cancer patients: Benefit based on purpose and intensity of cytotoxic therapy. The Canadian Fluconazole Prophylaxis Study Group. Clin. Infect. Dis. 28(2):331–340.
   PubMed Web of Science ®Google Scholar
• Rowe, J., Anderson, J., (1995). A randomized placebo-controlled phase III study of granulocyte-macrophage colony-stimulating factor in adult patients (>55 to 70 years of age) with acute myelogenous leukemia:A study of the Eastern Cooperative Oncology Group (E1490). Blood 86:457–462.
   PubMed Web of Science ®Google Scholar
• Rubnitz, J.E., Inaba, H., (2010). NKAML: A pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. J. Clin. Oncol. 28(6):955–959.
   PubMed Web of Science ®Google Scholar
• Safdar, A. (2006). Strategies to enhance immune function in hematopoietic transplantation recipients who have fungal infections. Bone Marrow Transplant 38(5):327–337.
   PubMed Web of Science ®Google Scholar
• Safdar, A., Hanna, H. A., (2004). Impact of high-dose granulocyte transfusions in patients with cancer with candidemia: Retrospective case-control analysis of 491 episodes of Candida species bloodstream infections. Cancer 101(12):2859–2865.
   PubMed Web of Science ®Google Scholar
• Safdar, A., Rodriguez, G., (2005). The safety of interferon-gamma-1b therapy for invasive fungal infections after hematopoietic stem cell transplantation. Cancer 103(4):731–739.
   PubMed Web of Science ®Google Scholar
• Safdar, A., Rodriguez, G. H., (2006). Recombinant interferon gamma1b immune enhancement in 20 patients with hematologic malignancies and systemic opportunistic infections treated with donor granulocyte transfusions. Cancer 106(12):2664–2671.
   PubMed Web of Science ®Google Scholar
• Schlahsa, L., Jaimes, Y., (2011). Granulocyte-colony-stimulatory factor: a strong inhibitor of natural killer cell function. Transfusion 51:293–305.
   PubMed Web of Science ®Google Scholar
• Schmidt, S., Tramsen, L., (2011). Human natural killer cells exhibit direct activity against Aspergillus fumigatus hyphae, but not against resting conidia. J. Infect. Dis. 203(3):430–435.
   PubMed Web of Science ®Google Scholar
• Seggewiss, R., Lore, K., (2007). Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood 110:441–449.
   PubMed Web of Science ®Google Scholar
• Seidel, M. G., Peters, C., (2008). Randomized phase III study of granulocyte transfusions in neutropenic patients. Bone Marrow Transplant 42(10):679–684.
   PubMed Web of Science ®Google Scholar
• Spielberger, R., Stiff, P., (2004). Palifermin for oral mucositis after intensive therapy for hematologic cancers. N. Engl. J. Med. 351(25):2590–2598.
   PubMed Web of Science ®Google Scholar
• Tomblyn, M., Young, J. A., (2010). Decreased infections in recipients of unrelated donor hematopoietic cell transplantation from donors with an activating KIR genotype. Biol. Blood Marrow Transplant 16(8):1155–1161.
   PubMed Web of Science ®Google Scholar
• Toren, A., Or, R., (1997). Invasive fungal infections in lymphoma patients receiving immunotherapy following autologous bone marrow transplantation (ABMT). Bone Marrow Transplant 20(1):67–69.
   PubMed Web of Science ®Google Scholar
• Tramsen, L., Beck, O., (2007). Generation and characterization of anti-Candida T cells as potential immunotherapy in patients with Candida infection after allogeneic hematopoietic stem-cell transplant. J. Infect. Dis. 196(3):485–492.
   PubMed Web of Science ®Google Scholar
• Tramsen, L., Koehl, U., (2009). Clinical-scale generation of human anti-Aspergillus T cells for adoptive immunotherapy. Bone Marrow Transplant 43(1):13–19.
   PubMed Web of Science ®Google Scholar
• Tsirigotis, P., Triantafyllou, K., (2008). Keratinocyte growth factor is effective in the prevention of intestinal mucositis in patients with hematological malignancies treated with high-dose chemotherapy and autologous hematopoietic SCT: A video-capsule endoscopy study. Bone Marrow Transplant 42(5):337–343.
   PubMed Web of Science ®Google Scholar
• van der Velden, W. J., Herbers, A. H., (2009). Palifermin in allogeneic HSCT: Many questions remain. Bone Marrow Transplant 43(1):85–86.
   PubMed Web of Science ®Google Scholar
• Volpi, I., Perruccio, K., (2001). Postgrafting administration of granulocyte colony-stimulating factor impairs functional immune recovery in recipients of human leukocyte antigen haplotype-mismatched hematopoietic transplants. Blood 97(8):2514–2521.
   PubMed Web of Science ®Google Scholar
• Walsh, T. J., Groll, A. (2004). Infections due to emerging and uncommon medically important fungal pathogens. Clin. Microbiol. Infect. 10 Suppl 1:48–66.
   PubMed Web of Science ®Google Scholar
• Wardley, A. M., Jayson, G. C., (2000). Prospective evaluation of oral mucositis in patients receiving myeloablative conditioning regimens and haemopoietic progenitor rescue. Br. J. Haematol. 110(2):292–299.
   PubMed Web of Science ®Google Scholar