Inhibition of c-Jun N-terminal kinase and nuclear factor κ B pathways mediates fisetin-exerted anti-inflammatory activity in lipopolysccharide-treated RAW264.7 cells

References

• Arai, Y., Watanabe, S., Kimira, M., Shimoi, K., Mochizuki, R., Kinae, N. Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr 2000, 130, 2243–2250.
   PubMed Web of Science ®Google Scholar
• Maher, P., Dargusch, R., Ehren, J.L., Okada, S., Sharma, K., Schubert, D. Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. PLoS ONE 2011, 6, e21226.
   Google Scholar
• Khan, N., Asim, M., Afaq, F., Abu Zaid, M., Mukhtar, H. A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice. Cancer Res 2008, 68, 8555–8563.
   PubMed Web of Science ®Google Scholar
• Ravichandran, N., Suresh, G., Ramesh, B., Siva, G.V. Fisetin, a novel flavonol attenuates benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice. Food Chem Toxicol 2011, 49, 1141–1147.
   PubMed Web of Science ®Google Scholar
• Touil, Y.S., Seguin, J., Scherman, D., Chabot, G.G. Improved antiangiogenic and antitumour activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice. Cancer Chemother Pharmacol 2011, 68, 445–455.
   PubMed Web of Science ®Google Scholar
• Arbiser, J.L., Fisher, D.E. Fisetin: a natural fist against melanoma? J Invest Dermatol 2011, 131, 1187–1189.
   PubMedGoogle Scholar
• Szliszka, E., Helewski, K.J., Mizgala, E., Krol, W. The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells. Int J Oncol 2011, 39, 771–779.
   PubMed Web of Science ®Google Scholar
• Lee, S.E., Jeong, S.I., Yang, H., Park, C.S., Jin, Y.H., Park, Y.S. Fisetin induces Nrf2-mediated HO-1 expression through PKC-d and p38 in human umbilical vein endothelial cells. J Cell Biochem 2011, 112, 2352–2360.
   PubMed Web of Science ®Google Scholar
• Chien, C.S., Shen, K.H., Huang, J.S., Ko, S.C., Shih, Y.W. Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells. Mol Cell Biochem 2010, 333, 169–180.
   PubMed Web of Science ®Google Scholar
• Prasath, G.S., Subramanian, S.P. Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in hepatic and renal tissues in streptozotocin-induced diabetic rats. Eur J Pharmacol 2011, 668, 492–496.
   PubMed Web of Science ®Google Scholar
• Maher, P., Dargusch, R., Bodai, L., Gerard, P.E., Purcell, J.M., Marsh, J.L. ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington’s disease. Hum Mol Genet 2011, 20, 261–270.
   PubMed Web of Science ®Google Scholar
• Maher, P. Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin. Genes Nutr 2009. In press.
   PubMedGoogle Scholar
• Ferrero-Miliani, L., Nielsen, O.H., Andersen, P.S., Girardin, S.E. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1β generation. Clin Exp Immunol 2007, 147, 227–235.
   PubMed Web of Science ®Google Scholar
• Rankin, J.A. Biological mediators of acute inflammation. AACN Clin Issues 2004, 15, 3–17.
   PubMedGoogle Scholar
• Huerre, M.R., Gounon, P. Inflammation: patterns and new concepts. Res Immunol 1996, 147, 417–434.
   PubMedGoogle Scholar
• Saklatvala, J., Dean, J., Clark, A. Control of the expression of inflammatory response genes. Biochem Soc Symp 2003, 95–106.
   PubMedGoogle Scholar
• Geraets, L., Haegens, A., Brauers, K., Haydock, J.A., Vernooy, J.H., Wouters, E.F., Bast, A., Hageman, G.J. Inhibition of LPS-induced pulmonary inflammation by specific flavonoids. Biochem Biophys Res Commun 2009, 382, 598–603.
