Complete blood count and acetylcholinesterase activity of lymphocytes of demyelinated and ovariectomized rats treated with resveratrol

References

• Whitten, P.L., Kudo, S., Okubo, K.K. (1997). Isoflavonoids. In: D’Mello, J.P.F., ed. Handbook of Plant and Fungal Toxicants. Boca Raton, FL: CRC Press, 117–137.
   Google Scholar
• Frémont, L. Biological effects of resveratrol. Life Sci 2000, 66, 663–673.
   PubMed Web of Science ®Google Scholar
• Kennedy, D.O., Wightman, E.L., Reay, J.L., Lietz, G., Okello, E.J., Wilde, A., Haskell, C.F. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr 2010, 91, 1590–1597.
   PubMed Web of Science ®Google Scholar
• Rocha-González, H.I., Ambriz-Tututi, M., Granados-Soto, V. Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases. CNS Neurosci Ther 2008, 14, 234–247.
   PubMed Web of Science ®Google Scholar
• Surh, Y.J., Hurh, Y.J., Kang, J.Y., Lee, E., Kong, G., Lee, S.J. Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells. Cancer Lett 1999, 140, 1–10.
   PubMed Web of Science ®Google Scholar
• Labinskyy, N., Csiszar, A., Veress, G., Stef, G., Pacher, P., Oroszi, G., Wu, J., Ungvari, Z. Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen. Curr Med Chem 2006, 13, 989–996.
   PubMed Web of Science ®Google Scholar
• Saiko, P., Szakmary, A., Jaeger, W., Szekeres, T. Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad? Mutat Res 2008, 658, 68–94.
   PubMed Web of Science ®Google Scholar
• Farooqui, T., Farooqui, A.A. Aging: an important factor for the pathogenesis of neurodegenerative diseases. Mech Ageing Dev 2009, 130, 203–215.
   PubMed Web of Science ®Google Scholar
• Norbury, R., Cutter, W.J., Compton, J., Robertson, D.M., Craig, M., Whitehead, M., Murphy, D.G. The neuroprotective effects of estrogen on the aging brain. Exp Gerontol 2003, 38, 109–117.
   PubMed Web of Science ®Google Scholar
• Appleyard, M.E. Secreted acetylcholinesterase: non-classical aspects of a classical enzyme. Trends Neurosci 1992, 15, 485–490.
   PubMed Web of Science ®Google Scholar
• Tayebati, S.K., El-Assouad, D., Ricci, A., Amenta, F. Immunochemical and immunocytochemical characterization of cholinergic markers in human peripheral blood lymphocytes. J Neuroimmunol 2002, 132, 147–155.
   PubMed Web of Science ®Google Scholar
• Kawashima, K., Fujii, T. The lymphocytic cholinergic system and its contribution to the regulation of immune activity. Life Sci 2003, 74, 675–696.
   PubMed Web of Science ®Google Scholar
• Kawashima, K., Fujii, T. Extraneuronal cholinergic system in lymphocytes. Pharmacol Ther 2000, 86, 29–48.
   PubMed Web of Science ®Google Scholar
• Santos, S.C., Vala, I., Miguel, C., Barata, J.T., Garção, P., Agostinho, P., Mendes, M., Coelho, A.V., Calado, A., Oliveira, C.R., e Silva, J.M., Saldanha, C. Expression and subcellular localization of a novel nuclear acetylcholinesterase protein. J Biol Chem 2007, 282, 25597–25603.
   PubMed Web of Science ®Google Scholar
• Paleari, L., Grozio, A., Cesario, A., Russo, P. The cholinergic system and cancer. Semin Cancer Biol 2008, 18, 211–217.
   PubMed Web of Science ®Google Scholar
• Battisti, V., Schetinger, M.R., Maders, L.D., Santos, K.F., Bagatini, M.D., Correa, M.C., Spanevello, R.M., do Carmo Araújo, M., Morsch, V.M. Changes in acetylcholinesterase (AchE) activity in lymphocytes and whole blood in acute lymphoblastic leukemia patients. Clin Chim Acta 2009, 402, 114–118.
