163
Views
19
CrossRef citations to date
0
Altmetric
Research Article

A possible role to nitric oxide in the anti-inflammatory effects of amitriptyline

, , &
Pages 578-585 | Received 25 Aug 2011, Accepted 31 Oct 2011, Published online: 02 Jan 2012

References

  • Medeiros, M.V., Binhara, I.M., Moreno Júnior, H., Zatz, R., De Nucci, G., Antunes, E. Effect of chronic nitric oxide synthesis inhibition on the inflammatory responses induced by carrageenin in rats. Eur J Pharmacol 1995, 285, 109–114.
  • Moncada, S., Higgs, E.A. Endogenous nitric oxide: Physiology, pathology and clinical relevance. Eur J Clin Invest 1991, 21, 361–374.
  • Sautebin, L., Ialenti, A., Ianaro, A., Di Rosa, M. Relationship between nitric oxide and prostaglandins in carrageenin pleurisy. Biochem Pharmacol 1998, 55, 1113–1117.
  • Tripathi, P., Tripathi, P., Kashyap, L., Singh, V. The role of nitric oxide in inflammatory reactions. FEMS Immunol Med Microbiol 2007, 51, 443–452.
  • Vassalle, C., Domenici, C., Lubrano, V., L’Abbate, A. Interaction between nitric oxide and cyclooxygenase pathways in endothelial cells. J Vasc Res 2003, 40, 491–499.
  • Farsky, S.H., Borelli, P., Fock, R.A., Proto, S.Z., Ferreira, J.M. Jr, Mello, S.B. Chronic blockade of nitric oxide biosynthesis in rats: Effect on leukocyte endothelial interaction and on leukocyte recruitment. Inflamm Res 2004, 53, 442–452.
  • Kubes, P., Suzuki, M., Granger, D.N. Nitric oxide: An endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991, 88, 4651–4655.
  • Suzuki, E., Yagi, G., Nakaki, T., Kanba, S., Asai, M. Elevated plasma nitrate levels in depressive states. J Affect Disord 2001, 63, 221–224.
  • Oliveira, R.M., Guimarães, F.S., Deakin, J.F. Expression of neuronal nitric oxide synthase in the hippocampal formation in affective disorders. Braz J Med Biol Res 2008, 41, 333–341.
  • Joca, S.R., Ferreira, F.R., Guimarães, F.S. Modulation of stress consequences by hippocampal monoaminergic, glutamatergic and nitrergic neurotransmitter systems. Stress 2007, 10, 227–249.
  • Bianchi, M., Sacerdote, P., Panerai, A.E. Fluoxetine reduces inflammatory edema in the rat: Involvement of the pituitary-adrenal axis. Eur J Pharmacol 1994, 263, 81–84.
  • Bianchi, M., Rossoni, G., Sacerdote, P., Panerai, A.E., Berti, F. Effects of chlomipramine and fluoxetine on subcutaneous carrageenin-induced inflammation in the rat. Inflamm Res 1995, 44, 466–469.
  • Abdel-Salam, O.M., Nofal, S.M., El-Shenawy, S.M. Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. Pharmacol Res 2003, 48, 157–165.
  • Szuster-Ciesielska, A., Tustanowska-Stachura, A., Slotwinska, M., Marmurowska-Michalowska, H., Kandefer-Szerszen, M. In vitro immunoregulatory effects of antidepressants in healthy volunteers. Pol J Pharmacol 2003, 55, 353–362.
  • O’Brien, S.M., Scully, P., Fitzgerald, P., Scott, L.V., Dinan, T.G. Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy. J Psychiatr Res 2007, 41, 326–331.
  • Achar, E., Maciel, T.T., Collares, C.F., Teixeira, V.P., Schor, N. Amitriptyline attenuates interstitial inflammation and ameliorates the progression of renal fibrosis. Kidney Int 2009, 75, 596–604.
  • Hwang, J., Zheng, L.T., Ock, J., Lee, M.G., Kim, S.H., Lee, H.W., Lee, W.H., Park, H.C., Suk, K. Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants. Neuropharmacology 2008, 55, 826–834.
  • Yaron, I., Shirazi, I., Judovich, R., Levartovsky, D., Caspi, D., Yaron, M. Fluoxetine and amitriptyline inhibit nitric oxide, prostaglandin E2, and hyaluronic acid production in human synovial cells and synovial tissue cultures. Arthritis Rheum 1999, 42, 2561–2568.
