1,462
Views
53
CrossRef citations to date
0
Altmetric
Research Article

Apoptosis and NET formation in the pathogenesis of SLE

, , , , , , & show all
Pages 597-601 | Received 30 Jun 2012, Accepted 05 Jul 2012, Published online: 17 Sep 2012

References

  • Burlingame RW, Boey ML, Starkebaum G, . The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus. J. Clin. Invest.. 1994; 94 1: 184–192.
  • Radic M, Herrmann M, van der Vlag J, Rekvig OP. Regulatory and pathogenetic mechanisms of autoantibodies in SLE. Autoimmunity. 2011; 44 5: 349–356.
  • Hakkim A, Fürnroh BG, Amann K, . Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc. Natl. Acad. Sci. USA. 2010; 107 21: 9813–9818.
  • Fransen JH, van der Vlag J, Ruben J, . The role of dendritic cells in the pathogenesis of systemic lupus erythematosus. Arthritis Res. Ther.. 2010; 12 2: 207.
  • Munoz LE, van Bavel C, Franz S, . Apoptosis in the pathogenesis of systemic lupus erythematosus. Lupus. 2008; 17 5: 371–375.
  • Herrmann M, Voll RE, Zoller OM, . Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum.. 1998; 41 7: 1241–1250.
  • Dieker JW, Fransen JH, van Bavel CC, . Apoptosis–induced acetylation of histones is pathogenic in systemic lupus erythematosus. Arthritis Rheum.. 2007; 56 6: 1921–1933.
  • Casciola-Rosen L, Andrade F, Ulanet D, Wong WB, Rosen A. Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autimmunity. J. Exp. Med.. 1999; 190 6: 815–826.
  • Utz PJ, Gensler TJ, Anderson P. Death, autoantigen modifications, and tolerance. Arthritis Res.. 2000; 2 2: 101–114.
  • Doyle HA, Mamula MJ. Posttranslational modifications of self-antigens. Ann. NY Acad. Sci.. 2005; 1050:1–9.
  • Van Bavel CC, Dieker JW, Kroeze Y, . Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus. Ann. Rheum. Dis.. 2011; 70 1: 201–207.
  • Van Bavel CC, Dieker J, Muller S, . Apoptosis-associated acetylation on histone H2B is an epitope for lupus autoantibodies. Mol Immunol.. 2009; 47 2-3: 511–516.
  • Urbonaviciute V, Fürnrohr BG, Meister S, . Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J. Exp. Med.. 2008; 205 13: 3007–3018.
  • Voll RE, Urbonaviciute V, Herrmann M, . High Mobility Group Box 1 in the pathogenesis of inflammatory and autoimmune diseases. Isr. Med. Assoc. J.. 2008; 10 1: 26–28.
  • Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature. 2002; 418:191–195.
  • Fransen JH, Hilbrands LB, Ruben J, . Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17. Arthritis Rheum.. 2009; 60 8: 2304–2313.
  • Fransen JH, Hilbrands LB, Jacobs CW, Adema GJ, Berden JH, Van Der Vlag J. Both early and late apoptotic blebs are taken up by DC and induce IL-6 production. Autoimmunity. 2009; 42 4: 325–327.
  • Korn T, Bettelli E, Oukka M, . IL-17 and Th17 cells. Annu. Rev. Immunol.. 2009; 27:485–517.
  • Wong CK, Lit LCW, Tam LS, . Hyperproduction of IL-23 and IL-7 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity. Clin. Immunol.. 2008; 127 3: 385–393.
  • Garrett-Sinha LA, John S, Gaffen SL. Il-17 and the TH17 lineage in systemic lupus erythematosus. Curr. Opin. Rheumatol.. 2008; 20 5: 519–525.
  • Yu JJ, Gaffen SL. Interleukin-17: A novel inflammatory cytokine that bridges innate and adaptive immunity. Front Biosci.. 2008; 13:170–177.
  • Kurasawa K, Hirose K, Sano H, . Increased interleukin-17 production in patients with systemic sclerosis. Arthritis Rheum.. 2000; 43 11: 2455–2463.
  • Boulé MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med.. 2004; 199 12: 1631–1640.
  • Båve U, Magnusson M, Eloranta ML, . FcyRIIa is expressed on natural IFN/a/producing cells plasmacytoid dendritic cells and is required for the IFN/a production induced by apoptotic cells combined with lupus IgG. J Immunol.. 2003; 171 6: 3296–3302.
  • Fuchs TA, Abed U, Goosmann C, . Novel cell death program leads to neutrophil extracellular traps. J. Cell Biol.. 2007; 176 2: 231–241.
  • Lande R, Ganguly D, Facchinetti V, . Neutrophils activate plasmacytoid dendritic cells by releasing Self-DNA-peptide complexes in systemic lupus erythematosus. Sci. Trans. Med.. 2011; 3 73: 73ra19.
  • Garcia-Romo GS, Caielli S, Vega B, . Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci. Transl. Med.. 2011; 73 3: 73ra20.
  • Bosch X. Systemic Lupus Erythematosus and the neutrophil. N. Engl. J. Med.. 2011; 365 8: 758–760.
  • Kaplan MJ. Neutrophils in the pathogenesis and manifestations of SLE. Nat. Rev. Rheumatol.. 2011; 7 12: 691–699.
  • Keith B, Stone E, Stone V. Type I interferon and systemic lupus erythematosus. Interferon Cytokine Res.. 2011; 31 11: 803–812.
  • Bengtsson AA, Sturfelt G, Truedsson L, . Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies. Lupus. 2000; 9 9: 664–671.
  • Ruuth K, Carlsson L, Hallberg B, . Interferon-α promotes survival of human primary B-lymphocytes via phosphatidylinositol 3-kinase. Biochem. Biophys. Res. Commun.. 2001; 284 3: 583–586.
  • Bonelli M, Savitskaya A, von Dalwigk K, . Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE). Int. Immunol.. 2008; 20 7: 861–868.
  • Suen JL, Li HT, Chiang BL, . Altered homeostasis of CD4+FoxP3+regulatory T-cell subpopulations in systemic lupus erythematosus. Immunology. 2009; 127 2: 196–205.
  • Braun D, Caramalho I, Demengeot J. IFN-a/B enhances BCR-dependent B cell responses. Int. Immunol.. 2002; 14 4: 411–419.
  • Blanco P, Palucka AK, Gill M, . Induction of dendritic cell differentiation by IFN-a in systemic lupus erythematosus. Science. 2001; 294 5546: 1540–1543.
  • Villanueva E, Yalavarthi S, Berthier CC, . Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J. Immunol.. 2011; 187 1: 538–552.
  • Denny MF, Yalavarthi S, Zhao W, . A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs. J. Immunol.. 2012; 184 6: 3284–3297.
  • Leffler J, Martin M, Gullstrand B, . Neutrophil extracellular traps that are not degraded in systemic lupus erythematosus activate complement exacerbating the disease. J. Immunol.. 2012; 188 7: 3522–3531.
  • Liu CL, Tangsombatvisit S, Rosenberg JM, . Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies. Arthritis Res. Ther.. 2012; 14 1: R25.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.