   PubMed Web of Science ®Google Scholar
• Wessler, I., Kilbinger, H., Bittinger, F., Unger, R., Kirkpatrick, C.J. The non-neuronal cholinergic system in humans: expression, function and pathophysiology. Life Sci 2003, 72, 2055–2061.
   PubMed Web of Science ®Google Scholar
• Siegel, G. (1999). Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 6th edition. Philadelphia: Lippincott Willians & Wilkins, pp. 1183.
   Google Scholar
• Levine, J.M., Reynolds, R. Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination. Exp Neurol 1999, 160, 333–347.
   PubMed Web of Science ®Google Scholar
• Stangel, M., Hartung, H.P. Remyelinating strategies for the treatment of multiple sclerosis. Prog Neurobiol 2002, 68, 361–376.
   PubMed Web of Science ®Google Scholar
• Das, U.N. Acetylcholinesterase and butyrylcholinesterase as possible markers of low-grade systemic inflammation. Med Sci Monit 2007, 13, RA214–RA221.
   PubMed Web of Science ®Google Scholar
• Mazzanti, C.M., Spanevello, R., Ahmed, M., Schmatz, R., Mazzanti, A., Salbego, F.Z., Graça, D.L., Sallis, E.S., Morsch, V.M., Schetinger, M.R. Cyclosporine A inhibits acetylcholinesterase activity in rats experimentally demyelinated with ethidium bromide. Int J Dev Neurosci 2007, 25, 259–264.
   PubMed Web of Science ®Google Scholar
• Mazzanti, C.M., Spanevello, R., Ahmed, M., Pereira, L.B., Gonçalves, J.F., Corrêa, M., Schmatz, R., Stefanello, N., Leal, D.B., Mazzanti, A., Ramos, A.T., Martins, T.B., Danesi, C.C., Graça, D.L., Morsch, V.M., Schetinger, M.R. Pre-treatment with ebselen and vitamin E modulate acetylcholinesterase activity: interaction with demyelinating agents. Int J Dev Neurosci 2009, 27, 73–80.
   PubMed Web of Science ®Google Scholar
• Nassar, C.C., Bondan, E.F., Alouche, S.R. Effects of aquatic exercises in a rat model of brainstem demyelination with ethidium bromide on the beam walking test. Arq Neuropsiquiatr 2009, 67, 652–656.
   PubMed Web of Science ®Google Scholar
• Schreiner, B., Heppner, F.L., Becher, B. Modeling multiple sclerosis in laboratory animals. Semin Immunopathol 2009, 31, 479–495.
   PubMed Web of Science ®Google Scholar
• Mossberg, N., Movitz, C., Hellstrand, K., Bergström, T., Nilsson, S., Andersen, O. Oxygen radical production in leukocytes and disease severity in multiple sclerosis. J Neuroimmunol 2009, 213, 131–134.
   PubMed Web of Science ®Google Scholar
• Beineke, A., Puff, C., Seehusen, F., Baumgärtner, W. Pathogenesis and immunopathology of systemic and nervous canine distemper. Vet Immunol Immunopathol 2009, 127, 1–18.
   PubMed Web of Science ®Google Scholar
• Crowell, J.A., Korytko, P.J., Morrissey, R.L., Booth, T.D., Levine, B.S. Resveratrol-associated renal toxicity. Toxicol Sci 2004, 82, 614–619.
   PubMed Web of Science ®Google Scholar
• Rotondo, S., Rajtar, G., Manarini, S., Celardo, A., Rotillo, D., de Gaetano, G., Evangelista, V., Cerletti, C. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Br J Pharmacol 1998, 123, 1691–1699.
   PubMed Web of Science ®Google Scholar
• Richard, N., Porath, D., Radspieler, A., Schwager, J. Effects of resveratrol, piceatannol, tri-acetoxystilbene, and genistein on the inflammatory response of human peripheral blood leukocytes. Mol Nutr Food Res 2005, 49, 431–442.
