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Laboratory Study

Naringin ameliorates sodium arsenite-induced renal and hepatic toxicity in rats: decisive role of KIM-1, Caspase-3, TGF-β, and TNF-α

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Pages 1396-1407 | Received 30 May 2015, Accepted 11 Jul 2015, Published online: 31 Aug 2015

References

  • Singh KP, DuMond JW. Genetic and epigenetic changes induced by chronic low dose exposure to arsenic of mouse testicular Leydig cells. Int J Oncol. 2007;30:253–260
  • Mazumder DG. Effect of chronic intake of arsenic-contaminated water on liver. Toxicol Appl Pharmacol. 2005;206:169–175
  • Humans IWGotEoCRt, Cancer IAfRo. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Geneva: World Health Organization; 2004
  • Szymanska-Chabowska A, Antonowicz-Juchniewicz J, Andrzejak R. Some aspects of arsenic toxicity and carcinogenicity in living organism with special regard to its influence on cardiovascular system, blood and bone marrow. Int J Occup Med Environ Health. 2002;15:101–116
  • Chowdhury UK, Rahman MM, Mandal B, et al. Groundwater arsenic contamination and human suffering in West Bengal, India and Bangladesh. Environ Sci. 2001;8:393–415
  • Liu SX, Athar M, Lippai I, Waldren C, Hei TK. Induction of oxyradicals by arsenic: Implication for mechanism of genotoxicity. Proc Natl Acad Sci USA. 2001;98:1643–1648
  • Lin A, Zhang X, Zhu YG, Zhao FJ. Arsenate-induced toxicity: Effects on antioxidative enzymes and DNA damage in Vicia faba. Environ Toxicol Chem. 2008;27:413–419
  • Nandi D, Patra R, Swarup D. Oxidative stress indices and plasma biochemical parameters during oral exposure to arsenic in rats. Food Chem Toxicol. 2006;44:1579–1584
  • Honmore V, Kandhare A, Zanwar AA, Rojatkar S, Bodhankar S, Natu A. Artemisia pallens alleviates acetaminophen induced toxicity via modulation of endogenous biomarkers. Pharm Biol. 2015;53:571–581
  • Kandhare A, Patil MV, Bodhankar S. L-arginine attenuates the ethylene glycol induced urolithiasis in uninephrectomized hypertensive rats: Role of KIM-1, NGAL and NOs. Ren Fail. 2015;37:709–721
  • Visnagri A, Kandhare AD, Bodhankar SL. Renoprotective effect of berberine via intonation on apoptosis and mitochondrial-dependent pathway in renal ischemia reperfusion-induced mutilation. Ren Fail. 2015;37:482–493
  • Tsai S-M, Wang T-N, Ko Y-C. Mortality for certain diseases in areas with high levels of arsenic in drinking water. Arch Environ Health Int J 1999;54:186–193
  • Hughes MF, Kenyon EM, Edwards BC, Mitchell CT, Del Razo LM, Thomas DJ. Accumulation and metabolism of arsenic in mice after repeated oral administration of arsenate. Toxicol Appl Pharmacol. 2003;191:202–210
  • Islam K, Haque A, Karim R, et al. Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: A cross sectional study in Bangladesh. Environ Health, 2011;10:64
  • Fowler BA, Woods JS, Schiller CM. Ultrastructural and biochemical effects of prolonged oral arsenic exposure on liver mitochondria of rats. Environ Health Perspect. 1977;19:197
  • Hubaux R, Becker-Santos DD, Enfield K, et al. Molecular features in arsenic-induced lung tumors. Mol Cancer. 2013;12:20
  • Manna P, Sinha M, Sil PC. Arsenic-induced oxidative myocardial injury: Protective role of arjunolic acid. Arch Toxicol. 2008;82:137–149
  • Singh N, Kumar D, Lal K, Raisuddin S, Sahu AP. Adverse health effects due to arsenic exposure: Modification by dietary supplementation of jaggery in mice. Toxicol Appl Pharmacol. 2010;242:247–255
  • Tripoli E, La Guardia M, Giammanco S, Di Majo D, Giammanco M. Citrus flavonoids: Molecular structure, biological activity and nutritional properties: A review. Food Chem. 2007;104:466–479
  • Kim D-H, Jung E-A, Sohng I-S, Han J-A, Kim T-H, Han MJ. Intestinal bacterial metabolism of flavonoids and its relation to some biological activities. Arch Pharm Res. 1998;21:17–23
