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Review Article

High Levels of Endorphin and Related Pathologies of Veterinary Concern. A Review

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Pages 575-626 | Published online: 27 Sep 2008

References

  • Kandel E. R., Schwartz J. H. Principles of Neural Science 2nd ed. Elsevier Science Publishing Co., New York 1985
  • Rosenzwig M., Leiman A. Physiological Psychology. D.C. Heath and Co., Lexington 1982
  • Chao D. M., Shen L. L., Tjen-A-Looi S., Pitsillides K. F., Li P., Longhurst J. C. Naloxone reverses inhibitory effects of electroacupuncture on sympathetic cardiovascular reflex responses. Am. J. Phisiol. 1999; 276: H2127
  • Eckert R. Animal Physiology. W.H. Freeman and Co., New York 1988
  • Shepherd G. M. Neurobiology 2nd. Oxford Press, New York 1988
  • Zadina J. E., Hackler L., Ge L. J., Kastin A. J. A potent and selective endogenous agonist for the mu-opiate receptor. Nature 1997; 386: 499
  • Hosohata K., Burkey T. H., Alfaro-Lopez J., Varga E., Hruby V. J., Roeske W. R., Yamamura H. I. Endomorphin-I and endomorphin-2 are partial agonist at the human mu-opioid receptor. Eur. J. Pharmacol. 1998; 346: 111
  • Reisine T., Pasternak G. in The Pharmacological Basis Of Therapeutics, J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Ruddon, A. Goodman, Gilman. McGrow-Hill. Inc., New York 1996; 521
  • Restak R. The Mind. Bantam Books, New York 1988
  • Prosser C. L. Neural and Integrative Animal Physiology. John Wiley and Sons, Inc., New York 1991
  • Siegal G. Basic Chemistry 3rd. Little Brown and Co., Boston 1981
  • Joshi D., Bennett H. P., James S., Tousignant P., Miller M. M. Hypothalamic processing of β-endorphin in female C57BL/6J mice is altered at middle age. J. Endocrinol. 1995; 144: 405
  • Goldberg I. E., Rossi G. C., Letchworth S. R., Mathis J. P., Ryan-Moro J., Levethal L., Su W., Emmel D., Boland E. A., Pasternak G. W. Pharmacological characterization of endomorphin-1 and endomorph-2 in mouse brain. J. Pharmacol. Exp. Ther. 1998; 286: 1007
  • Nishiwaki H., Saitoh N., Nishio H., Takeuchi T., Hata F. Inhibitory effect of endomorphin-1 and 2 on acetylcholine release from myenteric plexus of guinea pig ileum. Jpn. J. Pharmacol. 1998; 78: 83
  • Kwok E. H., Dun N. J. Endomorphin decrease heart rate and blood pressure possibly by activating vagal afferents in anaesthetised rats. Brain Res. 1998; 803: 204
  • Mima H., Morikawa H., Fukuda K., Kato S., Shoda T., Mori K. Ca2+ channel inhibition by endomorphins via the cloned mu-opioid receptor expressed in NG108–15 cells. Eur. J. Pharmacol. 1997; 340: R1
  • Melchiorri P., Negri L. in Farmacologia generale e molecolare, R. Paoletti, S. Nicosia, F. Clementi, G. Fumagalli. UTET, Torino 1996; 277
  • Katzung B. G. Farmacologia generale e clinica. Piccin, Padova 1992
  • Genazzani E., Giotti A., Mantegazza P., Pepeu G., Periti P. Trattato di Farmacologia e Chemioterapia. USES, Firenze 1986; Vol. 2
  • Shavit Y., Terman G. W., Martin F. C., Lewis J. W., Liebeskind J. C., Gale R. P. Stress, opioid peptides, the immune system, and cancer. J. Immunol. 1985; 135(2 suppl)834s
  • Morgan E. L., McClurg M. R., Janda J. A. Suppression of Human B lymphocyte activation by betaendorphin. J. Neuroimmunol 1990; 28: 209
  • Morch H., Pedersen B. K. Beta-endorphin and the immune system—possible role in autoimmune diseases. Autoimmunity 1995; 21: 161
  • Carpenter G. W., Breeden L., Can D. J. Acute exposure to morphine suppresses cytotoxic T-lymphocyte activity. Int. J. Immunopharmacol. 1995; 17: 1001
  • Lu Z. W., Dai W. J., Wang G. L., Lin Z. B. Subchronic in vivo treatments of morphine inhibit T-cell proliferation by acting on macrophages. Brain Behav. Immun. 1996; 10: 351
  • Govitrapong P., Suttitum T., Kotchabhakdi N., Uneklabh T. Alterations of immune functions in heroin addicts and heroin withdrawal subjects. J. Pharmacol. Exp. Ther. 1998; 286: 883
