Immunization of Balb/c Mice with a Monoclonal Anti-DNA Antibody Induces an Anti-Idiotypic Antibody Reactive with a Cell-Surface DNA Binding Protein

References

• Tan EM. Autoantibodies to nuclear antigens (ANA): Their immunobiology in medicine. Adv Immunol 1982; 33: 167–240
   PubMed Web of Science ®Google Scholar
• Lies RB, Messner RP, Williams RC. Relative T cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus. Arthritis Rheum 1973; 16: 362–375
   Google Scholar
• Morimoto C, Reinherz EL, Distaso JA. Relationship between systemic lupus erythematosus T cell subsets, anti-T cell antibodies, and T cell functions. J Clin Invest 1984; 73: 689–700
   PubMed Web of Science ®Google Scholar
• Messner RP, DeHoratius R, Ferrane S. Lymphocytoxic antibodies in systemic lupus erythematosus patients and their relatives. Reactivity with the HLA antigenic molecular complex. Arthritis Rheum 1980; 23: 265–272
   PubMedGoogle Scholar
• Agnello V. The immunopathogenesis of lupus nephritis. Adv Nephrol 1976; 6: 119
   PubMedGoogle Scholar
• Emlen W, Pisetsky DS, Taylor RP. Antibodies to DNA: A perspective. Arthritis Rheum 1986; 29: 1417–1426
   PubMed Web of Science ®Google Scholar
• Madaio MP, Hodder S, Stollar BD. Responsiveness of autoimmune and normal mice to nucleic acid antigens. J Immunol 1984; 132: 872–876
   PubMed Web of Science ®Google Scholar
• Schwartz RS, Stollar BD. Origins of anti-DNA autoantibodies. J Clin Invest 1985; 75: 321–327
   PubMed Web of Science ®Google Scholar
• Mendlovic S, Brocke S, Shoenfeld Y, Ben-Bassat M, Meshorer A, Bakimer R, Mozes E. Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype. Proc Natl Acad Sci USA 1988; 85: 2260–2264
   PubMed Web of Science ®Google Scholar
• Grayzel A, Solomon A, Aranow C, Diamond B. Antibodies elicited by pneumococcal antigens bear an anti-DNA-associated idiotype. J Clin Invest 1991; 87: 842–846
   PubMed Web of Science ®Google Scholar
• Meinke W, Hall MR, Goldstein DA. Physical properties of cytoplasmic membrane associated DNA. J Mol Biol 1973; 78: 43–56
   PubMed Web of Science ®Google Scholar
• Moyer MP. The association of DNA and RNA with membranes. Internal Rev Cytol 1979; 61: 1–61
   PubMedGoogle Scholar
• Reid BL, Charlson AJ. Cytoplasmic and surface deox-yribonucleic acids with consideration to their origin. Internal Rev Cytol 1979; 60: 27–52
   PubMedGoogle Scholar
• Lerner RA, Meinke W, Goldstein DA. Membrane associated DNA in the cytoplasm of diploid human lymphocytes. Proc Natl Acad Sci USA 1971; 68: 1212–1216
   PubMed Web of Science ®Google Scholar
• Meinke W, Goldstein DA. Reassociation and dissociation of cytoplasmic membrane-associated DNA. J Mol Biol 1974; 86: 757–773
   PubMed Web of Science ®Google Scholar
• Bennett RM, Davis J, Merritt MM. Anti-DNA antibodies react with DNA expressed on the surface of monocytes and B lymphocytes. J Rheum 1986; 13: 679–685
   PubMed Web of Science ®Google Scholar
• Pancer LB, Milazzo MF, Morris VL, Singhal SK, Bell DA. Immunogenicity and characterization of supernatant DNA released by murine spleen cells. J Immunol 1981; 127: 98–104
   PubMed Web of Science ®Google Scholar
• Bennett RM, Gabor GT, Merritt MM. Defective binding to human leukocytes: Evidence for a receptor-mediated association, internalization and degradation of DNA. J Clin Invest 1985; 76: 2182–2190
   PubMed Web of Science ®Google Scholar
• Gabor G, Bennett RM. Biotin labeled DNA: A novel approach for the recognition of a DNA binding site on cell membranes. Biophys Res Comm 1984; 122: 1034–1039
   PubMed Web of Science ®Google Scholar
• Hefeneider SH, Cornell KA, Brown LE, Bakke AC, McCoy SL, Bennett RM. Nucleosomes and DNA bind to specific cell-surface molecules on murine cells and induce cytokine production. Clin Immunol Immunopath 1992; 63: 245–251
   PubMedGoogle Scholar
• Bennett RM, Peller JS, Merritt MM. Defective DNA receptor function in systemic lupus erythematosus and related diseases: evidence for an autoantibody influencing cell physiology. Lancet 1986; 1: 186–188
   PubMed Web of Science ®Google Scholar
• Bennett RM, Kotzin BC, Merritt MM. DNA receptor dysfunction in systemic lupus erthymatosus and kindred disorders: Induction of anti-DNA antibodies, anti-histone antibodies and anti-receptor antibodies. J Exp Med 1988; 166: 850–863
   Web of Science ®Google Scholar
