92
Views
29
CrossRef citations to date
0
Altmetric
Research Article

Sesquiterpene lactone fraction from Artemisia khorassanica inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression through the inactivation of NF-κB

, , , &
Pages 688-695 | Received 13 Dec 2009, Accepted 04 Feb 2010, Published online: 17 Mar 2010

References

  • Moncada, S., Palmer, R.M., Higgs, E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 1991, 43, 109–142.
  • Lee, S.H., Soyoola, E., Chanmugam, P., Hart, S., Sun, W., Zhong, H., Liou, S., Simmons, D., Hwang, D. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J. Biol. Chem. 1992, 267, 25934–25938.
  • Maier, J.A., Hla, T., Maciag, T. Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. J. Biol. Chem. 1990, 265, 10805–10808.
  • Di Rosa, M., Ialenti, A., Ianaro, A., Sautebin, L. Interaction between nitric oxide and cyclooxygenase pathways. Prostaglandins Leukot. Essent. Fatty Acids 1996, 54, 229–238.
  • Guslandi, M. Nitric oxide and inflammatory bowel diseases. Eur. J. Clin. Invest. 1998, 28, 904–907.
  • Ritchlin, C.T., Haas-Smith, S.A., Li, P., Hicks, D.G., Schwarz, E.M. Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J. Clin. Invest. 2003, 111, 821–831.
  • Simons, R.K., Junger, W.G., Loomis, W.H., Hoyt, D.B. Acute lung injury in endotoxemic rats is associated with sustained circulating IL-6 levels and intrapulmonary CINC activity and neutrophil recruitment–role of circulating TNF-alpha and IL-beta? Shock 1996, 6, 39–45.
  • Leach, M., Hamilton, L.C., Olbrich, A., Wray, G.M., Thiemermann, C. Effects of inhibitors of the activity of cyclo-oxygenase-2 on the hypotension and multiple organ dysfunction caused by endotoxin: a comparison with dexamethasone. Br. J. Pharmacol. 1998, 124, 586–592.
  • Makarov, S.S. NF-kappaB as a therapeutic target in chronic inflammation: recent advances. Mol. Med. Today 2000, 6, 441–448.
  • de Vera, M.E., Shapiro, R.A., Nussler, A.K., Mudgett, J.S., Simmons, R.L., Morris, S.M., Jr, Billiar, T.R., Geller, D.A. Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 1054–1059.
  • Castrillo, A., de Las Heras, B., Hortelano, S., Rodriguez, B., Villar, A., Bosca, L. Inhibition of the nuclear factor kappa B (NF-kappa B) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK. J. Biol. Chem. 2001, 276, 15854–15860.
  • Keifer, J.A., Guttridge, D.C., Ashburner, B.P., Baldwin, A.S. Jr. Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity. J. Biol. Chem. 2001, 276, 22382–22387.
  • Mabberley, D. J. The Plant-Book. A Portable Dictionary of the Higher Plants. Cambridge: Cambridge University Press, 1993, p. 45.
  • Ling, Y. R. The old world seriphidium (Compositae), Bulletin of the Botanical Laboratory of the North-Eastern Forestry Institute, 1991a, 11, 1–40.
  • Ling, Y. R. The Old World Artemisia (Compositae). Bulletin of the Botanical Laboratory of the North-Eastern Forestry Institute, 1991b, 12, 1–108.
  • Mozaffarian, V. Compositae: Authemideae & Echinopeae, In M., Assadi (Eds.), Flora of Iran (in Persian). Tehran: Research institute of forests and rangelands publications, 2005, 199–260.
  • Emami, S.A., Aghazari, F. Les Phanerogames endemiques de la flore d’Iran, Publications de I’Université d’Iran des Sciences Médicales, Tèhèran, 2008, p. 405.
  • Rhazes, M. Z. Kitabu’l Hawi fi’ T-Tibb (in Arabic). Osmania Oriental Publications Bureau, Osmania University, Hyderabad, India,1968, vol. 20, pp. 118–123; vol. 21, pp. 106–107, 161–162, 270–273.
  • Aveccina, H. A. Al Qanun fiT-Tibb (English translation). Hamdard University, New Delhi, India, 1998, vol. 2, pp. 67–69, 294–295, 307, 377–378.
  • Leclerc, L. Le Trité des Simples par Ibn el-Beithar, in: Notices et Extraits des Manuscrits de la Biblotheque Nationale et Autres Biblotheques, Institut Nationale de France, Paris, France, 1883, vol 23, pp. 100–105, vol 25, pp. 355–356, 407–408, vol 26, pp. 124–125.
  • Tan, R.X., Zheng, W.F., Tang, H.Q. Biologically active substances from the genus Artemisia. Planta Med. 1998, 64, 295–302.
  • Zheng, G.Q. Cytotoxic terpenoids and flavonoids from Artemisia annua. Planta Med. 1994, 60, 54–57.
