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Clinical Study

Urinary Platelet-Derived Growth Factor-BB as an Early Marker of Nephropathy in Patients with Type 2 Diabetes: An Egyptian Study

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Pages 670-675 | Received 22 Jul 2011, Accepted 05 Mar 2012, Published online: 10 Apr 2012

REFERENCES

  • Molnar M, Wittmann I, Nagy J. Prevalence, course and risk factors of diabetic nephropathy in type 2 diabetes mellitus. Med Sci Monit. 2000;6:929–936.
  • Schmitz A, Gundersen HJ, Osterby R. Glomerular morphology by light microscopy in non-insulin dependent diabetes mellitus. Diabetes. 1988;37:38–43.
  • Schrijvers BF, De Vriese A, Flyvbjerg A. From hyperglycemia to diabetic kidney disease: The role of metabolic, hemodynamic, intracellular factors and growth factors/cytokines. Endocrine Rev. 2004;25:971–1010.
  • Chiarelli F, Gaspari S, Marcovecchio ML. Role of growth factors in diabetic kidney disease. Horm Metab Res. 2009;41:585–593.
  • Wolf G, Ziyadeh FN. Transforming growth factor-β and diabetic nephropathy. J Organ Dysfunction. 2009;5:130–139.
  • Tam FWK, Riser BL, Meeran K, Rambow J, Pusey CD, Frankel AH. Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy. Cytokine. 2009;47:37–42.
  • Ziyadeh FN. Different roles for TGF-β and VEGF in the pathogenesis of the cardinal features of diabetic nephropathy. Diabetes Res Clin Pract. 2008;82:S38–S41.
  • Ross R. Platelet-derived growth factor. Lancet. 1989;1:1179–1182.
  • Heldin CH, Westermark B. Platelet-derived growth factor: Mechanism of action and possible in vivo function. Cell Regul. 1990;1:555–566.
  • Ross R, Raines EW, Bowen-Pope DF. The biology of platelet-derived growth factor. Cell. 1986;46:155–169.
  • Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008;22:1276–1312.
  • Claesson-Welsh L. Platelet-derived growth factor receptor signals. J Biol Chem. 1994;269:32023–32026.
  • Gilbertson DG, Duff ME, West JW, . Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. J Biol Chem. 2001;276:27406–27414.
  • Changsirikulchai S, Hudkins KL, Goodpaster TA, . Platelet-derived growth factor-D expression in developing and mature human kidneys. Kidney Int. 2002;62:2043–2054.
  • Floege J, Eitner F, van Roeyen C, Ostendorf T. PDGF-D and renal disease: Yet another one of those growth factors? J Am Soc Nephrol. 2003;14:2690–2691.
  • Floege J, Eng E, Young BA, . Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats. J Clin Invest. 1993;92:2952–2962.
  • Floege J, Eitner F, Alpers CE. A new look at platelet-derived growth factor in renal disease. J Am Soc Nephrol. 2008;19:12–23.
  • Mauviel A. Transforming growth factor-beta: A key mediator of fibrosis. Methods Mol Med. 2005;117:69–80.
  • Ziyadeh FN. Mediators of diabetic renal disease: The case for TGF-β as the major mediator. J Am Soc Nephrol. 2004;15(Suppl. 1):S55–S57.
  • Langham RG, Kelly DJ, Maguire J, Dowling JP, Gilbert RE, Thomson NM. Over-expression of platelet-derived growth factor in human diabetic nephropathy. Nephrol Dial Transplant. 2003;18:1392–1396.
  • Uehara G, Suzuki D, Toyoda M, Umezono T, Sakai H. Glomerular expression of platelet-derived growth factor (PDGF)-A, -B chain and PDGF receptor-α, -β in human diabetic nephropathy. Clin Exp Nephrol. 2004;8:36–42.
  • Spooren PF, Lekker JF, Vermes I. Micral test: A qualitative dipstick test for microalbuminuria. Diabetes Res Clin Pract. 1992;18:83–87.
