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Research Article

Retinal Pigment Epithelial Detachments in Age-Related Macular Degeneration: Classification and Therapeutic Options

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Pages 198-208 | Received 12 Jan 2011, Accepted 07 Mar 2011, Published online: 24 May 2011

REFERENCES

  • Pauleikhoff D, Loffert D, Spital G, et al. Pigment epithelial detachment in the elderly. Clinical differentiation, natural course and pathogenetic implications. Graefes Archive for Clinical & Experimental Ophthalmology. 2002; 240(7):533–538.
  • Coscas F, Coscas G, Souied E, Tick S, Soubrane G. Optical coherence tomography identification of occult choroidal neovascularization in age-related macular degeneration. American Journal of Ophthalmology. 2007; 144(4):592–599.
  • Hartnett ME, Weiter JJ, Garsd A, Jalkh AE. Classification of retinal pigment epithelial detachments associated with drusen. Graefes Archive for Clinical & Experimental Ophthalmology. 1992; 230(1):11–19.
  • Cukras C, Agr E, et al. Natural history of drusenoid pigment epithelial detachment in age-related macular degeneration: Age-Related Eye Disease Study Report No. 28. Ophthalmology. 2010;117(3):489–499.
  • Age-Related Eye Disease Study Research G. The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: The Age-Related Eye Disease Study Report Number 6. American Journal of Ophthalmology. 2001; 132(5):668–681.
  • Casswell AG, Kohen D, Bird AC. Retinal pigment epithelial detachments in the elderly: Classification and outcome. British Journal of Ophthalmology. 1985; 69(6):397–403.
  • Roquet W, Roudot-Thoraval F, Coscas G, Soubrane G. Clinical features of drusenoid pigment epithelial detachment in age related macular degeneration. British Journal of Ophthalmology. 2004; 88(5):638–642.
  • Schuman SG, Koreishi AF, Farsiu S, Jung SH, Izatt JA, Toth CA. Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in vivo with spectral-domain optical coherence tomography. Ophthalmology. 2009; 116(3):488–496 e482.
  • Karadimas P, Bouzas EA. Fundus autofluorescence imaging in serous and drusenoid pigment epithelial detachments associated with age-related macular degeneration. Am J Ophthalmol. Dec 2005; 140(6):1163–1165.
  • Schmitz-Valckenberg S, Fleckenstein M, Scholl HP, Holz FG. Fundus autofluorescence and progression of age-related macular degeneration. Surv Ophthalmol. Jan-Feb 2009; 54(1):96–117.
  • von Ruckmann A, Fitzke FW, Bird AC. Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci. Feb 1997; 38(2):478–486.
  • Bird AC, Marshall J. Retinal pigment epithelial detachments in the elderly. Transactions of the Ophthalmological Societies of the United Kingdom. 1986; 105(Pt 6):674–682.
  • Yannuzzi LA, Hope-Ross M, Slakter JS, et al. Analysis of vascularized pigment epithelial detachments using indocyanine green videoangiography. Retina. 1994; 14(2):99–113.
  • Laude A, Cackett PD, Vithana EN, et al. Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: same or different disease? Prog Retin Eye Res. Jan; 29(1):19–29.
  • Anonymous. Laser photocoagulation of subfoveal neovascular lesions in age-related macular degeneration. Results of a randomized clinical trial. Macular Photocoagulation Study Group. Archives of Ophthalmology. 1991; 109(9):1220–1231.
  • Zayit-Soudry S, Moroz I, Loewenstein A. Retinal pigment epithelial detachment. Survey of Ophthalmology. 2007; 52(3):227–243.
  • Gass JD. Serous retinal pigment epithelial detachment with a notch. A sign of occult choroidal neovascularization. Retina. 1984; 4(4):205–220.
  • Elman MJ, Fine SL, Murphy RP, Patz A, Auer C. The natural history of serous retinal pigment epithelium detachment in patients with age-related macular degeneration. Ophthalmology. 1986; 93(2):224–230.
  • Sallet G, Lafaut BA, De Laey JJ. Indocyanine green angiography and age-related serous pigment epithelial detachment. Graefes Archive for Clinical & Experimental Ophthalmology. 1996; 234(1):25–33.
