235
Views
33
CrossRef citations to date
0
Altmetric
Original Article

L-Asparaginase (Leunase) Induced Pancreatitis in Childhood Acute Lymphoblastic Leukemia

, , &
Pages 533-538 | Received 18 Nov 1996, Accepted 17 Mar 1998, Published online: 09 Jul 2009

References

  • Ortega J A, Nesbit M E, Donaldson M H. L-Asparaginase, vincristine and prednisone for induction of first remission in acute lymphocytic leukemia. Cancer Res. 1977; 37: 535–540
  • Talla L, Tan C, Oettgen H. E. coli L-asparaginase in the treatment of leukemia and solid tumours in 131 children. Cancer 1970; 25: 306–320
  • Broom J D. Evidence that the L-asparaginase activity of guinea pig serum is responsible for its anti-lymphoma effects. Nature (London). 1961; 191: 1114–1115
  • Adamson R H, Fabro S. Antitumour activity and other biologic properties of L-asparaginase (NSC-109229): a review. Cancer Chemother Rep. 1968; 52: 617–626
  • Haskell C M, Canellos G P, Leventhal B G. L-Asparaginase: therapeutic and toxic effects in patients with neoplastic disease. N Engl J Med. 1969; 281: 1028–1034
  • Weetman R M, Baehner R L. Latent onset of clinical pancreatitis in children receiving L-asparaginase therapy. Cancer 1974; 34: 780–785
  • Anderson M C, Bergen J J. Significance of vascular injury as a factor in pathogenesis of pancreatitis. Ann Surg. 1961; 154: 56–67
  • Jenkins R, Perlin E. Severe hepatotoxicity from Escherichia coli L-asparaginase. J Natl Med Assoc. 1987; 79: 775–779
  • Gillete P C, Hill L, Starling K A. Transient diabetes mellitus secondary to L-asparaginase therapy in acute leukaemia. J Pediatr. 1972; 81: 109–111
  • Whitecar J P, Bodey G P, Hill C S. Effect of L-asparaginase on carbohydrate metabolism. Metabolism. 1970; 19: 581–586
  • Bonetti E, Abbdondanza A, Corte E D. The regulation of L-asparaginase activity in rats and mice: effects of normal and malignant growth, of sex, and of dietary changes. J Biochem. 1969; 115: 597–601
  • Weetman R M, Baehner R L. Latent onset of clinical pancreatitis in children receiving L-asparaginase therapy. Cancer 1974; 34: 780–785
  • Bertolene J S, Fuenfer M M, Groff D B. Delayed pancreatic pseudocyst formation: long-term complication of L-asparaginase treatment. Cancer 1982; 50: 2964–2966
  • Cooney D A, Handschumacher R E. L-Asparaginase and L-asparaginase metabolism. Annu Rev Pharmacol. 1970; 10: 421–440
  • Samuel B J, Culbert S J, Okamura J. Early detection of chemotherapy related pancreatic enlargement in children using abdominal sonography. Cancer 1976; 38: 1515–1523
  • Warren K W, Athanassiades S, Fredrick P. Surgical treatment of pancreatic cysts: review of 183 cases. Ann Surg. 1966; 163: 886–891
  • Jeffery R B. Sonography in acute pancreatitis. Radiol Clin N Am. 1989; 27: 5–17

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.