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Review

TAM receptors in apoptotic cell clearance, autoimmunity, and cancer

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Pages 294-297 | Received 02 Nov 2012, Accepted 05 Nov 2012, Published online: 10 May 2013

References

  • Savill J., Fadok V.. Corpse clearance defines the meaning of cell death. Nature. 2000; 407:784.
  • Fadok V. A., Bratton D. L., Konowal A., . Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J. Clin. Invest. 1998; 101:890.
  • Thorp E., Cui D., Schrijvers D. M., Kuriakos G., Tabas I.. Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/- mice. Arterioscler. Thromb. Vasc. Biol. 2008; 28:1421.
  • Wallet M. A., Sen P., Flores R. R., . MerTK is required for apoptotic cell-induced T cell tolerance. J. Exp. Med. 2008; 205:219.
  • Scott R. S., McMahon E. J., Pop S. M., . Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature. 2001; 411:207.
  • Botto M., Dell'Agnola C., Bygrave A. E., . Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat. Genet. 1998; 19:56.
  • Gaipl U. S., Kuhn A., Sheriff A., . Clearance of apoptotic cells in human SLE. Curr. Dir. Autoimmun. 2006; 9:173.
  • Elliott M. R., Ravichandran K. S.. Clearance of apoptotic cells: implications in health and disease. J. Cell. Biol. 2010; 189:1059.
  • Linger R. M., Keating A. K., Earp H. S., Graham D. K.. TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. Adv. Cancer Res. 2008; 100:35.
  • Cohen P. L., Caricchio R., Abraham V., . Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J. Exp. Med. 2002; 196:135.
  • Lu Q., Lemke G.. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science. 2001; 293:306.
  • Camenisch T. D., Koller B. H., Earp H. S., Matsushima G. K.. A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock. J. Immunol. 1999; 162:3498.
  • Sen P., Wallet M. A., Yi Z., . Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells. Blood. 2007; 109:653.
  • Gohlke P. R., Williams J. C., Vilen B. J.. The receptor tyrosine kinase MerTK regulates dendritic cell production of BAFF. Autoimmunity. 2009; 42:183.
  • Baumann I., Kolowos W., Voll R. E., . Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum. 2002; 46:191.
  • Shao W. H., Zhen Y., Eisenberg R. A., Cohen P. L.. The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells. Clin. Immunol. 2009; 133:138.
  • Shao W. H., Kuan A. P., Wang C., . Disrupted Mer receptor tyrosine kinase expression leads to enhanced MZ B-cell responses. J. Autoimmun. 2010; 35:368.
  • Rahman Z. S., Shao W. H., Khan T. N., Zhen Y., Cohen P. L.. Impaired apoptotic cell clearance in the germinal center by Mer-deficient tingible body macrophages leads to enhanced antibody-forming cell and germinal center responses. J. Immunol. 2010; 185:5859.
  • Cheong H. S., Lee S. O., Choi C. B.. MERTK polymorphisms associated with risk of haematological disorders among Korean SLE patients. Rheumatology (Oxford). 2007; 46:209.
  • Wu J., Ekman C., Jonsen A., . Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis. Arthritis Res. Ther. 2011; 13:R62.
  • Suh C. H., Hilliard B., Li S., Merrill J. T., Cohen P. L.. TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus. Arthritis Res. Ther. 2010; 12:R146.
  • Caberoy N. B., Zhou Y., Li W.. Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis. EMBO J. 2010; 29:3898.
  • Caberoy N. B., Alvarado G., Bigcas J. L., Li W.. Galectin-3 is a new MerTK-specific eat-me signal. J. Cell. Physiol. 2012; 227:401.
  • Wong C. C., Lee W. M.. The proximal cis-acting elements Sp1, Sp3 and E2F regulate mouse mer gene transcription in Sertoli cells. Eur. J. Biochem. 2002; 269:3789.
  • Mudduluru G., Leupold J. H., Stroebel P., Allgayer H.. PMA up-regulates the transcription of Axl by AP-1 transcription factor binding to TRE sequences via the MAPK cascade in leukaemia cells. Biol. Cell. 2010; 103:21.
  • McColl A., Bournazos S., Franz S., . Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages. J. Immunol. 2009; 183:2167.
  • Zahuczky G., Kristof E., Majai G., Fesus L.. Differentiation and glucocorticoid regulated apopto-phagocytic gene expression patterns in human macrophages. Role of Mertk in enhanced phagocytosis. PLoS One. 2011; 6:e21349.
  • Galvan M. D., Foreman D. B., Zeng E., Tan J. C., Bohlson S. S.. Complement component C1q regulates macrophage expression of Mer tyrosine kinase to promote clearance of apoptotic cells. J. Immunol. 2012; 188:3716.
  • Budagian V., Bulanova E., Orinska Z., . Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum. Mol. Cell Biol. 2005; 25:9324.
  • Seitz H. M., Camenisch T. D., Lemke G., Earp H. S., Matsushima G. K.. Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. J. Immunol. 2007; 178:5635.
  • Nandrot E. F., Silva K. E., Scelfo C., Finnemann S. C.. Retinal pigment epithelial cells use a MerTK-dependent mechanism to limit the phagocytic particle binding activity of alphavbeta5 integrin. Biol. Cell. 2012; 104:326.
  • Sandahl M., Hunter D. M., Strunk K. E., Earp H. S., Cook R. S.. Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation. BMC Dev. Biol. 2010; 10:122.
  • Rothlin C. V., Ghosh S., Zuniga E. I., Oldstone M. B., Lemke G.. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell. 2007; 131:1124.
  • Sharif M. N., Sosic D., Rothlin C. V., . Twist mediates suppression of inflammation by type I IFNs and Axl. J. Exp. Med. 2006; 203:1891.
  • Rothlin C. V., Lemke G.. TAM receptor signaling and autoimmune disease. Curr. Opin. Immunol. 2010; 22:740.
  • Png K. J., Halber N., Yoshida M., Tavazoie S. F.. A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature. 2011; 481:190.
  • Mudduluru G., Ceppi P., Kumarswamy R.. Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer. Oncogene. 2011; 30:2888.
  • Apetoh L., Ghiringhelli F., Tesniere A., . Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat. Med. 2007; 13:1050.
  • Holland S. J., Pan A., Franci C., . R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 2010; 70:1544.
  • Bondanza A., Zimmermann V. S., Rovere-Querini P., . Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo. J. Exp. Med. 2004; 200:1157.
  • He J., Yin Y., Luster T. A., Watkins L., Thorpe P. E.. Antiphosphatidylserine antibody combined with irradiation damages tumor blood vessels and induces tumor immunity in a rat model of glioblastoma. Clin. Cancer Res. 2009; 15:6871.
  • Marconescu A., Thorpe P. E.. Coincident exposure of phosphatidylethanolamine and anionic phospholipids on the surface of irradiated cells. Biochim. Biophys. Acta. 2008; 1778:2217.

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