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Research Article

Peritoneal adhesions in human and veterinary medicine: from pathogenesis to therapy. A review

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Pages 481-494 | Received 06 Oct 2009, Accepted 02 Dec 2009, Published online: 03 Feb 2010

References

  • Molinas, C.R., Binda, M.M., Koninckx, P.R. Angiogenic factors in peritoneal adhesion formation. Gynecol. Surg. 2006, 3, 157–167.
  • American Society for Reproductive Medicine. Pathogenesis, consequences and control of peritoneal adhesions in gynaecologic surgery. Fertil. Steril. 2007, 88, 21–26.
  • DeWilde, R.L., Trew, G. Postoperative abdominal adhesions and their prevention in gynaecological surgery. Expert consensus position. Part 2—Steps to reduce adhesions. Gynecol. Surg. 2007, 4, 243–253.
  • Fu, F., Hou, Y., Jiang, W., Wang, R., Liu, K. Escin: inhibiting inflammation and promoting gastrointestinal transit to attenuate formation of postoperative adhesions. World. J. Surg. 2005, 29, 1614–20, discussion 1621.
  • Diamond, M.P., Nezhat, F. Adhesions after resection of ovarian endometriomas. Fertil. Steril. 1993, 59, 934–5, author reply 935.
  • Wallwiener, M., Brucker, S., Hierlemann, H., Brochhausen, C., Solomayer, E., Wallwiener, C. Innovative barriers for peritoneal adhesion prevention: liquid or solid? A rat uterine horn model. Fertil. Steril. 2006, 86, 1266–1276.
  • diZerega, G.S. Peritoneum, peritoneal healing and adhesion formation. In: diZerega, G.S. (ed.) Peritoneal Surgery. New York: Springer, Berlin Heidelbergh, 2006, pp. 3–38.
  • Chegini, N., Rossi, M.J., Holmdahl, L. Cellular distribution of 5-lipoxygenase and leukotriene receptors in postsurgical peritoneal wound repair. Wound. Repair Regen. 1997, 5, 235–242.
  • Mueller, P.O.E. Advances in prevention and treatment of intra-abdominal adhesions in horses. Clin. Tech. Equine Pract. 2002, 1, 163–173.
  • Lu, H.R., Wu, Z., Pauwels, P., Lijnen, H.R., Collen, D. Comparative thrombolytic properties of tissue-type plasminogen activator (t-PA), single-chain urokinase-type plasminogen activator (u-PA) and K1K2Pu (a t-PA/u-PA chimera) in a combined arterial and venous thrombosis model in the dog. J. Am. Coll. Cardiol. 1992, 19, 1350–1359.
  • Bigatti, G., Boeckx, W., Gruft, L., Segers, N., Brosens, I. Experimental model for neoangiogenesis in adhesion formation. Hum. Reprod. 1995, 10, 2290–2294.
  • Gleadle, J.M., Ratcliffe, P.J. Hypoxia and the regulation of gene expression. Mol. Med. Today 1998, 4, 122–129.
  • Chegini, N. Peritoneal molecular environment, adhesion formation and clinical implication. Front. Biosci. 2002, 7, e91–115.
  • Slavin, J. The role of cytokines in wound healing. J. Pathol. 1996, 178, 5–10.
  • Cahill, R.A., Redmond, H.P. Cytokine orchestration in post-operative peritoneal adhesion formation. World J. Gastroenterol. 2008, 14, 4861–4866.
  • Ward, P.A., Lentsch, A.B. The acute inflammatory response and its regulation. Arch. Surg. 1999, 134, 666–669.
  • Rodgers, K.E., diZerega, G.S. Modulation of peritoneal re-epithelialization by postsurgical macrophages. J. Surg. Res. 1992, 53, 542–548.
  • Vural, B., Cantürk, N.Z., Esen, N., Solakoglu, S., Cantürk, Z., Kirkali, G., Sökmensüer, C. The role of neutrophils in the formation of peritoneal adhesions. Hum. Reprod. 1999, 14, 49–54.
