598
Views
84
CrossRef citations to date
0
Altmetric
Research Article

Recent advances on the immunomodulatory effects of IFN-α: Implications for cancer immunotherapy and autoimmunity

, &
Pages 204-209 | Received 25 Nov 2009, Accepted 25 Nov 2009, Published online: 26 Feb 2010

References

  • Vilcek J. Fifty years of interferon research: Aiming at a moving target. Immunity. 2006; 25:343–348.
  • Mogensen KE, Lewerenz M, Reboul J, Lutfalla G, Uze G. Type I IFN receptor: Structure, function, and evolution of a family business. J Interferon Cytokine Res. 1999; 19:1069–1098.
  • Gutterman JU. Cytokine therapeutics: Lessons from interferon-alpha. Proc Natl Acad Sci USA. 1994; 91:1198–1205.
  • Belardelli F, Gresser I. The neglected role of type I interferon in the T-cell response: Implications for its clinical use. Immunol Today. 1996; 17:369–372.
  • Gresser I. The antitumor effects of interferon: A personal history. Biochimie. 2007; 89:723–728.
  • Ferrantini M, Belardelli F. Cytokines as a link between innate and adaptive antitumor immunity. Trends Immunol. 2002; 23:201–208.
  • Santini SM, Lapenta C, Logozzi M, Parlato S, Spada M, Di Pucchio T, Belardelli F. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-scid mice. J Exp Med. 2000; 191:1777–1788.
  • Borg FA, Isenberg DA. Syndromes and complications of interferon therapy. Curr Opin Rheumatol. 2007; 19:61–66.
  • Gresser I. Can interferon induce disease?. Interferon. 1982; 4:95–127.
  • Crow MK. Type I interferon in systemic lupus erythematosus. Curr Top Microbiol Immunol. 2007; 316:359–386.
  • Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science. 2001; 294:1540–1543.
  • Banchereau J, Pascual V. Type I IFN in systemic lupus erythematosus and other autoimmune diseases. Immunity. 2006; 25:383–392.
  • Ferrantini M, Belardelli F. Gene therapy of cancer with interferon: Lessons from tumor models and perspectives for clinical applications. Semin Cancer Biol. 2000; 10:145–157.
  • Belardelli F, Ferrantini M, Proietti E, Kirkwood JM. Interferon-alpha in tumor immunity and immunotherapy. Cytokine Growth Factor Rev. 2002; 13:119–134.
  • Ferrantini M, Capone I, Belardelli F. Interferon-alpha and cancer: Mechanisms of action and new perspectives of clinical use. Biochimie. 2007; 89:884–893.
  • Gogas H, Ioannovich J, Dafni U, Stavropoulou-Giokas C, Frangia K, Tsoutsos D, Panagiotou P, Polyzos A, Papadopoulos O, Stratigos A, Markopoulos C, Bafaloukos D, Pectasides D, Fountzilas G, Kirkwood JM. Prognostic significance of autoimmunity during treatment of melanoma with interferon. N Engl J Med. 2006; 354:709–718.
  • Koon H, Atkins M. Autoimmunity and immunotherapy of cancer. New Engl J Med. 2006; 354:758–760.
  • Di Pucchio T, Pilla L, Capone I, Ferrantini M, Montefiore E, Urbani F, Patuzzo R, Pennacchioli E, Santinami M, Cova A, Sovena G, Arienti F, Lombardo C, Lombardi A, Caporaso P, D'Atri S, Marchetti P, Bonmassar E, Parmiani G, Belardelli F, Rivoltini L. Immunization of stage IV melanoma patients with Melan-A/MART-1 and gp100 peptides plus IFN-α results in the activation of specific CD8+ T cells and monocyte/dendritic cell precursors. Cancer Res. 2006; 66:4943–4951.
  • Le Bon A, Schiavoni G, D'Agostino G, Gresser I, Belardelli F, Tough DF. Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity. 2001; 14:461–470.
