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Original Articles

c-Rel is Required for the Induction of pTregs in the Eye but Not in the Gut Mucosa

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References

  • Abbas AK, Benoist C, Bluestone JA, et al. (2013). Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol, 14(4), 307–308.
  • Adalid-Peralta L, Fragoso G, Fleury A, Sciutto E. (2011). Mechanisms underlying the induction of regulatory T cells and its relevance in the adaptive immune response in parasitic infections. Int J Biol Sci, 7(9), 1412–26.
  • Bommireddy R, Doetschman T. (2007). TGFbeta1 and Treg cells: alliance for tolerance. Trends Mol Med, 13, 492–501.
  • Chauhan SK1, DR Saban, HK Lee, Dana R. (2009). Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation. J Immunol, 182(1), 148–153.
  • Chen W, Jin W, Hardegen N, Lei KJ, et al. (2003). Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198, 1875–1886.
  • Chen W, Konkel JE. (2010). TGF-beta and ‘adaptive’ Foxp3(+) regulatory T cells. J Mol Cell Biol, 2(1), 30–6.
  • Chen Y, Kuchroo VK, Inobe J, et al. (1994). Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis. Sci, 265, 1237–1240.
  • Denniston AK, Kottoor SH, Khan I, et al. (2011). Endogenous cortisol and TGF-beta in human aqueous humor contribute to ocular immune privilege by regulating dendritic cell function. J Immunol, 186, 305–311.
  • Hilliard BA, Mason N, Xu L, et al. (2002). Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. J Clin Invest, 110, 843–850.
  • Horwitz DA, Zheng SG, Gray JD. (2008). Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+)regulatory T cells are not mirror images of each other. Trends Immunol, 29(9), 429–35.
  • Huehn J, Polansky JK, Hamann A. (2009). Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Nat Rev Immunol, 9(2), 83–9.
  • Huguet C, Bouali F, Enrietto PJ, et al. (1998). The avian transcription factor c-Rel is expressed in lymphocyte precursor cells and antigen-presenting cells during thymus development. Dev Immunol, 5, 247–261.
  • Isomura I, Palmer S, Grumont RJ, et al. (2009). c–Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med. 206 (13), 3001–14.
  • Kaltschmidt B, Uherek M, Volk B,et al. (1997). Transcription factorNF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci U S A, 94, 2642–2647.
  • Keino H, Takeuchi M, Usui Y, et al. (2007). Supplementation of CD4+CD25+ regulatory T cells suppresses experimental autoimmune uveoretinitis. Br J Ophthalmol, 91, 105–110.
  • Kutlu B, Darville MI, Cardozo AK, Eizirik DL. (2003). Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells. Diabetes, 52, 348–355.
  • Liang S, Alard P, Zhao Y, et al. (2005). Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus. J Exp Med, 201, 127–137.
  • Lin X, Chen M, Liu Y, et al. (2013). Advances in distinguishing natural from induced Foxp3(+) regulatory T cells. Int J Clin Exp Pathol, 6(2), 116–23.
  • Lohr J, Knoechel B, Abbas AK. (2006). Regulatory T cells in the periphery. Immunol Rev, 212, 149–162.
  • McPherson SW, Heuss ND, Gregerson DS. (2013). Local “on-demand” generation and function of antigen-specific Foxp3+ regulatory T cells. J Immunol, 190, 4971–4981.
  • Mizrahi M, Ilan Y. (2009). The gut mucosa as a site for induction of regulatory T-cells. Curr Pharm Des, 15(11), 1191–202.
  • O’Garra A, Vieira P. (2004). Regulatory T cells and mechanisms of immune system control. Nat Med, 10, 801–805.
  • Pabst O, Mowat AM. (2012). Oral tolerance to food protein. Mucosal Immunol, 5(3), 232–9.
  • Ruan Q, Kameswaran V, Tone Y, et al. (2009). Development of foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immun, 31, 932–940.
  • Sakaguchi S, Ono M, Setoguchi R, et al. (2006). Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 212, 8–27.
  • Sha WC, Liou HC, Tuomanen EI, Baltimore D. (1995). Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell, 80, 321–330.
  • Shevach EM, DiPaolo RA, Andersson J, et al. (2006). The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells. Immunol Rev, 212, 60–73.
  • Streilein JW. (2003). Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation. J Leukocyte Biol, 74, 179–185.
  • Taylor AW, Streilein JW, Cousins SW. (1994) Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor. J Immunol, 153, 1080–1086.
  • Tone Y, Furuuchi K, Kojima Y, et al. (2008). Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat Immunol, 9, 194–202.
  • Zelenay S1, Lopes-Carvalho T, Caramalho I, et al. (2005). Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc Natl Acad Sci USA, 102(11), 4091–6.
  • Zhou R, Horai R, Silver PB, et al. (2012) The living eye “disarms” uncommitted autoreactive T cells by converting them to Foxp3(+) regulatory cells following local antigen recognition. J Immunol, 188, 1742–50.

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