  • ten Raa S., van den Tol M.P., Sluiter W., Hofland L.J., van Eijck C.H., Jeekel H. The role of neutrophils and oxygen free radicals in post-operative adhesions. J. Surg. Res. 2006, 136, 45–52.
  • Otterness, I.G., Chang, Y.H. Comparative study of cyclophosphamide, 6-mercaptopurine, azathiopurine and methotrexate. Relative effects on the humoral and the cellular immune response in the mouse. Clin. Exp. Immunol. 1976, 26, 346–354.
  • Zagorski, J., Wahl, S.M. Inhibition of acute peritoneal inflammation in rats by a cytokine-induced neutrophil chemoattractant receptor antagonist. J. Immunol. 1997, 159, 1059–1062.
  • Walzog, B., Scharffetter-Kochanek, K., Gaehtgens, P. Impairment of neutrophil emigration in CD18-null mice. Am. J. Physiol. 1999, 276, G1125–G1130.
  • Binda, M.M., Molinas, C.R., Koninckx, P.R. Reactive oxygen species and adhesion formation: clinical implications in adhesion prevention. Hum. Reprod. 2003, 18, 2503–2507.
  • Alpay, Z., Saed, G.M., Diamond, M.P. Female infertility and free radicals: potential role in adhesions and endometriosis. J. Soc. Gynecol. Investig. 2006, 13, 390–398.
  • Fletcher, N.M., Jiang, Z.L., Diamond, M.P., Abu-Soud, H.M., Saed, G.M. Hypoxia-generated superoxide induces the development of the adhesion phenotype. Free Radic. Biol. Med. 2008, 45, 530–536.
  • de la Portilla F., Ynfante I., Bejarano D., Conde J., Fernandez A., Ortega J.M., Carranza G. Prevention of peritoneal adhesions by intraperitoneal administration of vitamin E: an experimental study in rats. Dis. Colon. Rectum. 2004, 47, 2157–2161.
  • Portz, D.M., Elkins, T.E., White, R., Warren, J., Adadevoh, S., Randolph, J. Oxygen free radicals and pelvic adhesion formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model. Int. J. Fertil. 1991, 36, 39–42.
  • Kovacs, E.J., DiPietro, L.A. Fibrogenic cytokines and connective tissue production. FASEB J. 1994, 8, 854–861.
  • Zeyneloglu, H.B., Senturk, L.M., Seli, E., Oral, E., Olive, D.L., Arici, A. The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation. Hum. Reprod. 1998, 13, 1194–1199.
  • DiPietro, L.A., Polverini, P.J., Rahbe, S.M., Kovacs, E.J. Modulation of JE/MCP-1 expression in dermal wound repair. Am. J. Pathol. 1995, 146, 868–875.
  • Arici, A., Oral, E., Attar, E., Tazuke, S.I., Olive, D.L. Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells. Fertil. Steril. 1997, 67, 1065–1072.
  • Chung, D.R., Chitnis, T., Panzo, R.J., Kasper, D.L., Sayegh, M.H., Tzianabos, A.O. CD4+ T cells regulate surgical and postinfectious adhesion formation. J. Exp. Med. 2002, 195, 1471–1478.
  • Dixon, A.E., Mandac, J.B., Madtes, D.K., Martin, P.J., Clark, J.G. Chemokine expression in Th1 cell-induced lung injury: prominence of IFN-gamma-inducible chemokines. Am. J. Physiol. Lung Cell Mol. Physiol. 2000, 279, L592–L599.
  • Laan, M., Cui, Z.H., Hoshino, H., Lötvall, J., Sjöstrand, M., Gruenert, D.C., Skoogh, B.E., Lindén, A. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J. Immunol. 1999, 162, 2347–2352.
  • Witowski, J., Pawlaczyk, K., Breborowicz, A., Scheuren, A., Kuzlan-Pawlaczyk, M., Wisniewska, J., Polubinska, A., Friess, H., Gahl, G.M., Frei, U., Jörres, A. IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells. J. Immunol. 2000, 165, 5814–5821.
