The Prevalence and Outcomes of Thrombocytopenia in a Neonatal Intensive Care Unit: A Three-Year Report

REFERENCES

• Roberts I, Stanworth S, Murray NA. Thrombocytopenia in the neonate. Blood Rev. 2008;22:173–186.
   PubMed Web of Science ®Google Scholar
• Sola-Visner M, Saxonhouse MA, Brown RE. Neonatal thrombocytopenia: what we do and don't know. Early Hum Dev. 2008;84:499–506.
   PubMed Web of Science ®Google Scholar
• Sola MC, Rimsza LM. Mechanisms underlying thrombocytopenia in the neonatal intensive care unit. Acta Paediatr Suppl. 2002;91:66–73.
   Google Scholar
• Kahn DJ, Richardson DK, Billett HH. Association of thrombocytopenia and delivery method with intraventricular hemorrhage among very-low-birth-weight infants. Am J Obstet Gynecol. 2002;186:109–116.
   PubMed Web of Science ®Google Scholar
• Beiner ME, Simchen MJ, Sivan E, Risk factors for neonatal thrombocytopenia in preterm infants. Am J Perinatol. 2003;20:49–54.
   PubMed Web of Science ®Google Scholar
• Lupton BA, Hill A, Whitfield MF, Reduced platelet count as a risk factor for intraventricular hemorrhage. Am J Dis Child. 1988;142:1222–1224.
   Google Scholar
• Gerday E, Baer VL, Lambert DK, Testing platelet mass versus platelet count to guide platelet transfusions in the neonatal intensive care unit. Transfusion. 2009;49:2034–2039.
   PubMed Web of Science ®Google Scholar
• Andrew M, Vegh P, Caco C, A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants. J Pediatr. 1993;123:285–291.
   PubMed Web of Science ®Google Scholar
• Von Lindern JS, Hulzebos CV, Bos AF, Thrombocytopaenia and intraventricular haemorrhage in very premature infants: a tale of two cities. Arch Dis Child Fetal Neonatal Ed. 2012 , PMID 22294474.
   Google Scholar
• Sola MC. Evaluation and treatment of severe and prolonged thrombocytopenia in neonates. Clin Perinatol. 2004;31:1–14.
   Web of Science ®Google Scholar
• American Academy of Pediatrics. Intrapartum care. In: Guidelines for Perinatal Care. 4th ed. AAP; 1997:93–125.
   Google Scholar
• Vergnano S, Sharland M, Kazembe P, Neonatal sepsis: an international perspective. Arch Dis Child Fetal Neonatal Ed. 2005;90:F220–F224.
   PubMed Web of Science ®Google Scholar
• Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6:2–8.
   PubMedGoogle Scholar
• Bell MJ, Ternberg JL, Feigin RD, Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg. 1978;187:1–7.
   PubMed Web of Science ®Google Scholar
• Papile LA, Burstein J, Burstein R, Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92:529–534.
   PubMed Web of Science ®Google Scholar
• Baer VL, Lambert DK, Henry E, Severe thrombocytopenia in the NICU. Pediatrics. 2009;124:e1095–e1100.
   PubMed Web of Science ®Google Scholar
• Von Lindern JS, Brand A. The use of blood products in perinatal medicine. Semin Fetal Neonatal Med. 2008;13:272–281.
   Google Scholar
• Von Lindern JS, van den Bruele T, Lopriore E, Thrombocytopenia in neonates and the risk of intraventricular hemorrhage: a retrospective cohort study. BMC Pediatr. 2011;11:16.
   PubMedGoogle Scholar
• Baer VL, Lambert DK, Henry E, Do platelet transfusions in the NICU adversely affect survival? Analysis of 1600 thrombocytopenic neonates in a multihospital healthcare system. J Perinatol. 2007;27:790–796.
   PubMed Web of Science ®Google Scholar
• Strauss R, Wehler M, Mehler K, Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome. Crit Care Med. 2002;30:1765–1771.
   PubMed Web of Science ®Google Scholar
• Christensen RD. Advances and controversies in neonatal ICU platelet transfusion practice. Adv Pediatr. 2008;55:255–269.
   PubMedGoogle Scholar
• Stanworth SJ, Clarke P, Watts T, Prospective, observational study of outcomes in neonates with severe thrombocytopenia. Pediatrics. 2009;124:e826–e834.
