1,113
Views
7
CrossRef citations to date
0
Altmetric
Laboratory Study

Garlic Extract Ameliorates Renal and Cardiopulmonary Injury in the Rats with Chronic Renal Failure

, , &
Pages 718-725 | Received 25 Jan 2011, Accepted 11 May 2011, Published online: 25 Jul 2011

REFERENCES

  • Becker BN, Himmelfarb J, Henrich WL, Hakim RM. Reassessing the cardiac risk profile in chronic hemodialysis patients: A hypothesis on the role of oxidant stress and other non-traditional cardiac risk factors. J Am Soc Nephrol. 1997;8(3):475–486.
  • Tepel M, Echelmeyer M, Orie NN, Zidek W. Increased intracellular reactive oxygen species in patients with end-stage renal failure: Effect of hemodialysis. Kidney Int. 2000;58(2):867–872.
  • Witko-Sarsat V, Friedlander M, Nguyen Khoa T, Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure. J Immunol. 1998;161(5):2524–2532.
  • Terawaki H, Yoshimura K, Hasegawa T, Oxidative stress is enhanced in correlation with renal dysfunction: Examination with the redox state of albumin. Kidney Int. 2004;66(5):1988–1993.
  • Cottone S, Lorito MC, Riccobene R, Oxidative stress, inflammation and cardiovascular disease in chronic renal failure. J Nephrol. 2008;21(2):175–179.
  • Maruyama Y, Lindholm B, Stenvinkel P. Inflammation and oxidative stress in ESRD–the role of myeloperoxidase. J Nephrol. 2004;17(Suppl. 8):72–76.
  • Siems W, Quast S, Carluccio F, Oxidative stress in chronic renal failure as a cardiovascular risk factor. Clin Nephrol. 2002;58(Suppl. 1):12–19.
  • Sener G, Paskaloglu K, Satiroglu H, Alican I, Kaçmaz A, Sakarcan A. L-carnitine ameliorates oxidative damage due to chronic renal failure in rats. J Cardiovasc Pharmacol. 2004;43(5):698–705.
  • Cachofeiro V, Goicochea M, de Vinuesa SG, Oubina P, Lahera V, Luno J. Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease. Kidney Int Suppl. 2008;111:4–9.
  • Vaziri ND. Oxidative stress in uremia: Nature, mechanisms, and potential consequences. Semin Nephrol. 2004;24(5):469–473.
  • Rahman K, Billington D. Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. J Nutr. 2000;130(11):2662–2665.
  • Dorant E, van den Brandt PA, Goldbohm R, Goldbohm RA, Hermus RJ, Sturmans F. Garlic and its significance for the prevention of cancer in humans: A critical view. Br J Cancer. 1993;67(3):424–429.
  • Kleijnen J, Knipschild P, Terriet G. Garlic, onions and cardiovascular risk factors. A review of the evidence from human experiments with emphasis on commercially available preparations. Br J Clin Pharmacol. 1989;28(5):535–544.
  • Ide N, Matsuura H, Itakura Y. Scavenging effect of aged garlic extract and its constituents on active oxygen species. Phytother Res. 1996;10(4):340–341.
  • Moriguchi T, Takashina K, Chu P, Saito H, Nishiyama N. Prolongation of life span and improved learning in the senescence accelerated mouse produced by aged garlic extract. Biol Pharm Bull. 1994;17(12):1589–1594.
  • Sener G, Sakarcan A, Yegen BC. Role of garlic in the prevention of ischemia-reperfusion injury. Mol Nutr Food Res. 2007;51(11):1345–1352.
  • Rietz B, Isensee H, Strobach H, Makdessi S, Jacob R. Cardioprotective actions of wild garlic (Allium ursinum) in ischemia and reperfusion. Mol Cell Biochem. 1993;119(1–2):143–150.
  • Numagami Y, Suto S, Ohnishi ST. Attenuation of rat ischemic brain damage by aged garlic extracts: A possible protecting mechanism as antioxidants. Neurochem Int. 1996;29(2):135–143.
  • Augusti KT, Sheela CG. Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats. Experimentia. 1996;52(2):115–119.
  • Geng Z, Lau BHS. Aged garlic extract modulates glutathione redox cycle and superoxide dismutase activity in vascular endothelial cells. Phytother Res. 1997;11(1):54–56.
