Effect of administration of apoptotic blebs on disease development in lupus mice

References

• Gaipl US, Voll RE, Sheriff A, Franz S, Kalden JR, Herrmann M. Impaired clearance of dying cells in systemic lupus erythematosus. Autoimmun Rev. 2005; 4:189–194.
   PubMed Web of Science ®Google Scholar
• Fransen JH, Hilbrands LB, Koeter CM, Berden JHB, van der Vlag J. The role of apoptosis and removal of apoptotic cells in the genesis of systemic lupus erythematosus. Arch Med Sci. 2009; 5:S466–S477.
   Google Scholar
• Savill J, Dransfield I, Gregory C, Haslett C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol. 2002; 2:965–975.
   PubMed Web of Science ®Google Scholar
• Hepburn AL, Lampert IA, Boyle JJ, Horncastle D, Ng WF, Layton M, . In vivo evidence for apoptosis in the bone marrow in systemic lupus erythematosus. Ann Rheum Dis. 2007; 66:1106–1109.
   PubMed Web of Science ®Google Scholar
• Herrmann M, Voll RE, Zoller OM, Hagenhofer M, Ponner BB, Kalden JR. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum. 1998; 41:1241–1250.
   PubMed Web of Science ®Google Scholar
• Baumann I, Kolowos W, Voll RE, Manger B, Gaipl U, Neuhuber WL, . Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum. 2002; 46:191–201.
   PubMed Web of Science ®Google Scholar
• Licht R, Dieker JW, Jacobs CW, Tax WJ, Berden JH. Decreased phagocytosis of apoptotic cells in diseased SLE mice. J Autoimmun. 2004; 22:139–145.
   PubMed Web of Science ®Google Scholar
• Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med. 1994; 179:1317–1330.
   PubMed Web of Science ®Google Scholar
• Dieker JW, Fransen JH, van Bavel CC, Briand JP, Jacobs CW, Muller S, . Apoptosis-induced acetylation of histones is pathogenic in systemic lupus erythematosus. Arthritis Rheum. 2007; 56:1921–1933.
   PubMed Web of Science ®Google Scholar
• Utz PJ, Hottelet M, Schur PH, Anderson P. Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus. J Exp Med. 1997; 185:843–854.
   PubMed Web of Science ®Google Scholar
• Casciola-Rosen L, Andrade F, Ulanet D, Wong WB, Rosen A. Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. J Exp Med. 1999; 190:815–826.
   PubMed Web of Science ®Google Scholar
• Munoz LE, van Bavel C, Franz S, Berden J, Herrmann M, van der Vlag J. Apoptosis in the pathogenesis of systemic lupus erythematosus. Lupus. 2008; 17:371–375.
   PubMed Web of Science ®Google Scholar
• van Bavel CC, Dieker J, Muller S, Briand JP, Monestier M, Berden JH, . Apoptosis-associated acetylation on histone H2B is an epitope for lupus autoantibodies. Mol Immunol. 2009; 47:511–516.
   PubMed Web of Science ®Google Scholar
• van Bavel CC, Dieker JW, Kroeze Y, Tamboer WP, Voll R, Muller S, . Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus. Ann Rheum Dis. 2011; 70:201–207.
   PubMed Web of Science ®Google Scholar
• Fransen JH, Hilbrands LB, Ruben J, Stoffels M, Adema GJ, van der Vlag J, . Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17. Arthritis Rheum. 2009; 60:2304–2313.
   PubMed Web of Science ®Google Scholar
• Radic M, Marion T, Monestier M. Nucleosomes are exposed at the cell surface in apoptosis. J Immunol. 2004; 172:6692–6700.
   PubMed Web of Science ®Google Scholar
• Decker P, Singh-Jasuja H, Haager S, Kotter I, Rammensee HG. Nucleosome, the main autoantigen in systemic lupus erythematosus, induces direct dendritic cell activation via a MyD88-independent pathway: consequences on inflammation. J Immunol. 2005; 174:3326–3334.
   PubMed Web of Science ®Google Scholar
• Bettelli E, Korn T, Kuchroo VK. Th17: the third member of the effector T cell trilogy. Curr Opin Immunol. 2007; 19:652–657.
   PubMed Web of Science ®Google Scholar
• Fransen JH, van der Vlag J, Ruben J, Adema GJ, Berden JH, Hilbrands LB. The role of dendritic cells in the pathogenesis of systemic lupus erythematosus. Arthritis Res Ther. 2010; 12:207.
   PubMed Web of Science ®Google Scholar
• Bondanza A, Zimmermann VS, Dell'Antonio G, Cin ED, Balestrieri G, Tincani A, . Requirement of dying cells and environmental adjuvants for the induction of autoimmunity. Arthritis Rheum. 2004; 50:1549–1560.
   PubMed Web of Science ®Google Scholar
• Bondanza A, Zimmermann VS, Dell'Antonio G, Dal Cin E, Capobianco A, Sabbadini MG, . Cutting edge: dissociation between autoimmune response and clinical disease after vaccination with dendritic cells. J Immunol. 2003; 170:24–27.
   PubMed Web of Science ®Google Scholar
• Ma L, Chan KW, Trendell-Smith NJ, Wu A, Tian L, Lam AC, . Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains. Eur J Immunol. 2005; 35:3364–3375.
