T cell Immunity and Vaccines Against Invasive Fungal Diseases

REFERENCES

• Antachopoulos, C., Roilides, E. (2005). Cytokines and fungal infections. Br. J. Haematol. 129(5):583–596.
   PubMed Web of Science ®Google Scholar
• Bacci, A., Montagnoli, C., Perruccio, K., Bozza, S., Gaziano, R., Pitzurra, L., Velardi, A., d’Ostiani, C. F., Cutler, J. E., Romani, L. (2002). Dendritic cells pulsed with fungal RNA induce protective immunity to Candida albicans in hematopoietic transplantation. J. Immunol. 168(6):2904–2913.
   PubMed Web of Science ®Google Scholar
• Baddley, J.W., Andes, D.R., Marr, K.A., Kontoyiannis, D.P., Alexander, B.D., Kauffman, C.A., Oster, R.A., Anaissie, E.J., Walsh, T.J., Schuster, M.G., Wingard, J.R., Patterson, T. F., Ito, J.I., Williams, O.D., Chiller, T., Pappas, P.G. (2010). Factors associated with mortality in transplant patients with invasive aspergillosis. Clin. Infect. Dis. 50(12):1559–1567.
   PubMed Web of Science ®Google Scholar
• Barnes, P. J. (1998). Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin. Sci. (Lond.) 94(6):557–572.
   PubMed Web of Science ®Google Scholar
• Bellocchio, S., Bozza, S., Montagnoli, C., Perruccio, K., Gaziano, R., Pitzurra, L., Romani, L. (2005). Immunity to Aspergillus fumigatus: the basis for immunotherapy and vaccination. Med. Mycol. 43 Suppl 1:S181–188.
   PubMed Web of Science ®Google Scholar
• Bonifazi, P., D’Angelo, C., Zagarella, S., Zelante, T., Bozza, S., De Luca, A., Giovannini, G., Moretti, S., Iannitti, R. G., Fallarino, F., Carvalho, A., Cunha, C., Bistoni, F., Romani, L. (2010). Intranasally delivered siRNA targeting PI3K/Akt/mTOR inflammatory pathways protects from aspergillosis. Mucosal Immunol. 3(2),193–205.
   PubMed Web of Science ®Google Scholar
• Bozza, S., Clavaud, C., Giovannini, G., Fontaine, T., Beauvais, A., Sarfati, J., D’Angelo, C., Perruccio, K., Bonifazi, P., Zagarella, S., Moretti, S., Bistoni, F., Latge, J. P., Romani, L. (2009). Immune sensing of Aspergillus fumigatus proteins, glycolipids, and polysaccharides and the impact on Th immunity and vaccination. J. Immunol. 183(4): 2407–2414.
   PubMed Web of Science ®Google Scholar
• Bozza, S., Gaziano, R., Lipford, G. B., Montagnoli, C., Bacci, A., Di Francesco, P., Kurup, V. P., Wagner, H., Romani, L. (2002). Vaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligodeoxynucleotides as adjuvants. Microbes Infect. 4(13):1281–1290.
   PubMed Web of Science ®Google Scholar
• Bozza, S., Perruccio, K., Montagnoli, C., Gaziano, R., Bellocchio, S., Burchielli, E., Nkwanyuo, G., Pitzurra, L., Velardi, A., Romani, L. (2003). A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation. Blood 102(10):3807–3814.
   PubMed Web of Science ®Google Scholar
• Bozza, S., Zelante, T., Moretti, S., Bonifazi, P., DeLuca, A., D’Angelo, C., Giovannini, G., Garlanda, C., Boon, L., Bistoni, F., Puccetti, P., Mantovani, A., Romani, L. (2008). Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection. J. Immunol. 180(6): 4022–4031.
   PubMed Web of Science ®Google Scholar
• Brieland, J.K., Jackson, C., Menzel, F., Loebenberg, D., Cacciapuoti, A., Halpern, J., Hurst, S., Muchamuel, T., Debets, R., Kastelein, R., Churakova, T., Abrams, J., Hare, R., O’Garra, A. (2001). Cytokine networking in lungs of immunocompetent mice in response to inhaled Aspergillus fumigatus. Infect. Immun. 69(3):1554–1560.