  • Baumal CR, Reichel E, Duker JS, Wong J, Puliafito CA. Indocyanine green hyperfluorescence associated with serous retinal pigment epithelial detachment in age-related macular degeneration. Ophthalmology. 1997; 104(5):761–769.
  • Yannuzzi LA, Slakter JS, Sorenson JA, Guyer DR, Orlock DA. Digital indocyanine green videoangiography and choroidal neovascularization. Retina. 1992; 12(3):191–223.
  • Ahuja RM, Stanga PE, Vingerling JR, Reck AC, Bird AC. Polypoidal choroidal vasculopathy in exudative and haemorrhagic pigment epithelial detachments. British Journal of Ophthalmology. 2000; 84(5):479–484.
  • Iijima H, Iida T, Imai M, Gohdo T, Tsukahara S. Optical coherence tomography of orange-red subretinal lesions in eyes with idiopathic polypoidal choroidal vasculopathy. American Journal of Ophthalmology. 2000; 129(1):21–26.
  • Cho M, Athanikar A, Paccione J, Wald KJ. Optical coherence tomography features of acute central serous chorioretinopathy versus neovascular age-related macular degeneration. British Journal of Ophthalmology. 2010;94(5):597–599.
  • Koreen L, Hollar M, Cousins S. Where do PCV and RAP fit in the spectrum of AMD CNV subtypes? Determining lesion morphology provides for better diagnosis and treatment. Retinal Physician. 2010; October. http://www.retinalphysician.com/article.aspx?article=104848.
  • Spaide RF. Enhanced depth imaging optical coherence tomography of retinal pigment epithelial detachment in age-related macular degeneration. American Journal of Ophthalmology. 2009; 147(4):644–652.
  • Tsujikawa A, Sasahara M, Otani A, et al. Pigment epithelial detachment in polypoidal choroidal vasculopathy. American Journal of Ophthalmology. 2007; 143(1):102–111.
  • Watzke RC, Klein ML, Hiner CJ, Chan BK, Kraemer DF. A comparison of stereoscopic fluorescein angiography with indocyanine green videoangiography in age-related macular degeneration. Ophthalmology. 2000; 107(8):1601–1606.
  • Bressler NM, Bressler SB, Childs AL, et al. Surgery for hemorrhagic choroidal neovascular lesions of age-related macular degeneration: Ophthalmic findings: SST report no. 13. Ophthalmology. Nov 2004; 111(11):1993–2006.
  • Steel DH, Sandhu SS. Submacular haemorrhages associated with neovascular age-related macular degeneration. Br J Ophthalmol. Sep 2010.
  • Lee NY, Kim KS. Photodynamic therapy treatment for eyes with drusenoid pigment epithelium detachment. Korean Journal of Ophthalmology. 2008; 22(3):194–196.
  • Krishnan R, Lochhead J. Regression of soft drusen and drusenoid pigment epithelial detachment following intravitreal anti-vascular endothelial growth factor therapy. Canadian Journal of Ophthalmology. 2010;45(1):83–84.
  • Olk RJ, Friberg TR, Stickney KL, et al. Therapeutic benefits of infrared (810-nm) diode laser macular grid photocoagulation in prophylactic treatment of nonexudative age-related macular degeneration: Two-year results of a randomized pilot study. Ophthalmology. 1999; 106(11):2082–2090.
  • Ho AC, Maguire MG, Yoken J, et al. Laser-induced drusen reduction improves visual function at 1 year. Choroidal Neovascularization Prevention Trial Research Group. Ophthalmology. 1999; 106(7):1367– 1373; discussion 1374.
  • Friberg TR, Brennen PM, Freeman WR, Musch DC, Group PS. Prophylactic treatment of age-related macular degeneration report number 2: 810-nanometer laser to eyes with drusen: bilaterally eligible patients. Ophthalmic Surgery, Lasers & Imaging. 2009; 40(6):530–538.
  • Friberg TR, Musch DC, Lim JI, et al. Prophylactic treatment of age-related macular degeneration report number 1: 810-nanometer laser to eyes with drusen. Unilaterally eligible patients. Ophthalmology. 2006; 113(4):622 e621.