   PubMedGoogle Scholar
• Shoshan Y, Mevorach D. Accelerated autoimmune disease in MRL/MpJ-Fas(lpr) but not in MRL/MpJ following immunization with high load of syngeneic late apoptotic cells. Autoimmunity. 2004; 37:103–109.
   PubMed Web of Science ®Google Scholar
• Georgiev M, Agle LM, Chu JL, Elkon KB, Ashany D. Mature dendritic cells readily break tolerance in normal mice but do not lead to disease expression. Arthritis Rheum. 2005; 52:225–238.
   PubMed Web of Science ®Google Scholar
• Tzeng TC, Suen JL, Chiang BL. Dendritic cells pulsed with apoptotic cells activate self-reactive T-cells of lupus mice both in vitro and in vivo. Rheumatology (Oxford). 2006; 45:1230–1237.
   PubMedGoogle Scholar
• Mevorach D, Zhou JL, Song X, Elkon KB. Systemic exposure to irradiated apoptotic cells induces autoantibody production. J Exp Med. 1998; 188:387–392.
   PubMed Web of Science ®Google Scholar
• Emmer PM, van der Vlag J, Adema GJ, Hilbrands LB. Dendritic cells activated by lipopolysaccharide after dexamethasone treatment induce donor-specific allograft hyporesponsiveness. Transplantation. 2006; 81:1451–1459.
   PubMed Web of Science ®Google Scholar
• Greenberger JS, Sakakeeny MA, Humphries RK, Eaves CJ, Eckner RJ. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc Natl Acad Sci USA. 1983; 80:2931–2935.
   PubMed Web of Science ®Google Scholar
• Guchhait P, Tosi MF, Smith CW, Chakaraborty A. The murine myeloid cell line 32Dcl3 as a model system for studying neutrophil functions. J Immunol Meth. 2003; 283:195–204.
   PubMedGoogle Scholar
• Fransen JH, Hilbrands LB, Jacobs CW, Adema GJ, Berden JH, Van der Vlag J. Both early and late apoptotic blebs are taken up by DC and induce IL-6 production. Autoimmunity. 2009; 42:325–327.
   PubMed Web of Science ®Google Scholar
• van Bruggen MC, Walgreen B, Rijke TP, Corsius MJ, Assmann KJ, Smeenk RJ, . Heparin and heparinoids prevent the binding of immune complexes containing nucleosomal antigens to the GBM and delay nephritis in MRL/lpr mice. Kidney Int. 1996; 50:1555–1564.
   Google Scholar
• Dieker JW, Sun YJ, Jacobs CW, Putterman C, Monestier M, Muller S, . Mimotopes for lupus-derived anti-DNA and nucleosome-specific autoantibodies selected from random peptide phage display libraries: facts and follies. J Immunol Meth. 2005; 296:83–93.
   Google Scholar
• Mukundan L, Odegaard JI, Morel CR, Heredia JE, Mwangi JW, Ricardo-Gonzalez RR, . PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance. Nat Med. 2009; 15:1266–1272.
   PubMed Web of Science ®Google Scholar
• A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, . Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity. 2009; 31:245–258.
   PubMed Web of Science ®Google Scholar
• Sauter B, Albert ML, Francisco L, Larsson M, Somersan S, Bhardwaj N. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med. 2000; 191:423–434.
   PubMed Web of Science ®Google Scholar
• Demaria S, Santori FR, Ng B, Liebes L, Formenti SC, Vukmanovic S. Select forms of tumor cell apoptosis induce dendritic cell maturation. J Leukoc Biol. 2005; 77:361–368.
   PubMed Web of Science ®Google Scholar
• Tesniere A, Apetoh L, Ghiringhelli F, Joza N, Panaretakis T, Kepp O, . Immunogenic cancer cell death: a key-lock paradigm. Curr Opin Immunol. 2008; 20:504–511.
   PubMed Web of Science ®Google Scholar
• Zhang QH, Link H, Xiao BG. Efficacy of peripheral tolerance induced by dendritic cells is dependent on route of delivery. J Autoimmun. 2004; 23:37–43.
   Google Scholar
• Verdijk P, Aarntzen EH, Punt CJ, de Vries IJ, Figdor CG. Maximizing dendritic cell migration in cancer immunotherapy. Expert Opin Biol Ther. 2008; 8:865–874.
   PubMed Web of Science ®Google Scholar
• Eggert AA, Schreurs MW, Boerman OC, Oyen WJ, de Boer AJ, Punt CJ, . Biodistribution and vaccine efficiency of murine dendritic cells are dependent on the route of administration. Cancer Res. 1999; 59:3340–3345.
   PubMed Web of Science ®Google Scholar
• Lappin MB, Weiss JM, Delattre V, Mai B, Dittmar H, Maier C, . Analysis of mouse dendritic cell migration in vivo upon subcutaneous and intravenous injection. Immunology. 1999; 98:181–188.
   PubMed Web of Science ®Google Scholar
• Huck SP, Tang SC, Andrew KA, Yang J, Harper JL, Ronchese F. Activation and route of administration both determine the ability of bone marrow-derived dendritic cells to accumulate in secondary lymphoid organs and prime CD8+T cells against tumors. Cancer Immunol Immunother. 2008; 57:63–71.
   PubMed Web of Science ®Google Scholar