1,692
Views
30
CrossRef citations to date
0
Altmetric
Laboratory Study

Plasma Kynurenic Acid/Tryptophan Ratio: A Sensitive and Reliable Biomarker for the Assessment of Renal Function

Pages 648-653 | Received 19 Feb 2013, Accepted 19 Mar 2013, Published online: 07 May 2013

REFERENCES

  • Liu BC, Wu XC, Wang YL, Investigation of the prevalence of CKD in 13,383 Chinese hospitalized adult patients. Clin Chim Acta. 2008;387:128–132.
  • Filiopoulos V, Hadjiyannakos D, Vlassopoulos D. New insights into uric acid effects on the progression and prognosis of chronic kidney disease. Ren Fail. 2012;34:510–520.
  • Cai F, Ren L, Liu H, The relationship between the level of serum creatinine, modified diet and renal disease formula, Cockcroft-Gault formula, and renal tubulointerstitial lesion. Ren Fail. 2012;34:334–337.
  • Robles NR, Mena C, Cidoncha J. Estimated glomerular filtration rate from serum cystatin C: significant differences among several equations results. Ren Fail. 2012;34:871–875.
  • Warnock DG, Muntner P, McCullough PA, Kidney function, albuminuria, and all-cause mortality in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study. Am J Kidney Dis. 2010;56:861–871.
  • Pawlak K, Kowalewska A, Mysliwiec M, Pawlak D. Kynurenine and its metabolites—kynurenic acid and anthranilic acid are associated with soluble endothelial adhesion molecules and oxidative status in patients with chronic kidney disease. Am J Med Sci. 2009;338:293–300.
  • Saito K, Fujigaki S, Heyes MP, Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency. Am J Physiol Renal Physiol. 2000;279:F565–F572.
  • Pawlak K, Brzosko S, Mysliwiec M, Pawlak D. Kynurenine, quinolinic acid—the new factors linked to carotid atherosclerosis in patients with end-stage renal disease. Atherosclerosis. 2009;204:561–566.
  • Schefold JC, Zeden JP, Fotopoulou C, Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uratemic symptoms. Nephrol Dial Transplant. 2009;24:1901–1908.
  • Pawlak D, Tankiewicz A, Matys T, Buczko W. Peripheral distribution of kynurenine metabolites and activity of kynurenine pathway enzymes in renal failure. J Physiol Pharmacol. 2003;54:175–189.
  • K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis. 2002;39:S1–S266.
  • Xu B, Zhan Y, Gao P, Zhu D, Zhao J. Changes of plasma concentrations of tryptophan, kynurenine and kynurenic acid in essential hypertensive patients. Lab Med. 2012;27:624–627 (Chinese).
  • Zhao J, Gao P, Zhu D. Optimization of Zn2+-containing mobile phase for simultaneous determination of kynurenine, kynurenic acid and tryptophan in human plasma by high performance liquid chromatography. J Chromatogr B. 2010;878:603–608.
  • Stoy N, Mackay GM, Forrest CM, Tryptophan metabolism and oxidative stress in patients with Huntington’s disease. J Neurochem. 2005;93:611–623.
  • Pawlak D, Tankiewicz A, Buczko W. Kynurenine and its metabolites in the rat with experimental renal insufficiency. J Physiol Pharmacol. 2001;52:755–766.
  • Holmes EW. Determination of serum kynurenine and hepatic tryptophan dioxygenase activity by high-performance liquid chromatography. Anal Biochem. 1988;172:518–525.
  • Eleftheriadis T, Yiannaki E, Antoniadi G, Plasma indoleamine 2,3-dioxygenase and arginase type I may contribute to decreased blood T-cell count in hemodialysis patients. Ren Fail. 2012;34:1118–1122.
  • Eleftheriadis T, Antoniadi G, Liakopoulos V, Stefanidis I, Galaktidou G. Plasma indoleamine 2,3-dioxygenase concentration is increased in hemodialysis patients and may contribute to the pathogenesis of coronary heart disease. Ren Fail. 2012;34:68–72.
  • Knox WE, Auerbach VH. The hormonal control of tryptophan peroxidase in the rat. J Biol Chem. 1955;214:307–313.
  • Zhao J, Chen H, Ni P, Simultaneous determination of urinary tryptophan, tryptophan-related metabolites and creatinine by high performance liquid chromatography with ultraviolet and fluorimetric detection. J Chromatogr B. 2011;879:2720–2725.
  • Mason M. Kynurenine transaminase of rat kidney; a study of coenzyme dissociation. J Biol Chem. 1957;227:61–68.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.