  • Robson, R.L., McLoughlin, R.M., Witowski, J., Loetscher, P., Wilkinson, T.S., Jones, S.A., Topley, N. Differential regulation of chemokine production in human peritoneal mesothelial cells: IFN-gamma controls neutrophil migration across the mesothelium in vitro and in vivo. J. Immunol. 2001, 167, 1028–1038.
  • Cheong, Y.C., Shelton, J.B., Laird, S.M., Richmond, M., Kudesia, G., Li, T.C., Ledger, W.L. IL-1, IL-6 and TNF-alpha concentrations in the peritoneal fluid of women with pelvic adhesions. Hum. Reprod. 2002, 17, 69–75.
  • Zhdanov, A.V., Davydova, M.P., Gabuniya, T.G., Van’ko, L.V., Nazarenko, T.A., Kulakov, V.I., Sukhikh, G.T. Expression of cytokine genes in adhesions on uterine tubes. Bull. Exp. Biol. Med. 2002, 134, 467–470.
  • Kaidi, A.A., Nazzal, M., Gurchumelidze, T., Ali, M.A., Dawe, E.J., Silva, Y.J. Preoperative administration of antibodies against tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) and their impact on peritoneal adhesion formation. Am. Surg. 1995, 61, 569–572.
  • Berkkanoglu, M., Zhang, L., Ulukus, M., Cakmak, H., Kayisli, U.A., Kursun, S., Arici, A. Inhibition of chemokines prevents intraperitoneal adhesions in mice. Hum. Reprod. 2005, 20, 3047–3052.
  • Reckless, J., Tatalick, L.M., Grainger, D.J. The pan-chemokine inhibitor NR58-3.14.3 abolishes tumour necrosis factor-alpha accumulation and leucocyte recruitment induced by lipopolysaccharide in vivo. Immunology. 2001, 103, 244–254.
  • Basoglu, M., Kiziltunç, A., Akçay, F., Keles, S., Gündogdu, C., ören, D. Tumor necrosis factor-α and interleukin-6 in peritoneal adhesion formation. Tr. J. Med. Sci. 1998, 28, 253–258.
  • Tietze, L., Elbrecht, A., Schauerte, C., Klosterhalfen, B., Amo-Takyi, B., Gehlen, J., Winkeltau, G., Mittermayer, C., Handt, S. Modulation of pro- and antifibrinolytic properties of human peritoneal mesothelial cells by transforming growth factor beta1 (TGF-beta1), tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta). Thromb. Haemost. 1998, 79, 362–370.
  • Saba, A.A., Kaidi, A.A., Godziachvili, V., Dombi, G.W., Dawe, E.J., Libcke, J.H., Silva, Y.J. Effects of interleukin-6 and its neutralizing antibodies on peritoneal adhesion formation and wound healing. Am. Surg. 1996, 62, 569–572.
  • Chegini, N., Gold, L.I., Williams, R.S., Masterson, B.J. Localization of transforming growth factor beta isoforms TGF-beta 1, TGF-beta 2, and TGF-beta 3 in surgically induced pelvic adhesions in the rat. Obstet. Gynecol. 1994, 83, 449–454.
  • Williams, R.S., Rossi, A.M., Chegini, N., Schultz, G. Effect of transforming growth factor beta on postoperative adhesion formation and intact peritoneum. J. Surg. Res. 1992, 52, 65–70.
  • Hershlag, A., Otterness, I.G., Bliven, M.L., Diamond, M.P., Polan, M.L. The effect of interleukin-1 on adhesion formation in the rat. Am. J. Obstet. Gynecol. 1991, 165, 771–774.
  • te Velde A.A., Huijbens R.J., Heije K., de Vries J.E., Figdor C.G. Interleukin-4 (IL-4) inhibits secretion of IL-1 beta, tumor necrosis factor alpha, and IL-6 by human monocytes. Blood. 1990, 76, 1392–1397.