   PubMed Web of Science ®Google Scholar
• Andrew M, Castle V, Saigal S, Clinical impact of neonatal thrombocytopenia. J Pediatr. 1987;110:457–464.
   PubMed Web of Science ®Google Scholar
• Oren H, Irken G, Oren B, Assessment of clinical impact and predisposing factors for neonatal thrombocytopenia. Indian J Pediatr. 1994;61:551–558.
   Google Scholar
• Guinat M, Vincent JL. Thrombocytopenia in the critically ill patient. Rev Med Brux. 2011;32:513–522.
   Google Scholar
• Bonifacio L, Petrova A, Nanjundaswamy S, Thrombocytopenia related neonatal outcome in preterms. Indian J Pediatr. 2007;74:269–274.
   PubMed Web of Science ®Google Scholar
• Murray NA. Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit. Acta Paediatr Suppl. 2002;91:74–81.
   PubMedGoogle Scholar
• Jen HC, Graber JJ, Hill JL, Surgical necrotizing enterocolitis and intraventricular hemorrhage in premature infants below 1000 g. J Pediatr Surg. 2006;41:1425–1430.
   PubMed Web of Science ®Google Scholar
• Murray NA, Howarth LJ, McCloy MP, Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients. Transfus Med. 2002;12:35–41.
   PubMed Web of Science ®Google Scholar
• Zisk JL, Mackley A, Christensen RD, Is a small platelet mass associated with intraventricular hemorrhage in very low-birth-weight infants? J Perinatol. 2011;31:776–779.
   PubMed Web of Science ®Google Scholar
• Lodha A, Kamaluddeen M, Akierman A, Role of hemocoagulase in pulmonary hemorrhage in preterm infants: a systematic review. Indian J Pediatr. 2011;78:838–844.
   PubMed Web of Science ®Google Scholar
• Lodha A, Shah PS, Hellmann J. Pulmonary haemorrhage associated with neonatal neurological disease. Heart Lung Circ. 2009;18:45–48.
   Google Scholar
• Poralla C, Hertfelder HJ, Oldenburg J, Treatment of acute pulmonary haemorrhage in extremely preterm infants with recombinant activated factor VII. Acta Paediatr. 2010;99:298–300.
   Google Scholar
• Ballabh P. Intraventricular hemorrhage in premature infants: mechanism of disease. Pediatr Res. 2010;67:1–8.
   PubMed Web of Science ®Google Scholar
• Antoniuk S, da Silva RV. Periventricular and intraventricular hemorrhage in the premature infants. Rev Neurol. 2000;31:238–243.
   PubMedGoogle Scholar
• DiSalvo D. The correlation between placental pathology and intraventricular hemorrhage in the preterm infant. The developmental epidemiology network investigators. Pediatr Res. 1998;43:15–19.
   PubMed Web of Science ®Google Scholar
• Aly H, Hammad TA, Essers J, Is mechanical ventilation associated with intraventricular hemorrhage in preterm infants? Brain Dev. 2012;34:201–205.
   PubMed Web of Science ®Google Scholar
• Josephson CD, Su LL, Christensen RD, Platelet transfusion practices among neonatologists in the United States and Canada: results of a survey. Pediatrics. 2009;123:278–285.
   PubMed Web of Science ®Google Scholar
• Cawley MJ, Wittbrodt ET, Boyce EG, Potential risk factors associated with thrombocytopenia in a surgical intensive care unit. Pharmacotherapy. 1999;19:108–113.
   Google Scholar
• Vanderschueren S, De Weerdt A, Malbrain M, Thrombocytopenia and prognosis in intensive care. Crit Care Med. 2000;28:1871–1876.
   Google Scholar
• Rastogi S, Olmez I, Bhutada A, Drop in platelet counts in extremely preterm neonates and its association with clinical outcomes. J Pediatr Hematol Oncol. 2011;33:580–584.
   Google Scholar
• Del Vecchio A, Sola MC, Theriaque DW, Platelet transfusions in the neonatal intensive care unit: Factors predicting which patients will require multiple transfusions. Transfusion. 2001;41:803–808.
   PubMed Web of Science ®Google Scholar