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Research Article

The interferon-inducible HIN-200 gene family in apoptosis and inflammation: Implication for autoimmunity

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Pages 226-231 | Received 25 Nov 2009, Accepted 25 Nov 2009, Published online: 26 Feb 2010

References

  • Ludlow LE, Johnstone RW, Clarke CJ. The HIN-200 family: More than interferon-inducible genes?. Exp Cell Res. 2005; 308:1–17.
  • Asefa B, Klarmann KD, Copeland NG, Gilbert DJ, Jenkins NA, Keller JR. The interferon-inducible p200 family of proteins: A perspective on their roles in cell cycle regulation and differentiation. Blood Cells Mol Dis. 2004; 32:155–167.
  • Albrecht M, Choubey D, Lengauer T. The HIN domain of IFI-200 proteins consists of two OB folds. Biochem Biophys Res Commun. 2005; 327:679–687.
  • Yan H, Dalal K, Hon BK, Youkharibache P, Lau D, Pio F. RPA nucleic acid-binding properties of IFI16-HIN200. Biochim Biophys Acta. 2008; 1784:1087–1097.
  • Martinon F, Hofmann K, Tschopp J. The pyrin domain: A possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr Biol. 2001; 11:R118–R120.
  • Taniguchi S, Sagara J. Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC. Semin Immunopathol. 2007; 29:231–238.
  • Crow MK. Type I interferon in systemic lupus erythematosus. Curr Top Microbiol Immunol. 2007; 316:359–386.
  • Coelho LF, de Oliveira JG, Kroon EG. Interferons and scleroderma—a new clue to understanding the pathogenesis of scleroderma?. Immunol Lett. 2008; 118:110–115.
  • Nordmark G, Alm GV, Ronnblom L. Mechanisms of disease: Primary Sjogren's syndrome and the type I interferon system. Nat Clin Pract Rheumatol. 2006; 2:262–269.
  • Zandman-Goddard G, Blank M. Apoptosis and autoimmunity. Isr Med Assoc J. 2002; 4:722–724.
  • Briggs RC, Shults KE, Flye LA, McClintock-Treep SA, Jagasia MH, Goodman SA, Boulos FI, Jacobberger JW, Stelzer GT, Head DR. Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: Evidence for a role in apoptosis. Cancer Res. 2006; 66:4645–4651.
  • Choubey D, Panchanathan R. Interferon-inducible Ifi200-family genes in systemic lupus erythematosus. Immunol Lett. 2008; 119:32–41.
  • Chen IF, Ou-Yang F, Hung JY, Liu JC, Wang H, Wang SC, Hou MF, Hortobagyi GN, Hung MC. AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Mol Cancer Ther. 2006; 5:1–7.
  • Burckstummer T, Baumann C, Bluml S, Dixit E, Durnberger G, Jahn H, Planyavsky M, Bilban M, Colinge J, Bennett KL, Superti-Furga G. An orthogonal proteomic–genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol. 2009; 10:266–272.
  • Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 2009; 458:509–513.
  • Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 2009; 458:514–518.
  • Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S, Hardy LL, Garceau V, Sweet MJ, Ross IL, Hume DA, Stacey KJ. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science. 2009; 323:1057–1060.
  • Bergsbaken T, Fink SL, Cookson BT. Pyroptosis: Host cell death and inflammation. Nat Rev Microbiol. 2009; 7:99–109.
  • Aglipay JA, Lee SW, Okada S, Fujiuchi N, Ohtsuka T, Kwak JC, Wang Y, Johnstone RW, Deng C, Qin J, Ouchi T. A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene. 2003; 22:8931–8938.
  • Fujiuchi N, Aglipay JA, Ohtsuka T, Maehara N, Sahin F, Su GH, Lee SW, Ouchi T. Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. J Biol Chem. 2004; 279:20339–20344.
  • Caposio P, Gugliesi F, Zannetti C, Sponza S, Mondini M, Medico E, Hiscott J, Young HA, Gribaudo G, Gariglio M, Landolfo S. A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells. J Biol Chem. 2007; 282:33515–33529.
  • Chadwick N, Fennessy C, Nostro MC, Baron M, Brady G, Buckle AM. Notch induces cell cycle arrest and apoptosis in human erythroleukaemic TF-1 cells. Blood Cells Mol Dis. 2008; 41:270–277.
