1,665
Views
22
CrossRef citations to date
0
Altmetric
Clinical Study

Reduced Plasma Zinc Levels, Lipid Peroxidation, and Inflammation Biomarkers Levels in Hemodialysis Patients: Implications to Cardiovascular Mortality

, , , , , , & show all
Pages 680-685 | Received 29 Nov 2012, Accepted 19 Mar 2013, Published online: 07 May 2013

REFERENCES

  • Mafra D, Cuppari L, Cozzolino SM. Iron and zinc status of patients with chronic renal failure who are not on dialysis. J Ren Nutr. 2002;12:38–41.
  • Bozalioglu S, Ozkan Y, Turan M, Simşek B. Prevalence of zinc deficiency and immune response in short-term hemodialysis. J Trace Elem Med Biol. 2005;18:243–249.
  • Esfahani ST, Hamidian MR, Madani A, et al. Serum zinc and copper levels in children with chronic renal failure. Biol Trace Elem Res. 2006;124:103–109.
  • Hsieh YY, Shen WS, Lee LY, Wu TL, Ning HC, Sun CF. Long-term changes in trace elements in patients undergoing insulin activity in genetically obese (ob/ob) mice. Biol Trace Elem Res. 2006;61:303–311.
  • Kiziltas H, Ekin S, Erkoc R. Trace element status of chronic renal patients undergoing hemodialysis. Biol Trace Elem Res. 2008;124(2):103–109.
  • Lobo JC, Torres JPM, Fouque D, Mafra D. Zinc deficiency in chronic kidney disease: is there a relationship with adipose tissue and atherosclerosis? Biol Trace Elem Res. 2010;135:16–21.
  • Molavi B, Mehta JL. Oxidative stress in cardiovascular disease: molecular basis of its deleterious effects, its detection, and therapeutic considerations. Curr Opin Cardiol. 2010;19:488–493.
  • Pedrosa AM, Faine LA, Grosso DM, de Las Heras B, Boscá L, Abdalla DS. Electronegative LDL induction of apoptosis in macrophages: involvement of Nrf2. Biochim Biophys Acta. 2010;1801:430–437.
  • Sanchez-Quesada JL, Benıtez S, Ordonez-Llanos J. Electronegative low-density lipoprotein. Curr Opin Lipidol. 2004;15(3):329–335.
  • Chen HH, Hosken BD, Huang M, et al. Electronegative LDL from familial hypercholesterolemic patients are physico-chemically heterogeneous but uniformly proapoptotic. J Lipid Res. 2007;48:177–184.
  • Oliveira JA, Sevanian A, Rodrigues RJ, Apolinário E, Abdalla DS. Minimally modified electronegative LDL and its autoantibodies in acute and chronic coronary syndromes. Clin Biochem. 2006;39:708–714.
  • Yang CY, Chen HH, Huang MT, et al. Pro-apoptotic low-density lipoprotein subfractions in type II diabetes. Atherosclerosis. 2007;193:283–291.
  • Lobo J, Santos F, Grosso D, et al. Electronegative LDL and lipid abnormalities in patients undergoing hemodialysis and peritoneal. Nephron Clin Pract. 2008;108(4):298–304.
  • Keys A, Fidanza KMJ, Kimura N, Taylor HL. Indices of relative weight and obesity. J Chronic Dis. 1972;25:329–343.
  • Rodriguez MP, Narizano A, Demczylo V, Cid A. A simple method for the determination of zinc human plasma levels by flame atomic absorption spectrophotometry. At Spectrosc. 1989;10(2):68–70.
  • Gibson RS. Principles of Nutritional Assessment. New York: Oxford University; 1990:543–553.
  • Faulin TES, Sena KCM, Telles AER, Grosso DM, Faulin EJB, Abdalla DS. Validation of a novel ELISA for measurement of electronegative low-density lipoprotein. Clin Chem Lab Med. 2008;46(12):1769–1775.
  • Freedman JE, Loscalzo J. Platelet–monocyte aggregates: bridging thrombosis and inflammation. Circulation. 2002;105:2130–2132.
  • Anderson TJ. Nitric oxide, atherosclerosis and the clinical relevance of endothelial dysfunction. Heart Fail Rev. 2003;8:71–86.
  • Zou MH, Shi C, Cohen RA. Oxidation of the zinc thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest. 2002;109:817–826.
  • Beattie JH, Kwun IS. Is zinc deficiency a risk factor for atherosclerosis? Br J Nutr. 2004;91:177–181.
  • Torra IP, Chinetti G, Duval C, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice. Curr Opin Lipidol. 2001;12:245–254.
  • Reiterer G, MacDonal R, Browning JD, et al. Zinc deficiency increases plasma lipids and atherosclerotic markers in LDL-receptor-deficient mice. J Nutr. 2005;135:2114–2118.