  • Cakir, A., Kilic, H., Kodali, S., Mavi, A., Yildirim, A. Screening of chemical composition and antifungal and antioxidant activities of the essential oils from three Turkish Artemisia species. J Agr Food Chem 2005, 53: 1408–1416.
  • Ryu, J.H., Ahn, H., Kim, J.Y., Kim, Y.K. Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages. Phytother. Res. 2003, 17, 485–489.
  • Lim, B.O., Chung, H.G., Lee, W.H., Lee, H.W., Suk, K. Inhibition of microglial neurotoxicity by ethanol extract of Artemisia asiatica Nakai. Phytother. Res. 2008, 22, 279–282.
  • Pires, J.M., Mendes, F.R., Negri, G., Duarte-Almeida, J.M., Carlini, E.A. Antinociceptive peripheral effect of Achillea millefolium L. and Artemisia vulgaris L.: both plants known popularly by brand names of analgesic drugs. Phytother. Res. 2009, 23, 212–219.
  • Mucciaralli, M., Maffel, M. Introduction of the genus, in: C.W., Wright (Eds), Artemisia, Taylor and Francis, London, 2002, 1–50.
  • Damre, A.A., Damre, A.S., Saraf, M.N. Evaluation of sesquiterpene lactone fraction of Saussurea lappa on transudative, exudative and proliferative phases of inflammation. Phytother. Res. 2003, 17, 722–725.
  • Li, C.Q., He, L.C., Jin, J.Q. Atractylenolide I and atractylenolide III inhibit Lipopolysaccharide-induced TNF-alpha and NO production in macrophages. Phytother. Res. 2007, 21, 347–353.
  • Jin, H.Z., Lee, J.H., Lee, D., Hong, Y.S., Kim, Y.H., Lee, J.J. Inhibitors of the LPS-induced NF-kappaB activation from Artemisia sylvatica. Phytochemistry 2004, 65, 2247–2253.
  • Reddy, A.M., Lee, J.Y., Seo, J.H., Kim, B.H., Chung, E.Y., Ryu, S.Y., Kim, Y.S., Lee, C.K., Min, K.R., Kim, Y. Artemisolide from Artemisia asiatica: nuclear factor-kappaB (NF-kappaB) inhibitor suppressing prostaglandin E2 and nitric oxide production in macrophages. Arch. Pharm. Res. 2006, 29, 591–597.
  • Jang, S.I., Kim, Y.J., Lee, W.Y., Kwak, K.C., Baek, S.H., Kwak, G.B., Yun, Y.G., Kwon, T.O., Chung, H.T., Chai, K.Y. Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-gamma Plus LPS. Arch. Pharm. Res. 2005, 28, 203–208.
  • Bork, P.M., Schmitz, M.L., Kuhnt, M., Escher, C., Heinrich, M. Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB. FEBS Lett. 1997, 402, 85–90.
  • Fischer, N. H. Sesquiterpene lactones, in: methods in plant biochemistry. Charlwood BV, Banthrope DV (Eds). Academic Press, London, 2007, p. 349.
  • Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65, 55–63.
  • Green, L.C., Wagner, D.A., Glogowski, J., Skipper, P.L., Wishnok, J.S., Tannenbaum, S.R. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem. 1982, 126, 131–138.
  • Chang, Y.H., Lee, S.T., Lin, W.W. Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. J. Cell. Biochem. 2001, 81, 715–723.
  • Dinarello, C.A. Anti-cytokine therapies in response to systemic infection. J. Investig. Dermatol. Symp. Proc. 2001, 6, 244–250.
  • Feldmann, M., Brennan, F.M., Williams, R.O., Elliott, M.J., Maini, R.N. Cytokine expression and networks in rheumatoid arthritis: rationale for anti-TNF alpha antibody therapy and its mechanism of action. J. Inflamm. 1995, 47, 90–96.
  • Kagari, T., Doi, H., Shimozato, T. The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J. Immunol. 2002, 169, 1459–1466.
  • Pinheiro, R.M., Calixto, J.B. Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation. Inflamm. Res. 2002, 51, 603–610.
  • Stefanovic-Racic, M., Meyers, K., Meschter, C., Coffey, J.W., Hoffman, R.A., Evans, C.H. N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats. Arthritis Rheum. 1994, 37, 1062–1069.
  • Mathison, J.C., Wolfson, E., Ulevitch, R.J. Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits. J. Clin. Invest. 1988, 81, 1925–1937.
  • Li, Q., Verma, I.M. NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2002, 2, 725–734.
  • Berg, J., Fellier, H., Christoph, T., Grarup, J., Stimmeder, D. The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro. Inflamm. Res. 1999, 48, 369–379.
  • Kiemer, A.K., Hartung, T., Huber, C., Vollmar, A.M. Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappaB pathway. J. Hepatol. 2003, 38, 289–297.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.