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Original Article

Inherent β-Cell Dysfunction Induced by Transgenic Expression of Allogeneic Major Histocompatibility Complex Class I Antigen in Islet Cells

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Pages 47-53 | Received 29 May 1990, Accepted 07 Aug 1990, Published online: 07 Jul 2009

References

  • Allison J, Campbell I L, Morahan G, Mandel T E, Harrison L C, Miller J FAP. Diabetes in transgenic mice resulting from over-expression of class I histocompatability molecules in pancreatic B cells. Nature 1988; 333: 529–533
  • Sarvetnick N, Liggitt D, Pitts S L, Hansen S E, Stewart T A. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 1988; 52: 773–782
  • Lo D, Burkly L C, Widera G, Cowing C, Flavell R A, Palmiter R D, Brinster R L. Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell 1988; 53: 159–168
  • Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y. Breeding of a non-obese, diabetic strain of mice. Exp Anim 1980; 1: 1–13
  • Fujita T, Yui R, Kusumoto Y, Serizawa Y, Makino S, Tochino Y. Lymphocytic insulitis in a “Non-Obese Diabetic (NOD)” strain of mice: an immunohistochemical and electron miscroscope investigation. Biochem Res 1980; 3: 429–443
  • Kanazawa K, Komeda K, Sato S, Mori S, Akanuma K, Takaku F. Non-obese-diabetic mice: immune mechanisms of pancreatic B cell destruction. Diabetologia 1984; 27: 113–115
  • Nakhooda A F, Like A A, Chappel C I, Murray F T, Marliss E B. The spontaneously diabetic Wistar rat. Metabolic and morphologic studies. Diabetes 1977; 26: 100–112
  • Seemayer T A, Tannenbaum G S, Goldman H, Colle E. Dynamic time course studies of the spontaneously diabetic BB Wistar rat. III. Light microscopy and ultrastructural ohservations of pancreatic islets of Langerhans. Amer J Pathol 1982; 106: 237–249
  • Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965; 14: 619–633
  • Junker K, Egeberg J, Kromann H, Nerup J. An autopsy study of the islets of Langerhans in acute-onset juvenile diabetes mellitus. Acta Pathol Microbiol Scand Sect A 1977; 85: 699–706
  • Foulis A K, Liddle C N, Farquharson M A, Richmond J A, Weir R S. The histopathology of the pancreas in Type I (in sulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 1986; 29: 267–214
  • Epstein P N, Overbeek P A, Means A R. Calmodulin-induced early-onset diabetes in transgenic mice. Cell 1989; 58: 1067–1073
  • Efran S, Fleischer N, Hanahan D. Diabetes induced in male transgenic mice by expression of human H-ras oncoprotein in pancreatic β cells. Molec Cell Biol 1990; 10: 1779–1783
  • Drell D W, Notkins A L. Multiple immunological abnormalities in patients with Type I (insulin-dependent) diabetes mellitus. Diabetologia 1987; 30: 132–143
  • Laupacis A, Stiller C R, Gardell L C, Keown P, Dupre J, Wallace A C, Thibert P. Cyclosporin prevents diabetes in BB Wistar rats. Lancey 1983; 21: 10–11
  • Rossini A A, Faustman D, Woda B A, Like A A, Szymanski I, Mordes J P. Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester Rat. J Clin Invest 1984; 74: 39–46
  • Hahn H J, Lucke S, Kloting I, Volk H D, Baehr R V, Diamanstein T. Curing BB rats of freshly manifested diabetes by short- term treatment with a combination of a monoclonal anti-interleukin 2 receptor antibody and a subtherapeutic dose of cy closporin A. Eur J Immunol 1987; 17: 1075–1078
  • Mordes J P, Gallina D L, Handler E S, Greiner D L, Nakamura N, Pelletier A, Rossini A A. Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat. Diabetologia 1987; 30: 22–26
  • Mori Y, Suko M, Okudaira H, Matsuba I, Tsuruoka A, Sasaki A, Yokoyama H, Tanase T, Shida T, Nishimura M, Terada E, Ikeda Y. Preventive effects of Cyclosporin on diabetes in NOD mice. Diabetologia 1986; 29: 244–247
