Capillarisin inhibits iNOS, COX-2 expression, and proinflammatory cytokines in LPS-induced RAW 264.7 macrophages via the suppression of ERK, JNK, and NF-κB activation

References

• Fujihara, M., Muroi, M., Tanamoto, K., Suzuki, T., Azuma, H., Ikeda, H. Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol Ther 2003, 100, 171–194.
   PubMed Web of Science ®Google Scholar
• Larsen, G.L., Henson, P.M. Mediators of inflammation. Annu Rev Immunol 1983, 1, 335–359.
   PubMed Web of Science ®Google Scholar
• Lawrence, T., Willoughby, D.A., Gilroy, D.W. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat Rev Immunol 2002, 2, 787–795.
   PubMed Web of Science ®Google Scholar
• Takeda, K., Akira, S. Toll-like receptors in innate immunity. Int Immunol 2005, 17, 1–14.
   PubMed Web of Science ®Google Scholar
• Aderem, A., Ulevitch, R.J. Toll-like receptors in the induction of the innate immune response. Nature 2000, 406, 782–787.
   PubMed Web of Science ®Google Scholar
• Ahn, K.S., Aggarwal, B.B. Transcription factor NF-kappaB: a sensor for smoke and stress signals. Ann N Y Acad Sci 2005, 1056, 218–233.
   PubMed Web of Science ®Google Scholar
• Barnes, P.J., Karin, M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997, 336, 1066–1071.
   PubMed Web of Science ®Google Scholar
• Anderson, K.V. Toll signaling pathways in the innate immune response. Curr Opin Immunol 2000, 12, 13–19.
   PubMed Web of Science ®Google Scholar
• Ulevitch, R.J., Tobias, P.S. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol 1995, 13, 437–457.
   PubMed Web of Science ®Google Scholar
• Craig, R., Larkin, A., Mingo, A.M., Thuerauf, D.J., Andrews, C., McDonough, P.M., Glembotski, C.C. p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system. J Biol Chem 2000, 275, 23814–23824.
   PubMed Web of Science ®Google Scholar
• Chu, C.Y., Tseng, T.H., Hwang, J.M., Chou, F.P., Wang, C.J. Protective effects of capillarisin on tert-butylhydroperoxide-induced oxidative damage in rat primary hepatocytes. Arch Toxicol 1999, 73, 263–268.
   PubMed Web of Science ®Google Scholar
• Chang, W.S., Lee, Y.J., Lu, F.J., Chiang, H.C. Inhibitory effects of flavonoids on xanthine oxidase. Anticancer Res 1993, 13, 2165–2170.
   PubMed Web of Science ®Google Scholar
• Okada, Y., Miyauchi, N., Suzuki, K., Kobayashi, T., Tsutsui, C., Mayuzumi, K., Nishibe, S., Okuyama, T. Search for naturally occurring substances to prevent the complications of diabetes. II. Inhibitory effect of coumarin and flavonoid derivatives on bovine lens aldose reductase and rabbit platelet aggregation. Chem Pharm Bull 1995, 43, 1385–1387.
   PubMed Web of Science ®Google Scholar
• Lee, E.J., Kim, C., Kim, J.Y., Kim, S.M., Nam, D., Jang, H.J., Kim, S.H., Shim, B.S., Ahn, K.S., Choi, S.H., Jung, S.H., Ahn, K.S. Inhibition of LPS-induced inflammatory biomarkers by ethyl acetate fraction of Patrinia scabiosaefolia through suppression of NF-?B activation in RAW 264.7 cells. Immunopharmacol Immunotoxicol 2012, 34, 282–291.
   PubMed Web of Science ®Google Scholar
• Lee, G., Choi, T.W., Kim, C., Nam, D., Lee, S.G., Jang, H.J., Lee, J.H., Um, J.Y., Jung, S.H., Shim, B.S., Ahn, K.S., Ahn, K.S. Anti-inflammatory activities of Reynoutria elliptica through suppression of mitogen-activated protein kinases and nuclear factor-?B activation pathways. Immunopharmacol Immunotoxicol 2012, 34, 454–464.
   PubMed Web of Science ®Google Scholar
• Kim, J.Y., Kim, H.J., Kim, S.M., Park, K.R., Jang, H.J., Lee, E.H., Jung, S.H., Ahn, K.S. Methylene chloride fraction of the leaves of Thuja orientalis inhibits in vitro inflammatory biomarkers by blocking NF-?B and p38 MAPK signaling and protects mice from lethal endotoxemia. J Ethnopharmacol 2011, 133, 687–695.
