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Research Article

Protective effect of apocynin in an established alcoholic steatohepatitis rat model

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Pages 633-638 | Received 29 Oct 2011, Accepted 05 Dec 2011, Published online: 11 Jan 2012

References

  • WHO: Global status report on alcohol 2004. Geneva: World Health Organization; 2004.
  • O’Shea, R.S., Dasarathy, S., McCullough, A.J.; Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease. Hepatology 2010, 51, 307–328.
  • Lefkowitch, J.H. Morphology of alcoholic liver disease. Clin Liver Dis 2005, 9, 37–53.
  • Mandrekar, P., Szabo, G. Signalling pathways in alcohol-induced liver inflammation. J Hepatol 2009, 50, 1258–1266.
  • Albano, E. Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med 2008, 29, 9–16.
  • Cunningham, C.C., Bailey, S.M. Ethanol consumption and liver mitochondria function. Biol Signals Recept 2001, 10, 271–282.
  • Stolk, J., Hiltermann, T.J., Dijkman, J.H., Verhoeven, A.J. Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am J Respir Cell Mol Biol 1994, 11, 95–102.
  • Picchi, A., Gao, X., Belmadani, S., Potter, B.J., Focardi, M., Chilian, W.M., Zhang, C. Tumor necrosis factor-α induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res 2006, 99, 69–77.
  • Barbieri, S.S., Cavalca, V., Eligini, S., Brambilla, M., Caiani, A., Tremoli, E., Colli, S. Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox-dependent mechanisms. Free Radic Biol Med 2004, 37, 156–165.
  • Pechánová, O., Jendeková, L., Vranková, S. Effect of chronic apocynin treatment on nitric oxide and reactive oxygen species production in borderline and spontaneous hypertension. Pharmacol Rep 2009, 61, 116–122.
  • Meng, R., Zhu, D.L., Bi, Y., Yang, D.H., Wang, Y.P. Apocynin improves insulin resistance through suppressing inflammation in high-fat diet-induced obese mice. Mediators Inflamm 2010, 2010, 858735.
  • Liu, P.G., He, S.Q., Zhang, Y.H., Wu, J. Protective effects of apocynin and allopurinol on ischemia/reperfusion-induced liver injury in mice. World J Gastroenterol 2008, 14, 2832–2837.
  • Lu, L.S., Wu, C.C., Hung, L.M., Chiang, M.T., Lin, C.T., Lin, C.W., Su, M.J. Apocynin alleviated hepatic oxidative burden and reduced liver injury in hypercholesterolaemia. Liver Int 2007, 27, 529–537.
  • Bustin, S.A., Benes, V., Garson, J.A., Hellemans, J., Huggett, J., Kubista, M., Mueller, R., Nolan, T., Pfaffl, M.W., Shipley, G.L., Vandesompele, J., Wittwer, C.T. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 2009, 55, 611–622.
  • Beier, J.I., McClain, C.J. Mechanisms and cell signaling in alcoholic liver disease. Biol Chem 2010, 391, 1249–1264.
  • McVicker, B.L., Tuma, D.J., Casey, C.A. Effect of ethanol on pro-apoptotic mechanisms in polarized hepatic cells. World J Gastroenterol 2007, 13, 4960–4966.
  • Bataller, R., Sancho-Bru, P., Ginès, P., Lora, J.M., Al-Garawi, A., Solé, M., Colmenero, J., Nicolás, J.M., Jiménez, W., Weich, N., Gutiérrez-Ramos, J.C., Arroyo, V., Rodés, J. Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II. Gastroenterology 2003, 125, 117–125.
  • Sancho-Bru, P., Bataller, R., Gasull, X., Colmenero, J., Khurdayan, V., Gual, A., Nicolás, J.M., Arroyo, V., Ginès, P. Genomic and functional characterization of stellate cells isolated from human cirrhotic livers. J Hepatol 2005, 43, 272–282.
  • Wheeler, M.D., Kono, H., Yin, M., Nakagami, M., Uesugi, T., Arteel, G.E., Gäbele, E., Rusyn, I., Yamashina, S., Froh, M., Adachi, Y., Iimuro, Y., Bradford, B.U., Smutney, O.M., Connor, H.D., Mason, R.P., Goyert, S.M., Peters, J.M., Gonzalez, F.J., Samulski, R.J., Thurman, R.G. The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radic Biol Med 2001, 31, 1544–1549.
  • Bataller, R., Schwabe, R.F., Choi, Y.H., Yang, L., Paik, Y.H., Lindquist, J., Qian, T., Schoonhoven, R., Hagedorn, C.H., Lemasters, J.J., Brenner, D.A. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest 2003, 112, 1383–1394.
  • Hirose, A., Ono, M., Saibara, T., Nozaki, Y., Masuda, K., Yoshioka, A., Takahashi, M., Akisawa, N., Iwasaki, S., Oben, J.A., Onishi, S. Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis. Hepatology 2007, 45, 1375–1381.
  • Yang, L., Bataller, R., Dulyx, J., Coffman, T.M., Ginès, P., Rippe, R.A., Brenner, D.A. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol 2005, 43, 317–323.
  • Nantel, P., René de Cotret, P. The evolution of angiotensin blockade in the management of cardiovascular disease. Can J Cardiol 2010, 26 Suppl E, 7E–13E.
  • Grande, M.T., Pascual, G., Riolobos, A.S., Clemente-Lorenzo, M., Bardaji, B., Barreiro, L., Tornavaca, O., Meseguer, A., López-Novoa, J.M. Increased oxidative stress, the renin-angiotensin system, and sympathetic overactivation induce hypertension in kidney androgen-regulated protein transgenic mice. Free Radic Biol Med 2011, 51, 1831–1841.
  • Cao, W., Zhou, Q.G., Nie, J., Wang, G.B., Liu, Y., Zhou, Z.M., Hou, F.F. Albumin overload activates intrarenal renin-angiotensin system through protein kinase C and NADPH oxidase-dependent pathway. J Hypertens 2011, 29, 1411–1421.

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