   PubMed Web of Science ®Google Scholar
• Lee, J.D., Huh, J.E., Jeon, G., Yang, H.R., Woo, H.S., Choi, D.Y., Park, D.S. Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models. Int Immunopharmacol 2009, 9, 268–276.
   PubMed Web of Science ®Google Scholar
• Lee, S., Kim, Y.J., Kwon, S., Lee, Y., Choi, S.Y., Park, J., Kwon, H.J. Inhibitory effects of flavonoids on TNF-α-induced IL-8 gene expression in HEK 293 cells. BMB Rep 2009, 42, 265–270.
   PubMed Web of Science ®Google Scholar
• Sung, B., Pandey, M.K., Aggarwal, B.B. Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-κB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBα kinase activation. Mol Pharmacol 2007, 71, 1703–1714.
   PubMed Web of Science ®Google Scholar
• Seo, H.J., Huh, J.E., Han, J.H., Jeong, S.J., Jang, J., Lee, E.O., Lee, H.J., Lee, H.J., Ahn, K.S., Kim, S.H. Polygoni Rhizoma Inhibits Inflammatory Response through Inactivation of Nuclear Factor-κB and Mitogen Activated Protein Kinase Signaling Pathways in RAW264.7 Mouse Macrophage Cells. Phytother Res 2011. In press.
   Google Scholar
• Kim, S.H., Ahn, K.S., Jeong, S.J., Kwon, T.R., Jung, J.H., Yun, S.M., Han, I., Lee, S.G., Kim, D.K., Kang, M., Chen, C.Y., Lee, J.W., Kim, S.H. Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells. Eur J Pharmacol 2011, 654, 10–16.
   PubMed Web of Science ®Google Scholar
• Fujiwara, N., Kobayashi, K. Macrophages in inflammation. Curr Drug Targets Inflamm Allergy 2005, 4, 281–286.
   PubMedGoogle Scholar
• Manthey, C.L., Wang, S.W., Kinney, S.D., Yao, Z. SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes. J Leukoc Biol 1998, 64, 409–417.
   PubMed Web of Science ®Google Scholar
• Schindler, J.F., Monahan, J.B., Smith, W.G. p38 pathway kinases as anti-inflammatory drug targets. J Dent Res 2007, 86, 800–811.
   PubMed Web of Science ®Google Scholar
• Kyriakis, J.M., Woodgett, J.R., Avruch, J. The stress-activated protein kinases. A novel ERK subfamily responsive to cellular stress and inflammatory cytokines. Ann N Y Acad Sci 1995, 766, 303–319.
   PubMed Web of Science ®Google Scholar
• Liu, S.F., Malik, A.B. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 2006, 290, L622–L645.
   PubMed Web of Science ®Google Scholar
• Macêdo, S.B., Ferreira, L.R., Perazzo, F.F., Carvalho, J.C. Anti-inflammatory activity of Arnica montana 6cH: preclinical study in animals. Homeopathy 2004, 93, 84–87.
   PubMedGoogle Scholar
• Alghaithy, A.A., El-Beshbishy, H.A., AbdelNaim, A.B., Nagy, A.A., Abdel-Sattar, E.M. Anti-inflammatory effects of the chloroform extract of Pulicaria guestii ameliorated the neutrophil infiltration and nitric oxide generation in rats. Toxicol Ind Health 2011, 27, 899–910.
   PubMed Web of Science ®Google Scholar
• Wu, S.J., Tam, K.W., Tsai, Y.H., Chang, C.C., Chao, J.C. Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats. Am J Chin Med 2010, 38, 99–111.
   PubMed Web of Science ®Google Scholar
• Jiang, J.S., Shih, C.M., Wang, S.H., Chen, T.T., Lin, C.N., Ko, W.C. Mechanisms of suppression of nitric oxide production by 3-O-methylquercetin in RAW 264.7 cells. J Ethnopharmacol 2006, 103, 281–287.
