Bacterial Metabolism in Humans of the Carcinogen IQ to the Direct Acting Mutagen Hydroxy-IQ

References

• Alldrick A J, Flynn J, Rowland I R. Effects of plant-derived flavanoids and polyphenols acids on the activity of mutagens from cooked food. Mutation Research 1986a; 163: 225–232
   PubMed Web of Science ®Google Scholar
• Barnes W S, Lovelette C A, Tong C, Williams G M, Weisburger J H. Genotoxicity of the food mutagen 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and analogs. Carcinogenesis 1985; 6: 441–444
   Web of Science ®Google Scholar
• Barnes W S, Maiello J, Weisburger J H. In vitro binding of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline to dietary fibers. Journal of the National Cancer Institute 1983; 70: 757–760
   PubMedGoogle Scholar
• Bashir M, Kingston D GI, Carman R J, Van Tassell R L, Wilkins T D. Anaerobic metabolism of 2-arnino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ) by human fecal flora. Mutation Research 1987; 190: 187–190
   PubMed Web of Science ®Google Scholar
• Bashir M, Kingston D GI, Carman R J, Van Tassell R L, Wilkins T D. Biological formation and chemical synthesis of 2-amino-3,6-dihydro-3-methyl-7H-imidazo[4,5-f]quinoline-7-one, the major metabolite of dietary carcinogen IQ by normal intestinal bacteria. Heterocycle 1987; 26: 2877–2886
   Web of Science ®Google Scholar
• Carman R J, Van Tassell R L, Bashir M, Kingston D GI, Wilkins T D. Metabolism of the dietary pyrolysis carcinogen 2-amino-3-methyl-3H-imidazo[4,5-f]quinohne (IQ) by Eubacterium spp. Abstracts of the 87th Annual Meeting of the American Society for Microbiology 1987; 017: 263
   Google Scholar
• Carman R J, Van Tassell R L, Kingston D GI, Bashir M, Wilkins T D. Conversion of IQ, a dietary pyrolysis carcinogen to a direct-acting mutagen by normal intestinal bacteria of humans. Mutation Research 1988a; 206: 335–342
   PubMed Web of Science ®Google Scholar
• Carman R J, Van Tassell R L, Bashir M, Kingston D GI, Wilkins T D. In vitro and in vivo metabolism of the dietary pyrolysis carcinogen, IQ, to a direct acting mutagen, HOIQ, by human intestinal microflora. Anaerobes Today, JM Hardie, SP Bordello. John Wiley & Sons, Chichester 1988b; 224–225
   Google Scholar
• Commoner B, Vithayathil A J, Dolara P, Nair S, Madyastha P, Cuca G C. Formation of mutagens in beef and beef extract during cooking. Science 1978; 201: 913–916
   PubMed Web of Science ®Google Scholar
• Grivas S, Jagerstad M. Mutagenicity of some synthetic quinolines and quinoxalines related to IQ, MelQ or MelQx in Ames test. Mutation Research 1984; 137: 29–32
   Google Scholar
• Grivas S, Nyhammar T. Analysis of mutagenic imadazo[4,5-f]quinolines and quinoxalines (IQ compounds); comparison of electrochemical and ultraviolet detection. Mutation Research 1985; 142: 5–8
   PubMed Web of Science ®Google Scholar
• Hargraves W A, Pariza M W. Purification and mass spectral characterization of bacterial mutagens from commercial beef extract. Cancer Research 1983; 43: 1467–1472
   PubMed Web of Science ®Google Scholar
• Hayatsu H, Matsui Y, Ohara Y, Oka T, Hayatsu T. Characterization of mutagenic fractions in beef extracts and in cooked beef. Use of blue cotton for efficient extraction. Gann 1983; 74: 472–482
   PubMedGoogle Scholar
• Hayatsu H, Hayatsu T, Wataya Y, Mower H F. Fecal mutagenicity arising from ingestion of fried ground beef in the human. Mutation Research 1985; 143: 207–211
   Google Scholar
• Hayatsu H, Hayatsu T, Wataya Y. Use of blue cotton for detection of mutagenicity in human feces excreted after ingestion of cooked meat. Environmental Health Perspectives 1986; 67: 31–34
   PubMed Web of Science ®Google Scholar
• Holdeman L V, Cato E P, Moore W EC. Anaerobe Lab Manual, 4th edition. Virginia Polytechnic Institute, Blacksburg, Va. 1977, 24061
   Google Scholar
• Maron D M, Ames B N. Revised methods for the salmonella mutagenicity test. Mutation Research 1983; 113: 173–215
   PubMed Web of Science ®Google Scholar
• Morotomi M, Mutai M. In vitro binding of potent mutagenic pyrolysates to intestinal bacteria. Journal of the National Cancer Institute 1986; 77: 195–201
   PubMed Web of Science ®Google Scholar
• Nakayasu M, Nakasato F, Sakamoto H, Terada M, Sugimura T. Mutagenic activity of heterocyclic amines in Chinese hamster lung cells with diptheria toxin resistance as a marker. Mutation Research 1983; 118: 91–102
   PubMed Web of Science ®Google Scholar
• Nilsson L, Overvik E, Fredholm L, Levin O, Nord C-E, Gustafsson J-A. Influence of frying fat on mutagenicity in lean pork. Mutation Research 1986; 171: 115–121
   PubMedGoogle Scholar
• Ohgaki H, Hasegawa H, Kato T, Suenaga M, Ubukata M, Sato S, Takayama S, Sugimura T. Carcinogenicity in mice and rats of heterocyclic amines in cooked foods. Environmental Health Perspective 1986; 67: 129–134
   PubMed Web of Science ®Google Scholar
• Pariza M W, Ashoor S H, Chu F S, Lund D B. Effects of temperature and time on mutagen formation in pan-fried hamburger. Cancer Letters 1979; 7: 63–69
   PubMed Web of Science ®Google Scholar
• Spingarn N E, Garvie-Gould C, Vuolo L V, Weisburger J H. Formation of mutagens in cooked foods. IV. Effect of fat content in fried beef patties. Cancer Letters 1981; 12: 93–97
   PubMed Web of Science ®Google Scholar
• Spingarn N E, Slocum L A, Weisburger J H. Formation of mutagens in cooked foods. II. Food with high starch content. Cancer Letters 1980; 9: 7–12
   PubMed Web of Science ®Google Scholar
• Sugimura T, Sato S. Mutagens-carcinogens in foods. Cancer Research 1983; 43: 2415S–2421S
   PubMed Web of Science ®Google Scholar
• Sugimura T, Sato S, Ohgaki H, Takayama S, Nagao M, Wakabayashi K. Mutagens-carcinogens in cooked food. Genetic Toxicology of the Diet, T. Knudsen. Alan R. Liss, Inc., New York 1986; 85–107
   Google Scholar
• Weisburger J H, Barnes W S, Lovelette C A, Tong C, Tanaka T, Williams G M. Genotoxicity, carcinogenicity and mode of action of the fried food mutagen 2-amino-3-methylimidazolo[4,5-f]-quinoline (IQ). Environmental Health Perspectives 1986; 67: 121–127
   Web of Science ®Google Scholar
• Wild D, Kaiser G, King M-T, Harnasch D. Genotoxic activity of IQ (2-amino-3-methylimidazo-[4,5-f]quinoline) and structural analogs. Genetic Toxicology of the Diet, I. Knudsen. Alan R Liss, Inc., New York 1986; 145–154
   Google Scholar
• Willis A T. Anaerobic Bacteriology, Clinical and Laboratory Practice, 3rd edition. Butterworths and Co. Ltd, London 1977; 58
   Google Scholar