  • Singhal Pravin C., Pan C., Gibbons N. Effect of Morphine on Uptake of immunoglobulin G complexes by mesangial cells macrophages. Am. J. Physiol. 1993; 264: F859
  • Keren O., Gioannini T. L., Hiller J. M., Simon E. J. Affinity crosslinking of 1251-labeled human beta-endorphin to cell lines possessing either mu-or delta-type opioid binding sites. Brain Res. 1988; 440: 280
  • Przewlocki R., Hassan A. H., Lason W., Epplen C., Hen A., Stein C. Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception. Neuroscience 1992; 48: 491
  • Machelska H., Cabot P. J., Mousa S. A., Zhang Q., Stein C. Pain Control in inflammation governed by selectins. Nat. Med. 1998; 4: 1425
  • Minoia P., Sciorsci R. L. II ruolo del calcio nelle patologie endorfino mediate. Meccanismi Biologici. Possibilità diagnostiche. Orientamenti terapeutici. Accademia Pugliese delle Scienze, Grafischena, Fasano. 1994
  • Stein C., Schafer M., Cabot P. J. Peripheral opioid analgesia. Pain Rev. 1997; 4: 171
  • Mousa S. A., Schafer M., Mitchell W. M., Hassan A. H.S., Stein C. Local upregulation of corticotropin releasing hormone and interleukin-1 receptors in rats with painful hindlimb inflammation. Eur. J. Pharmacol. 1996; 311: 221
  • Heijnen C. J., Kavelaars A., Ballieux R. E. β-Endorphin: Cytokine and neuropeptide. Immunol. Rev. 1991; 119: 41
  • Kowalski J. Immunomodulatory action of class mu-, delta-and kappa-opioid receptor agonisks in mice. Neuropeptides 1998; 32: 301
  • Molotkovskaya I. M., Malyukova I. V., Zakharova L. A. Opioid agonist modulation of cytoplasmic free Ca++ level in concanavalin A-stimulated mouse lymphocytes. Biochemistry 1999; 64: 546
  • Buratti T., Scratzberger P., Dunzendorfer S., Manfreda S. E., Peachlaner C., Jannidis M., Sacerdote P., Panerai A. E., Wiedermann C. J. Decreased levels of beta-endorphin in circulating mononuclear leukmyte from patients with acute myocardial infarction. Cardiology 1998; 90: 43
  • Panerai A. E., Sacerdote P., Bianchi M., Manfredi B. Intermittent but not continuous inescapable footshock stress and intracerebroventricular interleukin-1 similarly affect immune responses and immunocyte beta-endorphin concentration in the rat. Int. J. Clin. Pharmacol. Res. 1997; 17: 115
  • Pike J. L., Smith T. L., Hauger R. L., Nicassio P. M., Patterson T. L., McClintick J., Costlow C., Irwin M. R. Chronic life stress alters sympathetic, neuroendocrine and immune responsivity to an acute psychological stressor in humans. Psychosom. Med. 1997; 59: 447
  • Jonsdottir I. H., Hoffmann P., Thoren P. Physical exercise, endogenous opioids and immune function. Acta Physiol. Scand. Suppl. 1997; 640: 47
  • De Riu P. L., Petmzi V., Caria M. A., Mameli O., Casu A. R, Nuvoli S., Spanu A., Madeddu G. Beta endorphin and cortisol levels in plasma and CSF following acute experimental spinal traumas. Physiol. Behav. 1997; 62: 1
  • Cruse J. M., Keith J. C., Bryant M. L., Jr, Lewis R. E., Jr. Immune system-neuroendocrine dysregulation in spinal cord injury. Immunol. Res. 1996; 15: 306
  • Aymerich M. S., Bengoechea-Alonso M. T., Lopez-Zabalza M. J., Santiago E., Lopez-Moratalla N. Inducible nitric oxide synphase (iNOS) expression in human monocytes triggered by beta-endorphin through an increase in cAMP. Biochem. Biophys. Res. Commun. 1998; 245: 717
  • Levinthal C. Messengers of Paradise: Opiates and the Brain. Doubleaday, New York 1988
  • Trafton J. A., Abbadie C., Marchand S., Mantyh P. W., Basbaum A. I. Spinal opioid analgesia: how critical is the regulation of substance P. Signaling. J. Neurosci. 1999; 19: 9642
  • Page C. P., Curtis M. J., Sutter M. C., Walker M. j.a., Hoffman B. Integrated pharmacology. Mosby, London 1997
  • Pu S., Horvath T. L., Diano S., Naftolin F., Kalra P. S., Kalra S. P. Evidence showing that beta-endorphin regulates cyclic guanosine 3′, 5′-monophosphate (cGMP) efflux: anatomical and functional support for an interaction between opiates and nitric oxide. Endocrinology 1997; 138: 1537