  • Verteporfin In Photodynamic Therapy Study G. Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: Two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization–verteporfin in photodynamic therapy report 2. American Journal of Ophthalmology. 2001; 131(5):541–560.
  • Anonymous. Retinal pigment epithelial detachments in the elderly: A controlled trial of argon laser photocoagulation. British Journal of Ophthalmology. 1982; 66(1):1–16.
  • Braunstein RA, Gass JD. Serous detachments of the retinal pigment epithelium in patients with senile macular disease. American Journal of Ophthalmology. 1979; 88(4):652–660.
  • Ho PC, Namperumalsamy P, Pruett RC. Photocoagulation of serous detachments of the retinal pigment epithelium in patients with senile macular disease. Annals of Ophthalmology. 1984; 16(3):213–218.
  • Lim JI, Aaberg TM, Capone A, Jr., Sternberg P Jr. Indocyanine green angiography-guided photocoagulation of choroidal neovascularization associated with retinal pigment epithelial detachment. American Journal of Ophthalmology. 1997; 123(4):524–532.
  • Gomez-Ulla F, Gonzalez F, Abelenda D, Rodr ED, Guez-Cid MJ. Diode laser photocoagulation of choroidal neovascularization associated with retinal pigment epithelial detachment. Acta Ophthalmologica Scandinavica. 2001; 79(1):39–44.
  • Wygnanski-Jaffe T, Desatnik H, Alhalel A, et al. ICG angiography-guided photodynamic therapy for large pigment epithelial detachments in age-related macular degeneration. Ophthalmic Surgery, Lasers & Imaging. 2006; 37(5):358–363.
  • Axer-Siegel R, Ehrlich R, Rosenblatt I, et al. Photodynamic therapy for occult choroidal neovascularization with pigment epithelium detachment in age-related macular degeneration. Archives of Ophthalmology. 2004; 122(4):453–459.
  • Pece A, Isola V, Vadal, E, Calori G. Photodynamic therapy with verteporfin for choroidal neovascularization associated with retinal pigment epithelial detachment in age-related macular degeneration. Retina. 2007; 27(3):342–348.
  • Lommatzsch A, Heimes B, Gutfleisch M, Spital G, Zeimer M, Pauleikhoff D. Serous pigment epithelial detachment in age-related macular degeneration: comparison of different treatments. Eye. 2009; 23:2163–2168.
  • Costa RA, Rocha KM, Calucci D, Cardillo JA, Farah ME. Neovascular ingrowth site photothrombosis in choroidal neovascularization associated with retinal pigment epithelial detachment. Graefes Archive for Clinical & Experimental Ophthalmology. 2003; 241(3):245–250.
  • Krebs I, Binder S, Stolba U. A new treatment regimen in combined intravitreal injection of triamcinolone acetonide and photodynamic therapy. Graefes Archive for Clinical & Experimental Ophthalmology. 2006; 244(7):863–867.
  • Freund KB, Klais CM, Eandi CM, et al. Sequenced combined intravitreal triamcinolone and indocyanine green angiography-guided photodynamic therapy for retinal angiomatous proliferation. Archives of Ophthalmology. 2006; 124(4):487–492.
  • Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: One-year results of 2 randomized clinical trials–TAP report. Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group. Arch Ophthalmol. Oct 1999; 117(10):1329–1345.
  • Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: Two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization–verteporfin in photodynamic therapy report 2. Am J Ophthalmol. May 2001; 131(5):541–560.
  • Bolz M, Michels S, Geitzenauer W, Prager F, Schmidt-Erfurth U. Effect of systemic bevacizumab therapy on retinal pigment epithelial detachment. British Journal of Ophthalmology. 2007; 91(6):785–789.
  • Chen E, Kaiser RS, Vander JF. Intravitreal bevacizumab for refractory pigment epithelial detachment with occult choroidal neovascularization in age-related macular degeneration. Retina. 2007; 27(4):445–450.
  • Ach T, Hoeh AE, Ruppenstein M, Kretz FT, Dithmar S. Intravitreal bevacizumab in vascular pigment epithelium detachment as a result of subfoveal occult choroidal neovascularization in age-related macular degeneration. Retina. Oct 2010; 30(9):1420–1425.