  • Chen C, Chen C, Wu M, Kuo T. Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Br J Cancer. 1992;66:888
  • Gopinath K, Prakash D, Sudhandiran G. Neuroprotective effect of naringin, a dietary flavonoid against 3-nitropropionic acid-induced neuronal apoptosis. Neurochem Int. 2011;59:1066–1073
  • Zbarsky V, Datla KP, Parkar S, Rai DK, Aruoma OI, Dexter DT. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic Res. 2005;39:1119–1125
  • Jeon S-M, Park YB, Choi M-S. Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits. Clin Nutr. 2004;23:1025–1034
  • So FV, Guthrie N, Chambers AF, Moussa M, Carroll KK. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr Cancer. 1996;26:167–81
  • Kandhare AD, Alam J, Patil MVK, Sinha A, Bodhankar SL. Wound healing potential of naringin ointment formulation via regulating the expression of inflammatory, apoptotic and growth mediators in experimental rats. Pharm Biol. 2015;1–14. doi:10.3109/13880209.2015.1038755
  • Kandhare AD, Ghosh P, Bodhankar SL. Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats. Chem Biol Interact. 2014;219C:101–112
  • Kandhare AD, Raygude KS, Ghosh P, Ghule AE, Bodhankar SL. Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. Fitoterapia. 2012;83:650–659
  • Kumar VS, Rajmane AR, Adil M, Kandhare AD, Ghosh P, Bodhankar SL. Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats. J Biomed Res. 2014;28:132–145
  • Lee M-H, Yoon S, Moon J-O. The flavonoid naringenin inhibits dimethylnitrosamine-induced liver damage in rats. Biol Pharm Bull. 2004;27:72–6
  • Badary OA, Abdel-Maksoud S, Ahmed WA, Owieda GH. Naringenin attenuates cisplatin nephrotoxicity in rats. Life Sci. 2005;76:2125–2135
  • Butterfield DA, Howard B, Yatin S, et al. Elevated oxidative stress in models of normal brain aging and Alzheimer's disease. Life Sci. 1999;65:1883–1892
  • Gaur V, Aggarwal A, Kumar A. Protective effect of naringin against ischemic reperfusion cerebral injury: Possible neurobehavioral, biochemical and cellular alterations in rat brain. Eur J Pharmacol. 2009;616:147–154
  • Golechha M, Chaudhry U, Bhatia J, Saluja D, Arya DS. Naringin protects against kainic acid-induced status epilepticus in rats: Evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. Biol Pharm Bull. 2011;34:360–365
  • Rajadurai M, Prince PSM. Preventive effect of naringin on isoproterenol-induced cardiotoxicity in Wistar rats: An in vivo and in vitro study. Toxicology. 2007;232:216–225
  • Adil M, Visnagri A, Kumar VS, Kandhare AD, Ghosh P. Protective effect of naringin on sodium arsenite induced testicular toxicity via modulation of biochemical perturbations in experimental rats. Pharmacologia. 2014;5:222–234
  • El-Demerdash FM, Yousef MI, Radwan FM. Ameliorating effect of curcumin on sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs. Food Chem Toxicol. 2009;47:249–254
  • Visnagri A, Kandhare AD, Shiva Kumar V, et al. Elucidation of ameliorative effect of Co-enzyme Q10 in streptozotocin-induced diabetic neuropathic perturbation by modulation of electrophysiological, biochemical and behavioral markers. Biomed Aging Pathol. 2012;2:157–172
  • Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL. Elucidation of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol induced neuropathic pain. Fundam Clin Pharmacol. 2013;27:603–622
  • Badole SL, Chaudhari SM, Jangam GB, Kandhare AD, Bodhankar SL. Cardioprotective activity of Pongamia pinnata in streptozotocin-nicotinamide induced diabetic rats. BioMed Res Int. 2015;2015:403291
  • Gosavi TP, Ghosh P, Kandhare AD, et al. Therapeutic effect of H. pylori nosode, a homeopathic preparation in healing of chronic H. pylori infected ulcers in laboratory animals. Asian Pacif J Trop Dis. 2012;2:S603–S611
  • Gosavi TP, Kandhare AD, Ghosh P, Bodhankar SL. Anticonvulsant activity of Argentum metallicum, a homeopathic preparation. Pharm Lett. 2012;4:626–637