   PubMed Web of Science ®Google Scholar
• Casadevall, A. (1995). Antibody immunity and invasive fungal infections. Infect. Immun. 63(11): 4211–4218.
   PubMed Web of Science ®Google Scholar
• Cenci, E., Mencacci, A., Bacci, A., Bistoni, F., Kurup, V. P., Romani, L. (2000). T cell vaccination in mice with invasive pulmonary aspergillosis. J. Immunol. 165(1)381–388.
   PubMed Web of Science ®Google Scholar
• Chai, L. Y., van de Veerdonk, F., Marijnissen, R. J., Cheng, S. C., Khoo, A. L., Hectors, M., Lagrou, K., Vonk, A. G., Maertens, J., Joosten, L. A., Kullberg, B. J., Netea, M. G. (2010). Anti-Aspergillus human host defence relies on type 1 T helper (Th1), rather than type 17 T helper (Th17), cellular immunity. Immunology 130(1):46–54.
   PubMed Web of Science ®Google Scholar
• Cutler, J. E. (2005). Defining criteria for anti-mannan antibodies to protect against candidiasis. Curr. Mol. Med. 5(4):383–392.
   PubMed Web of Science ®Google Scholar
• Denikus, N., Orfaniotou, F., Wulf, G., Lehmann, P. F., Monod, M., Reichard, U. (2005). Fungal antigens expressed during invasive aspergillosis. Infect. Immun. 73(8):4704–4713.
   PubMed Web of Science ®Google Scholar
• Diaz-Arevalo, D., Bagramyan, K., Hong, T. B., Ito, J. I., Kalkum, M. (2011). CD4+ T cells mediate the protective effect of the recombinant Asp f3-based anti-aspergillosis vaccine. Infect. Immun. 79(6):2257–2266.
   PubMed Web of Science ®Google Scholar
• Gafa, V., Lande, R., Gagliardi, M. C., Severa, M., Giacomini, E., Remoli, M. E., Nisini, R., Ramoni, C., Di Francesco, P., Aldebert, D., Grillot, R., Coccia, E. M. (2006). Human dendritic cells following Aspergillus fumigatus infection express the CCR7 receptor and a differential pattern of interleukin-12 (IL-12), IL-23, and IL-27 cytokines, which lead to a Th1 response. Infect. Immun. 74(3),1480–1489.
   PubMed Web of Science ®Google Scholar
• Gafa, V., Remoli, M. E., Giacomini, E., Gagliardi, M. C., Lande, R., Severa, M., Grillot, R., Coccia, E. M. (2007). In vitro infection of human dendritic cells by Aspergillus fumigatus conidia triggers the secretion of chemokines for neutrophil and Th1 lymphocyte recruitment. Microbes Infect. 9(8):971–980.
   PubMed Web of Science ®Google Scholar
• Glocker, E. O., Hennigs, A., Nabavi, M., Schaffer, A. A., Woellner, C., Salzer, U., Pfeifer, D., Veelken, H., Warnatz, K., Tahami, F., Jamal, S., Manguiat, A., Rezaei, N., Amirzargar, A. A., Plebani, A., Hannesschlager, N., Gross, O., Ruland, J., Grimbacher, B. (2009). A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N. Engl. J. Med. 361(18):1727–1735.
   PubMed Web of Science ®Google Scholar
• Han, Y., Ulrich, M. A., Cutler, J. E. (1999). Candida albicans mannan extract-protein conjugates induce a protective immune response against experimental candidiasis. J. Infect. Dis. 179(6):1477–1484.
   PubMed Web of Science ®Google Scholar
• Haraguchi, N., Ishii, Y., Morishima, Y., Yoh, K., Matsuno, Y., Kikuchi, N., Sakamoto, T., Takahashi, S., Hizawa, N. (2010). Impairment of host defense against disseminated candidiasis in mice overexpressing GATA-3. Infect. Immun. 78(5):2302–2311.
   PubMed Web of Science ®Google Scholar
• Hebart, H., Bollinger, C., Fisch, P., Sarfati, J., Meisner, C., Baur, M., Loeffler, J., Monod, M., Latge, J.-P., Einsele, H. (2002). Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies. Blood 100(13):4521–4528.
