References
- Feagan BG, Alfadhli A. Methotrexate in inflammatory bowel disease. Gastroenterol Clin North Am. 2004;33:407–420
- Abraham P, Kolli VK, Rabi S. Melatonin attenuates methotrexate-induced oxidative stress and renal damage in rats. Cell Biochem Funct. 2010;28(5):426–433
- Jahovic N, Cevik H, Sehirli AO, Yegen BC, Sener G. Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats. J Pineal Res. 2003;34(4):282–287
- Kolli VK, Abraham P, Isaac B, Selvakumar D. Neutrophil infiltration and oxidative stress may play a critical role in methotrexate-induced renal damage. Chemotherapy. 2009;55(2):83–90
- Sener G, Ekşioğlu-Demiralp E, Çetiner M, et al. l-Carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death. Cell Biol Toxicol. 2006;22:47–60
- Elik M, Serdaroglu G, Ozkan R. Mirisetin ve Kuersetin Bilesiklerinin Antioksidan Etkinliklerinin DFT Yontemiyle İncelenmesi. Fen Bilimleri Dergisi. 2007;28(2):53–65
- Kahraman A, Erkasap N, Koken T, Serteser M, Aktepe F, Erkasap S. The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions. Toxicology. 2003;183:133–142
- Abdel-Raheem IT, Abdel-Ghany AA, Mohamed A. Protective effect of quercetin against gentamicin-induced nephrotoxicty. Biol Pharm Bull. 2009;32(1):61–67
- Ishikawa Y, Kitamura M. Bioflavonoid quercetin inhibits mitosis and apoptosis of glomerular cells in vitro and in vivo. Biochem Biophys Res Commun. 2000;279:629–634
- Acipayam C, Bayram I, Daglioglu K, et al. The protective effect of hesperidin on methotrexate-induced intestinal epithelial damage in rats: An experimental study. Med Princ Pract. 2014;23(1):45–52
- Bozkurt M, Em S, Oktayoglu P, et al. Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats. Clin Invest Med. 2014;37(1):19–25
- Asvadi I, Hajipour B, Asvadi A, Asl NA, Roshangar L, Khodadadi A. Protective effect of pentoxyfilline in renal toxicity after methotrexate administration. Eur Rev Med Pharmacol Sci. 2011;15(9):1003–1009
- Vardi N, Parlakpinar H, Ates B, Cetin A, Otlu A. The protective effects of Prunus armeniaca L (apricot) against methotrexate-induced oxidative damage and apoptosis in rat kidney. J Physiol Biochem. 2013;69:371–381
- Aktoz T, Kanter M, Uz YH, Aktas C, Erboga M, Atakan IH. Protective effect of quercetin against renal toxicity induced by cadmium in rats. Balkan Med J. 2012;29:56–61
- Jawan B, Goto S, Pan TL, et al. The protective mechanism of magnolol, a Chinese herb drug, against warm ischemia–reperfusion injury of rat liver. J Surg Res. 2003;110:378–382
- Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265–275
- Buege AJ, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. 1978;52:302–310
- Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988;34:497–500
- Aebi H. Catalase. In: Bergmeyer HU, ed. Methods of Enzymatic Analysis. New York and London: Academic Press; 1974: 673–677
- Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70:158–169
- Tilling L, Townsend S, David J. Methotrexate and hepatic toxicity in rheumatoid arthritis and psoriatic arthritis. Clin Drug Invest. 2006;26:55–62
- Sendur N, Karaman G, Savk H. Akut Metotreksat Toksisitesinin Erken Belirtisi; Deri Ülserleri. T Klin Tıp Bilimleri. 2002;22:593–596
- Al-Motagabani MA. Histological and histochemical studies on the effects of methotrexate on the liver of adult male albino rat. Int J Morphol. 2006;24(3):417–422