  • Goswami S, Kandhare A, Zanwar AA, et al. Oral l-glutamine administration attenuated cutaneous wound healing in Wistar rats. Int Wound J 2014. doi:10.1111/iwj.12246
  • Kandhare AD, Shivakumar V, Rajmane A, Ghosh P, Bodhankar SL. Evaluation of the neuroprotective effect of chrysin via modulation of endogenous biomarkers in a rat model of spinal cord injury. J Nat Med. 2014;68:586–603
  • Visnagri A, Kandhare AD, Chakravarty S, Ghosh P, Bodhankar SL. Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions. Pharm Biol. 2014;52:814–828
  • Kandhare AD, Bodhankar SL, Mohan V, Thakurdesai PA. Prophylactic efficacy and possible mechanisms of oligosaccharides based standardized fenugreek seed extract on high-fat diet-induced insulin resistance in C57BL/6 mice. J Appl Pharm Sci. 2015;5:035–045
  • Ketkar S, Rathore A, Kandhare A, et al. Alleviating exercise induced muscular stress using neat and processed bee pollen: Oxidative markers, mitochondrial enzymes and myostatin expression in rats. Integr Med Res 2015. doi:10.1016/j.imr.2015.02.003
  • Bhadauria S, Flora S. Response of arsenic-induced oxidative stress, DNA damage, and metal imbalance to combined administration of DMSA and monoisoamyl-DMSA during chronic arsenic poisoning in rats. Cell Biol Toxicol. 2007;23:91–104
  • Kitchin KT, Ahmad S. Oxidative stress as a possible mode of action for arsenic carcinogenesis. Toxicol Lett. 2003;137:3–13
  • Brunati AM, Pagano MA, Bindoli A, Rigobello MP. Thiol redox systems and protein kinases in hepatic stellate cell regulatory processes. Free Radic Res. 2010;44:363–378
  • Yousef MI, El-Demerdash FM, Radwan FM. Sodium arsenite induced biochemical perturbations in rats: Ameliorating effect of curcumin. Food Chem Toxicol. 2008;46:3506–3511
  • Nandi D, Patra R, Swarup D. Effect of cysteine, methionine, ascorbic acid and thiamine on arsenic-induced oxidative stress and biochemical alterations in rats. Toxicology. 2005;211:26–35
  • Kaltreider RC, Davis AM, Lariviere JP, Hamilton JW. Arsenic alters the function of the glucocorticoid receptor as a transcription factor. Environ Health Perspect 2001;109:245
  • Bashir S, Sharma Y, Irshad M, Gupta SD, Dogra T. Arsenic-induced cell death in liver and brain of experimental rats. Basic Clin Pharm Toxicol. 2006;98:38–43
  • Jana K, Jana S, Samanta PK. Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: Possible an estrogenic mode of action. Reprod Biol Endocrinol. 2006;4:1–13
  • Rahman M, Tondel M, Ahmad SA, Axelson O. Diabetes mellitus associated with arsenic exposure in Bangladesh. Am J Epidemiol. 1998;148:198–203
  • Kimura A, Ishida Y, Hayashi T, et al. Interferon-γ plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression. Am J Pathol. 2006;169:1118–1128
  • Ayala-Fierro F, Baldwin AL, Wilson LM, Valeski JE, Carter DE. Structural alterations in the rat kidney after acute arsine exposure. Lab Invest. 2000;80:87–97
  • Dalal P, Gangopadhyay A, Roychowdhury A. Identification of indicators of arsenic induced nephrotoxicity in humans. Internet J Toxicol 2008;5
  • Madden EF, Fowler BA. Mechanisms of nephrotoxicity from metal combinations: A review. Drug Chem Toxicol. 2000;23:1–12
  • Gross JL, De Azevedo MJ, Silveiro SP, Canani LH, Caramori ML, Zelmanovitz T. Diabetic nephropathy: Diagnosis, prevention, and treatment. Diabetes Care. 2005;28:164–176
  • Saxena PN, Anand S, Saxena N, Bajaj P. Effect of arsenic trioxide on renal functions and its modulation by Curcuma aromatica leaf extract in albino rat. J Environ Biol. 2009;30:527–531
  • Zhang J, Pan X, Li N, et al. Grape seed extract attenuates arsenic-induced nephrotoxicity in rats. Exp Ther Med 2014;7:260–266
  • Masella R, Di Benedetto R, Varì R, Filesi C, Giovannini C. Novel mechanisms of natural antioxidant compounds in biological systems: Involvement of glutathione and glutathione-related enzymes. J Nutr Biochem. 2005;16:577–586