  • Shizuru J A, Taylor-Edwards C, Banks B A, Gregory A K, Fathman C G. Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes. Science 1988; 240: 659–662
  • Charlton B, Bacelj A, Mandel T E. Administration of silica particles or anti-Lyt2 antibody prevents β-cell destruction in NOD mice given cyclophosphamide. Diabetes 1988; 37: 930–935
  • Charlton B, Mandel T E. Progression from insulitis to β-cell destruction in NOD mouse requires L3T4+ T-lymphocytes. Diabetes 1988; 37: 1108–112
  • Elliott R B, Crossley J R, Berryman C C, James A G. Partial preservation of pancreatic B cell function in children with diabetes. Lancet 1981; 11: 1–4
  • Stiller C R, Dupre J, Gent M, Jenner M R, Keown P A, Laupacis A, Martell R, Rodger N W. Graffenried Bv Wolfe BMJ: Effects of Cyclosporin immunosuppression in insulin- dependent diabetes mellitus of recent onset. Science 1984; 223: 1362–1367
  • Feutren G, Papoz L, Assan R, Vialetes B, Karsenty G, Vexiau P, DuRostu H, Rodier M, Sirmai J, Lallemand A, Bach J -F. Cyclosporin increases the rate and length of remission in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial. Lancet 1986; 11: 119–124
  • The Canadian-European Randomized Control Trial Group. Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. Diabetes 1988; 37: 1574–1582
  • Morahan G, Allison J, Miller J FAP. Tolerance of class I histocompatibility antigens expressed extrathymicaly. Nature 1989; 339: 622–624
  • Theiler K. The house mouse: development and normal stage. from fertilization to four weeks of age. Springer Verlag, Heidelberg 1972
  • Mandel T E, Kennedy M M. The differentiation of murine thymocytes in vivo and in vitro. Immunology 1978; 35: 317–331
  • Mandel T E, Hoffman L, Collier S A, Carter W M, Koulmanda M. Organ culture of fetal mouse and fetal human pancreatic islets for allografting. Diabetes 1982; 31(suppl 4)39–47
  • Morgan C R, Lazarow A. Immunoassay of insulin. Two antibody systems. Plasma levels of normal, subdiabetic and diabetic rats. Diabetes 1963; 12: 115–126
  • Collier S A, Mandel T E, Hoffman L, Caruso G. Organ culture of fetal mouse pancreas: the effect of various culture conditions on insulin secretion. Diabetes 1982; 30: 804–812
  • Mandel T E, Koulmanda M. Effect of ischemia and tem perature on fetal mouse pancreas. Insulin production in vitro, and function after isotransplantation. Diabetes 1984; 33: 376–382
  • Mandel T E, Koulmanda M. Effect of culture conditions on fetal mouse pancreas in vitro and after transplantation in syngeneic and allogeneic recipients. Diabetes 1985; 34: 1082–1087
  • Bonner-Weir S, Trent D, Weir G C. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest 1983; 71: 1544–1553
  • Parham P. Intolerable secretion in tolerant transgenic mice. Nature 1988; 333: 500–503
  • Foulis A K, Farquharson M A, Hardman R. Aberrant expression of Class II major histocompatibility complex molecules by B cells and hyperexpression of class I major histocompatibility complex molecules by insulin containing islets in Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1987; 30: 333–343
  • Leiter E H, Prochazka M, Schultz L D. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice. J Immunol 1987; 138: 3224–3229
  • Leiter E H. Type C retrovirus production by pancreatic Beta cells. Association with accelerated pathogenesis in C3H-db/db (“Diabetes”) mice. Amer J Pathol 1985; 119: 22–32
  • Suenaga K, Yoon J -W. Association of β cell-specific expression of endogenous retrovirus with development of insulitis and diabetes in NOD mouse. Diabetes 1988; 37: 1722–1726
  • Serreze D V, Leiter E H, Kuff E L, Jardieu P, Ishizaka K. Molecular mimicry between insulin and retroviral antigen p 73. Development of cross-reactive autoantibodies in sera of NOD and C57BL/KsJ db/db mice. Diabetes 1988; 37: 351–358

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