  • Wilderman M. J., Armestead W. M. Role of neuronal NO synthase in relationship between NO andopioids in hypoxia-induced pial artery dilation. Am. J. Physiol. 1997; 273: H1–807
  • Hauser K. F., Harris-White M. E., Jackson J. A., Opanashuk L. A., Carney J. M. Opioid disrupt Ca2+ homeostasis and induced carbonyl oxyradical production in mouse astrocytes in vitro: transient increase and adaptation to sustained exposure. Exp. Neurol. 1998; 151: 70
  • Sciorsci R. L., Lacalandra G., Minoia P. Evoluzione terapeutica in clinica della riproduzione. Atti S.I.B. 1996; 28: 473
  • Can J. A. β-endorphin inhibition of endogenous norepinephrine release from the A2 noradrenergic nucleus in vitro: role of mu opiate receptors and Na+ ion permeability. Brain Res. Bull 1997; 4: 19
  • Evans C. J., Keith D. E., Morrison H., Magendzo K., Edwards R. H. Cloning of a Delta Opioid Receptor by Functional Expression. Science 1992; 258: 1952
  • Barker R. A. Neuroscience. Ellis Horwood, New York 1991
  • Ehrenpreis S., Sicuteri F. Degradation of Endogenous Opioids: its Relevance in Human Pathology and Therapy. Raven Press, New York 1983
  • Curtis M. T., Lefer A. M. Actions of opioate antagonists with selective receptor interactions in hemorrhagic shock. Circ. Shock 1983; 10: 131
  • Panerai A. E., Martini A., Casanueva F., Petraglia F., Di Giulio A. M., Mantegazza P. Opiates and their antagonists modulate luteinizing hormone acting outside the blood brain barrier. Life Sci. 1983; 32: 1751
  • Ingram S. L., Williams J. T. Opioid inhibition of Ih via adenylyl cyclase. Neuron 1994; 13: 179
  • Bianchi C. P. Cell Calcium Butterworth 1968; 1111: 65
  • Bianchi C. P. Role of calcium channels in the sarcolemma and the sarcoplasmic reticulum in skeletal muscle functions. Adv. Exp. Med. Biol. 1992; 311: 237
  • Sarada B., Thiele D., Dang T., Safavi A., Hersh L. B., Cottam G. L. Increased expression of an endopeptidase (gamma-EGE/IDE) hydrolyzing beta-endorphin during differentation and maturation of bone marrow macrophages. J. Leukoc. Biol. 1997; 62: 753
  • Meng Q. C., Oparil S. Purification and assay methods for angiotensin-converting enzyme. J. Chromatogr. A 1996; 743: 105
  • Turner A. Neuropeptides and their peptidases. Ellis Horwood, New York 1987
  • Puig M. M., Pol O. Peripheral effects of opiods in a model of chronic intestinal inflammation in mice. J. Pharmacol. Exp. Ther. 1998; 287: 1068
  • Hopson J., Wessells N. Essentials of Biology. McGraw-Hill Publishing Co., New York 1990
  • Cesselin F., Benoliel J. J., Bourgoin S., Collin E., Phol M., Hamon M. in Opioids in pain control, C. Stein. University Press, Cambridge 1999; 70
  • Suh H. W., Song D. K., Choi S. R., Huh S. O., Kim Y. H. Differential effects of omega-conotoxin GVIA, nimodipine calmidazolium and KN-62 injected intrathecally on the antinociception induced by beta-endorphin morphin, and [D-Ala2, N-MePhe4, Gly-o15]-enkephalin administered intracerebroventricularly in the mouse. J. Pharmacol. Exp. Ther. 1997; 282: 961
  • Sacerdote P., Bianchi M., Panerai A. E. Involvement of beta-endorphin in the modulation of paw inflammatory edema in the rat. Regul. Pept. 1996; 63: 79
  • Abdulla F. A, Smith P. A. Axotomy reduces the effect of analgesic opioids yet increases the effect of nociceptin on dorsal root ganglion neurons. J. Neurosci. 1998; 18: 9685
  • Kalra S. P., Sahu A., Kalra P. S. Ageing of the neuropeptidergic signals in rats. J. Reprod. Fert. Suppl. 1993; 46: 11
  • Ghosh B. R., Wu J. C., Miller W. L. GnRH stimulated Ca++ mobilization is absent in anestrous ewe pituitaries. Biol. Reprod. 1994; 50((1 suppl))170, [Abstr. 462]
  • De Marinis L., Mancini A., Valle D., Fiumara C., Conte G., Bianchi A., Perrelli M., Gentinella R., Giustina A. Physiological role of the opioid-cholinergic interaction in growth hormone neuroregulation: effect of sex and food intake. Metabolism 1997; 46: 740