  • Holschneider, C.H., Cristoforoni, P.M., Ghosh, K., Punyasavatsut, M., Abed, E., Montz, F.J. Endogenous versus exogenous IL-10 in postoperative intraperitoneal adhesion formation in a murine model. J. Surg. Res. 1997, 70, 138–143.
  • Coleman, M.G., McLain, A.D., Moran, B.J. Impact of previous surgery on time taken for incision and division of adhesions during laparotomy. Dis. Colon Rectum 2000, 43, 1297–1299.
  • Van Der Krabben A.A., Dijkstra F.R., Nieuwenhuijzen M., Reijnen M.M., Schaapveld M., Van Goor H. Morbidity and mortality of inadvertent enterotomy during adhesiotomy. Br. J. Surg. 2000, 87, 467–471.
  • Marana, R., Muzii, L. Infertility and adhesions. In: DiZerega, G.S. (Ed.): Peritoneal surgery. New York, Springer-Verlag, pp. 329–333.
  • Miller, G., Boman, J., Shrier, I., Gordon, P.H. Etiology of small bowel obstruction. Am. J. Surg. 2000, 180, 33–36.
  • Oboh, A., Trehan, A.K. Pelvic adhesion formation at second look surgery after laparoscopic partial and total peritoneal excision for women with endometriosis. Gynecol. Surg. 2007, 4, 261–265.
  • The Practice Committee of the American Society for Reproductive Medicine. Endometriosis and infertility. Fertil. Steril. 2004, 81, 1441–1446.
  • Parker, J.D., Sinaii, N., Segars, J.H., Godoy, H., Winkel, C., Stratton, P. Adhesion formation after laparoscopic excision of endometriosis and lysis of adhesions. Fertil. Steril. 2005, 84, 1457–1461.
  • Lower, A.M., Hawthorn, R.J., Ellis, H., O’Brien, F., Buchan, S., Crowe, A.M. Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24046 patients. Hum. Reprod. 2000, 19, 1877–1885.
  • Pouly, J.L., Seak-San, S. Adhesions: laparoscopy versus laparotomy. In:DiZerega, G.S. (Ed.): Peritoneal surgery. New York, Springer-Verlag, 2006, pp. 183–192.
  • Elkelani, O.A., Binda, M.M., Molinas, C.R., Koninckx, P.R. Effect of adding more than 3% oxygen to carbon dioxide pneumoperitoneum on adhesion formation in a laparoscopic mouse model. Fertil. Steril. 2004, 82, 1616–1622.
  • Gray, R.I., Ott, D.E., Henderson, A.C., Cochran, S.A., Roth, E.A. Severe local hypothermia from laparoscopic gas evaporative jet cooling: a mechanism to explain clinical observations. JSLS. 1999, 3, 171–177.
  • Ott, D.E. Laparoscopy and tribology: the effect of laparoscopic gas on peritoneal fluid. J. Am. Assoc. Gynecol. Laparosc. 2001, 8, 117–123.
  • Volz, J., Köster, S., Spacek, Z., Paweletz, N. Characteristic alterations of the peritoneum after carbon dioxide pneumoperitoneum. Surg. Endosc. 1999, 13, 611–614.
  • Hazebroek, E.J., Schreve, M.A., Visser, P., De Bruin R.W., Marquet R.L., Bonjer H.J. Impact of temperature and humidity of carbon dioxide pneumoperitoneum on body temperature and peritoneal morphology. J. Laparoendosc. Adv. Surg. Tech. A 2002, 12, 355–364.
  • Molinas, C.R., Campo, R., Dewerchin, M., Eriksson, U., Carmeliet, P., Koninckx, P.R. Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil. Steril. 2003, 80 Suppl 2, 803–811.
  • Fenghua, F., Yuezhi, H., Wanglin, J., Ronghua, W., Ke, L. Escin: Inhibiting Inflammation and Promoting Gastrointestinal Transit to Attenuate Formation of Postoperative Adhesions. World J. Surg. 2005, 29, 1614–1620.
