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Research Article

In Vitro Treatment with Interleukin-2 Normalizes Type-1 Cytokine Production by Lymphocytes from Elderly

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Pages 195-203 | Published online: 27 Sep 2008

References

  • Pawelec G., Effros R. B., Caruso C., Remarque E., Barnett Y., Solana R. T cells and aging. Front. Biosci. 1999; 15: 9
  • Thoman M. L., Weigle W. O. The cellular and subcellular bases of immunosenescence. Adv. Immunol. 1989; 46: 221
  • Caruso C., Candore G., Cigna D., Di Lorenzo G., Sireci G., Dieli F., Salerno A. Cytokine production pathway in elderly. Immunol. Res. 1996; 15: 84
  • Shearer G. M. Th1/Th2 changes in aging. Mech. Ageing. Develop. 1997; 94: 1
  • Mosmann T. R., Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 1996; 17: 138
  • Romagnani S. The Th1/Th2 paradigm. Immunol. Today 1997; 18: 263
  • Lucey D. R., Clerici M., Shearer G. M. Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin. Microbiol. Rev. 1996; 9: 532
  • Caruso C., Di Lorenzo G., Modica M. A., Candore G., Portelli M. R., Crescimanno G., Ingrassia A., Barbagallo Sangiorgi G., Salerno A. Soluble interleukin-2 receptor secretion defect in vitro in elderly subjects. Mech. Ageing Dev. 1991; 59: 27
  • Weksler M. E., Schwab R. The immunogenetics of immune senescence. Exp. Clin. Immunogenet. 1992; 9: 82
  • Candore G., Di Lorenzo G., Melluso M., Cigna D., Colucci A. T., Modica M. A., Caruso C. Gamma-interferon, interleukin-4 and interleukin-6 in vitro production in old subjects. Autoimmunity 1993; 16: 275
  • Cakman I., Rohwer J., Schutz R. M., Kirchner H., Rink L. Dysregulation between Th1 and Th2 T cell subpopulations in the elderly. Mech. Ageing Dev. 1996; 87: 197
  • Castle S., Uyemura K., Wong W., Modlin R., Effros R. Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents. Mech. Ageing. Develop. 1997; 94: 7
  • Rink L., Cakman I., Kirchner H. Altered cytokine production in the elderly. Mech. Ageing Dev. 1998; 102: 199
  • Lio D., D'Anna C., Gervasi F., Scola L., Potestio M., Di Lorenzo G., Colombo A., Listi F., Candore G., Caruso C. Interleukin-12 release by mitogen stimulated mononuclear cells in elderly. Mech Ageing Dev. 1998; 102: 211
  • Lio D., D'Anna C., Scola L., Di Lorenzo G., Colombo A., Listi F., Balistreri C. R., Candore G., Caruso C. IL-5 interleukin-5 production by mononuclear cells from aged individuals: implication for autoimmunity. Mech. Ageing Dev. 1999; 106: 297
  • Zhang Y., Cosyns M., Levin M. J., Hayward A. R. Cytokine production in varicella zoster virus-stimulated limiting dilution lymphocyte cultures. Clin. Exp. Immunol. 1994; 98: 128
  • Di Lorenzo G., Balistreri C. R., Candore G., Cigna D., Colombo A., Colonna Romano G., Colucci A. T., Gervasi F., Listí F., Potestio M., Caruso C. Granulocyte and natural killer activity in the elderly. Mech. Ageing Dev. 1999; 108: 25
  • Franceschi C., Monti D., Barbieri D., Salvioli S., Grassilli E., Capri M., Troiano L., Guido M., Bonafe M., Tropea F., Salomoni P., Benatti F., Bellesia E., Macchioni S., Anderlini R., Sansoni P., Mariotti S., Wratten M. L., Tetta C., Cossarizza A. Successful immunosenescence and the remodelling of immune responses with ageing. Nephrol. Dial. Transplant. 1996; 11S: 18
  • Globerson A. T lymphocytes and aging. Int. Arch. Allergy Immunol. 1995; 107: 91
  • Miller R. A. The Ageing immune system: primer and prospectus. Science 1996; 273: 70
  • Cossarizza A., Ortolani C., Monti D., Franceschi C. Cytometric analysis of immunosenescence. Cytometry 1997; 27: 97
  • Constant S. L., Bottomly K. Induction of TH1 and TH2 CD4+ T cell responses: the alternative approaches. Annu. Rev. Immunol. 1997; 15: 297
  • Caruso C., Candore G., Modica M. A., Bonanno C. T., Sireci G., Dieli F., Salerno A. Major Histocompatibility Complex regulation of cytokine production. J. Interferon Cytokine Res 1996; 16: 983
  • Bahr G. M., Darcissac E., Pouillart P. R., Chedid L. A., Vacsyn S. A. Synergistic effects between recombinant interleukin-2 and the synthetic immunomodulator murabutide: selective enhancement of cytokine release and potentiation of antitumor activity. J. Interferon Cytokine Res. 1996; 16: 169
  • Kirman I., Zhao K. S., Tschepen I., Szabo P., Richter G., Nguyen H., Weksler M. E. Treatment of old mice with IL-2 corrects dysregulated IL-2 and IL-4 production. Int. Immunol. 1996; 8: 1009
  • Candore G., Di Lorenzo G., Caruso C., Modica M. A., Colucci A. T., Crescimanno G., Ingrassia A., Barbagallo Sangiorgi G., Salerno A. The effect of age on mitogen responsive T cell precursors in human beings is completely restored by interleukin-2. Mech. Ageing Dev. 1992; 63: 297
  • Potestio M., Caruso C., Gervasi F., Scialabba G., D'Anna C., Di Lorenzo G., Balistreri C. R., Candore G., Colonna Romano G. Apoptosis and ageing. Mech Ageing Dev. 1998; 102: 221
  • Weyand C. M., Brandes J. C., Schmidt D., Fulbright J. W., Goronzy J. J. Functional properties of CD4+ CD28? T cells in the aging immune system. Mech. Ageing Dev. 1998; 102: 131
  • Potestio M., Pawelec G., Di Lorenzo G., Candore G., D'anna C., Gervasi F., Lio D., Tranchida G., Caruso C., Colonna Romano G. Age-related changes in the expression of Cd95 (Apo1/Fas) on blood lymphocytes. Exp. Gerontol. 1999, in press

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