30
Views
1
CrossRef citations to date
0
Altmetric
Original Article

Failure of Exogenously Administered Interferon-γ or Blockage of Endogenous Interleukin-4 with Specific Inhibitors to Augment the Incidence of Autoimmune Diabetes in Male NOD Mice

, , , , , , , & show all
Pages 71-80 | Received 01 Aug 1998, Accepted 07 Dec 1998, Published online: 07 Jul 2009

References

  • Rossini A. A., Handler E. S., Mordes J. P., Greiner D. L. Human autoimmune diabetes mellitus: Lessons from BB rats and NOD mice - Caveat Emptor. Clin. Immunol. Immunopathol. 1995; 74: 2–9
  • Rabinovitch A., Suarez W. L., Sorensen O., Bleackley R. C., Power R. F. IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J. Immunol. 1995; 154: 4874–4882
  • Fox C. J., Danska J. S. IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in non-obese diabetic mice. J. Immunol. 1997; 158: 2414–2424
  • Rabinovitch A., Suarez-Pinzon W. L., Sorensen O. Interleukin 12 mRNA expression in islets correlates with beta-cell destruction in NOD mice. J. Autoimmun. 1996; 9: 645–651
  • Rothe H., Faust A., Schade U., Kleeman R., Bosse G., Hibino T., Martin S., Kolb H. CvcloDhosuhamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4. Diabetologia 1994; 37: 1154–1158
  • Pennline K. J., Roque-Gaffney E., Monahan M. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin. Immunol. Immunopathol. 1994; 71: 169–175
  • Nicoletti F., Zaccone P., Di Marco R., Di Mauro M., Magro G., Grasso S., Mughini L., Meroni P. L., Garotta G. The effects of a nonimmunogenic form of murine soluble interferon-gamma receptor on the development of autoimmune diabetes in NOD mouse. Endocrinology 1996; 137: 5567–5575
  • Rapoport M. A., Jaramillo D., Zipris D., Lazarus A. H., Serreze D., Leiter E. H., Cyopick P., Danska J. S., Delovitch T. L. Interleukin-4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in non-obese diabetic mice. J. Exp. Med. 1993; 178: 87–99
  • Mueller R., Krahl T., Sarvetnick N. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 1996; 184: 1093–1099
  • Rabinovitch A. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation?. Diabetes 1994; 43: 613–621
  • Mandrup-Poulsen T., Nerup J., Reimers J. I., Pociot F., Andersen H. U., Karlsen A., Bjerre U., Bergholdt R. Cytokines and the endocrine system. II. Roles in substrate metabolism, modulation of thyroidal and pancreatic endocrine cell functions and autoimmune endocrine diseases. Eur. J. Endocrinol. 1996; 134: 21–30
  • Van der Meide P. H., Dubbeld M., Vijverberg K., Kos T., Schellekens H. The purification and characterization of rat gamma interferon by the use of two monoclonal antibodies. J. General. Virol. 1986; 67: 1059–1071
  • Gray P. W., Goeddel D. V. Cloning and expression of murine interferon cDNA. Proc. Natl. Acad. Sci. USA 1983; 80: 5842–5846
  • Boissier M. C., Chiocchia G., Bessis N., Hajnal J., Garotta G., Nicoletti F., Fournier C. Biphasic effect of interferon-y in murine collagen-induced arthritis. Eur. J. Immunol. 1995; 25: 1184–1190
  • Kawakami Y., Kuzuka N., Watanabe T., Uchiyama Y., Yamashita K. Induction of experimental thyroiditis in mice by recombinant interferon y administration. Acta Endocrinol. (Copenh.) 1990; 122: 41–48
  • Jacob C. H., van der Meide P. H., McDevitt H. O. In vivo treatment of (NZB x NZW)FI lupus-like nephritis with monoclonal antibody to γ interferon. J. Exp. Med. 1987; 166: 798–802
  • Prat M., Gribaudo C., Comoglio P., Cavallo G., Landolfo S. Monoclonal antibodies against murine y interferon. Proc. Natl. Acad. Sci. USA 1984; 81: 4515–4519
  • Tang H., Mignon-Godefroy K., Meroni P. L., Garotta G., Charreire J., Nicoletti F. The effects of a monoclonal antibody to interferon-γ on Experimental Autoimmune Thyroiditis (EAT): prevention of disease and decrease of EAT-specific T cells. Eur. J. Immunol. 1993; 23: 275–279
  • Jacobs M. J.M., Van Den A. E.M., van Hoeck P. L.E.M., van de Lent A. J.J., Loovan de Putte L. B.A., Vander Berg W. B. Role of IL-2 and IL-4 in exacerbations of murine antigen-induced arthritis. Immunology 1994; 83: 390–396
  • Joosten L. A.B., Lubberts E., Durez P., Helsen M. A., Jacobs M. A., Goldman M., Van den Berg W. Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis. Arthritis and Rheum. 1997; 40: 249–260
  • Hesse M., Bayrak S., Mitchison A. Protective major histocompatibility complex genes and the role of interleukin-4 in collagen-induced arthritis. Eur. J. Immunol. 1996; 26: 3234–3237
  • Mosley B., Beckmann M. P., March C. J., Idzerda R. L., Gimpcl S. D., Van den Bos T., Friend D., Alpert A., Anderson D., Jackson J., et al. The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane hound forms. Cell 1989; 59: 335–348