   PubMed Web of Science ®Google Scholar
• Marcondes, F.K., Bianchi, F.J., Tanno, A.P. Determination of the estrous cycle phases of rats: some helpful considerations. Braz J Biol 2002, 62, 609–614.
   PubMedGoogle Scholar
• Yener, T., Turkkani Tunc, A., Aslan, H., Aytan, H., Cantug Caliskan, A. Determination of oestrous cycle of the rats by direct examination: how reliable? Anat Histol Embryol 2007, 36, 75–77.
   PubMed Web of Science ®Google Scholar
• Schmatz, R., Mazzanti, C.M., Spanevello, R., Stefanello, N., Gutierres, J., Corrêa, M., da Rosa, M.M., Rubin, M.A., Chitolina Schetinger, M.R., Morsch, V.M. Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. Eur J Pharmacol 2009, 610, 42–48.
   PubMed Web of Science ®Google Scholar
• Böyum, A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl 1968, 97, 77–89.
   PubMedGoogle Scholar
• Bergmeyer, H.U. Methods of Enzymatic Analysis. (1983). 3rd volume. London: Academic Press, 118–133.
   Google Scholar
• Ellman, G.L., Courtney, K.D., Andres, V. Jr, Feather-Stone, R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961, 7, 88–95.
   PubMed Web of Science ®Google Scholar
• Fitzgerald, B.B., Costa, L.G. Modulation of muscarinic receptors and acetylcholinesterase activity in lymphocytes and in brain areas following repeated organophosphate exposure in rats. Fundam Appl Toxicol 1993, 20, 210–216.
   PubMedGoogle Scholar
• Juan, M.E., Vinardell, M.P., Planas, J.M. The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful. J Nutr 2002, 132, 257–260.
   PubMed Web of Science ®Google Scholar
• Gao, X., Deeb, D., Media, J., Divine, G., Jiang, H., Chapman, R.A., Gautam, S.C. Immunomodulatory activity of resveratrol: discrepant in vitro and in vivo immunological effects. Biochem Pharmacol 2003, 66, 2427–2435.
   PubMed Web of Science ®Google Scholar
• Schmatz, R., Perreira, L.B., Stefanello, N., Mazzanti, C., Spanevello, R., Gutierres, J., Bagatini, M., Martins, C.C., Abdalla, F.H., Daci da Silva Serres, J., Zanini, D., Vieira, J.M., Cardoso, A.M., Schetinger, M.R., Morsch, V.M. Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats. Biochimie 2012, 94, 374–383.
   PubMed Web of Science ®Google Scholar
• Gautam, S.C., Xu, Y.X., Dumaguin, M., Janakiraman, N., Chapman, R.A. Resveratrol selectively inhibits leukemia cells: a prospective agent for ex vivo bone marrow purging. Bone Marrow Transplant 2000, 25, 639–645.
   PubMed Web of Science ®Google Scholar
• Tedesco, I., Russo, M., Russo, P., Iacomino, G., Russo, G.L., Carraturo, A., Faruolo, C., Moio, L., Palumbo, R. Antioxidant effect of red wine polyphenols on red blood cells. J Nutr Biochem 2000, 11, 114–119.
   PubMed Web of Science ®Google Scholar
• Jang, M., Cai, L., Udeani, G.O., Slowing, K.V., Thomas, C.F., Beecher, C.W., Fong, H.H., Farnsworth, N.R., Kinghorn, A.D., Mehta, R.G., Moon, R.C., Pezzuto, J.M. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997, 275, 218–220.
   PubMed Web of Science ®Google Scholar
• Bienzle, D., Stanton, J.B., Embry, J.M., Bush, S.E., Mahaffey, E.A. Evaluation of an in-house centrifugal hematology analyzer for use in veterinary practice. J Am Vet Med Assoc 2000, 217, 1195–1200.
   PubMed Web of Science ®Google Scholar
• Thrall, M.A. (2006). Hematologia e bioquímica clínica veterinária. São Paulo: Roca, pp. 582.