  • Binda, M.M., Molinas, C.R., Bastidas, A., Koninckx, P.R. Effect of reactive oxygen species scavengers, antiinflammatory drugs, and calcium-channel blockers on carbon dioxide pneumoperitoneum-enhanced adhesions in a laparoscopic mouse model. Surg. Endosc. 2007, 21, 1826–1834.
  • Oncel, M., Kurt, N., Remzi, F.H., Sensu, S.S., Vural, S., Gezen, C.F., Cincin, T.G., Olcay, E. The effectiveness of systemic antibiotics in preventing postoperative, intraabdominal adhesions in an animal model. J. Surg. Res. 2001, 101, 52–55.
  • De Iaco P.A., Muzzupapa, G., Bigon, E., Pressato, D., Donà, M., Pavesio, A., Bovicelli, L. Efficacy of a hyaluronan derivative gel in postsurgical adhesion prevention in the presence of inadequate hemostasis. Surgery. 2001, 130, 60–64.
  • Greene, A.K., Alwayn, I.P., Nose, V., Flynn, E., Sampson, D., Zurakowski, D., Folkman, J., Puder, M. Prevention of intra-abdominal adhesions using the antiangiogenic COX-2 inhibitor celecoxib. Ann. Surg. 2005, 242, 140–146.
  • Kim, S., Lee, S., Greene, A.K., Arsenault, D.A., Le, H., Meisel, J., Novak, K., Flynn, E., Heymach, J.V., Puder, M. Inhibition of intra-abdominal adhesion formation with the angiogenesis inhibitor sunitinib. J. Surg. Res. 2008, 149, 115–119.
  • Kilik, N. The effect of Aloe Vera gel on experimentally induced peritoneal adhesions in rats. Revue Med. Vet. 2005, 156, 409–413.
  • Duansak, D., Somboonwong, J., Patumraj, S. Effects of Aloe vera on leukocyte adhesion and TNF-alpha and IL-6 levels in burn wounded rats. Clin. Hemorheol. Microcirc. 2003, 29, 239–246.
  • Brolin, J., Lahnborg, G., Nord, C.E. The effect of one prophylactic dosage of antibiotics on experimentally induced lethal intraabdominal sepsis. Acta. Chir. Scand. 1984, 150, 239–244.
  • Heydrick, S.J., Reed, K.L., Cohen, P.A., Aarons, C.B., Gower, A.C., Becker, J.M., Stucchi, A.F. Intraperitoneal administration of methylene blue attenuates oxidative stress, increases peritoneal fibrinolysis, and inhibits intraabdominal adhesion formation. J. Surg. Res. 2007, 143, 311–319.
  • Ara, C., Kirimlioglu, H., Karabulut, A.B., Coban, S., Hascalik, S., Celik, O., Yilmaz, S., Kirimlioglu, V. Protective effect of melatonin against oxidative stress on adhesion formation in the rat cecum and uterine horn model. Life Sci. 2005, 77, 1341–1350.
  • Sogutlu, G., Karabulut, A.B., Ara, C., Cinpolat, O., Isik, B., Piskin, T., Celik, O. The effect of resveratrol on surgery-induced peritoneal adhesions in an experimental model. Cell Biochem. Funct. 2007, 25, 217–220.
  • Chien, C.T., Yu, H.J., Lin, T.B., Lai, M.K., Hsu, S.M. Substance P via NK1 receptor facilitates hyperactive bladder afferent signaling via action of ROS. Am. J. Physiol. Renal Physiol. 2003, 284, F840–F851.
  • Chen, W.C., Hayakawa, S., Shimizu, K., Chien, C.T., Lai, M.K. Catechins prevents substance P-induced hyperactive bladder in rats via the downregulation of ICAM and ROS. Neurosci. Lett. 2004, 367, 213–217.
  • Quinlan, K.L., Song, I.S., Naik, S.M., Letran, E.L., Olerud, J.E., Bunnett, N.W., Armstrong, C.A., Caughman, S.W., Ansel, J.C. VCAM-1 expression on human dermal microvascular endothelial cells is directly and specifically up-regulated by substance P. J. Immunol. 1999, 162, 1656–1661.