  • Zakharyan RA, Aposhian HV. Enzymatic reduction of arsenic compounds in mammalian systems: The rate-limiting enzyme of rabbit liver arsenic biotransformation is MMAV reductase. Chem Res Toxicol. 1999;12:1278–1283
  • Afzal M, Afzal A, Jones A, Armstrong D. A rapid method for the quantification of GSH and GSSG in biological samples. Methods Mol Biol. 2002;186:117–122
  • Muthumani M. Tetrahydrocurcumin potentially attenuates arsenic induced oxidative hepatic dysfunction in rats. J Clin Toxicol. 2013;3:1000168
  • Hemalatha P, Reddy AG, Reddy YR, Shivakumar P. A study on arsenic-induced toxicity in rats. J Chem Pharm Res 2012;4:4459--4461
  • Singh D, Chopra K. The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats. Pharmacol Res. 2004;50:187–193
  • Fiers W, Beyaert R, Declercq W, Vandenabeele P. More than one way to die: Apoptosis, necrosis and reactive oxygen damage. Oncogene. 1999;18:7719–7730
  • Aswar UM, Kandhare AD, Mohan V, Thakurdesai PA. Anti-allergic effect of intranasal administration of type-A procyanidin polyphenols based standardized extract of cinnamon bark in ovalbumin sensitized BALB/c mice. Phytother Res. 2014;29:423--433
  • Kamble H, Kandhare AD, Bodhankar S, Mohan V, Thakurdesai P. Effect of low molecular weight galactomannans from fenugreek seeds on animal models of diabetes mellitus. Biomed Aging Pathol. 2013;3:145–151
  • Kandhare AD, Bodhankar SL, Mohan V, Thakurdesai PA. Acute and repeated doses (28 days) oral toxicity study of glycosides based standardized fenugreek seed extract in laboratory mice. Regul Toxicol Pharmacol. 2015;72:323–334
  • Kandhare A, Raygude K, Ghosh P, Bodhankar S. The ameliorative effect of fisetin, a bioflavonoid, on ethanol-induced and pylorus ligation-induced gastric ulcer in rats. Int J Green Pharm. 2011;5:236–243
  • Kandhare AD, Bodhankar SL, Singh V, Mohan V, Thakurdesai PA. Anti-asthmatic effects of type-A procyanidine polyphenols from cinnamon bark in ovalbumin-induced airway hyperresponsiveness in laboratory animals. Biomed Aging Pathol. 2013;3:23–30
  • Sarkar A, Sengupta A, Mukhrjee A, et al. Antiulcer potential of morin in acetic acid-induced gastric ulcer via modulation of endogenous biomarkers in laboratory animals. Pharmacologia. 2015;6:273–281
  • Visnagri A, Kandhare AD, Ghosh P, Bodhankar SL. Endothelin receptor blocker bosentan inhibits hypertensive cardiac fibrosis in pressure overload-induced cardiac hypertrophy in rats. Cardiovasc Endocrinol. 2013;2:85–97
  • Usoh I, Akpan E, Etim E, Farombi E. Antioxidant actions of dried flower extracts of Hibiscus sabdariffa L. on sodium arsenite-induced oxidative stress in rats. Pak J Nutr. 2005;4:135–141
  • Raygude KS, Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL. Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. Inflammopharmacology. 2012;20:331–341
  • Saraswathi KY, Muthal A, Kandhare A, Rojatkar S, Bodhankar S. Study of methanolic extract of Artemisia pallens wall on endurance of laboratory animals. Pharmacologia. 2014;5:298–309
  • Yamanaka K, Okada S. Induction of lung-specific DNA damage by metabolically methylated arsenics via the production of free radicals. Environ Health Perspect. 1994;102:37
  • Kandhare AD, Ghosh P, Ghule AE, Zambare GN, Bodhankar SL. Protective effect of Phyllanthus amarus by modulation of endogenous biomarkers and DNA damage in acetic acid induced ulcerative colitis: Role of phyllanthin and hypophyllanthin. Apollo Med. 2013;10:87–97
  • Kandhare AD, Kumar VS, Adil M, Rajmane AR, Ghosh P, Bodhankar SL. Investigation of gastro protective activity of Xanthium strumarium L. by modulation of cellular and biochemical marker. Orient Pharm Exp Med. 2012;12:287–299