  • Mocchegiani E, Costarelli L, Giacconi R, et al. Nutrient-gene interaction in ageing and successful ageing. A single nutrient (zinc) and some target genes related to inflammatory/immune response. Mech Ageing Dev. 2006;127:517–525.
  • Prasad A. Clinical, immunological, anti-inflammatory and antioxidant roles of zinc. Exp Gerontol. 2008;43:370–377.
  • Prasad AS, Beck FW, Bao B, et al. Zinc supplementation decreases incidence of infections in the elderly effect of zinc in generation of cytokines and oxidative stress. Am J Clin Nutr. 2007;85:837–844.
  • Shen H, Oesterling E, Stromberg TM, MacDonald R, Hennig B. Zinc deficiency induces vascular pro-inflammatory parameters associated with NF-kappa B and PPAR signaling. J Am Coll Nutr. 2008;27:577–587.
  • Prasad AS, Bao B, Beck FW, Sarkar FH. Zinc-suppressed inflammatory cytokines by induction of A20-mediated inhibition of nuclear factor-κB. Nutrition. 2011;27:816–823.
  • Wilkins GM, Leake DS. The oxidation of low density lipoprotein by cells or iron is inhibited by zinc. FEBS Lett. 1994;341:259–262.
  • Meerarani P, Ramadass P, Toborek M, Bauer HC, Bauer H, Hennig B. Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. Am J Clin Nutr. 2000;71:81–87.
  • Bao B, Prasad AS, Frances WJB, et al. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects a potential implication of zinc as an atheroprotective agent. Am J Clin Nutr. 2010(91):1634–1641.
  • Benítez S, Camacho M, Bancells C, Vila L, Sánchez-Quesada JL, Ordóñez-Llanos J. Wide proinflammatory effect of electronegative low-density lipoprotein on human endothelial cells assayed by a protein array. Biochim Biophys Acta. 2006;1761(9):1014–1021.
  • Hennig B, Meerarani P, Toborek M, McClain CJ. Antioxidant-like properties of zinc in activated endothelial cells. J Am Col Nut. 1999;18(2):152–158.
  • Davis SR, Cousins RJ. Metallothionein expression in animals: a physiological perspective on function. J Nutr. 2000;130:1085–1088.
  • Mocchegiani E, Giacconi R, Cipriano C, et al. Zinc, metallothioneins, and longevity effect of zinc supplementation: zincage study. Ann NY Acad Sci. 2007;1119:129–146.
  • Mariani E, Mangialasche F, Feliziani FT, et al. Effects of zinc supplementation on antioxidant enzyme activities in healthy old subjects. Exp Gerontol. 2008;43:445–451.
  • Balsam A, El Kossi MM, Lord R, El Nahas AM. Cardiovascular disease on hemodialysis: predictors of atherosclerosis and survival. Hemodialysis Int. 2009;13:278–285.
  • Holme I, Aastveit AH, Hammar N, Jungner I, Walldius G. Inflammatory markers, lipoprotein components and risk of major cardiovascular events in 65,005 men and women in the Apolipoprotein Mortality Risk study (AMORIS). Atherosclerosis. 2010;213:299–305.
  • Fan ZX, Hua Q, Li YP, Liu RK, Yang Z. Interleukin-6, but not soluble adhesion molecules, predicts a subsequent mortality from cardiovascular disease in patients with acute ST-segment elevation myocardial infarction. Cell Biochem Biophys. 2011;61:443–448.
  • Pararameswaran N, Patial S. Tumor necrosis factor-α signaling in macrophages. Crit Rev Eukaryot Gene Expr. 2010;20(2):87–103.
  • Zoccali C, Mallamaci F, Tripepi G, Cutrupi S, Pizzini P. Low triiodothyronine and survival in end-stage renal disease. Kidney Int. 2006;70(3):523–528.
  • Fellah H, Hammami MB, Fek M, et al. Predictors for cardiovascular morbidity and overall mortality in Tunisian ESRD patients: a six year prospective study. Clin Biochem. 2009;42(7–8):648–653.
  • Kuragano T, Itoh K, Shimonaka Y, et al. Hepcidin as well as TNF-α are significant predictors of arterial stiffness in patients on maintenance hemodialysis. Nephrol Dial Transplant. 2011;26(8):2663–2667 10.
  • Roberts MA, Polkinghorne KR, McDonal SP, Ierin FL. Secular trends in cardiovascular mortality rates of patients receiving dialysis compared with the general population. Am J Kidney Dis. 2011;58:654–72.
  • Iseki K. Role of chronic kidney disease in cardiovascular disease: are we different from others? Clin Exp Nephrol. 2011;15(4):450–455.
  • Afsar B, Elsurer R, Akgul A, Sezer S, Ozdemir FN. Factors related to silent myocardial damage in hemodialysis patients. Ren Fail. 2009;31(10):933–941.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.