  • Reed, K.L., Heydrick, S.J., Aarons, C.B., Prushik, S., Gower, A.C., Stucchi, A.F., Becker, J.M. A neurokinin-1 receptor antagonist that reduces intra-abdominal adhesion formation decreases oxidative stress in the peritoneum. Am. J. Physiol. Gastrointest. Liver Physiol. 2007, 293, G544–G551.
  • Yeo, Y., Kohane, D.S. Polymers in the prevention of peritoneal adhesions. Eur. J. Pharm. Biopharm. 2008, 68, 57–66.
  • Reijnen, M.M., Skrabut, E.M., Postma, V.A., Burns, J.W., van Goor H. Polyanionic polysaccharides reduce intra-abdominal adhesion and abscess formation in a rat peritonitis model. J. Surg. Res. 2001, 101, 248–253.
  • Liu, Y., Li, H., Shu, X.Z., Gray, S.D., Prestwich, G.D. Crosslinked hyaluronan hydrogels containing mitomycin C reduce postoperative abdominal adhesions. Fertil. Steril. 2005, 83 Suppl 1, 1275–1283.
  • diZerega, G.S., Verco, S.J., Young, P., Kettel, M., Kobak, W., Martin, D., Sanfilippo, J., Peers, E.M., Scrimgeour, A., Brown, C.B. A randomized, controlled pilot study of the safety and efficacy of 4% icodextrin solution in the reduction of adhesions following laparoscopic gynaecological surgery. Hum. Reprod. 2002, 17, 1031–1038.
  • Reid, R.L., Hahn, P.M., Spence, J.E., Tulandi, T., Yuzpe, A.A., Wiseman, D.M. A randomized clinical trial of oxidized regenerated cellulose adhesion barrier (Interceed, TC7) alone or in combination with heparin. Fertil. Steril. 1997, 67, 23–29.
  • Carta, G., Cerrone, L., Iovenitti, P. Postoperative adhesion prevention in gynecologic surgery with hyaluronic acid. Clin. Exp. Obstet. Gynecol. 2004, 31, 39–41.
  • Franklin, R.R., Ovarian Adhesion Study Group. Reduction of nidation index on the Interceed side were significantly higher ovarian adhesions by the use of Interceed. Obstet. Gynecol. 1995, 86, 335–340.
  • Haney, A.F., Hesla, J., Hurst, B.S., Kettel, L.M., Murphy, A.A., Rock, J.A., Rowe, G., Schlaff, W.D. Expanded polytetrafluoroethylene (Gore-Tex Surgical Membrane) is superior to oxidized regenerated cellulose (Interceed TC7+) in preventing adhesions. Fertil. Steril. 1995, 63, 1021–1026.
  • Magro, B., Mita, P., Bracco, G.L., Coccia, E., Scarselli, G. Expanded polytetrafluoroethylene surgical membrane in ovarian surgery on the rabbit. Biocompatibility, adhesion prevention properties and ability to preserve reproductive capacity. J. Reprod. Med. 1996, 41, 73–78.
  • Jia, X., Colombo, G., Padera, R., Langer, R., Kohane, D.S. Prolongation of sciatic nerve blockade by in situ cross-linked hyaluronic acid. Biomaterials. 2004, 25, 4797–4804.
  • Kohane, D.S., Tse, J.Y., Yeo, Y., Padera, R., Shubina, M., Langer, R. Biodegradable polymeric microspheres and nanospheres for drug delivery in the peritoneum. J. Biomed. Mater. Res. A 2006, 77, 351–361.
  • Höckel, M., Ott, S., Siemann, U., Kissel, T. Prevention of peritoneal adhesions in the rat with sustained intraperitoneal dexamethasone delivered by a novel therapeutic system. Ann. Chir. Gynaecol. 1987, 76, 306–313.
  • Reid, R.L., Lie, K., Spence, J.E., Tulandi, T., Yuzpe, A. Clinical evaluation of the efficacy of heparin-saturated intercede for prevention of adhesion reformation in the pelvic sidewall of the human. In: Diamond M.P., diZerega G.S., Linsky C.B., Reid R.L. editors. Gynecologic surgery and adhesion prevention. Wiley-Liss Inc., New York, 1993, pp. 261–264.