  • Arias L. Treatment of retinal pigment epithelial detachment with antiangiogenic therapy. Clinical Ophthalmology. 2010; 4:369–374.
  • Joeres S, Kaplowitz K, Brubaker JW, et al. Quantitative comparison of optical coherence tomography after pegaptanib or bevacizumab in neovascular age-related macular degeneration. Ophthalmology. Feb 2008; 115(2):347–354 e342.
  • Ladas ID, Kotsolis AI, Papakostas TD, Rouvas AA, Karagiannis DA, Vergados I. Intravitreal bevacizumab combined with photodynamic therapy for the treatment of occult choroidal neovascularization associated with serous pigment epithelium detachment in age-related macular degeneration. Retina. 2007; 27(7):891–896.
  • Shima C, Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Tano Y. One-year results of combined photodynamic therapy and intravitreal bevacizumab injection for retinal pigment epithelial detachment secondary to age-related macular degeneration. Graefes Archive for Clinical & Experimental Ophthalmology. 2009; 247(7):899–906.
  • el Matri L, Chebil A, Kort F, Bouraoui R, Baklouti K, Mghaieth F. Intravitreal injection of triamcinolone combined with bevacizumab for choroidal neovascularization associated with large retinal pigment epithelial detachment in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. Jun 2010; 248(6):779–784.
  • Haupert CL, McCuen BW 2nd, Jaffe GJ, et al. Pars plana vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-gas exchange for displacement of thick submacular hemorrhage in age-related macular degeneration. Am J Ophthalmol. Feb 2001; 131(2):208–215.
  • Fine HF, Iranmanesh R, Del Priore LV, et al. Surgical outcomes after massive subretinal hemorrhage secondary to age-related macular degeneration. Retina. Nov-Dec 2010; 30(10):1588–1594.
  • Meyer CH, Scholl HP, Eter N, Helb HM, Holz FG. Combined treatment of acute subretinal haemorrhages with intravitreal recombined tissue plasminogen activator, expansile gas and bevacizumab: A retrospective pilot study. Acta Ophthalmol. Aug 2008; 86(5):490–494.
  • Mruthyunjaya P, Stinnett SS, Toth CA. Change in visual function after macular translocation with 360 degrees retinectomy for neovascular age-related macular degeneration. Ophthalmology. Sep 2004; 111(9):1715–1724.
  • Stifter E, Michels S, Prager F, et al. Intravitreal bevacizumab therapy for neovascular age-related macular degeneration with large submacular hemorrhage. Am J Ophthalmol. Dec 2007; 144(6):886–892.
  • Chang MA, Do DV, Bressler SB, Cassard SD, Gower EW, Bressler NM. Prospective one-year study of ranibizumab for predominantly hemorrhagic choroidal neovascular lesions in age-related macular degeneration. Retina. 2010;30(8):1171–1176.
  • Chang LK, Sarraf D. Tears of the retinal pigment epithelium: An old problem in a new era. Retina. 2007; 27(5):523–534.
  • Hoskin A, Bird AC, Sehmi K. Tears of detached retinal pigment epithelium. British Journal of Ophthalmology. 1981; 65(6):417–422.
  • Gelisken F, Inhoffen W, Partsch M, Schneider U, Kreissig I. Retinal pigment epithelial tear after photodynamic therapy for choroidal neovascularization. American Journal of Ophthalmology. 2001; 131(4):518–520.
  • Pece A, Introini U, Bottoni F, Brancato R. Acute retinal pigment epithelial tear after photodynamic therapy. Retina. 2001; 21(6):661–665.
  • Goldstein M, Heilweil G, Barak A, Loewenstein A. Retinal pigment epithelial tear following photodynamic therapy for choroidal neovascularization secondary to AMD. Eye. 2005; 19(12):1315–1324.
  • Arnold JJ, Blinder KJ, Bressler NM, et al. Acute severe visual acuity decrease after photodynamic therapy with verteporfin: case reports from randomized clinical trials-TAP and VIP report no. 3. American Journal of Ophthalmology. 2004; 137(4):683–696.
  • Gass JD. Pathogenesis of tears of the retinal pigment epithelium. British Journal of Ophthalmology. 1984; 68(8):513–519.