   PubMed Web of Science ®Google Scholar
• Hohl, T. M., Feldmesser, M. (2007). Aspergillus fumigatus: principles of pathogenesis and host defense. Eukaryot. Cell 6(11):1953–1963.
   PubMedGoogle Scholar
• Huang, W., Na, L., Fidel, P. L., Schwarzenberger, P. (2004). Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J. Infect. Dis. 190(3):624–631.
   PubMed Web of Science ®Google Scholar
• Ibrahim, A. S., Spellberg, B. J., Avanesian, V., Fu, Y., Edwards, J. E., Jr. (2006). The anti-Candida vaccine based on the recombinant N-terminal domain of Als1p is broadly active against disseminated candidiasis. Infect. Immun. 74(5):3039–3041.
   PubMed Web of Science ®Google Scholar
• Ibrahim, A. S., Spellberg, B. J., Avenissian, V., Fu, Y., Filler, S. G., Edwards, J. E., Jr. (2005). Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunity. Infect. Immun. 73(2):999–1005.
   PubMed Web of Science ®Google Scholar
• Ito, J. I., Lyons, J. M. (2002). Vaccination of corticosteroid immunosuppressed mice against invasive pulmonary aspergillosis. J. Infect. Dis. 186(6):869–871.
   PubMed Web of Science ®Google Scholar
• Ito, J. I., Lyons, J. M., Hong, T. B., Tamae, D., Liu, Y. K., Wilczynski, S. P., Kalkum, M. (2006). Vaccinations with recombinant variants of Aspergillus fumigatus allergen Asp f 3 protect mice against invasive aspergillosis. Infect. Immun. 74(9):5075–5084.
   PubMed Web of Science ®Google Scholar
• Kavishwar, A., Shukla, P. K. (2006). Candidacidal activity of a monoclonal antibody that binds with glycosyl moieties of proteins of Candida albicans. Med. Mycol. 44(2):159–167.
   PubMed Web of Science ®Google Scholar
• Kim, K. D., Zhao, J., Auh, S., Yang, X., Du, P., Tang, H., Fu, Y. X. (2007). Adaptive immune cells temper initial innate responses. Nat. Med. 13(10):1248–1252.
   PubMed Web of Science ®Google Scholar
• Koh, A. Y., Kohler, J. R., Coggshall, K. T., Van Rooijen, N., Pier, G. B. (2008). Mucosal damage and neutropenia are required for Candida albicans dissemination. PLoS Pathog. 4(2), e35.
   PubMed Web of Science ®Google Scholar
• Kontoyiannis, D. P., Marr, K. A., Park, B. J., Alexander, B. D., Anaissie, E. J., Walsh, T. J., Ito, J., Andes, D. R., Baddley, J. W., Brown, J. M., Brumble, L. M., Freifeld, A. G., Hadley, S., Herwaldt, L. A., Kauffman, C. A., Knapp, K., Lyon, G. M., Morrison, V. A., Papanicolaou, G., Patterson, T. F., Perl, T. M., Schuster, M. G., Walker, R., Wannemuehler, K. A., Wingard, J. R., Chiller, T. M., Pappas, P. G. (2010). Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001–2006: Overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) database. Clin. Infect. Dis. 50(8):1091–1100.
   PubMed Web of Science ®Google Scholar
• Luo, G., Ibrahim, A.S., Spellberg, B., Nobile, C.J., Mitchell, A.P., Fu, Y. (2010). Candida albicans Hyr1p confers resistance to neutrophil killing and is a potential vaccine target. J. Infect. Dis. 201(11):1718–1728.
   PubMed Web of Science ®Google Scholar
• Magliani, W., Conti, S., Salati, A., Arseni, S., Ravanetti, L., Frazzi, R., Polonelli, L. (2004). Engineered killer mimotopes: New synthetic peptides for antimicrobial therapy. Curr. Med. Chem. 11(13):1793–1800.
   PubMed Web of Science ®Google Scholar
• Matthews, R. C., Burnie, J. P. (2004). Recombinant antibodies: A natural partner in combinatorial antifungal therapy. Vaccine 22(7):865–871.