  • Proietti E, Bracci L, Puzelli S, Di Pucchio T, Sestili P, De Vincenzi E, Venditti M, Capone I, Seif I, De Maeyer E, Tough D, Donatelli I, Belardelli F. Type I IFN as a natural adjuvant for a protective immune response: Lessons from the influenza vaccine model. J Immunol. 2002; 169:375–383.
  • Rizza P, Capone I, Urbani F, Montefiore E, Rapicetta M, Chionne P, Candido A, Tosti ME, Grimaldi M, Palazzini E, Viscomi G, Cursaro C, Margotti M, Scuteri A, Andreone P, Taylor E, Haygreen EA, Tough DF, Borrow P, Selleri M, Castilletti C, Capobianchi M, Belardelli F. Evaluation of the effects of human leukocyte IFN-alpha on the immune response to the HBV vaccine in healthy unvaccinated individuals. Vaccine. 2008; 26:1038–1049.
  • Nisticò P, Capone I, Palermo B, Del Bello D, Ferraresi V, Moschella F, Aricò E, Valentini M, Bracci L, Cognetti F, Ciccarese M, Vercillo G, Roselli M, Fossile E, Tosti ME, Wang E, Marincola F, Imberti L, Catricalà C, Natali PG, Belardelli F, Proietti E. Chemotherapy enhances vaccine-induced antitumor immunity in melanoma patients. Int J Cancer. 2009; 124:1309.
  • Romagnani S. Induction of TH1 and TH2 responses: A key role for the ‘natural’ immune response?. Immunol Today. 1992; 13:379–381.
  • Palmer KJ, Harries M, Gore ME, Collins MK. Interpheron-alpha (IFN-alpha) stimulates anti-melanoma cytotoxic T lymphocyte (CTL) generation in mixed lymphocyte tumor cultures (MLTC). Clin Exp Immunol. 2000; 119:412–418.
  • Tough DF, Borrow P, Sprent J. Induction of bystander T-cell proliferation by viruses and type I interferon in vivo. Science. 1996; 272:1947–1950.
  • Sun S, Zhang X, Tough DF, Sprent J. Type I interferon-mediated stimulation of T cells by CpG DNA. J Exp Med. 1998; 188:2335–2342.
  • Marrack P, Kappler J, Mitchell T. Type I interferons keep activated T cells alive. J Exp Med. 1999; 189:521–530.
  • Matikainen S, Sareneva T, Ronni T, Lehtonen A, Koskinen PJ, Julkunen I. Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells. Blood. 1999; 93:1980–1991.
  • Santini SM, Di Pucchio T, Lapenta C, Logozzi M, Parlato S, Belardelli F. The natural alliance between type I IFN and dendritic cells and its role in linking innate and adaptive immunity. J Interferon Cytokine Res. 2002; 22:1071–1080.
  • Santini SM, Di Pucchio T, Lapenta C, Parlato S, Logozzi M, Belardelli F. A new type I IFN-mediated pathway for the rapid differentiation of monocytes into highly active dendritic cells. Stem Cells. 2003; 21:357–362.
  • Cella M, Sallusto F, Lanzavecchia A. Origin, maturation, and antigen-presenting function of dendritic cells. Curr Opin Immunol. 1997; 9:10–16.
  • Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature. 2007; 449:419–426.
  • Belardelli F, Ferrantini M, Parmiani G, Schlom J, Garaci E. International meeting on cancer vaccines: How can we enhance efficacy of therapeutic vaccines?. Cancer Res. 2004; 64:6827–6830.
  • Paquette RL, Hsu NC, Kiertscher SM, Park AN, Tran L, Roth MD, Glaspy JA. Interferon-alpha and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cells. J Leukoc Biol. 1998; 64:358–367.
  • Luft T, Pang KC, Thomas E, Hertzog P, Hart DN, Trapani J, Cebon J. Type I IFNs enhance the terminal differentiation of dendritic cells. J Immunol. 1998; 161:1947–1953.