  • Hill-West, J.L., Dunn, R.C., Hubbell, J.A. Local release of fibrinolytic agents for adhesion prevention. J. Surg. Res. 1995, 59, 759–763.
  • Chowdhury, S.M., Hubbell, J.A. Adhesion prevention with ancrod released via a tissue-adherent hydrogel. J. Surg. Res. 1996, 61, 58–64.
  • Harris, E.S., Morgan, R.F., Rodeheaver, G.T. Analysis of the kinetics of peritoneal adhesion formation in the rat and evaluation of potential antiadhesive agents. Surgery. 1995, 117, 663–669.
  • Palaia, I., Boni, T., Angioli, R., Muzii, L., Polidori, N.F., Andrei, N.F., Musella, A., De Oronzo, M.A., Guzzo, F. Benedetti, Panici, P. [Prevention of postoperative adhesions]. Minerva. Ginecol. 2009, 61, 57–66.
  • Davey, A.K., Maher, P.J. Surgical adhesions: a timely update, a great challenge for the future. J. Minim. Invasive Gynecol. 2007, 14, 15–22.
  • Phillips, T.J., Walmsley, J.P. Retrospective analysis of the results of 151 exploratory laparotomies in horses with gastrointestinal disease. Equine Vet. J. 1993, 25, 427–431.
  • Southwood, L.L., Baxter, G.M. Current concepts in management of abdominal adhesions. Vet. Clin. North Am. Equine Pract. 1997, 13, 415–435.
  • Kuebelbeck, K.L., Slone, D.E., May, K.A. Effect of omentectomy on adhesion formation in horses. Vet. Surg. 1998, 27, 132–137.
  • Lundin, C., Sullins, K.E., White, N.A., Clem, M.F., Debowes, R.M., Pfeiffer, C.A. Induction of peritoneal adhesions with small intestinal ischaemia and distention in the foal. Equine Vet. J. 1989, 21, 451–458.
  • Nieto, J.E., Snyder, J.R., Kollias-Baker, C., Stanley, S. In vitro effects of 5-hydroxytryptamine and cisapride on the circular smooth muscle of the jejunum of horses. Am. J. Vet. Res. 2000, 61, 1561–1565.
  • Cable, C.S., Fubini, S.L., Erb, H.N., Hakes, J.E. Abdominal surgery in foals: a review of 119 cases (1977-1994). Equine Vet. J. 1997, 29, 257–261.
  • Eggleston, R.B., Mueller, P.O. Prevention and treatment of gastrointestinal adhesions. Vet. Clin. North Am. Equine Pract. 2003, 19, 741–763.
  • Bouré, L.P., Pearce, S.G., Kerr, C.L., Lansdowne, J.L., Martin, C.A., Hathway, A.L., Caswell, J.L. Evaluation of laparoscopic adhesiolysis for the treatment of experimentally induced adhesions in pony foals. Am. J. Vet. Res. 2002, 63, 289–294.
  • Sullins, K.E., White, N.A., Lundin, C.S., Dabareiner, R., Gaulin, G. Prevention of ischaemia-induced small intestinal adhesions in foals. Equine Vet. J. 2004, 36, 370–375.
  • Parker, J., Fubini, S.L, Todhunter, R.J. Prevention of intra-abdominal adhesions in ponies by low dose heparin therapy. Vet. Surg. 1989, 18, 424–431.
  • Sahin, Y., Saglam, A. Synergistic effects of carboxymethylcellulose and low molecular weight heparin in reducing adhesion formation in the rat uterine horn model. Acta. Obstet. Gynecol. Scand. 1994, 73, 70–73.
  • Moll, H.D., Schumacher, J., Wright, J.C., Spano, J.S. Evaluation of sodium carboxymethylcellulose for prevention of experimentally induced abdominal adhesions in ponies. Am. J. Vet. Res. 1991, 52, 88–91.