  • Ding Y, Wang L, Su LK, Frey JA, Shao R, Hunt KK, Yan DH. Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer. Oncogene. 2004; 23:4556–4566.
  • Ding Y, Lee JF, Lu H, Lee MH, Yan DH. Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. Mol Cell Biol. 2006; 26:1979–1996.
  • Schett G. Review: Immune cells and mediators of inflammatory arthritis. Autoimmunity. 2008; 41:224–229.
  • Miranda RN, Briggs RC, Shults K, Kinney MC, Jensen RA, Cousar JB. Immunocytochemical analysis of MNDA in tissue sections and sorted normal bone marrow cells documents expression only in maturing normal and neoplastic myelomonocytic cells and a subset of normal and neoplastic B lymphocytes. Hum Pathol. 1999; 30:1040–1049.
  • Schroder K, Muruve DA, Tschopp J. Innate immunity: Cytoplasmic DNA sensing by the AIM2 inflammasome. Curr Biol. 2009; 19:R262–R265.
  • Raffaella R, Gioia D, De Andrea M, Cappello P, Giovarelli M, Marconi P, Manservigi R, Gariglio M, Landolfo S. The interferon-inducible IFI16 gene inhibits tube morphogenesis and proliferation of primary, but not HPV16 E6/E7-immortalized human endothelial cells. Exp Cell Res. 2004; 293:331–345.
  • Gariglio M, Azzimonti B, Pagano M, Palestro G, De Andrea M, Valente G, Voglino G, Navino L, Landolfo S. Immunohistochemical expression analysis of the human interferon-inducible gene IFI16, a member of the HIN200 family, not restricted to hematopoietic cells. J Interferon Cytokine Res. 2002; 22:815–821.
  • Wei W, Clarke CJ, Somers GR, Cresswell KS, Loveland KA, Trapani JA, Johnstone RW. Expression of IFI 16 in epithelial cells and lymphoid tissues. Histochem Cell Biol. 2003; 119:45–54.
  • Gugliesi F, Mondini M, Ravera R, Robotti A, de Andrea M, Gribaudo G, Gariglio M, Landolfo S. Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells. J Leukoc Biol. 2005; 77:820–829.
  • Mondini M, Vidali M, Airo P, De Andrea M, Riboldi P, Meroni PL, Gariglio M, Landolfo S. Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders. Ann N Y Acad Sci. 2007; 1110:47–56.
  • Sponza S, De Andrea M, Mondini M, Gugliesi F, Gariglio M, Landolfo S. Role of the interferon-inducible IFI16 gene in the induction of ICAM-1 by TNF-alpha. Cell Immunol. 2009; 257:55–60.
  • Rozzo SJ, Allard JD, Choubey D, Vyse TJ, Izui S, Peltz G, Kotzin BL. Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. Immunity. 2001; 15:435–443.
  • Mondini M, Vidali M, De Andrea M, Azzimonti B, Airo P, D'Ambrosio R, Riboldi P, Meroni PL, Albano E, Shoenfeld Y, Gariglio M, Landolfo S. A novel autoantigen to differentiate limited cutaneous systemic sclerosis from diffuse cutaneous systemic sclerosis: The interferon-inducible gene IFI16. Arthritis Rheum. 2006; 54:3939–3944.
  • Hueber W, Zeng D, Strober S, Utz PJ. Interferon-alpha-inducible proteins are novel autoantigens in murine lupus. Arthritis Rheum. 2004; 50:3239–3249.
  • Maniati E, Potter P, Rogers NJ, Morley BJ. Control of apoptosis in autoimmunity. J Pathol. 2008; 214:190–198.
  • Navratil JS, Liu CC, Ahearn JM. Apoptosis and autoimmunity. Immunol Res. 2006; 36:3–12.
  • Schultz DR, Harrington WJJr. Apoptosis: Programmed cell death at a molecular level. Semin Arthritis Rheum. 2003; 32:345–369.
  • Perniok A, Wedekind F, Herrmann M, Specker C, Schneider M. High levels of circulating early apoptic peripheral blood mononuclear cells in systemic lupus erythematosus. Lupus. 1998; 7:113–118.
  • Gaipl US, Voll RE, Sheriff A, Franz S, Kalden JR, Herrmann M. Impaired clearance of dying cells in systemic lupus erythematosus. Autoimmun Rev. 2005; 4:189–194.
  • Gatzka M, Walsh CM. Apoptotic signal transduction and T cell tolerance. Autoimmunity. 2007; 40:442–452.
  • Tincani A, Andreoli L, Bazzani C, Bosiso D, Sozzani S. Inflammatory molecules: A target for treatment of systemic autoimmune diseases. Autoimmun Rev. 2007; 7:1–7.

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