  • Decker WL, Sanborn GE, Ridley M, Annesley WH, Jr., Sorr EM. Retinal pigment epithelial tears. Ophthalmology. 1983; 90(5):507–512.
  • Yeo JH, Marcus S, Murphy RP. Retinal pigment epithelial tears. Patterns and prognosis. Ophthalmology. 1988; 95(1):8–13.
  • Dhalla MS, Blinder KJ, Tewari A, Hariprasad SM, Apte RS. Retinal pigment epithelial tear following intravitreal pegaptanib sodium. American Journal of Ophthalmology. 2006; 141(4):752–754.
  • Singh RP, Sears JE. Retinal pigment epithelial tears after pegaptanib injection for exudative age-related macular degeneration. American Journal of Ophthalmology. 2006; 142(1):160–162.
  • Chang LK, Flaxel CJ, Lauer AK, Sarraf D. RPE tears after pegaptanib treatment in age-related macular degeneration. Retina. 2007; 27(7):857–863.
  • Meyer CH, Mennel S, Schmidt JC, Kroll P. Acute retinal pigment epithelial tear following intravitreal bevacizumab (Avastin) injection for occult choroidal neovascularisation secondary to age related macular degeneration. British Journal of Ophthalmology. 2006; 90(9):1207–1208.
  • Nicol F, Ghiglione D, Calabria G. Retinal pigment epithelial tear following intravitreal injection of bevacizumab (Avastin). European Journal of Ophthalmology. 2006; 16(5):770–773.
  • Shah CP, Hsu J, Garg SJ, Fischer DH, Kaiser R. Retinal pigment epithelial tear after intravitreal bevacizumab injection. American Journal of Ophthalmology. 2006; 142(6):1070–1072.
  • Spandau UH, Jonas JB. Retinal pigment epithelium tear after intravitreal bevacizumab for exudative age-related macular degeneration. American Journal of Ophthalmology. 2006; 142(6):1068–1070.
  • Gelisken F, Ziemssen F, Voelker M, Bartz-Schmidt KU. Retinal pigment epithelial tear following intravitreal bevacizumab injection for neovascular age-related macular degeneration. Acta Ophthalmologica Scandinavica. 2006; 84(6):833–834.
  • Lee GK, Lai TY, Chan WM, Lam DS. Retinal pigment epithelial tear following intravitreal ranibizumab injections for neovascular age-related macular degeneration. Graefes Archive for Clinical & Experimental Ophthalmology. 2007; 245(8):1225–1227.
  • Carvounis PE, Kopel AC, Benz MS. Retinal pigment epithelium tears following ranibizumab for exudative age-related macular degeneration. American Journal of Ophthalmology. 2007; 143(3):504–505.
  • Giovannini A, Amato G, Mariotti C, Scassellati-Sforzolini B. Optical coherence tomography in the assessment of retinal pigment epithelial tear. Retina. 2000; 20(1):37–40.
  • Chalam K, Murthy R, Gupta S, Brar V. Spectral domain optical coherence tomography features of multiple subfoveal retinal pigment epithelial tears after intravitreal bevacizumab. Indian Journal of Ophthalmology. 2011; 59(1):47–48.
  • Kook D, Wolf A, Neubauer AS, et al. Retinal pigment epithelial tears after intravitreal injection of bevacizumab for AMD. Frequency and progress. Ophthalmologe. 2008; 105(2):158–164.
  • Chan CK, Abraham P, Meyer CH, et al. Optical coherence tomography-measured pigment epithelial detachment height as a predictor for retinal pigment epithelial tears associated with intravitreal bevacizumab injections. Retina. 2010;30(2):203–211.
  • Sarraf D, Reddy S, Chiang A, Yu F, Jain A. A new grading system for retinal pigment epithelial tears. Retina. Jul-Aug 2010;30(7):1039–1045.
  • Cantrill HL, Ramsay RC, Knobloch WH. Rips in the pigment epithelium. Archives of Ophthalmology. 1983; 101(7):1074–1079.
  • Coscas G, Koenig F, Soubrane G. The pretear characteristics of pigment epithelial detachments. A study of 40 eyes. Arch Ophthalmol. Dec 1990; 108(12):1687–1693.

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