- Caglar Y, Ozgur H, Matur I, et al. Ultrastructural evaluation of the effect of N-acetylcysteine on methotrexate nephrotoxicity in rats. Histol Histopathol. 2013;28:865–874
- Cakır T, Ozkan E, Dulundu E, et al. Caffeic acid phenethyl ester (CAPE) prevents methotrexate-induced hepatorenal oxidative injury in rats. J Pharm Pharmacol. 2011;63(12):1566–1571
- Pinheiro FV, Pimentel VC, De Bona KS, et al. Decrease of adenosine deaminase activity and increase of the lipid peroxidation after acute methotrexate treatment in young rats: Protective effects of grape seed extract. Cell Biochem Funct. 2010;28(1):89–94
- Chaudhary S, Ganjoo P, Raiusddin S, Parvez S. Nephroprotective activities of quercetin with potential relevance to oxidative stress induced by valproic acid. Protoplasma. 2015;252(1):209–217
- Hou Y, Zeng Y, Li S, et al. Effect of quercetin against dichlorvos induced nephrotoxicity in rats. Exp Toxicol Pathol. 2014;66(4):211–218
- Cetinkaya A, Bulbuloglu E, Kurutas EB, Kantarceken B. N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats. Med Sci Monit. 2006;12:274–278
- Abdel-Raheem IT, Khedr NF. Renoprotective effects of montelukast, a cysteinyl leukotriene receptor antagonist, against methotrexate-induced kidney damage in rats. Naunyn-Schmiedeberg's Arch Pharmacol. 2014;387:341–353
- Uzar E, Sahin O, Koyuncuoglu HR, et al. The activity of adenosine deaminaz and the level of nitric oxide in spinal cord of methotrexate administered rats: Protective effect of caffeic acid phenethyl ester. Toxicology. 2006;218(2–3):125–133
- Cetiner M, Sener G, Sehirli AO, et al. Taurine protects against methotrexate-induced toxicity and inhibits leukocyte death. Toxicol Appl Pharmacol. 2005;209(1):39–50
- Lankelma J, van der Klein E, Ramaekers F. The role of 7-hydroxymethotrexate during methotrexate anti-cancer therapy. Cancer Lett. 1980;9:133–142
- Oktem F, Yilmaz HR, Ozguner F, et al. Methotrexate-induced renal oxidative stress in rats the role of a novel antioxidant caffeic acid phenethyl ester. Toxicol Ind Health. 2006;22:241–247
- Kose E, Beytur A, Vardı N, Turkoz Y, Ekinci N, Ekincioglu Z. Metotreksat'ın neden olduğu akut böbrek hasarına karşı montelukast'ın etkileri. İnönü Üniv Tıp Fak Derg. 2011;18:73–77
- Morsy MA, Ibrahim SA, Amin EF, Kamel MY, Rifaai RA, Hassan MK. Curcumin ameliorates methotrexate-induced nephrotoxicity in rats. Adv Pharmacol Sci. 2013;2013:387071
- Uraz S, Tahan V, Aygun C, et al. Role of ursodeoxycholic acid in prevention of methotrexate-induced liver toxicity. Dig Dis Sci. 2008;53:1071–1077
- Papaconstantinou HT, Xie C, Zhang W, et al. The role of caspases on methotrexate induced gastrointestinal toxicity. Surgery. 2001;130:859–865
- Kocaman N, Colakoglu N. Tekrarlayan Dozlarda Metotreksat Uygulamasının Sıçan Böbrek Dokusu Üzerine Etkileri. Firat Med J. 2013;18(4):198–202
- Liu CM, Ma JQ, Sun YZ. Quercetin protects the rat kidney against oxidative stress-mediated DNA damage and apoptosis induced by lead. Environ Toxicol Pharmacol. 2010;30(3):264–271
- Ozyurt H, Cevik O, Ozgen Z, et al. Quercetin protects radiation-induced DNA damage and apoptosis in kidney and bladder tissues of rats. Free Radic Res. 2014;48(10):1247–1255