  • Teppo AM. Immunoturbidimetry of albumin and immunoglobulin G in urine. Clin Chem. 1982;28:1359–1361.
  • Maquart FX, Gillery P, Bernard JF, Mante JP, Borel JP. A method for specifically measuring hemoglobin A1c with a disposable commercial ion-exchange column. Clin Chim Acta. 1980;108:329–332.
  • Harrison AA, Dunbar PR, Neale TJ. Immunoassay of platelet-derived growth factor in the blood of patients with diabetes mellitus. Diabetologia. 1994;37:1142–1146.
  • Steffes MW, Osterby R, Chavers B, Mauer SM. Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients. Diabetes. 1989;38:1077–1081.
  • Frampton G, Hildreth G, Hartley B, Cameron JS, Heldin CH, Wasteson A. Could platelet-derived growth factor have a role in the pathogenesis of lupus nephritis? Lancet. 1988;2:343.
  • Naito T, Nitta K, Ozu H, . Clinical assessment of the significance of platelet-derived growth factor in patients with immunoglobulin A nephropathy. J Lab Clin Med. 1997;130:63–68.
  • Liu G, Changsirikulchai S, Hudkins KL, . Identification of platelet-derived growth factor D in human chronic allograft nephropathy. Hum Pathol. 2008;39:393–402.
  • Gesualdo L, Pinzani M, Floriano JJ, . Platelet-derived growth factor expression in mesangial proliferative glomerulonephritis. Lab Invest. 1991;65:160–167.
  • Wang Q, Guan Q, Chen F. The changes of platelet-derived growth factor-BB (PDGF-BB) in T2DM and its clinical significance for early diagnosis of diabetic nephropathy. Diabetes Res Clin Pract. 2009;85:166–170.
  • Fagerudd JA, Groop PH, Honkanen E, Teppo AM, Gronhagen-Riska C. Urinary excretion of TGF-β1, PDGF-BB and fibronectin in insulin-dependent diabetes mellitus patients. Kidney Int. 1997;52(Suppl. 63):S195–S197.
  • Lev-Ran A, Hwang DL. Epidermal growth factor and platelet-derived growth factor in blood in diabetes mellitus. Acta Endocrinol (Copenh). 1990;123:326–330.
  • Guillausseau PJ, Dupuy E, Bryckaert MC, . Platelet-derived growth factor (PDGF) in type 1 diabetes mellitus. Eur J Clin Invest. 1989;19:172–175.
  • Nakagawa H, Sasahara M, Haneda M, Koya D, Hazama F, Kikkawa R. Immunohistochemical characterization of glomerular PDGF-B chain and PDGF-beta receptor expression in diabetic rats. Diabetes Res Clin Pract. 2000;48:87–98.
  • Inaba T, Ishibashi S, Gotoda T, . Enhanced expression of platelet-derived growth factor-beta receptor by high glucose. Involvement of platelet-derived growth factor in diabetic angiopathy. Diabetes. 1996;45:507–512.
  • Nishida Y, Oda H, Yorioka N. Effect of lipoproteins on mesangial cell proliferation. Kidney Int. 1999;54(Suppl. 71):S51–S53.
  • Tang WW, Ulich TR, Lacey DL, . Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis. Am J Pathol. 1996;148:1169–1180.
  • Wang SN, Hirschberg R. Growth factor ultrafiltration in experimental diabetic nephropathy contributes to interstitial fibrosis. Am J Physiol Renal Electrolyte Physiol. 2000;278:554–560.
  • Fraser D, Wakefield L, Phillips A. Independent regulation of transforming growth factor-beta1 transcription and translation by glucose and platelet-derived growth factor. Am J Pathol. 2002;161:1039–1049.
  • Vieitez P, Gomez O, Uceda ER, Vera ME, Molina-Holqado E. Systemic and local effects of angiotensin II blockade in experimental diabetic nephropathy. J Renin Angiotensin Aldosterone Syst. 2008;9:96–102.

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