   Google Scholar
• Yajima, K., Suzuki, K. Demyelination and remyelination in the rat central nervous system following ethidium bromide injection. Lab Invest 1979, 41, 385–392.
   PubMed Web of Science ®Google Scholar
• Bondan, E.F. (1997). Estudo morfológico do processo de remielinização no tronco encefálico de ratos wistar submetidos experimentalmente ao modelo gliotóxico do brometo de etídio e tratados com ciclofosfamida ou ciclosporina - Doctorate Thesis. São Paulo: Universidade de São Paulo, pp. 190.
   Google Scholar
• Bondan, E.F., Lallo, M.A., Dagli, M.L.Z., Pereira, L.A.V.D., Graça, D.L. Ruptura da barreira hematoencefálica após injeção de droga gliotóxica no tronco encefálico de ratos wistar. Arq Neuro-Psiquiatr 2002, 60, 582–589.
   PubMedGoogle Scholar
• Kaur, G., Roberti, M., Raul, F., Pendurthi, U.R. Suppression of human monocyte tissue factor induction by red wine phenolics and synthetic derivatives of resveratrol. Thromb Res 2007, 119, 247–256.
   PubMed Web of Science ®Google Scholar
• Rao, A.A., Sridhar, G.R., Das, U.N. Elevated butyrylcholinesterase and acetylcholinesterase may predict the development of type 2 diabetes mellitus and Alzheimer’s disease. Med Hypotheses 2007, 69, 1272–1276.
   PubMed Web of Science ®Google Scholar
• Wang, Q., Xu, J., Rottinghaus, G.E., Simonyi, A., Lubahn, D., Sun, G.Y., Sun, A.Y. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res 2002, 958, 439–447.
   PubMed Web of Science ®Google Scholar
• Jannin, B., Menzel, M., Berlot, J.P., Delmas, D., Lançon, A., Latruffe, N. Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake. Biochem Pharmacol 2004, 68, 1113–1118.
   PubMed Web of Science ®Google Scholar
• Nizri, E., Hamra-Amitay, Y., Sicsic, C., Lavon, I., Brenner, T. Anti-inflammatory properties of cholinergic up-regulation: A new role for acetylcholinesterase inhibitors. Neuropharmacology 2006, 50, 540–547.
   PubMed Web of Science ®Google Scholar
• Kawashima, K., Fujii, T. Basic and clinical aspects of non-neuronal acetylcholine: overview of non-neuronal cholinergic systems and their biological significance. J Pharmacol Sci 2008, 106, 167–173.
   PubMed Web of Science ®Google Scholar
• Bondan, E.F., Lallo, M.A., Orsini, H., Bentubo, H.L., Yazbek, A., Macrini, D.J., Bernardi, M.M., Graça, D.L. [Evaluation of locomotor activity after a local induction of toxic demyelination in the brainstem of Wistar rats]. Arq Neuropsiquiatr 2006, 64, 496–503.
   PubMed Web of Science ®Google Scholar
• Sallis, E.S., Mazzanti, C.M., Mazzanti, A., Pereira, L.A., Arroteia, K.F., Fustigatto, R., Pelizzari, C., Rodrigues, A., Graça, D.L. OSP-Immunofluorescent remyelinating oligodendrocytes in the brainstem of toxically-demyelinated Wistar rats. Arq Neuropsiquiatr 2006, 64, 240–244.
   PubMed Web of Science ®Google Scholar
• Mazzanti, C.M., Spanevello, R.M., Pereira, L.B., Gonçalves, J.F., Kaizer, R., Corrêa, M., Ahmed, M., Mazzanti, A., Festugatto, R., Graça, D.L., Morsch, V.M., Schetinger, M.R. Acetylcholinesterase activity in rats experimentally demyelinated with ethidium bromide and treated with interferon beta. Neurochem Res 2006, 31, 1027–1034.
   PubMed Web of Science ®Google Scholar