  • Wei Z, Lau BHS. Garlic inhibits free radical generation and augments antioxidant enzyme activity in vascular endothelial cells. Nutr Res. 1998;18(1):61–70.
  • Kabasakal L, Sehirli O, Cetinel S, Cikler E, Gedik N. Protective effect of aqueous garlic extract against renal ischemia/reperfusion injury in rats. J Med Food. 2005;8(3):319–326.
  • Sener G, Sehirli O, Ipci Y, Aqueous garlic extract alleviates ischemia-reperfusion-induced oxidative hepatic injury in rats. J Pharm Pharmacol. 2006;57(1):145–150.
  • Batirel FH, Aktan S, Aykut C, Yegen BC, Coskun T. The effect of aqueous garlic extract on the levels of arachidonic acid metabolites (leukotriene C4 and prostaglandin E2) in rat forebrain after ischemia-reperfusion injury. Prostaglandins Leukot Essent Fatty Acids. 1996;54(4):289–292.
  • Vaziri ND, Ni Z, Oveisi F, Liang K, Pandian R. Enhanced nitric oxide inactivation and protein nitration by reactive oxygen species in renal insufficiency. Hypertension. 2002;39(1):135–141.
  • Gedik N, Kabasakal L, Sehirli O, Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats. Life Sci. 2005;76(22):2593–2606.
  • Talke H, Schubert GE. Enzymatic urea determination in the blood and serum in the Warburg optical test. Wien Klin Wochenschr. 1965;43:174–175.
  • Slot C. Plasma creatinine determination: A new and specific Jaffe reaction method. Scand J Clin Lab Invest. 1965;17(4):381–387.
  • Cuzzocrea S, Reiter RJ. Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury. Eur J Pharmacol. 2001;426(1–2):1–10.
  • Hillegass LM, Griswold DE, Brickson B, Albrightson-Winslow C. Assessment of myeloperoxidase activity in whole rat kidney. J Pharmacol Meth. 1990;24(4):285–295.
  • Bradley PP, Priebat DA, Christerser RD, Rothstein G. Measurement of cutaneous inflammation. Estimation of neutrophil content with an enzyme marker. J Invest Dermatol. 1982;78(3):206–209.
  • Beuge JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. 1978;52:302–310.
  • Beutler E. Glutathione in red blood cell metabolism. In: Beutler E, ed. A Manual of Biochemical Methods. New York, NY: Grune & Stratton; 1975:112–114.
  • Remuzzi G, Benigni A, Remuzzi A. Mechanism of progression and regression of renal lesions of chronic nephropathies and diabetes. J Clin Invest. 2006;116(2):228–296.
  • Cho KH, Kim HJ, Rodriguez-Iturbe B, Vaziri ND. Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure. Am J Physiol Renal Physiol. 2009;297(1):F106–F113.
  • Nakagawa S, Kasuga S, Matsuura H. Prevention of liver damage by aged garlic extract. Phytother Res. 1989;3(2):50–53.
  • Kourounakis PN, Rekka EA. Effect of active oxygen species of alliin and allium sativum (garlic) powder. Res Commun Chem Pathol Pharmacol. 1991;74(2):249–252.
  • Horie T, Awazu S, Itakura Y, Fuwa T. Identified diallyl polysulfides from an aged garlic extract which protect the membranes from lipid peroxidation. Planta Med. 1992;58:468–469.
  • Arora RC, Arora S, Gupta RK. The long-term use of garlic in ischemic heart disease – An appraisal. Atherosclerosis. 1981;40(2):175 –179.
  • Kiesewetter H, Jung F, Jung E, Effects of garlic coated tablets in peripheral arterial occlusive disease. Clin Investig. 1993;71(5):383–386.
  • Foushee DB, Ruffin J, Banerjee U. Garlic as a natural agent for the treatment of hypertension: A preliminary report. Cytobios. 1982;34(134-35):45–152.
  • Ernst E, Weihmayr TH, Matrai A. Garlic and blood lipids. Br Med J. 1985;291(6488):139.
  • Horie T, Matsumoto H, Kasagi M, Protective effect of aged garlic extract on the small intestinal damage of rats induced by methotrexate administration. Planta Med. 1999;65(6):545–548.
  • Pedraza-Chaverri J, Maldonado PD, Medina-Campos ON, Garlic ameliorates gentamicin nephrotoxicity: Relation to antioxidant enzymes. Free Radic Biol Med. 2000;29(7):602 –611.