  • Darmas, B. Use of barrier products in the prevention of adhesion formation following surgery. J. Wound Care 2008, 17, 405–8, 411.
  • Mueller, P.O., Hay, W.P., Harmon, B., Amoroso, L. Evaluation of a bioresorbable hyaluronate-carboxymethylcellulose membrane for prevention of experimentally induced abdominal adhesions in horses. Vet. Surg. 2000, 29, 48–53.
  • Wang, X.C., Gui, C.Q., Zheng, Q.S. Combined therapy of allantoin, metronidazole, dexamethasone on the prevention of intra-abdominal adhesion in dogs and its quantitative analysis. World J. Gastroenterol. 2003, 9, 568–571.
  • Jalali, F.S.S., Farshid, A.A., Saifzadeh, S., Javanmardi, S. Evaluation of topical application of honey in prevention of post-operative peritoneal adhesion formation in dogs. Iran. J. Vet. Res. 2006, 7, 59–62.
  • Molan, P.C. The role of honey in the management of wounds. J. Wound Care 1999, 8, 415–418.
  • Mathews, K.A., Binning, A.G. Wound management using honey. Compend. Con. Edu. 2002, 24, 53–59.
  • Chase, J.P., Beard, W.L., Bertone, A.L., Goltz, K. Open peritoneal drainage in horses with experimentally induced peritonitis. Vet. Surg. 1996, 25, 189–194.
  • van Goethem B., Schaefers-Okkens A., Kirpensteijn J. Making a rational choice between ovariectomy and ovariohysterectomy in the dog: a discussion of the benefits of either technique. Vet. Surg. 2006, 35, 136–143.
  • Scharl, A., Costa, S.D., Duell, N., Göhring, U.J., Gaetje, R. [Suspicion for intraabdominal adhesions – is open laparoscopy the gold standard?]. Zentralbl. Gynakol. 2005, 127, 380–384.
  • Ott, D.E. Laparoscopy and adhesion formation, adhesions and laparoscopy. Semin. Reprod. Med. 2008, 26, 322–330.
  • Schäfer, M., Krähenb hl L., Büchler, M.W. Comparison of adhesion formation in open and laparoscopic surgery. Dig. Surg. 1998, 15, 148–152.
  • Jorgensen, J.O., Lalak, N.J., Hunt, D.R. Is laparoscopy associated with a lower rate of postoperative adhesions than laparotomy? A comparative study in the rabbit. Aust. N. Z. J. Surg. 1995, 65, 342–344.
  • Molinas, C.R., Mynbaev, O., Pauwels, A., Novak, P., Koninckx, P.R. Peritoneal mesothelial hypoxia during pneumoperitoneum is a cofactor in adhesion formation in a laparoscopic mouse model. Fertil. Steril. 2001, 76, 560–567.
  • Volz, J., Kuster, S., Leweling, H. Surgical trauma and metabolic changes induced by surgical laparoscopy versus laparotomy. Gynecol. Endosc. 1997, 6, 1–6.
  • Taskin, O., Buhur, A., Birincioglu, M., Burak, F., Atmaca, R., Yilmaz, I., Wheeler, J.M. The effects of duration of CO2 insufflation and irrigation on peritoneal microcirculation assessed by free radical scavengers and total glutathion levels during operative laparoscopy. J. Am. Assoc. Gynecol. Laparosc. 1998, 5, 129–133.
  • Minoia, G., Rizzo, A., Mutinati, M., Spedicato, M., Roscino, M.T., Sciorsci, R.L. Comparison between Combined Laparoscopic-Open Ovariectomy (CLOO) and laparotomic ovariectomy. 16th International Congress on Animal Reproduction, 13–17 July 2008, Budapest, Hungary.
  • Sciorsci, R.L., Minoia, G., Trisolini, C., Manca, R., Rizzo, A., Minoia, P. Ovariectomia combinata nella cagna: laparoscopica e tradizionale. Proceedings 3rd National Congress of the Italian Society of Animal Reproduction 2005, Rome, Italy, pp. 1–5.

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