  • Gupta R, Flora S. Effect of Centella asiatica on arsenic induced oxidative stress and metal distribution in rats. J Appl Toxicol. 2006;26:213–222
  • Prabu SM, Muthumani M. Silibinin ameliorates arsenic induced nephrotoxicity by abrogation of oxidative stress, inflammation and apoptosis in rats. Mol Biol Rep. 2012;39:11201–11216
  • Chen Y, Nie Y-c, Luo Y-l, et al. Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. Food Chem Toxicol. 2013;58:133–140
  • Ahmad S, Kitchin KT, Cullen WR. Arsenic species that cause release of iron from ferritin and generation of activated oxygen. Arch Biochem Biophys. 2000;382:195–202
  • Farber JL, Kyle ME, Coleman JB. Mechanisms of cell injury by activated oxygen species. Lab Invest. 1990;62:670
  • Kandhare AD, Raygude KS, Shiva Kumar V, et al. Ameliorative effects quercetin against impaired motor nerve function, inflammatory mediators and apoptosis in neonatal streptozotocin-induced diabetic neuropathy in rats. Biomed Aging Pathol. 2012;2:173–186
  • Patil M, Kandhare A, Bhise S. Pharmacological evaluation of ameliorative effect of aqueous extract of Cucumis sativus L. fruit formulation on wound healing in Wistar rats. Chron Young Sci. 2011;2:207–213
  • Patil M, Kandhare A, Bhise S. Anti-inflammatory effect of Daucus carota root on experimental colitis in rats. Int J Pharm Pharm Sci. 2012;4:337–343
  • Raygude KS, Kandhare AD, Ghosh P, Bodhankar SL. Anticonvulsant effect of fisetin by modulation of endogenous biomarkers. Biomed Prev Nutr. 2012;2:215–222
  • Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H. Glucose toxicity in β-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes. 2003;52:581–587
  • Kandhare AD, Raygude KS, Ghosh P, et al. Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn. leaves in experimental colitis in rats. Asian Pac J Trop Biomed. 2012;5:337–344
  • Patil MVK, Kandhare AD, Bhise SD. Anti-arthritic and anti-inflammatory activity of Xanthium srtumarium L. ethanolic extract in Freund's complete adjuvant induced arthritis. Biomed Aging Pathol 2012;2:6–15
  • Patil MVK, Kandhare AD, Bhise SD. Effect of aqueous extract of Cucumis sativus Linn. fruit in ulcerative colitis in laboratory animals. Asian Pac J Trop Biomed. 2012;2:S962–S969
  • Girotti AW. Mechanisms of lipid peroxidation. J Free Radic Biol Med. 1985;1:87–95
  • Kandhare AD, Raygude KS, Ghosh P, Ghule AE, Bodhankar SL. Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals. Neurosci Lett. 2012;511:18–22
  • Patil MVK, Kandhare AD, Bhise SD. Pharmacological evaluation of ethanolic extract of Daucus carota Linn root formulated cream on wound healing using excision and incision wound model. Asian Pac J Trop Biomed 2012;2:S646–S655
  • Mahmoud M, Hamdan D, Wink M, El-Shazly A. Naringin and rutin prevent D-Galactosamine-induced hepatic injury in rats via attenuation of the inflammatory cascade and oxidative stress. Eur Sci J. 2013;9:141--155
  • Ignarro LJ, Fukuto JM, Griscavage JM, Rogers NE, Byrns RE. Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: Comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci USA. 1993;90:8103–8107
  • Lala PK, Chakraborty C. Role of nitric oxide in carcinogenesis and tumour progression. Lancet Oncol. 2001;2:149–156
  • Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA. 1990;87:1620–1624
  • Leaf CD, Wishnok JS, Tannenbaum SR. Endogenous incorporation of nitric oxide from L-arginine into N-nitrosomorpholine sitmulated by Escherichia coli lipopolysaccharide in the rat. Carcinogenesis. 1991;12:537–539
  • Mukherjee S, Das D, Mukherjee M, Das AS, Mitra C. Synergistic effect of folic acid and vitamin B 12 in ameliorating arsenic-induced oxidative damage in pancreatic tissue of rat. J Nutr Biochem. 2006;17:319–327
  • Kempaiah RK, Srinivasan K. Beneficial influence of dietary curcumin, capsaicin and garlic on erythrocyte integrity in high-fat fed rats. J Nutr Biochem. 2006;17:471–478