   PubMed Web of Science ®Google Scholar
• Matthews, R. C., Rigg, G., Hodgetts, S., Carter, T., Chapman, C., Gregory, C., Illidge, C., Burnie, J. (2003). Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90. Antimicrob. Agents Chemother. 47(7):2208–2216.
   PubMed Web of Science ®Google Scholar
• Mencacci, A., Cenci, E., Del Sero, G., d’Ostiani, C. F., Montagnoli, C., Bacci, A., Bistoni, F., Romani, L. (1999). Innate and adaptive immunity to Candida albicans: A new view of an old paradigm. Rev. Iberoam. Micol. 16(1):4–7.
   PubMedGoogle Scholar
• Mircescu, M. M., Lipuma, L., van Rooijen, N., Pamer, E. G., Hohl, T. M. (2009). Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection. J. Infect. Dis. 200(4):647–656.
   PubMed Web of Science ®Google Scholar
• Montagnoli, C., Fallarino, F., Gaziano, R., Bozza, S., Bellocchio, S., Zelante, T., Kurup, W. P., Pitzurra, L., Puccetti, P., Romani, L. (2006). Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J. Immunol. 176(3):1712–1723.
   PubMed Web of Science ®Google Scholar
• Montagnoli, C., Sandini, S., Bacci, A., Romani, L., La Valle, R. (2004). Immunogenicity and protective effect of recombinant enolase of Candida albicans in a murine model of systemic candidiasis. Med. Mycol. 42(4):319–324.
   PubMed Web of Science ®Google Scholar
• Moragues, M. D., Omaetxebarria, M. J., Elguezabal, N., Sevilla, M. J., Conti, S., Polonelli, L., Ponton, J. (2003). A monoclonal antibody directed against a Candida albicans cell wall mannoprotein exerts three anti-C. albicans activities. Infect. Immun. 71(9):5273–5279.
   PubMed Web of Science ®Google Scholar
• Mosmann, T. R., Coffman, R. L. (1989). TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145–173.
   PubMed Web of Science ®Google Scholar
• Netea, M. G., Sutmuller, R., Hermann, C., Van der Graaf, C. A., Van der Meer, J. W., van Krieken, J. H., Hartung, T., Adema, G., Kullberg, B. J. (2004). Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J. Immunol. 172(6):3712–3718.
   PubMed Web of Science ®Google Scholar
• Pachl, J., Svoboda, P., Jacobs, F., Vandewoude, K., van der Hoven, B., Spronk, P., Masterson, G., Malbrain, M., Aoun, M., Garbino, J., Takala, J., Drgona, L., Burnie, J., Matthews, R. (2006). A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis. Clin. Infect. Dis. 42(10):1404–1413.
   PubMed Web of Science ®Google Scholar
• Rivera, A., Pamer, E. G. (2009). CD4+ T-Cell Resproses to Aspergillus fumigatus. In J.-P. Latgé & W. J. Steinbach ( Eds.), Aspergillus fumigatus and aspergillosis ( pp. 263–277). Washington, DC: ASM Press.
   Google Scholar
• Rivera, A., Van Epps, H. L., Hohl, T. M., Rizzuto, G., Pamer, E. G. (2005). Distinct CD4+-T-cell responses to live and heat-inactivated Aspergillus fumigatus conidia. Infect. Immun. 73(11):7170–7179.
   PubMed Web of Science ®Google Scholar
• Roilides, E., Blake, C., Holmes, A., Pizzo, P. A., Walsh, T. J. (1996). Granulocyte-macrophage colony-stimulating factor and interferon-gamma prevent dexamethasone-induced immunosuppression of antifungal monocyte activity against Aspergillus fumigatus hyphae. J. Med. Vet. Mycol. 34(1):63–69.
   PubMedGoogle Scholar
• Romani, L. (2008). Cell mediated immunity to fungi: A reassessment. Med. Mycol. 46(6):515–529.
   PubMed Web of Science ®Google Scholar
• Romani, L. (2009). Dendritic cells in Aspergillus infection and allergy In J.-P. Latgé & W. J. Steinbach ( Eds.), Aspergillus fumigatus and aspergillosis ( pp. 247–261). Washington, DC: ASM Press.