  • Amos M. L., Smith M. E. The effect of pyridostigmine administration on the expression of pro-opiomelanocortin-derived peptides in motoneurones. Neurotoxicology 1998; 19: 799
  • Yokotani K., Osumi Y. Involvment of mu-receptor in endogenous opioid peptide-mediated inhibition of acetylcholine release from the rat stomach. Jpn. J. Pharmacol. 1998; 78: 93
  • Pau K. Y., Spies H. G. Neuroendocrine signals in the regulation of gonadotropin-releasing hormone secretion. Chin. J. Phisiol. 1997; 40: 181
  • Laxmi N. A., Vijayan E. Effects of chronic systemic administration of opioid peptides, naloxone and n-acetyl betaendorphin antiserum on gonadotropins and testicular functions in the rat. Indian J. Exp. Biol. 1998; 36: 361
  • Yamauchi N., Shibasaki T., Wakabayashi I., Demura H. Brain beta-endorphin and other opioids are involved in restraint stress-induced stimulation of the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system, and the adrenal medulla in the rat. Brain Res. 1997; 777: 140
  • Ornstein R., Swencionis C. The Healing Brain. The Guiford Press, NewYork 1991
  • Troullos E., Haargreaverss K. M., Donne R. A. Ibuprofen elevates immunoreactive beta-endorphin levels in humans during surgical stress. Clin. Pharmacol. Ther. 1997; 62: 74
  • Kjaer A. Neurohypphysial peptides. Histaminergic regulation and function in adenohypophysial secretion. Dan. Med. Bull 1996; 43: 391
  • Jessop D. S., Douthwaite J. A., Conde G. L., Lightman S. L., Dayan C. M., Harbuz M. S. Effects of acute stress or centrally injected interleukin-lbeta on neuropeptide expression in the immune system. Stress 1997; 2: 133
  • Legakis I., Saramantis A., Voros D., Chalevelakis G., Tolis G. Dissociation of ACTH, beta-endorphin and cortisol in graded sepsis. Horn. Metab. Res. 1998; 30: 570
  • Berczi I., Chalmers I. M., Nagy E., Warrington R. J. The immune effects of neuropeptides. Baillieres Clin. Rheumatol. 1996; 10: 227
  • Berridge M. J., Bootman D. M., Lipp P. P. Calcium-a life and death signal. Nature 1998; 395: 645
  • Means A R. Calcium, calmodulin and cell cycle regulation. FEBS Lett. 1994; 347: 1
  • Sheng M., Thompson M. A., Greenberg M. E. CREB: a Ca2+ regulated transcription factor phosphorylated by calmodulin dependent kinases. Science 1991; 252: 1427
  • Bading H., Ginty D. D., Greenberg M. E. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 1993; 260: 181
  • Negulescu P. A., Shastri N., Cahalan M. D. Intracellular calcium dependence of gene expression in single T lymphocytes. Proc. Natl. Acad. Sci. 1994; 91: 2873
  • Bums K., Duggan B., Atkinson E. A., Famulski K. S., Nemer M., Bleackley R. C., Michalak M. Modulation of gene expression by calreticulin binding to the glucocorticoid receptor. Nature 1994; 367: 476
  • Nicotera P., Zhivotovsky B., Orrenius S. Nuclear calcium transport and the role of calcium in apoptosis. Cell calcium 1994; 16: 279
  • Yin D., Mufson R. A., Wang R., Shi Y. Fas-mediated cell death promoted by opioids. Nature 1999; 397: 218
  • Shy Y. F., Sahai B. M., Green D. R. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and Thymocytes. Nature 1989; 339: 625
  • Brunner T., Mogil R. J., LaFace D., Yoo N. J., Mahboubi A., Echeverri F., Martin S. J., Force W. R., Lynch D. H., Ware C. F., Green D. R. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 1995; 373: 441
  • Ghosh A., Greenberg M. E. Calcium signaling in neurons: molecular mechanism and cellular consequences. Science 1995; 268: 239
  • Clapham D. E. Calcium signaling. Cell 1995; 80: 259
  • Dolmetsch R. E., Levis R. S., Goodnow C. C., Healy J. I. Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature 1997; 386: 855
  • Bauerle P. A., Henkel T. Function and activation of NF-kB in the immune system. Annu. Rev. Immunol. 1994; 12: 141
  • Su B., Jacinto E., Hibi M., Kallunki T., Karin M., Ben-Neriah Y. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 1994; 77: 727