  • Mukherjee S, Banerjee KS, Maulik M, Dinda AK, Talwar KK, Maulik SK. Protection against acute adriamycin-induced cardiotoxicity by garlic: Role of endogenous antioxidants and inhibition of TNF-alpha expression. BMC Pharmacol. 2003;3:16.
  • Omurtag GZ, Guranlioglu FD, Sehirli O, Protective effect of aqueous garlic extract against naphthalene-induced oxidative stress in mice. J Pharm Pharmacol. 2005;57:623 –630.
  • Devasagayam TPA, Sundquist AR. Di Mascio P, Kaiser S, Sies H. Activity of thiols as singlet molecular oxygen quenchers. J Photochem Photobiol B. 1991;9(1):105–116.
  • Yamasaki T, Li L, Lau BHS. Garlic compounds protect vascular endothelial cells from hydrogen peroxide-induced oxidant injury. Phytother Res. 1994;8(7):408–412.
  • Numagami Y, Suto S, Ohnishi ST. Attenuation of rat ischemic brain damage by aged garlic extracts: A possible protecting mechanism as antioxidants. Neurochem Int. 1996;29(2):135–143.
  • Savas M, Yeni E, Ciftci H, The antioxidant role of oral administration of garlic oil on renal ischemia-reperfusion injury. Ren Fail. 2010;32(3):362–367.
  • Del Rio D, Stewart AJ, Pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis. 2005;15(4):316–328.
  • Sağlam B, Cikler E, Zeybek A, Cetinel S, Sener G, Ercan F. An aqueous garlic extract alleviates water avoidance stress-induced degeneration of the urinary bladder. BJU Int. 2006;98(6):1250–1254.
  • Wongmekiat O, Thamprasert K. Investigating the protective effects of aged garlic extract on cyclosporin-induced nephrotoxicity in rats. Fundam Clin Pharmacol. 2005;19(5):555–562.
  • Sener G, Sehirli AO, Ipçi Y, Cetinel S, Cikler E, Gedik N. Chronic nicotine toxicity is prevented by aqueous garlic extract. Plant Foods Hum Nutr. 2005;60(2):77–86.
  • Ross D. Glutathione, free radicals and chemotherapeutic agents. Mechanisms of free-radical induced toxicity and glutathione-dependent protection. Pharmacol Ther. 1988;37(2):231–249.
  • Szabo S, Nagy L, Plebani M. Glutathione, protein sulfhydryls and cysteine proteases in gastric mucosal injury and protection. Clin Chim Acta. 1992;206(1–2):95–105.
  • Banerjee SK, Maulik M, Mancahanda SC, Dinda AK, Gupta SK, Maulik SK. Dose- dependent induction of endogenous antioxidants in rat heart by chronic administration of garlic. Life Sci. 2002;70(13):1509–1518.
  • Zeybek A, Ercan F, Cetinel S, Cikler E, Saglam B, Sener G. Protective effects of aqueous garlic extract in reducing water avoidance stress-induced degeneration of the stomach, ileum, and liver: Morphological and biochemical study. Dig Dis Sci. 2007;52(11):2984–2992.
  • Zeybek A, Cikler E, Sağlam B, Ercan F, Cetinel S, Sener G. Aqueous garlic extract inhibits protamine sulfate-induced bladder damage. Urol Int. 2006;76(2):173–179.
  • Suru SM. Onion and garlic extracts lessen cadmium-induced nephrotoxicity in rats. Biometals. 2008;21(6):623–633.
  • Sullivan GW, Sarembock IJ, Linden J. The role of inflammation in vascular diseases. J Leukoc Biol. 2000;67(5):591–602.
  • Kettle AJ, Winterbourn CC. Myeloperoxidase: A key regulator of neutrophil oxidant production. Redox Rep. 1997;3:3–15.
  • Sener G, Satıroglu H, Sehirli AO, Kacmaz A. Protective effect of aqueous garlic extract against oxidative organ damage in a rat model of thermal injury. Life Sci. 2003;73(1):81–89.
  • Lee EN, Choi YW, Kim HK, Chloroform extract of aged black garlic attenuates TNF-alpha-induced ROS generation, VCAM-1 expression, NF-kappaB activation and adhesiveness for monocytes in human umbilical vein endothelial cells. Phytother Res. 2011;25(1):92–100.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.