• Bennett RM, Cornell KA, Merritt MM, Bakke AC, Hsu PH, Hefeneider SH. Autoimmunity to a 28–30 kD cell membrane DNA binding protein: occurrence in selected sera from patients with SLE and mixed connective tissue disease (MCTD). Clin Exp Immunol 1991; 86: 374–379
   PubMed Web of Science ®Google Scholar
• Hefeneider SH, McCoy SL, Morton JI, Bakke AC, Cornell KA, Brown LE, Bennett RM. DNA binding to mouse cells is mediated by cell-surface molecules: The role of these DNA binding molecules as target antigens in murine lupus. Lupus 1992; 1(3)167–173
   PubMed Web of Science ®Google Scholar
• Bennett RM, Cornell KA, Merritt MM, Bakke AC, Mourich D, Hefeneider SH. idiotypic mimicry of a cell surface DNA receptor: Evidence for anti-DNA antibodies being a subset of anti-anti-DNA receptor antibodies. Clin Exp Immunol 1992; 90: 428–433
   PubMed Web of Science ®Google Scholar
• Kaye J, Gillis S, Mizel SB, Shevach EM, Malek TR, Dinarello CA, Lachman LB, Janeway CA. Growth of a cloned helper T-cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin-1 is required for the expression of receptors for interleukin-2. J Immunol 1984; 133: 1339–1346
   PubMed Web of Science ®Google Scholar
• Rosenbaum JT, Cugnini R, Damm DC, Hefeneider SH, Ansel JC. Production and modulation of interleukin-6 synthesis by synoviocytes derived from patients with arthritic disease. Anal Rheum Dis 1992; 51: 198–202
   PubMed Web of Science ®Google Scholar
• Marion TN, Tillman DM, Jou NT. Interclonal and intraclonal diversity among anti-DNA antibodies from an (NZBXNZW)F1 mouse. J Immunol 1990; 145: 2322–2332
   PubMed Web of Science ®Google Scholar
• Marion TN, Bothwell A, Briles DE, Janeway CA. IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection. J Immunol 1989; 142: 4269–4274
   PubMed Web of Science ®Google Scholar
• Davidson A, Manheimer-Lory A, Aranow C, Peterson R, Hannigan N, Diamond B. Molecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypes. J Clin Invest 1990; 85: 1401–1409
   PubMed Web of Science ®Google Scholar
• Shlomchick MS, Aucoin AH, Pisetsky DS, Weigert MG. The structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci USA 1987; 84: 9150–9154
   PubMed Web of Science ®Google Scholar
• Gohill J, Cary PD, Couppez M, Fritzler MJ. Antibodies from patients with drug-induced and idiopathic lupus erythe-matosus react with epitopes restricted to the amino and car-boxyl termini of histone. J Immunol 1985; 135: 3116–3121
   PubMed Web of Science ®Google Scholar
• Portanova JP, Arndt RE, Tan EM, Kotzin BL. Anti-histone antibodies in idiopathic and drug-induced lupus recognize distinct intrahistone regions. J Immunol 1987; 138: 446–451
   PubMed Web of Science ®Google Scholar
• Portanova JP, Cheronis JC, Blodgett JK, Kotzin BL. Histone autoantigens in murine lupus. Definition of a major epitope within an accessible region of chromatin. J Immunol 1990; 144: 4633–4640
   PubMed Web of Science ®Google Scholar
• Pisetsky DS, Grudier JP, Gilkeson GS. A role for immuno-genic DNA in the pathogenesis of systemic lupus erythe-matosus. Arthritis Rheum 1990; 33: 153–159
   PubMed Web of Science ®Google Scholar
• Gilkeson GS, Pritchard AJ, Pisetsky DS. Specificity of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Clin Immunol Immunopathol 1991; 59: 288–300
   PubMedGoogle Scholar
• Abdou NI, Wall H, Lindsley HB, Halsey JF, Suzuki T. In vitro supression of serum anti-DNA antibody binding to DNA by anti-idiotypic antibody in systemic lupus erythematosus. J Clin Invest 1981; 67: 1297–1304
   PubMed Web of Science ®Google Scholar
• Mendlovic S, Brocke S, Shoenfeld Y, Ben-Bassat M, MEsharer A, Bakimer R, Mozes E. Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype. Proc Natl Acad Sci 1988; 85: 2260–2264
   PubMed Web of Science ®Google Scholar
• Reeves WH, Chiorazzi N. Interaction between anti-DNA and anti-DNA-binding protein autoantibodies in cryogloubulin from sera of patients with systemic lupus erythematosus. J Exp Med 1986; 164: 1029–1042
   PubMed Web of Science ®Google Scholar
• Evans MJ, Suenaga R, Abdou NI. Detection and purification of antiidiotypic antibody against anti-DNA in intravenous immune globulin. J Clin Invest 1991; 11: 291–295
   Google Scholar