  • Karin M., Hunter T. Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr. Biol. 1995; 5: 747
  • Rao A. NF-ATp: a transcription factor required for the coordinate induction of several cytokine genes. Immunol. Today 1994; 15: 274
  • Healy J. I., Dolmetsch R. E., Timerman L. A., Cyster J. G., Thomas M. L., Crabtree G. R., Lewis R. S., Goodnow C. C. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity 1997; 6: 419
  • Segal M., Manor D. Confocal microscopic imaging of [Ca2+], in cultured rat hippocampal neurons following exposure to N-methyl D-aspartate. J. Physiol. 1992; 448: 655
  • Dolmetsch R. E., Xu K., Lewis R. S. Calcium oscillations increase the efficiency and specificity of gene expression. Nature 1998; 392: 933
  • O'Malley D. M. Calcium permeability of the neuronal nuclear envelope: evaluation using confocal voluines and intracellular perfusion. J. Neurosci 1994; 14: 5741
  • Hardingham G. E., Chawla S., Johnson C. M., Bading H. Distint functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature 1997; 385: 260
  • Jensen K. F., Ohmstede C. A., Fisher R. S., Sahyoun N. Nuclear and axonal localization of Ca2+/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex. Roc. Natl. Acad. Sci. 1991; 88: 2850
  • Miranti C. K., Ginty D. D., Huang G., Chatila T., Greenberg M. E. Calcium activates serum response factor-dependent transcription by a Ras and Elk-1 independent mechanism that involves a Ca2+/calmodulin-dependent kinase. Mol. Cell. Biol. 1995; 15: 3672
  • Albillos A., Carbone E., Gandia L., Garcia A. G., Pollo A. Opioid inhibition of Ca2+ channel subtypes in bovine chromaffin cells: selectivity of action and voltage-dependence. Eur. J. Neurosci. 1996; 8: 1561
  • Brown E. M., Gamba G., Riccardi D., Lombard M., Butters R., Kifor O., Sun A., Hediger M. A., Lytton J., Hebert S. C. Cloning and characterization of an extracellular Ca (2+) sensing receptor from bovine parathyroid. Nature 1993; 366: 575
  • Tsukamoto K., Watanabe I., Shiba T., Emi M. Isolation and radiation hybrid mapping of a dinucleotide repeat polymorphism at the human calcium-sensing receptor (CASR) locus. J. Hum. Genet. 1998; 43: 280
  • Nielsen P. K., Rasmussen A. K., Butters R., Feldt-Rassmussen U., Bendtzen K., Dim R., Brown E. M., Olgaard K. Inhibition of PTH secretion by interlukin-1 beta in bovine parathyroid glands in vitro is associated with an up-regulation of the calcium-sensing receptor mRNA. Biochem. Biophys. Res. Commun. 1997; 238: 880
  • Chattopadhyay N., Mithal A., Brown E. M. The calcium sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism. Endocr. Rev. 1996; 17: 289
  • Cheng I., Klingensmith M. E., Chattopadhyay N., Kifor O., Butters R. R., Soybell D. I., Brown E. M. Identification and localization of the extracellular calcium-sensing receptor in human breast. J. Clin. Endocrinol. Metab. 1998; 83: 703
  • Hebert S. C., Brown E. M, Harris H. W. Role of the Ca (2+)-sensing receptor in divalent mineral ion homeostasis. J. Exp. Biol. 1997; 200: 295
  • Chattopadhyay N., Ye C. P., Yamaguchi T., Kifor O., Vassilev P. M., Nishimura R., Brown E. M. Extracellular calcium-sensing receptor in rat oligodendrocytes: expression and potential role in regulation of cellular proliferation and an outward K+ channel. Glia 1998; 24: 449
  • Brown E. M., Pollak M., Chou Y. H., Seidman C. E., Seidman J. G., Hebert S. C. Cloning and functional characterization of extracellular Ca (2+)-sensing receptors from parathyroid and kidney. Bone 1995; 17: 7S
  • McNeil L., Hobson S., Nipper V., Rodland K. D. Functional calcium-sensing receptor in ovarian surface epithelial cells. Am. J. Obstet. Gynecol. 1998; 178: 305
  • McGehee D. S., Aldersberg M., Liu K. P., Hsuing S., Heath M. J., Tamir H. Mechanism of extracellular Ca2+ receptor-stimulated hormone release from sheep thyroid parafollicular cells. J. Physiol. 1997; 502: 31
  • Rutherford J. D. Pharmacologic management of angina and acute myocardial infarction. Am. J. Cardiol. 1993; 72: 16C