  • Faria, M.S., Muscará, M.N., Moreno Júnior, H., Teixeira, S.A., Dias, H.B., De Oliveira, B., Graeff, F.G., De Nucci, G. Acute inhibition of nitric oxide synthesis induces anxiolysis in the plus maze test. Eur J Pharmacol 1997, 323, 37–43.
  • Lazzarini, R., Paulino, C.A., Malucelli, B.E., Palermo-Neto, J. Effects of high doses of diazepam on carrageenin-induced paw edema in rats. Braz J Med Biol Res 1996, 29, 1525–1529.
  • Lazzarini, R., Malucelli, B.E., Muscará, M.N., de Nucci, G., Palermo-Neto, J. Reduction of inflammation in rats by diazepam: Tolerance development. Life Sci 2003, 72, 2361–2368.
  • Muscará, M.N., de Nucci, G. Simultaneous determination of nitrite and nitrate anions in plasma, urine and cell culture supernatants by high-performance liquid chromatography with post-column reactions. J Chromatogr B, Biomed Appl 1996, 686, 157–164.
  • Finkel, M.S., Laghrissi-Thode, F., Pollock, B.G., Rong, J. Paroxetine is a novel nitric oxide synthase inhibitor. Psychopharmacol Bull 1996, 32, 653–658.
  • Harvey, B.H., Retief, R., Korff, A., Wegener, G. Increased hippocampal nitric oxide synthase activity and stress responsiveness after imipramine discontinuation: Role of 5HT 2A/C-receptors. Metab Brain Dis 2006, 21, 211–220.
  • Salvemini, D., Wang, Z.Q., Wyatt, P.S., Bourdon, D.M., Marino, M.H., Manning, P.T., Currie, M.G. Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br J Pharmacol 1996, 118, 829–838.
  • Handy, R.L., Moore, P.K. A comparison of the effects of L-NAME, 7-NI and L-NIL on carrageenan-induced hindpaw oedema and NOS activity. Br J Pharmacol 1998, 123, 1119–1126.
  • Fukatsu, K., Saito, H., Han, I., Furukawa, S., Hashiguchi, Y., Lin, M.T., Matsuda, T., Inaba, T., Inoue, T., Ikeda, S., Yasuhara, H., Muto, T. Nitric oxide inhibition decreases neutrophil adhesion at the inflammatory site, while increasing adhesion in remote organs in peritonitis. J Surg Res 1997, 68, 79–86.
  • Vismari, L., Alves, G.J., Palermo-Neto, J. Amitriptyline and acute inflammation: A study using intravital microscopy and the carrageenan-induced paw edema model. Pharmacology 2010, 86, 231–239.
  • Sacerdote, P., Bianchi, M., Panerai, A.E. Chlorimipramine and nortriptyline but not fluoxetine and fluvoxamine inhibit human polymorphonuclear cell chemotaxis in vitro. Gen Pharmacol 1994, 25, 409–412.
  • Obuchowicz, E., Kowalski, J., Labuzek, K., Krysiak, R., Pendzich, J., Herman, Z.S. Amitriptyline and nortriptyline inhibit interleukin-1 release by rat mixed glial and microglial cell cultures. Int J Neuropsychopharmacol 2006, 9, 27–35.
  • Selmeczy, Z., Szelényi, J., Vizi, E.S. Intact noradrenaline transporter is needed for the sympathetic fine-tuning of cytokine balance. Eur J Pharmacol 2003, 469, 175–181.
  • Janssen, D.G., Caniato, R.N., Verster, J.C., Baune, B.T. A psychoneuroimmunological review on cytokines involved in antidepressant treatment response. Hum Psychopharmacol 2010, 25, 201–215.
  • Hebeda, C.B., Teixeira, S.A., Muscará, M.N., Vinolo, M.A., Curi, R., de Mello, S.B., Farsky, S.H. In vivo blockade of Ca(+2)-dependent nitric oxide synthases impairs expressions of L-selectin and PECAM-1. Biochem Biophys Res Commun 2008, 377, 694–698.
  • Zilberberg, J., Harris, N.R. Synergism between leukocyte adherence and shear determines venular permeability in the presence of nitric oxide. Microvasc Res 2001, 62, 410–420.
  • Norman, M.U., Zbytnuik, L., Kubes, P. Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium: A nitric oxide regulatory feedback mechanism. Eur J Immunol 2008, 38, 1368–1380.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.