   Google Scholar
• Romani, L., Bistoni, F., Gaziano, R., Bozza, S., Montagnoli, C., Perruccio, K., Pitzurra, L., Bellocchio, S., Velardi, A., Rasi, G., Di Francesco, P., Garaci, E. (2004). Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling. Blood 103(11):4232–4239.
   PubMed Web of Science ®Google Scholar
• Saijo, S., Ikeda, S., Yamabe, K., Kakuta, S., Ishigame, H., Akitsu, A., Fujikado, N., Kusaka, T., Kubo, S., Chung, S. H., Komatsu, R., Miura, N., Adachi, Y., Ohno, N., Shibuya, K., Yamamoto, N., Kawakami, K., Yamasaki, S., Saito, T., Akira, S., Iwakura, Y. (2010). Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity 32(5):681–691.
   PubMed Web of Science ®Google Scholar
• Sandini, S., La Valle, R., De Bernardis, F., Macri, C.,Cassone, A. (2007). The 65 kDa mannoprotein gene of Candida albicans encodes a putative beta-glucanase adhesin required for hyphal morphogenesis and experimental pathogenicity. Cell Microbiol. 9(5): 1223–1238.
   PubMed Web of Science ®Google Scholar
• Schaffner, A. (1985). Therapeutic concentrations of glucocorticoids suppress the antimicrobial activity of human macrophages without impairing their responsiveness to gamma interferon. J. Clin. Invest. 76(5):1755–1764.
   PubMed Web of Science ®Google Scholar
• Schaffner, A., Douglas, H., Braude, A. (1982). Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes. J. Clin. Invest. 69(3):617–631.
   PubMed Web of Science ®Google Scholar
• Spellberg, B. J., Ibrahim, A. S., Avanesian, V., Fu, Y., Myers, C., Phan, Q. T., Filler, S. G., Yeaman, M. R., Edwards, J. E., Jr. (2006). Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasis. J. Infect. Dis. 194(2): 256–260.
   PubMed Web of Science ®Google Scholar
• Sutmuller, R. P., den Brok, M. H., Kramer, M., Bennink, E. J., Toonen, L. W., Kullberg, B. J., Joosten, L. A., Akira, S., Netea, M. G., Adema, G. J. (2006). Toll-like receptor 2 controls expansion and function of regulatory T cells. J. Clin. Invest. 116(2):485–494.
   PubMed Web of Science ®Google Scholar
• Tomblyn, M., Chiller, T., Einsele, H., Gress, R., Sepkowitz, K., Storek, J., Wingard, J. R., Young, J. A., Boeckh, M. J. (2009). Guidelines for preventing infectious complications among hematopoietic cell transplant recipients: a global perspective. Preface. Bone Marrow Transplant 44(8):453–455.
   PubMed Web of Science ®Google Scholar
• Torosantucci, A., Bromuro, C., Chiani, P., De Bernardis, F., Berti, F., Galli, C., Norelli, F., Bellucci, C., Polonelli, L., Costantino, P., Rappuoli, R., Cassone, A. (2005). A novel glyco-conjugate vaccine against fungal pathogens. J. Exp. Med. 202(5):597–606.
   PubMed Web of Science ®Google Scholar
• van de Veerdonk, F. L.,Netea, M. G. (2010). T-cell subsets and antifungal host defenses. Curr. Fungal Infect. Rep. 4(4):238–243.
   PubMedGoogle Scholar
• Werner, J. L., Metz, A. E., Horn, D., Schoeb, T. R., Hewitt, M. M., Schwiebert, L. M., Faro-Trindade, I., Brown, G. D., Steele, C. (2009). Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J. Immunol. 182(8):4938–4946.
   PubMed Web of Science ®Google Scholar
• Zelante, T., De Luca, A., Bonifazi, P., Montagnoli, C., Bozza, S., Moretti, S., Belladonna, M. L., Vacca, C., Conte, C., Mosci, P., Bistoni, F., Puccetti, P., Kastelein, R. A., Kopf, M., Romani, L. (2007). IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur. J. Immunol. 37(10):2695–2706.
   PubMed Web of Science ®Google Scholar