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Research Article

Engagement of NK receptor NKG2D, but not 2B4, results in self-reactive CD8+T cells and autoimmune vitiligo

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Pages 599-606 | Received 15 Feb 2011, Accepted 31 May 2011, Published online: 13 Sep 2011

References

  • Das PK, van den Wijngaard RM, Wankowicz-Kalinska A, Le Poole IC. A symbiotic concept of autoimmunity and tumour immunity: Lessons from vitiligo. Trends Immunol. 2001; 22 3: 130–136.
  • Le Poole IC, van den Wijngaard RM, Westerhof W, Das PK. Presence of T cells and macrophages in inflammatory vitiligo skin parallels melanocyte disappearance. Am J Pathol. 1996; 148 4: 1219–1228.
  • Wankowicz-Kalinska A, van den Wijngaard RM, Tigges BJ, Westerhof W, Ogg GS, Cerundolo V, Storkus WJ, Das PK. Immunopolarization of CD4+ and CD8+T cells to Type-1-like is associated with melanocyte loss in human vitiligo. Lab Invest. 2003; 83 5: 683–695.
  • Ernst B, Lee DS, Chang JM, Sprent J, Surh CD. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity. 1999; 11 2: 173–181.
  • Nikolic-Zugic J, Bevan MJ. Role of self-peptides in positively selecting the T-cell repertoire. Nature. 1990; 344 6261: 65–67.
  • Tanchot C, Lemonnier FA, Perarnau B, Freitas AA, Rocha B. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science. 1997; 276 5321: 2057–2062.
  • Dyall R, Bowne WB, Weber LW, LeMaoult J, Szabo P, Moroi Y, Piskun G, Lewis JJ, Houghton AN, Nikolic-Zugic J. Heteroclitic immunization induces tumor immunity. J Exp Med. 1998; 188 9: 1553–1561.
  • Engelhorn ME, Guevara-Patino JA, Noffz G, Hooper AT, Lou O, Gold JS, Kappel BJ, Houghton AN. Autoimmunity and tumor immunity induced by immune responses to mutations in self. Nat Med. 2006; 12 2: 198–206.
  • Guevara-Patino JA, Engelhorn ME, Turk MJ, Liu C, Duan F, Rizzuto G, Cohen AD, Merghoub T, Wolchok JD, Houghton AN. Optimization of a self antigen for presentation of multiple epitopes in cancer immunity. J Clin Invest. 2006; 116 5: 1382–1390.
  • Engelhorn ME, Guevara-Patino JA, Merghoub T, Liu C, Ferrone CR, Rizzuto GA, Cymerman DH, Posnett DN, Houghton AN, Wolchok JD. Mechanisms of immunization against cancer using chimeric antigens. Mol Ther. 2008; 16 4: 773–781.
  • Duan F, Lin Y, Liu C, Engelhorn ME, Cohen AD, Curran M, Sakaguchi S, Merghoub T, Terzulli S, Wolchok JD, . Immune rejection of mouse tumors expressing mutated self. Cancer Res. 2009; 69 8: 3545–3553.
  • Moretta L, Bottino C, Cantoni C, Mingari MC, Moretta A. Human natural killer cell function and receptors. Curr Opin Pharmacol. 2001; 1 4: 387–391.
  • Biassoni R, Cantoni C, Marras D, Giron-Michel J, Falco M, Moretta L, Dimasi N. Human natural killer cell receptors: insights into their molecular function and structure. J Cell Mol Med. 2003; 7 4: 376–387.
  • Cerwenka A, Bakker AB, McClanahan T, Wagner J, Wu J, Phillips JH, Lanier LL. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity. 2000; 12 6: 721–727.
  • Jamieson AM, Diefenbach A, McMahon CW, Xiong N, Carlyle JR, Raulet DH. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity. 2002; 17 1: 19–29.
  • Houchins JP, Yabe T, McSherry C, Bach FH. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J Exp Med. 1991; 173 4: 1017–1020.
  • Diefenbach A, Jamieson AM, Liu SD, Shastri N, Raulet DH. Ligands for the murine NKG2D receptor: Expression by tumor cells and activation of NK cells and macrophages. Nat Immunol. 2000; 1 2: 119–126.
  • Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 1999; 285 5428: 727–729.
