Silymarin exacerbates p53-mediated tubular apoptosis in glycerol-induced acute kidney injury in rats

REFERENCES

• Kroll DJ, Shaw HS, Oberlies NH. Milk thistle nomenclature: Why it matters in cancer research and pharmacokinetic studies. Integr Cancer Ther. 2007;6:110–119.
   PubMed Web of Science ®Google Scholar
• Mansour HH, Hafez HF, Fahmy NM. Silymarin modulates cisplatin-induced oxidative stress and hepatotoxicity in rats. J Biochem Mol Biol. 2006;39:656–661.
   PubMedGoogle Scholar
• Pradeep K, Mohan CV, Gobianand K, Karthikeyan S. Silymarin modulates the oxidant-antioxidant imbalance during diethyonitrosinamine induced oxidative stress in rats. Eur J Pharmacol. 2007;560:110–116.
   PubMed Web of Science ®Google Scholar
• Comelli MC, Mengs U, Schneider C, Prosdomici M. Toward definition of the mechanism of action of silymarin: Activities related to cellular protection from toxic damage induced by chemotherapy. Integr Cancer Ther. 2007;6:120–139.
   PubMed Web of Science ®Google Scholar
• Singh RP, Gu M, Agarwal R. Silibinin inhibits colorectal growth by inhibiting tumor cell proliferation and angiogenesis. Cancer Res. 2008;68:2043–2050.
   PubMed Web of Science ®Google Scholar
• Tyagi A, Singh RP, Agarwal C, Agarwal R. Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: Evidence for a regulatory loop between p53 and caspase 2. Carcinogenesis. 2006;27:2269–2280.
   PubMed Web of Science ®Google Scholar
• Singh RP, Dhanalakshmi S, Agarwal C, Agarwal R. Silibinin strongly inhibits growth of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: Implications for angioprevention and antiangiogenic therapy. Oncogene. 2005;24:1188–1202.
   PubMed Web of Science ®Google Scholar
• Dhanalaklshmi S, Agarwal C, Singh RP, Agarwal R. Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells. J Biol Chem. 2005;280:20375–20383.
   PubMed Web of Science ®Google Scholar
• Mallikarjuna G, Dhanalaklshmi S, Singh RP, Agarwal C, Agarwal R. Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling. Cancer Res. 2004;64:6349–6356.
   PubMed Web of Science ®Google Scholar
• Paller MS. Hemoglobin and myoglobin induced acute renal failure in rats: Role of iron in nephrotoxicity. Am J Physiol. 1988;255:F539–F544.
   PubMed Web of Science ®Google Scholar
• Moore KP, Holt GS, Patel RP, A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure. J Biol Chem. 1998;273:31731–31737.
   PubMed Web of Science ®Google Scholar
• Zager RA, Burkhart KM, Conrad DS, Gmur DJ. Iron, heme oxygenase and glutathione: Effects on myohemoglobinuric proximal tubular injury. Kidney Int. 1995;48:1624–1634.
   PubMed Web of Science ®Google Scholar
• Shah SV, Walker PD. Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failure. Am J Physiol. 1988;255:F438–F443.
   PubMed Web of Science ®Google Scholar
• Guidet B, Shah SV. Enhanced in vivo H2O2 generation by rat kidney in glycerol-induced renal failure. Am J Physiol. 1989;257:F440–F445.
   PubMed Web of Science ®Google Scholar
• Homsi E, Janino P, de Faria JB. Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure. Kidney Int. 2006;69:1385–1392.
   PubMed Web of Science ®Google Scholar
• Shulman LM, Yuhas Y, Folkis I, Gavendo S, Knecht A, Eliahou HE. Glycerol-induced acute renal failure is mediated by tumor necrosis factor. Kidney Int. 1993;43:1397–1401.
   PubMed Web of Science ®Google Scholar
• Wolfert AI, Oken DE. Glomerular hemodynamics in established glycerol-induced acute renal failure in the rat. J Clin Invest. 1989;84:1967–1973.
   PubMed Web of Science ®Google Scholar
• Turgut F, Bayrak O, Catal F, Antioxidant and protective effects of silymarin on ischemia and reperfusion injury in the kidney of rats. Int Urol Nephrol. 2008;40:453–460.
   PubMed Web of Science ®Google Scholar
• Senturk H, Kabay S, Bayramoglu G, Silymarin attenuates the renal ischemia/reperfusion injury-induced morphological changes in the rat kidney. World J Urol. 2008;26:401–407.
   PubMed Web of Science ®Google Scholar
• Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB. Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis. J Immunol. 1999;163:6800–6809.