  • Ithayarasi AP, Devi C. Effect of a-tocopherol on lipid peroxidation in isoproterenol induced myocardial infarction in rats. Indian J Physiol Pharmacol. 1997;41:369–376
  • Park S, Jung Y. Combined actions of Na+/K+-ATPase, NCX1 and glutamate dependent NMDA receptors in ischemic rat brain penumbra. Anat Cell Biol. 2010;43:201–210
  • Miyake H, Kadoya A, Ohyashiki T. Increase in molecular rigidity of the protein conformation of brain Na+-K+-ATPase by modification with 4-hydroxy-2-nonenal. Biol Pharm Bull. 2003;26:1652–1656
  • Ercal N, Gurer-Orhan H, Aykin-Burns N. Toxic metals and oxidative stress part I: Mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem. 2001;1:529–539
  • Li Y, Ling M, Xu Y, et al. The repressive effect of NF-κB on p53 by Mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite. Toxicol Sci. 2010;116:174–182
  • Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV. Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury. Kidney Int. 2002;62:237–244
  • Kandhare AD, Raygude KS, Ghosh P, Gosavi TP, Bodhankar SL. Patentability of Animal Models: India and the Globe. Int J Pharm Biol Arch. 2011;2:1024–1032
  • Prozialeck W, Vaidya V, Liu J, et al. Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity. Kidney Int. 2007;72:985–993
  • Vaidya VS, Ramirez V, Ichimura T, Bobadilla NA, Bonventre JV. Urinary kidney injury molecule-1: A sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Ren Physiol. 2006;290:F517–F529
  • Maeda H, Hori S, Nishitoh H, et al. Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer. Cancer Res. 2001;61:5432–5440
  • Belzacq A-S, El Hamel C, Vieira H, et al. Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437. Oncogene. 2001;20:7579–7587
  • Banerjee N, Banerjee M, Ganguly S, et al. Arsenic-induced mitochondrial instability leading to programmed cell death in the exposed individuals. Toxicology. 2008;246:101–111
  • Li D, Morimoto K, Takeshita T, Lu Y. Formamidopyrimidine-DNA glycosylase enhances arsenic-induced DNA strand breaks in PHA-stimulated and unstimulated human lymphocytes. Environ Health Perspect 2001;109:523
  • Bratton SB, Cohen GM. Apoptotic death sensor: An organelle's alter ego? Trends Pharmacol Sci. 2001;22:306–315
  • Majumdar S, Karmakar S, Maiti A, et al. Arsenic-induced hepatic mitochondrial toxicity in rats and its amelioration by dietary phosphate. Environ Toxicol Pharmacol. 2011;31:107–118
  • Samarakoon R, Overstreet JM, Higgins SP, Higgins PJ. TGF-β1→ SMAD/p53/USF2→ PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis. Cell Tissue Res. 2012;347:117–128
  • Bissell DM, Roulot D, George J. Transforming growth factor β and the liver. Hepatology. 2001;34:859–867
  • Ghosh D, Ghosh S, Sarkar S, et al. Quercetin in vesicular delivery systems: Evaluation in combating arsenic-induced acute liver toxicity associated gene expression in rat model. Chem Biol Interact. 2010;186:61–71
  • Ernandez T, Mayadas T. Immunoregulatory role of TNFα in inflammatory kidney diseases. Kidney Int. 2009;76:262–276
  • Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J. 1991;10:2247
  • Mazumder DG. Chronic arsenic toxicity & human health. Indian J Med Res. 2008;128:436–447
  • Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology. 2008;134:1655–1669
  • Fouqueray B, Philippe C, Herbelin A, Perez J, Ardaillou R, Baud L. Cytokine formation within rat glomeruli during experimental endotoxemia. J Am Soc Nephrol. 1993;3:1783–1791
  • Donnahoo KK, Shames BD, Harken AH, Meldrum DR. Review article: The role of tumor necrosis factor in renal ischemia-reperfusion injury. J Urol. 1999;162:196–203
  • Ramanathan K, Anusuyadevi M, Shila S, Panneerselvam C. Ascorbic acid and α-tocopherol as potent modulators of apoptosis on arsenic induced toxicity in rats. Toxicol Lett. 2005;156:297–306

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