799
Views
16
CrossRef citations to date
0
Altmetric
Laboratory Study

Protective Effects of N-Acetylcysteine Amide (NACA) on Gentamicin-Induced Apoptosis in LLC-PK1 Cells

, , &
Pages 487-494 | Received 09 Nov 2011, Accepted 02 Jan 2012, Published online: 10 Apr 2012

REFERENCES

  • El Mouedden M, Laurent G, Mingeot-Leclercq MP, Tulkens PM. Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts. Toxicol Sci. 2000;56:229–239.
  • Martinez-Salgado C, Eleno N, Morales AI, Perez-Barriocanal F, Arevalo M, Lopez-Novoa JM. Gentamicin treatment induces simultaneous mesangial proliferation and apoptosis in rats. Kidney Int. 2004;65:2161–2171.
  • Yang TH, Young YH, Liu SH. EGb 761 (Ginkgo biloba) protects cochlear hair cells against ototoxicity induced by gentamicin via reducing reactive oxygen species and nitric oxide-related apoptosis. J Nutr Biochem. 2011;22(9):886–894.
  • Servais H, Jossin Y, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP. Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation. Antimicrob Agents Chemother. 2006;50:1213–1221.
  • Juan SH, Chen CH, Hsu YH, . Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin. Nephrol Dial Transplant. 2007;22:732–739.
  • Cuzzocrea S, Mazzon E, Dugo L, . A role for superoxide in gentamicin-mediated nephropathy in rats. Eur J Pharmacol. 2002;450:67–76.
  • Reiter RJ, Tan DX, Sainz RM, Mayo JC, Lopez-Burillo S. Melatonin: Reducing the toxicity and increasing the efficacy of drugs. J Pharm Pharmacol. 2002;54:1299–1321.
  • Gong X, Celsi G, Carlsson K, Norgren S, Chen M. N-acetylcysteine amide protects renal proximal tubular epithelial cells against iohexol-induced apoptosis by blocking p38 MAPK and iNOS signaling. Am J Nephrol. 2010;31:178–188.
  • Polat A, Parlakpinar H, Tasdemir S, . Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats. Acta Histochem. 2006;108:365–371.
  • Denamur S, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM. Apoptosis induced by aminoglycosides in LLC-PK1 cells: Comparative study of neomycin, gentamicin, amikacin, and isepamicin using electroporation. Antimicrob Agents Chemother. 2008;52:2236–2238.
  • Servais H, Van Der Smissen P, Thirion G, . Gentamicin-induced apoptosis in LLC-PK1 cells: Involvement of lysosomes and mitochondria. Toxicol Appl Pharmacol. 2005;206:321–333.
  • Santucci RA, Krieger JN. Gentamicin for the practicing urologist: Review of efficacy, single daily dosing and “switch” therapy. J Urol. 2000;163:1076–1084.
  • Gibbons CE, Maldonado-Perez D, Shah AN, Riccardi D, Ward DT. Calcium-sensing receptor antagonism or lithium treatment ameliorates aminoglycoside-induced cell death in renal epithelial cells. Biochim Biophys Acta. 2008;1782:188–195.
  • Kwon CH, Yoon CS, Kim YK. Ciglitazone induces caspase-independent apoptosis via p38-dependent AIF nuclear translocation in renal epithelial cells. Toxicology. 2008;244:13–24.
  • Volpini RA, Balbi AP, Costa RS, Coimbra TM. Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin. Braz J Med Biol Res. 2006;39:817–823.
  • Ozbek E, Cekmen M, Ilbey YO, Simsek A, Polat EC, Somay A. Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-kappaB pathways. Ren Fail. 2009;31:382–392.
  • Rupesh KR, Priya AM, Sundarakrishnan B, Venkatesan R, Lakshmi BS, Jayachandran S. 2,2′-Bipyridyl based copper complexes down regulate expression of pro-inflammatory cytokines and suppress MAPKs in mitogen induced peripheral blood mononuclear cells. Eur J Med Chem. 2010;45:2141–2146.
  • Kole L, Giri B, Manna SK, Pal B, Ghosh S. Biochanin-A, an isoflavon, showed anti-proliferative and anti-inflammatory activities through the inhibition of iNOS expression, p38-MAPK and ATF-2 phosphorylation and blocking NFkappaB nuclear translocation. Eur J Pharmacol. 2011;653:8–15.
  • Liu H, Bargouti M, Zughaier S, . Osteoinductive LIM mineralization protein-1 suppresses activation of NF-kappaB and selectively regulates MAPK pathways in pre-osteoclasts. Bone. 2010;46:1328–1335.
  • Serbecic N, Beutelspacher SC. Anti-oxidative vitamins prevent lipid-peroxidation and apoptosis in corneal endothelial cells. Cell Tissue Res. 2005;320:465–475.
  • Jang SH, Lim JW, Kim H. Beta-carotene inhibits Helicobacter pylori-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in human gastric epithelial AGS cells. J Physiol Pharmacol. 2009;60(Suppl. 7):131–137.
  • Al-Majed AA, Mostafa AM, Al-Rikabi AC, Al-Shabanah OA. Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats. Pharmacol Res. 2002;46:445–451.
  • Ghatan S, Larner S, Kinoshita Y, p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J Cell Biol. 2000;150:335–347.
  • Vause CV, Durham PL. CGRP stimulation of iNOS and NO release from trigeminal ganglion glial cells involves mitogen-activated protein kinase pathways. J Neurochem. 2009;110:811–821.
  • Kar S, Ukil A, Sharma G, Das PK. MAPK-directed phosphatases preferentially regulate pro- and anti-inflammatory cytokines in experimental visceral leishmaniasis: Involvement of distinct protein kinase C isoforms. J Leukoc Biol. 2010;88:9–20.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.