  • Radvanyi LG, Banerjee A, Weir M, Messner H. Low levels of interferon-alpha induce CD86 (B7.2) expression and accelerates dendritic cell maturation from human peripheral blood mononuclear cells. Scand J Immunol. 1999; 50:499–500.
  • Santodonato L, D'Agostino G, Nisini R, Mariotti S, Monque DM, Spada M, Lattanzi L, Perrone MP, Andreotti M, Belardelli F, Ferrantini M. Monocyte-derived dendritic cells generated after a short-term culture with IFN-α and granulocyte-macrophage colony-stimulating factor stimulate a potent Epstein-Barr virus-specific CD8+ T-cell response. J Immunol. 2003; 170:5195–5202.
  • Lapenta C, Santini SM, Logozzi M, Spada M, Andreotti M, Di Pucchio T, Parlato S, Belardelli F. Potent immune response against HIV-1 and protection from virus challenge in hu-PBL-SCID mice immunized with inactivated-virus-pulsed dendritic cells generated in the presence of IFN-α. J Exp Med. 2003; 198:361–367.
  • Tosi D, Valenti R, Cova A, Sovena G, Huber V, Pilla L, Arienti F, Belardelli F, Parmiani G, Rivoltini L. Role of cross-talk between IFN-α-induced monocyte-derived dendritic cells and NK cells in priming CD8+ T-cell responses against human tumor antigens. J Immunol. 2004; 172:5363–5370.
  • Lapenta C, Santini SM, Spada M, Donati S, Urbani F, Accapezzato D, Franceschini D, Andreotti M, Barnaba V, Belardelli F. IFN-α-conditioned dendritic cells are highly efficient in inducing cross-priming CD8+ T-cells against exogenous viral antigens even in the absence of CD4+ T-cell help. Eur J Immunol. 2006; 36:2046–2060.
  • Gabriele L, Borghi P, Rozera C, Sestili P, Andreotti M, Guarini A, Montefusco E, Foà R, Belardelli F. IFN-α promotes the rapid differentiation of monocytes from patients with chronic myeloid leukemia into activated dendritic cells tuned to undergo full maturation after LPS treatment. Blood. 2004; 103:980–987.
  • Albert ML, Sauter B, Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature. 1998; 392:386–389.
  • Franzke A, Peest D, Probst-Kepper M, Buer J, Kirchner GI, Brabant G, Kirchner H, Ganser A, Atzpodien J. Autoimmunity resulting from cytokine treatment predicts long-term survival in patients with metastatic renal cell cancer. J Clin Oncol. 1999; 17:529–533.
  • Sanderson K, Scotland R, Lee P, Liu D, Groshen S, Snively J, Sian S, Nichol G, Davis T, Keler T, Yellin M, Weber J. Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and montanide ISA 51 for patients with resected stages III and IV melanoma. J Clin Oncol. 2005; 23:741–750.
  • Dudley ME, Wunderlich JR, Robbins PF, Yang JC, Hwu P, Schwartzentruber DJ, Topalian SL, Sherry R, Restifo NP, Hubicki AM, Robinson MR, Raffeld M, Duray P, Seipp CA, Rogers-Freezer L, Morton KE, Mavroukakis SA, White DE, Rosenberg SA. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science. 2002; 298:850–854.
  • Overwijk WW, Theoret MR, Finkelstein SE, Surman DR, de Jong LA, Vyth-Dreese FA, Dellemijn TA, Antony PA, Spiess PJ, Palmer DC, Heimann DM, Klebanoff CA, Yu Z, Hwang LN, Feigenbaum L, Kruisbeek AM, Rosenberg SA, Restifo NP. Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells. J Exp Med. 2003; 198:569–580.
  • van Elsas A, Hurwitz AA, Allison JP. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med. 1999; 190:355–366.
  • Overwijk WW, Restifo NP. Autoimmunity and the immunotherapy of cancer: Targeting the “self” to destroy the “other”. Crit Rev Immunol. 2000; 20:433–450.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.