149
Views
2
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE Solid Tumors

Gene Expression of TRK Neurotrophin Receptors in Advanced Neuroblastomas in Singapore—A Pilot Study

, PhD, , MBBS, , MBBS, MRCS (Edin), M Med (Surg), FAMS (Ped Surg), , MBBS, MRCS (Edin), M Med (Surg), FAMS (Ped Surg), , MSc (MedSci), MHGSA, , PhD, ABMG, , MBBS, FRCP (Path)(C), , MBBS, M Med (Peds), MRCP (Peds) (UK), , MBBS, FRACS (Neurosurgery), FAMS (Neurosurgery), , MB BCh (Ireland), BAO, LRCP & SI, FRCSI Part One, FRCS (Edin), M Med (Surg), FAMS (Ped Surg) & , MBBS, FRCS (Glasgow), FAMS (Ped Surg) show all
Pages 571-578 | Received 11 Feb 2011, Accepted 23 Mar 2011, Published online: 05 Jul 2011

REFERENCES

  • Unpublished data from Singapore Childhood Cancer Registry 2003–2007.
  • Brodeur GM, Maris JM. Neuroblastoma. In: Pizzo PA, Poplack DG eds. Principles and Practice of Pediatric Oncology. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2002:895–938.
  • Brodeur GM, Pritchard J, Berthold F, Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol. 1993;11:1466–1477.
  • Schwab M, Shimada H, Joshi V, Brodeu GM. Neuroblastic tumours of adrenal gland and sympathetic nervous system. In: Kleiheus P, Cavenee WK, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of the Nervous System. Geneva: IARC Press; 2000:153–161.
  • Cohn SL, Tweddle DA. MYCN amplification remains prognostically strong 20 years after its “clinical debut.” Eur J Cancer. 2004;40:2639–2642.
  • Seeger RC, Brodeur GM, Sather H, Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med. 1985;313:1111–1116.
  • De Bernardi B, Nicolas B, Boni L, Disseminated neuroblastoma in children older than one year at diagnosis: comparable results with three consecutive high-dose protocols adopted by the Italian Co-Operative Group for Neuroblastoma. J Clin Oncol. 2003;21:1592–1601.
  • Matthay KK, Villablanca JG, Seeger RC, Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group. N Engl J Med. 1999;341:1165–1173.
  • Nakagawara A, Arima-Nakagawara M, Scavarda NJ, Association between high levels of expression of the Trk gene and favourable outcome in human neuroblastoma. New Engl J Med. 1993;328:847–854.
  • Middlemas DS, Lindberg RA, Hunter T. TrkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol Cell Biol. 1991;11:143–153.
  • Lamballe F, Tapley P, Barbacid M. TrkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities. EMBO J. 1993;12:3083–3094.
  • Nakagawara A, Azar CG, Scavarda NJ, Expression and function of TrkB and BDNF in human neuroblastomas. Mol Cell Biol. 1994;14:759–767.
  • Eggert A, Grotzer MA, Ikegaki N, Expression of neurotrophin receptor TrkA inhibits angiogenesis in neuroblastoma. Med Pediatr Oncol. 2000;35:569–572.
  • Ho R, Eggert A, Hishiki T, Resistance to chemotherapy mediated by TrkB in neuroblastomas. Cancer Res. 2002;62:6462–6466.
  • Yamashiro DJ, Nakagawara A, Ikegaki N, Expression of TrkC in favourable human neuroblastomas. Oncogene. 1996;12:37–41.
  • Ryden M, Sehgal R, Dominici C, Expression of mRNA for the neurotrophin receptor TrkC in neuroblastomas with favourable tumor stage and good prognosis. Br J Cancer. 1996;74:773–779.
  • Rong D, Zhang J, Li X, The studies on the gene expression of tyrosine-kinases receptors and neurotrophins in human neuroblastomas. Zhongguo Zhongliu Linchuang. 2005;32:244–247.
  • Lucarelli E, Kaplan D, Thiele CJ. Activation of TrkA but not TrkB signal transduction pathway inhibits growth of neuroblastoma cells. Eur J Cancer. 1997;33:2068–2070.
  • Lavoie JF, Lesauteur L, Kohn J, TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism. J Biol Chem. 2005;280:29199–29207.
  • Eggert A, Ikegaki N, Liu X, Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells. Oncogene. 2000;19:2043–2051.
  • Svensson T, Rydén M, Schilling FH, Coexpression of mRNA for the full-length neurotrophin receptor trk-C and trk-A in favourable neuroblastoma. Eur J Cancer. 1997;33:2058–2063.
  • Tanaka T, Iehara T, Sugimoto T, Diversity in neuroblastomas and discrimination of the risk to progress. Cancer Lett. 2005;228:267–270.
  • Nakagawara A, Arima M, Azar CG, Inverse relationship between trk expression and N-myc amplification in human neuroblastomas. Cancer Res. 1992;52:1634–1638.
  • Eggert A, Ho R, Ikegaki N, Different effects of TrkA expression in neuroblastoma cell lines with or without MYCN amplification. Med Pediatr Oncol. 2000;35:623–627.
  • Schulte JH, Schramm A, Klein-Hitpass L, Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas. Oncogene. 2005;24:165–177.
  • Cimmino F, Schulte JH, Zollo, Galectin-1 is a major effector of TrkB-mediated neuroblastoma aggressiveness. Oncogene. 2009;28:2015–2023.
  • Haapasalo A, Koponen E, Hoppe E, Truncated TrkB.T1 is dominant negative inhibitor of TrkB.TK+-mediated cell survival. Biochem Biophys Res Commun. 2001;280:1352–1358.
  • Eide FF, Vining ER, Eide BL, Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling. J Neurosci. 1996;16:3123–3129.
  • Biffo S, Offenhauser N, Carter BD, Selective binding and internalization by truncated receptors restrict the availability of BDNF during development. Development. 1995;121:2461–2470.
  • Haapasalo A, Saarelainen T, Moshnyakov M, Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells. Oncogene. 1999;18:1285–1296.
  • Baxter GT, Radeke MJ, Kuo RC, Signal transduction mediated by the truncated trkB receptor isoforms, trkB.T1 and trkB.T2. J Neurosci. 1997;17:2683–2690.
  • Brodeur GM, Nakagawara A, Yamashiro DJ, Expression of TrkA, TrkB and TrkC in human neuroblastomas. J Neuro-Oncol. 1997;31:49–55.
  • Yamashiro DJ, Nakagawara A, Ikegaki N, Expression of TrkC in favorable human neuroblastomas. Oncogene. 1996;12:37–41.
  • Yamashiro DJ, Liu XG, Lee CP, Expression and function of Trk-C in favourable human neuroblastomas. Eur J Cancer. 1997;33:2054–2057.
  • Grotzer MA, Janss AJ, Fung K, TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors. J Clin Oncol. 2000;18:1027–1035.
  • White PS, Versteeg R. Allelic loss and neuroblastoma suppressor genes. In: Brodeur GM, Sawada T, Tsuchida S, Voute PA, eds. Neuroblastoma. Amsterdam: Elsevier; 2000:57–74.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.