• Jacob L, Viaril JP, Alluet B, Arin MF, Slama FB, Vandeker-chhove J, Primo J, Markovitz J, Jacob F. A monoclonal anti-double stranded DNA autoantibody binds to a 90 kDa cell surface protein on various cell types via nucleosomes or DNA-histone complex. Proc Natl Acad Sci USA 1989; 86: 4669–4673
   PubMed Web of Science ®Google Scholar
• Subiza JL, Caturla A, Pascual-Salcedo D, Chamorro MJ, Gazapo E, Figueredo MA, De La Concha EG. DNA-anti-DNA complexes account for part of the antihistone activity found in patients with systemic lupus erythgematosus. Arthritis Rheum 1989; 32: 406–412
   PubMedGoogle Scholar
• Hefeneider SH, Brown LE, McCoy SL, Cornell KA, Bennett RM. Immunization of BALB/c mice with a monoclonal anti-DNA antibody generates idiotypic antibodies reactive with a 69 kD cell-surface DNA binding protein. Lupus I 1992
   Google Scholar
• Abdou NI, Suenaga R, Hatfield M, Evans M, Hassanein KM. Antiidiotypic antibodies against anti-DNA antibodies in sera of families of lupus patients. J Clin Immunol 1989; 9: 16–21
   PubMed Web of Science ®Google Scholar
• Puccetti A, Migliorini P, Sabbaga J, Madaio MP. Human and murine anti-DNA antibodies induce the production of antiidiotypic antibodies with autoantigen-binding properties (epibodies) through immune-network interactions. J Immunol 1990; 145: 4229–4237
   PubMed Web of Science ®Google Scholar
• Bakimer R, Krause I, Abu-Shakra M, Teplizki-Amital H, Isenberg DA, Alarcon-Segovia D, Villareal GM, Shoenfeld Y. The frequency of a common anti-DNA antibody idiotype (16/6) in different populations of patients with systemic lupus erythematosus. J Rheumatol 1991; 18: 1035–1037
   PubMed Web of Science ®Google Scholar
• Suenaga R, Munoz PA, Bright SW, Abdou NI. Spontaneous shift of anti-DNA antibody idiotypes in systemic lupus erythematosus. J Immunol 1988; 140: 3508–3514
   PubMed Web of Science ®Google Scholar
• Suenaga R, Evans M, Abdou NI. idiotypic and immuno-chemical differences of anti-DNA antibodies of a lupus patient during active and inactive disease. Clin Immunol Immunopathol 1991; 61: 320–331
   PubMedGoogle Scholar
• Taniguchi B, Chia DS, Barnett EV. Auto-anti-anti-DNA antibodies from SLE patients and normals. J Rheumatol 1984; 11: 291–295
   PubMed Web of Science ®Google Scholar
• Sasaki T, Muryoi T, Takai O, Tamate E, Saito H, Yoshinaga K. Binding specificity of antiidiotypic autoantibodies to anti-DNA antibodies in humans. J Clin Invest 1988; 82: 748–754
   PubMed Web of Science ®Google Scholar
• Prabhakar BS, Allaway GP, Srinivasappa J, Notkins AL. Cell surface expression of the 70-kD component of Ku, a DNA-binding nuclear autoantigen. J Clin Invest 1990; 86: 1301–1305
   PubMed Web of Science ®Google Scholar
• Sudar F, Csaba G, Robenek H, Themann H. Localization and internalization of cell surface DNA in macrophages. Mol Cell Biol 1986; 32: 87–91
   Web of Science ®Google Scholar
• Gasparro FP, DallAmico R, O'Malley M, Heald PW, Edelson R. Cell membrane DNA: A new target psoralen photo adduct formation. Photochem and Photobiol 1990; 52: 315–321
   PubMed Web of Science ®Google Scholar
• Emlen W, Rifai A, Magilvavy D, Mannik M. Hepatic binding of DNA is mediated by a receptor on nonparenchymal cells. Am J Pathol 1988; 133: 54–59
   PubMed Web of Science ®Google Scholar
• Hefeneider SH, Bennett RM, Pham TQ, Cornell KA, McCoy SL, Heinrich MC. Identification of a cell-surface DNA receptor and its association with systemic lupus erythematosus. J Invest Derm 1990; 94S: 79S–84S
   Google Scholar
• Bennett RM, Hefeneider SH, Bakke AC, Merritt MM, Smith CA, Mourich D, Heinrich MC. The production and characterization of murine monoclonal antibodies to a DNA receptor on human leukocytes. J Immunol 1988; 140: 2937–2942
   PubMed Web of Science ®Google Scholar
• Emlen W, Holers VM, Arend WP, Kotzin B. Regulation of nuclear antigen expression on the cell surface of human monocytes. J Immunol 1992; 148: 3042–3048
   PubMed Web of Science ®Google Scholar
• Bell DA, Morrison B, VandenBygaart P. Immunogenic DNA-related factors. Nucleosomes spontaneously released from normal murine lymphoid cells stimulate proliferation and immunoglobulin synthesis of normal mouse lymphocytes. J Clin Invest 1990; 85: 1487–1496
   PubMed Web of Science ®Google Scholar
• Atkinson MJ, Bell DA, Singhal SK. A naturally occurring polyclonal B cell activator of normal and autoantibody responses. J Immunol 1985; 135: 2524–2533
   PubMed Web of Science ®Google Scholar