  • Furberg C. D., Psaty B. M., Meyer J. V. Nifedipine. Dose-related increase in mortality in patients with coronary heart disease. Circulation 1995; 92: 1326
  • Sciorsci R L., Minoia P. Nuova ipotesi etiopatogenetica. del collasso puerperale nella Bovina, Proceedings 18th World Buiatrics Congress 1994; 1: 337
  • Moises H. C., Rusin K. I., Macdonald R. L. Mu and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons. J. Neurosci. 1994; 14: 5903
  • Osawa T., Nakao T., Moriyoshi M., Nakada K. Plasma beta-endorphin around parturition and its relationship to cortisol level and resumption of pituitary and ovarian functions in dairy cows. Anim. Reprod. Sci. 1998; 52: 27
  • Hydbring E., Madej A., MacDonald E., Drugge-Boholm G., Berglund B., Olsson K. Hormonal changes during parturition in heifers and goats are related to the phases and severity of labour. J. Edocrinol. 1999; 160: 75
  • Minoia P., Sciorsci R. L. Studio del collasso puerperale. Contributo Casistico. Ulteriore valutazione etiopatogenetica. Atti S.I.B. 1995; 27: 231
  • Minoia P., Caira M., Dell'Aquila M. E., Sciorsci R. L. High level of endogenous opioid peptides (EOP) as a risk factor for milk fever, accepted at the 14th. International Congress on Animal Reproduction. Stockholm 2000
  • Andre R. A. Sudden death following naloxone administration. Anesth. Analg. 1980; 59: 782
  • Smith G., Pinnock C. Naloxone paradox or panacea. Br. J. Anesth. 1985; 57: 547
  • Lograno M. D., Daniele E., Sciorsci R. L., Minoia P. The opioid antagonist Naloxone controls L-Type calcium channel activity, 1st World Congress on Calcium and. Vitamin D in Human Life 1996; 12, Abstr.
  • Buzas B., Rosenberger J., Cox B. M. Ca2+/calmodulin dependent transcriptional activation of dclta-opioid receptor gene expression induced by membrane depolarization in NG108–15 cells. J. Neurochem. 1998; 70: 105
  • Bell J. A. Selective blockade of spinal reflexes by omega-conotoxin in the isolated spinal cord of the neonatal rat. Neuroscience 1993; 52: 711
  • Carabelli V., Lovallo M., Magnelli V., Zucker H., Carbone E. Voltage-dependent modulation of single N-Type Ca2+ channel Kinetics by receptor agonists in IMR32 cells. Biophys. J. 1996; 70: 2144
  • Adams D. J., Trequattrini C. Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons. J. Neurophysiol. 1998; 79: 753
  • Vallar L., Vicentini L. in Farmacologia generale e molecolare, R. Paoletti, S. Nicosia, F. Clemeiiti, G. Fumagalli. UTET, Torino 1996; 60
  • Graves C. R. in The Pharmacological Basis Of Therapeutics, J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Rubdon, A. Goodman, Gilman. McGraw-Hill, Inc., New York 1996; 939
  • Wang D., Sadee W., Quillan J. M. Calmodulin binding to G protein-coupling domain of opioid receptors. J. Biol. Chem. 1999; 274: 22081
  • Steinhoff M., Vergnolle N., Young S. H., Tognetto M., Amadesi S., Ennes H. S., Trevisani M., Hollenberg M. D., Wallace J. L., Caughey G. H., Mitchell S. E., Williams L. M., Geppetti P., Mayer E. A., Bunnett N. W. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat. Med. 2000; 6: 151
  • Patel V. K., Abbott L. C., Rattan A. K., Tejwani G. A. Increased methionine-enkephalin levels in genetically epileptic (tg/tg) mice. Brain Res. Bull 1991; 27: 849
  • Smith M. E., Hughes S. Pro-opiomelanocortin neuropeptide receptors on developing and dystrophic muscle fibers. Mol. Chem. Neuropathol. 1993; 19: 137
  • Weld J. M., Kamerling S. G., Combie J. D., Nugent T. E., Woods W. E., Oeltgen P., Tobin T. The effects of Naloxone on endotoxic and hemorrhagic shock in horses. Res. Commun. Chem. Pathol. Pharmacol. 1984; 44: 227
  • Slominski A., Paus R., Wortsman J. On the potential role of proopiomelanocortin in skin physiology and pathology. Mol. Cell. Endocrinol. 1993; 93: C1
  • Chatikhine V. A., Delpech B., Duval C., Chauzy C., d'hiou J., Chevrier A. Expression of β-endorphin in human breast cancer and adenofibromas. Ann. N.Y. Acad. Sci. 1993; 680: 473