  • Fanslow W. C., Clifford K. N., Park L. S., Rubin A. S., Voice R. F., Beckmann M. P., Widmer M. B. Regulation of alloreactivity in vivo by IL-4 and the soluble IL-4 receptor. J. Immunol. 1991; 147: 535–540
  • Gessner A., Schroppel K., Enssle K. H., Lauffer L., Rollinghoff M. Recombinant soluble interleukin-4 (IL-4) receptor acts as an antagonist of IL-4 in murine cutaneous Leishmaniasis. Infect. Immun. 1994; 62: 4112–4117
  • Bagenstose L. M., Salgame P., Monestier M. IL-12 down-regulates autoantibody production in mercury-induced autoimmunity. J. Immunol. 1998; 160: 1612–1617
  • Parish N. M., Hutchings P. R., O'Reilly L., Quartey-Papafio L., Healey D., Ozegbe P., Cooke A. Tolerance induction as a therapeutic strategy for the control of autoimmune endocrine disease in mouse models. Immunol. Rev. 1995; 144: 269–300
  • Kelin B., Brailly H. Cytokine-binding proteins: stimulating antagonists. Immunol. Today 1995; 16: 216–220
  • Swain S. L. CD4 T cell development and cytokine polarization: an overview. J. Leukoc. Bid. 1995; 57: 795–798
  • Satoh J., Seino H., Abo T., Tanaka S.-I., Shintani S., Ohta S., Taniura K., Sawai T., Nobunaga T., Oteki T., Kumagai K., Toyota T. Recombinant human tumor necrosis factor-α suppresses autoimmune diabetes in non-obese diabetic mice. J. Clin. Invest. 1989; 84: 1345–1348
  • Jacob C. O., Aiso S., Schreiber R. D., McDevitt H. O. Monoclonal anti-tumor necrosis factor antibody renders non-obese diabetic mice hypersensitive to irradiation and enhances insulitis development. Int. Immunol. 1992; 4: 611–614
  • Campbell I. L., Oxbrow L., Harrison L. C. Reduction of insulitis following administration of IFN-γ and TNF-α in the NOD mouse. J. Autoimmun. 1991; 4: 249–262
  • Piccirillo C. A., Chang Y., Prud G. J. 'honime. TGF-β1 somatic gene therapy prevents autoimmune diabetes in nonobese diabetic mice. J. Immunol. 1998; 161: 3950–3956
  • Rothe H., O'Hara R. M., Martin S., Kolb H. Suppression of cyclophosphamide induced diabetes development and and pancreatic Thl reactivity in NOD mice treated with the interleukin (IL)-12 antagonist IL-12(p40)2. Diabetologia 1996; 39: 119–122
  • Trembleau S., Penna G., Gregori S., Gately M. C., Adorini L. Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes. Eur. J. Immunol. 1997; 27: 2330–2339
  • Doth M., Fricke M., Nicoletti F., Garotta G., Van-Velthuhysen M.-L., Brujin J. A., Gleichmann E. Genetic differences in immune reactivity to mercuric chloride (HgCl2): immunosuppression of H-2d mice is mediated by interferon-γ (TFN-γ). Clin. ESP. Immunol. 1997; 109: 149–156
  • Ochel M., Vohr H.-W., Pfeiffer C., Gleichman E. IL-4 required for the TgE and IgGl increase and IgGl autoantibody formation in mice treated with mercuric chloride. J. Immunol. 1991; 146: 3006–3011
  • Nicoletti F., Di Marco R., Barcellini W., Magro G., Schorlemmer H. U., Kurrle R., Lunetta M., Grasso S., Zaccone P., Meroni P. L. Protection from experimental autoimmune diabetes in the nonobese diabetic mouse with soluble interleukin-1 receptor. Eur. J. Immunol. 1994; 24: 1843–1847
  • Nicoletti F., Zaccone P., Di Marco R., Magro G., Grasso S., Stivala F., Calori G., Mughini L., Meroni P. L., Garotta G. Paradoxical antidiabetogenic effect of γ-interferon in DP-BB rats. Diabetes 1998; 47: 32–38
  • Valente G., Ozmen L., Novelli F., Geuna M., Palestro G., Forni G., Garotta G. Distribution of interferon-y receptor in human tissues. Eur. J. Immunol. 1992; 22: 2403–2412
  • Landolfo S., Garotta G. IFN-γ. An immunomodulatory and proinflammatory lymphokine. J. Immunol. Res. 1991; 9: 81–94
  • Wang B., Gonzalez A., Hoglund P., Katz J. D., Benoist C., Mathis D. Interleukin-4 deficiency does not exacerbate disease in NOD mice. Diabetes 1998; 47: 1207–1211
  • Bendtzen K. Cytokines and natural regulatur of cytokines. Immunol. Lett. 1994; 43: 111–123
  • McKenzie G. J., Bancroft A., Grencis R. K., McKenzie A. N. A distinct role for interleukin-13 in Th2 cell mediated immune responses. Curr. Biol. 1998; 8: 339–342
  • Yang X. D., Tisch R., Singer S. M., Cao Z. A., Liblau R. S., Schreiber R. D., McDevitt H. O. Effect of tumor necrosis factor-α on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J. Exp. Med. 1994; 180: 995–1004
  • Amital H., Levi Y., Blank M., Barak V., Langevitz P., Afek A., Nicoletti F., Kopolovic J., Gilburd B., Meroni P. L., Shoenfeld Y. Immunomodulation of murine experimental SLE-like disease by interferon-γ. Lupus 1998; 7: 445–454

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.