   PubMed Web of Science ®Google Scholar
• Mansour HH, Hafez HF, Fahmy HM. Silymarin modulates cisplatin-induced oxidative stress and hepatotoxicity in rats. J Biochem Mol Biol. 2006;39:656–661.
   PubMedGoogle Scholar
• Schuman J, Prockl J, Kiemer AK, Vollmar AM, Bang R, Tiegs G. Silibilin protects mice fom T cell-dependent liver injury. J Hepatol. 2003;39:333–340.
   PubMed Web of Science ®Google Scholar
• Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1079;95:351–358.
   Google Scholar
• Krajewska M, Smith LH, Rong J, Image analysis algorithms for immunohistochemical assessment of cell death events and fibrosis in tissue sections. J Histochem Cytochem. 2009;57:649–663.
   PubMed Web of Science ®Google Scholar
• Gupta A, Berg DT, Gerlitz B, Role of protein C in renal dysfunction after polymicrobial sepsis. J Am Soc Nephrol. 2007;18:860–867.
   Web of Science ®Google Scholar
• Duan WR, Garner DS, Williams SD, Funckes-Shippy CL, Spath IS, Blomme EA. Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts. J Pathol. 2003;199:221–228.
   PubMed Web of Science ®Google Scholar
• Homsi E, Janino P, Amano M, Camara NOS. Endogenous hepatocyte growth factor attenuates inflammatory response in glycerol-induced acute kidney injury. Am J Nephrol. 2009;29:283–290.
   PubMed Web of Science ®Google Scholar
• Bulavin DV, Saito S, Hollander MC, Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J. 1999;18:6845–6854.
   PubMed Web of Science ®Google Scholar
• Xie S, Wang Q, Wu H, Reactive oxygen species induced-phosphorylation of p53 on serine 20 is mediated in part by PIk3. J Biol Chem. 2001;276:36194–36199.
   PubMed Web of Science ®Google Scholar
• Hirao A, Kong YY, Matsuoka S, DNA damage-induced activation of p53 by the checkpoint kinase (Chk2). Science. 2000;287:1824–1827.
   PubMed Web of Science ®Google Scholar
• Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem. 2000;275:8945–8951.
   PubMed Web of Science ®Google Scholar
• Martindale JL, Holbrook NJ. Cellular response to oxidative stress: Signaling for suicide and survival. J Cell Physiol. 2002;192:1–5.
   PubMed Web of Science ®Google Scholar
• Miyashita T, Krajewski S, Krajewska M, Tumor suppressor 53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 1994;9:1799–1805.
   PubMed Web of Science ®Google Scholar
• Nakano K, Vousden KH. PUMA, a novel proapoptotic gene,is induced by p53. Mol Cell. 2001;7:683–694.
   PubMed Web of Science ®Google Scholar
• Oda E, Ohki R, Murasawa H, Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science. 2000;288:1053–1058.
   PubMed Web of Science ®Google Scholar
• Oda K, Arakawa H, Tanaka T, p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell. 2000;102:849–862.
   PubMed Web of Science ®Google Scholar
• Mirza A, McGuirk TN, Hockenberry Q, Wu H, Ashar S, Black S. Human survivin is negatively regulated by wild type p53 and participate in p53-dependent apoptotic pathway. Oncogene. 2002;2:2613–2622.
   Google Scholar
• Hoffman WH, Biade JT, Zilfou J, Chen J, Murphy M. Transcription repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem. 2002;277:3247–3257.
   PubMed Web of Science ®Google Scholar
• Katiyar SK, Roy AM, Baliga MS. Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation. Mol Cancer Ther. 2005;4:207–216.
   PubMed Web of Science ®Google Scholar
• Lechler P, Wu X, Bernhardt W, Campean V, The tumor gene survivin is highly expressed in adult tubular cells. Implications for a pathophysiological role in the kidney. Am J Pathol. 2007;171:1483–1489.
   PubMed Web of Science ®Google Scholar
• Rao PR, Viswanath RK. Cardioprotective activity of silymarin in ischemia-reperfusion-induced myocardial infarction in albino rats. Exp Clin Cardiol. 2007;12:179–187.
   PubMedGoogle Scholar
• Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. A model for p53-induced apoptosis. Nature. 1997;389:300–395.
   PubMed Web of Science ®Google Scholar
• Drane P, Bravard A, Bouvard V, May E. Reciprocal down-regulation of p53 and SOD2 gene expression-implication in p53 mediated apoptosis. Oncogene. 2001;20:430–439.
   PubMed Web of Science ®Google Scholar