  • Minoia P., Zanghi A., Sciorsci R. L., Gimbo A. Immunoistochemical demonstration of b-endorphin in mammary tumours in the bitch, Proceedings: 25th World Veterinary Congress WVA. WSAVA, Yokohama 1995, Abstr. PS12.2
  • Chemushenko E. F. Immunodeficency states in lung diseases and the possible ways for their correction. Lik Sprava 1992; 3: 6
  • Sundar K. S., Kamaraju L. S., Dingfelder J., McMahon J., Gollapudi S., Wilson W. H., Kong L. Y., Hong J. S., Weiss J. M., Lee J. E. β-endorphin enhances the replication of neurotropic human immudeficiency virus in fetal perivascular microglia. J. Neuroimmunol. 1995; 6: 97
  • Perez-Castrillon J. L, Perez-Arellano J. L., Garcia-Palomo J. D., Jimenez-Lopez A, De-Castro S. Opioids depress in vitro human monocyte chemotaxis. Immunopharmacology 1992; 23: 57
  • Kawashinia S., Fukutake N., Nishian K., Asakuma S., Iwasaki T. Elevated plasma β-endorphin levels in patients with congestive heart failure. J. Am. Coll. Cardiol. 1991; 17: 53
  • Koiwa M., Shiga H., Nakamura H., Yoshino S. Role of opioid peptide in rheumatoid arthritis–detection of β-endorphin in synovial tissue. Arerugi 1992; 41: 1423
  • Guillemin R. Peptides in the brain: the new endocrinology of the neuron. Science 1978; 202: 390
  • Booth N. H., Mc Donald L. E. Farmacologia e terapeutica veterinaria. EMSI, Roma 1991
  • Oka T. 5-HT and narcotic induced hypotermia. Gen. Pharmacol. 1978; 9: 151
  • Shemano I., Wendel H. Effects of nieperidine hydrochloride and morphhe sulfate on the lung capacity of intact dogs. J. Phannacol. Exp. Ther. 1965; 149: 379
  • Goldstein A. Heroin addiction: neurobiology, pharmacology, and policy. J. Psychoactive Drugs 1991; 23: 123
  • Flacke J. W., Flacke W. E., Williams G. D. Acute pulmonary, edema following naloxone reversal of high dose morphine anesthesia. Anesthesiology 1977; 47: 376
  • Paoletti R., Nicosia S., Clementi F., Fumagalli G. Neuropsicofarmacologia. UTET, Torino 1998
  • Plumb D. C. Veterinary Drug Handbook. Iowa State University Press, Ames 1999
  • Casavola V., Guerra L., Reshkin S. J., Camosino M., Di Sole F., Sciorsci R. L., Minoia P. The effect of Naloxone on intracellular calcium in epithelial cell system. Ist. World Congress on Calcium and Vitamin D in Human life 1996; 11, Abstr.
  • Prie D., Friedllander G., Coureau C., Vandewalle A, Cassingena R., Ronco P. M. Role of adenosine on glugagon-induced cAMP in human cortical collecting duct cell line. Kidney Int. 1995; 47: 1310
  • Albrizio M., Dell'Aquila M. E., Sciorsci R. L., Maritato F., Minoia P. Effects of naloxone on bovine in vitro maturation and opioids μ-preceptor gene expression in the cumulus-oocyte complex. Theriogenology 2000; 53: 446
  • Guerra L., Casavola V., Dell'Aquila M. E., Sciorsci R. L., Albrizio M., Minoia P. Naloxone and β-endorphins increase intracellular calcium in cumulus cells of bovine oocytes, accepted at Symposium Calcium as a Molecule for Cellular Integration, UK 2000
  • Dell'Aquila M. E., Albrizio M., Zarrilli A., Sciorsci R. L., Manitato F., Minoia P. Effects of β-Endorphin on in vitro maturation of bovine oocytes, accepted at the 14th International Congress on Animal Reproduction. Stockholm 2000
  • Minoia P., Guena L., Reshkin S. J., Di Sole F., Bagorda A., Albrizio M., Sciorsci R. L., Casavola V. Naloxone increases calcium via mobilization of intracellular stores and the opening of calcium channels in a renal cell line derived from xenopus laevis, accepted at Symposium Calcium as a Molecule for Cellular Integration, UK 2000
  • Zanghi A., Gimbo A., Nicotina P A, Sciorsci R. L. Localizzazione immunoistochimica di β-endorfina nel testicolo di cavallo. Atti S.I.S. Vet. 1997; 51: 515
  • Zanghi A, Gimbo A., Nicotina P. A., Mmoia P., Sciorsci R. L., Ferm D. β-endorphin immunoistochemistry in equine female genital tract, Annual Meeting selcted abstracts. AMoI 1999; vol.1: 1631, Abstr.