  • Schwartz RH. Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell. 1992; 71 7: 1065–1068.
  • Lee KM, Bhawan S, Majima T, Wei H, Nishimura MI, Yagita H, Kumar V. Cutting edge: The NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells. J Immunol. 2003; 170 10: 4881–4885.
  • Klem J, Verrett PC, Kumar V, Schatzle JD. 2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: Properties required for 2B4 lytic function. J Immunol. 2002; 169 1: 55–62.
  • Lee KM, McNerney ME, Stepp SE, Mathew PA, Schatzle JD, Bennett M, Kumar V. 2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells. J Exp Med. 2004; 199 9: 1245–1254.
  • Kumaresan PR, Stepp SE, Verrett PC, Chuang SS, Boles KS, Lai WC, Ryan JC, Bennett M, Kumar V, Mathew PA. Molecular characterization of the rat NK cell receptor 2B4. Mol Immunol. 2000; 37 12–13: 735–744.
  • Kambayashi T, Assarsson E, Michaelsson J, Berglund P, Diehl AD, Chambers BJ, Ljunggren HG. Emergence of CD8+T cells expressing NK cell receptors in influenza A virus-infected mice. J Immunol. 2000; 165 9: 4964–4969.
  • Kambayashi T, Assarsson E, Chambers BJ, Ljunggren HG. Cutting edge: Regulation of CD8(+) T cell proliferation by 2B4/CD48 interactions. J Immunol. 2001; 167 12: 6706–6710.
  • Wu Z, Kim HP, Xue HH, Liu H, Zhao K, Leonard WJ. Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. Mol Cell Biol. 2005; 25 22: 9741–9752.
  • Olcese L, Cambiaggi A, Semenzato G, Bottino C, Moretta A, Vivier E. Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells. J Immunol. 1997; 158 11: 5083–5086.
  • McNerney ME, Lee KM, Kumar V. 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+T cells. Mol Immunol. 2005; 42 4: 489–494.
  • Chlewicki LK, Velikovsky CA, Balakrishnan V, Mariuzza RA, Kumar V. Molecular basis of the dual functions of 2B4 (CD244). J Immunol. 2008; 180 12: 8159–8167.
  • Houghton CS, Engelhorn ME, Liu C, Song D, Gregor P, Livingston PO, Orlandi F, Wolchok JD, McCracken J, Houghton AN, . Immunological validation of the EpitOptimizer program for streamlined design of heteroclitic epitopes. Vaccine. 2007; 25 29: 5330–5342.
  • Westerhof W, d'Ischia M. Vitiligo puzzle: The pieces fall in place. Pigment Cell Res. 2007; 20 5: 345–359.
  • Guevara-Patino JA, Turk MJ, Wolchok JD, Houghton AN. Immunity to cancer through immune recognition of altered self: Studies with melanoma. Adv Cancer Res. 2003; 90:157–177.
  • Houghton AN, Guevara-Patino JA. Immune recognition of self in immunity against cancer. J Clin Invest. 2004; 114 4: 468–471.
  • Han R, Baden HP, Brissette JL, Weiner L. Redefining the skin's pigmentary system with a novel tyrosinase assay. Pigment Cell Res. 2002; 15 4: 290–297.
  • Van Belle TL, von Herrath MG. The role of the activating receptor NKG2D in autoimmunity. Mol Immunol. 2009; 47 1: 8–11.
  • Strid J, Roberts SJ, Filler RB, Lewis JM, Kwong BY, Schpero W, Kaplan DH, Hayday AC, Girardi M. Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis. Nat Immunol. 2008; 9 2: 146–154.
  • Speiser DE, Colonna M, Ayyoub M, Cella M, Pittet MJ, Batard P, Valmori D, Guillaume P, Lienard D, Cerottini JC, . The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells. J Immunol. 2001; 167 11: 6165–6170.
  • Latchman Y, McKay PF, Reiser H. Identification of the 2B4 molecule as a counter-receptor for CD48. J Immunol. 1998; 161 11: 5809–5812.
  • Gonzalez-Cabrero J, Wise CJ, Latchman Y, Freeman GJ, Sharpe AH, Reiser H. CD48-deficient mice have a pronounced defect in CD4(+) T cell activation. Proc Natl Acad Sci USA. 1999; 96 3: 1019–1023.

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