   PubMed Web of Science ®Google Scholar
• Zhu, X., Liu, Q., Wang, M., Liang, M., Yang, X., Xu, X., Zou, H., Qiu, J. Activation of Sirt1 by resveratrol inhibits TNF-a induced inflammation in fibroblasts. PLoS ONE 2011, 6, e27081.
   PubMed Web of Science ®Google Scholar
• Ha, M.K., Song, Y.H., Jeong, S.J., Lee, H.J., Jung, J.H., Kim, B., Song, H.S., Huh, J.E., Kim, S.H. Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytes. Biol Pharm Bull 2011, 34, 1432–1437.
   PubMed Web of Science ®Google Scholar
• Wang, L., Tu, Y.C., Lian, T.W., Hung, J.T., Yen, J.H., Wu, M.J. Distinctive antioxidant and antiinflammatory effects of flavonols. J Agric Food Chem 2006, 54, 9798–9804.
   PubMed Web of Science ®Google Scholar
• Jeannin, P., Duluc, D., Delneste, Y. IL-6 and leukemia-inhibitory factor are involved in the generation of tumor-associated macrophage: regulation by IFN-? Immunotherapy 2011, 3, 23–26.
   PubMedGoogle Scholar
• Parameswaran, N., Patial, S. Tumor necrosis factor-a signaling in macrophages. Crit Rev Eukaryot Gene Expr 2010, 20, 87–103.
   PubMed Web of Science ®Google Scholar
• Keyel, P.A., Heid, M.E., Salter, R.D. Macrophage responses to bacterial toxins: a balance between activation and suppression. Immunol Res 2011, 50, 118–123.
   PubMedGoogle Scholar
• Wright, S.D., Ramos, R.A., Tobias, P.S., Ulevitch, R.J., Mathison, J.C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990, 249, 1431–1433.
   PubMed Web of Science ®Google Scholar
• Adair-Kirk, T.L., Senior, R.M. Fragments of extracellular matrix as mediators of inflammation. Int J Biochem Cell Biol 2008, 40, 1101–1110.
   PubMed Web of Science ®Google Scholar
• MacMicking, J., Xie, Q.W., Nathan, C. Nitric oxide and macrophage function. Annu Rev Immunol 1997, 15, 323–350.
   PubMed Web of Science ®Google Scholar
• Haddad, J.J. The role of inflammatory cytokines and NF-κB/MAPK signaling pathways in the evolution of familial Mediterranean fever: current clinical perspectives and potential therapeutic approaches. Cell Immunol 2009, 260, 6–13.
   PubMed Web of Science ®Google Scholar
• Kramer, H.F., Goodyear, L.J. Exercise, MAPK, and NF-κB signaling in skeletal muscle. J Appl Physiol 2007, 103, 388–395.
   PubMed Web of Science ®Google Scholar
• Saklatvala, J. Inflammatory signaling in cartilage: MAPK and NF-κB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis. Curr Drug Targets 2007, 8, 305–313.
   PubMed Web of Science ®Google Scholar
• Malemud, C.J., Miller, A.H. Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugs. Expert Opin Ther Targets 2008, 12, 171–183.
   PubMed Web of Science ®Google Scholar
• Duan, W., Wong, W.S. Targeting mitogen-activated protein kinases for asthma. Curr Drug Targets 2006, 7, 691–698.
   PubMed Web of Science ®Google Scholar
• Kaminska, B. MAPK signalling pathways as molecular targets for anti-inflammatory therapy–from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta 2005, 1754, 253–262.
   PubMed Web of Science ®Google Scholar
• Aggarwal, B.B., Gehlot, P. Inflammation and cancer: how friendly is the relationship for cancer patients? Curr Opin Pharmacol 2009, 9, 351–369.
   PubMed Web of Science ®Google Scholar
• Gupta, S.C., Kim, J.H., Prasad, S., Aggarwal, B.B. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev 2010, 29, 405–434.
   PubMed Web of Science ®Google Scholar