  • Mason R. P., Leeds P. R., Jacob R. F., Hough C. J., Zhang K. G., Mason P. E., Chuang D. M. Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells. J. Neurochem. 1999; 72: 1448
  • Sciorsci R. L., Albrizio M., Dell'Aquila M. E., Cinone M., Aiudi G., Lacalandra G. M., Ricci L., Minoia P. Follicular growth in anestrus mares treated with naloxone and calcium: role of opioids in the control of apoptosis in granulosa cells. Theriogenology 2000; 53: 382
  • Lacalandra G. M., Sciorsci R. L., Ricci L., Minoia P. Effects of Naloxone and calcium administration on ovarian activity in anestrus mares. Theriogenology 2000; 53: 374
  • Minoia P., Sciorsci R. L., Dell'Aquila M. E. Effects of naloxone on calcium turnover in cows affected by milk fever. submitted to Theriogenology 2000
  • Sciorsci R. L., Robbe D., Di Matteo A., Lacalandra G. M., Minoia P. Treatment of ovarian follicular cysts in dairy cows with epidural calcium-naloxone and systemic GnRH administration: a preliminary field study, accepted at the 14th International Congress on Animal Reproduction. Stockholm 2000
  • Sciorsci R. L., Robbe D., Cavalli A., Buonavoglia D., Minoia P. Interazione tra oppioidi endogeni ed immunità. Influenza di calcio e Naloxone sui livelli anticorpali in pecore vaccinate nei confronti dell'lBR, Atti 13th Congresso Nazionale S.I.P.A.O.C. 1998; 150
  • Cinone M., Farstad W., Fougner J. A., Sanson G., Sciorsci R. L., Minoia P. Induction of Oesrus in the silver fox (Vulpes vulpes) by means of HCG, opioid antagonist and calcium, Proceedings: 23th congress of the World small animal veterinary association 1998; 2: 740, Abstr.p. 314
  • Robbe D., Lacalandra G., Zarrilli A., Campanella F., Sciorsci R. L. Livelli di idrossiprolina serica e monitoraggio clinico dell' involuzione uterina in bovine trattate con Naloxone e calcio. Atti S.I.B. 1999; 31: 231
  • Minoia P. Deficit di calcio nell'intervallo parto concepimento nella bovina. Atti S.I.B 1999; 31: 228
  • Cinone M., Aiudi G., Lacalandra G. M., Sciorsci R. L. Accrescimento follicolare nella cagna mediante modulazione neuroendocrina. Atti S.I.S. Vet. 1999; 53: 99
  • Minoia P., Sciorsci R. L. Somministrazione epidurale di calcio gluconato e Naloxone. Attivia terapeutica in van processi fisiopatologici. Atti S.I.S. Vet. 1999; 53: 87
  • Hirst G. A calcium window to the gut. Nature 1999; 399: 16
  • Daniel E. E., Fox-Threlkeld J. E.T. in Advances in the innervation of the gastrointestinal tract, G. H. Holle, J. D. Wood. Elsevier, Amsterdam 1992; 329
  • Kummerle J. F., Grider J. R., Murthy K. S., Souquet J. C., Hellstrom P., Martin D. C., Makjlouf G. M. in Advances in the innervation of the gastrointestinal tract, G. H. Holle, J. D. Wood. Elsevier, Amsterdam 1992; 341
  • Bagnol D., Mansour A., Akil H., Waston S. J. Localization of mu and kappa opioid receptors in ral colon by antibodies to the cloned opioid receptors. Analgesia 1995; 1: 4
  • Bagnol D., Mansour A., Akil H., Waston S. J. Cellular localization and distribution of the cloned mu and kappa receptors in rat colon gastrointestinal tract. Neuroscience 1997; 81: 579
  • Sciorsci R. L., Zanilli A., Console A., Giannandrea B., Minoia P. Influence of Naloxone on calcium turnover in women, 3rd International Symposium Women's Health and Menopause 1998; 68, Abstr.
  • Sciorsci R. L., Zanilli A, Console A., Giannandrea B., Minoia P. Influence of Naloxone in postmenopausal women, accepted at Symposium Calcium as a Molecule for Cellular Integration, UK 2000
  • Przewlocki R, Parsons K. L., Sweeney D. D., Trotter C., Netzeband J. G., Siggins G. R, Gruol D. L. Opioid enhancement of calcium oscillations and burst events involving NMDA receptors and L-type calcium channels in cultured hippocampal neurons. J. Neurosci. 1999; 19: 9705

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