163
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells

, , &
Pages 115-128 | Received 04 Jan 2010, Accepted 07 Jun 2010, Published online: 09 Aug 2010

References

  • Brown BA, Kantesaria PP, McDevitt LM. Fingolimod: A novel immunosuppressant for multiple sclerosis. Ann Pharm. 2007; 41:1660–1668.
  • Maki T, Gottschalk R, Monaco AP. Prevention of autoimmune diabetes by FTY720 in nonobese diabetic mice. Transplantation. 2002; 74:1684–1686.
  • Maki T, Gottschalk R, Ogawa N, Monaco AP. Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720. Transplantation. 2005; 79:1051–1055.
  • Yang Z, Chen M, Gialkow LB, Ellett JD, Wu R, Brinkmann V, Nadler JL, Lynch KR. The immune modulator FTY720 prevents autoimmune diabetes in nonobese diabetic mice. Clin Immunol. 2003; 107:30–35.
  • Alperovich G, Rama I, Lloberas N, Franquesa M, Poveda R, Goma M, Herrerok-Fresneda I, Cruzado JM, Bolanos N, Carrera M, Grinyo JM, Torras J. New immunosuppressor strategies in the treatment of murine lupus nephritis. Lupus. 2007; 16:18–24.
  • Penaranda C, Tang Q, Ruddle NH, Bluestone JA. Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs. Diabetes59 6: 1461–1468.
  • Morris MA, Gibb DR, Picard F, Brinkmann V, Straume M, Ley K. Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720. Eur J Immunol. 2005; 35:3570–3580.
  • Liu Y, Wada R, Yamashita T, Mi Y, Deng C-X, Hobson JP, Rosenfeldt HM, Nava VE, Chae S-S, Lee M-J, Liu CH, Hla T, Spiegel S, Proia RL. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest. 2000; 106:951–961.
  • Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004; 427:355–360.
  • Allende ML, Dreier JL, Mandala S, Proia RL. Expression of the sphingosine-1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J Biol Chem. 2004; 279:15396–15401.
  • Rosen H, Sanna MG, Cahalan SM, Gonzalez-Cabrera PJ. Tipping the gatekeeper: S1P regulation of endothelial barrier function. TRENDS Immunol. 2007; 28:102–107.
  • Chiba K, Yanagawa Y, Masubuchi Y, Kataoka H, Kawaguchi T, Ohtsuki M, Hoshino Y. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J Immunol. 1998; 160:5037–5044.
  • Yanagawa Y, Sugahara K, Kataoka H, Kawaguchi T, Masubuchi Y, Chiba K. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo. J Immunol. 1998; 160:5493–5499.
  • Bohler T, Waiser J, Schuetz M, Neumayer HH, Budde K. FTY720 exerts differential effects on CD4+ and CD8+ T-lymphocyte subpopulations expressing chemokine and adhesion receptors. Nephrol Dial Trans. 2004; 19:702–713.
  • Wicker LS, Miller BJ, Mullen Y. Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes. 1986; 35:855–860.
  • Peterson JD, Haskins K. Transfer of diabetes in the NOD-scid mouse by CD4 T-cell clones: Differential requirement for CD8 T-cells. Diabetes. 1996; 45:328–336.
  • Berdyshev EV, Gorshkova IA, Garcia JGN, Natarajan V, Hubbard WC. Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. Anal Biochem. 2005; 339:129–136.
  • Chakrabarti SK, Cole BK, Wen Y, Keller SR, Nadler JL. 12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes. Obesity. 2009; 17:1657–1663.
  • You S, Belghith M, Cobbold S, Alyanakian M-A, Gouarin C, Barriot S, Garcia C, Waldmann H, Bach J-F, Chatenoud L. Autoimmune diabetes onset results from qualitative rahter than quantitative age-dependent changes in pathogenic T cells. Diabetes. 2005; 54:1415–1422.
  • Scheuplein F, Schwarz N, Adriouch S, Krebs C, Bannas P, Rissiek B, Seman M, Haag F, Koch-Nolte F. NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells. J Immunol. 2009; 182:2898–2908.
  • Shultz LD, Schweitzer PA, Christianson SW, Gott B, Schweitzer IB, Tennet B, McKenna S, Mobraaten L, Rajan TV, Greiner DL, Leiter EH. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol. 1995; 154:180.
  • Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P, Foster CA, Zollinger M, Lynch KR. The immune modulator FTY720 targets sphingosine-1-phosphate receptors. J Biol Chem. 2002; 277:21453–21457.
  • Pyne S, Pyne NJ. Review article: Sphingosine 1-phosphate signalling in mammalian cells. Biochem J. 2000; 349:385–402.
  • Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J. T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med. 2009; 206:2469–2481.
  • Krupica T, Fry TJ, Mackall CL. Autoimmunity during lymphopenia: A two-hit model. Clin Immunol. 2006; 120:121–128.
  • Boitard C, Yasunami R, Dardenne M, Bach J-F. T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice. J Exp Med. 1989; 169:1669–1680.
  • Popovic J, Kover KL, Moore WV. The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat. Ped Diab. 2004; 5:3–9.
  • von Herrath M. Can we learn from viruses how to prevent type 1 diabetes? The role of viral infections in the pathogenesis of type 1 diabetes and the development of novel combination therapies. Diabetes. 2009; 58:2–11.
  • Mandala S, Hajdu R, Bergstrom J, Quackenbush E, Xie J, Milligan J, Thornton R, Shei G-J, Card D, Keohane CA, Rosenbach M, Hale J, Lynch CL, Rupprecht K, Parsons W, Rosen H. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science. 2002; 296:346–349.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.