   PubMed Web of Science ®Google Scholar
• Lee, H.J., Choi, T.W., Kim, H.J., Nam, D., Jung, S.H., Lee, E.H., Lee, H.J., Shin, E.M., Jang, H.J., Ahn, K.S., Shim, B.S., Choi, S.H., Kim, S.H., Sethi, G., Ahn, K.S. Anti-Inflammatory activity of Angelica keiskei through suppression of mitogen-activated protein kinases and nuclear factor-kappaB activation pathways. J Med Food 2010, 13, 691–699.
   PubMed Web of Science ®Google Scholar
• Baeuerle, P.A., Baltimore, D. NF-kappa B: ten years after. Cell 1996, 87, 13–20.
   PubMed Web of Science ®Google Scholar
• Mi Jeong, S., Davaatseren, M., Kim, W., Sung Kwang, P., Kim, S.H., Haeng Jeon, H., Myung Sunny, K., Kim, Y.S., Dae Young, K. Vitisin A suppresses LPS-induced NO production by inhibiting ERK, p38, and NF-kappaB activation in RAW 264.7 cells. Int Immunopharmacol 2009, 9, 319–323.
   PubMed Web of Science ®Google Scholar
• Ahn, K.S., Sethi, G., Aggarwal, B.B. Nuclear factor-kappa B: from clone to clinic. Curr Mol Med 2007, 7, 619–637.
   PubMed Web of Science ®Google Scholar
• Posadas, I., Terencio, M.C., Guillén, I., Ferrándiz, M.L., Coloma, J., Payá, M., Alcaraz, M.J. Co-regulation between cyclo-oxygenase-2 and inducible nitric oxide synthase expression in the time-course of murine inflammation. Naunyn Schmiedebergs Arch Pharmacol 2000, 361, 98–106.
   PubMed Web of Science ®Google Scholar
• Aggarwal, B.B., Prasad, S., Reuter, S., Kannappan, R., Yadev, V.R., Park, B., Kim, J.H., Gupta, S.C., Phromnoi, K., Sundaram, C., Prasad, S., Chaturvedi, M.M., Sung, B. Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: “reverse pharmacology” and “bedside to bench” approach. Curr Drug Targets 2011, 12, 1595–1653.
   PubMed Web of Science ®Google Scholar
• Marcus, J.S., Karackattu, S.L., Fleegal, M.A., Sumners, C. Cytokine-stimulated inducible nitric oxide synthase expression in astroglia: role of Erk mitogen-activated protein kinase and NF-kappaB. Glia 2003, 41, 152–160.
   PubMed Web of Science ®Google Scholar
• Schrader, L.I., Kinzenbaw, D.A., Johnson, A.W., Faraci, F.M., Didion, S.P. IL-6 deficiency protects against angiotensin II induced endothelial dysfunction and hypertrophy. Arterioscler Thromb Vasc Biol 2007, 27, 2576–2581.
   PubMed Web of Science ®Google Scholar
• Männel, D.N., Echtenacher, B. TNF in the inflammatory response. Chem Immunol 2000, 74, 141–161.
   PubMedGoogle Scholar
• Glauser, M.P. The inflammatory cytokines. New developments in the pathophysiology and treatment of septic shock. Drugs 1996, 52 Suppl 2, 9–17.
   PubMed Web of Science ®Google Scholar
• Mase, A., Makino, B., Tsuchiya, N., Yamamoto, M., Kase, Y., Takeda, S., Hasegawa, T. Active ingredients of traditional Japanese (kampo) medicine, inchinkoto, in murine concanavalin A-induced hepatitis. J Ethnopharmacol 2010, 127, 742–749.
   PubMed Web of Science ®Google Scholar
• Lee, S.O., Jeong, Y.J., Kim, M., Kim, C.H., Lee, I.S. Suppression of PMA-induced tumor cell invasion by capillarisin via the inhibition of NF-kappaB-dependent MMP-9 expression. Biochem Biophys Res Commun 2008, 366, 1019–1024.
   PubMed Web of Science ®Google Scholar
• Ghosh, S., Karin, M. Missing pieces in the NF-kappaB puzzle. Cell 2002, 109 Suppl, S81–S96.
   PubMed Web of Science ®Google Scholar
• Zhang, W., Liu, H.T. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 2002, 12, 9–18.
   PubMed Web of Science ®Google Scholar
• Hommes, D.W., Peppelenbosch, M.P., van Deventer, S.J. Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. Gut 2003, 52, 144–151.
   PubMed Web of Science ®Google Scholar
• Bhat, N.R., Zhang, P., Lee, J.C., Hogan, E.L. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 1998, 18, 1633–1641.
   PubMed Web of Science ®Google Scholar
• Ajizian, S.J., English, B.K., Meals, E.A. Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. J Infect Dis 1999, 179, 939–944.
   PubMed Web of Science ®Google Scholar
• Uto, T., Fujii, M., Hou, D.X. 6-(Methylsulfinyl)hexyl isothiocyanate suppresses inducible nitric oxide synthase expression through the inhibition of Janus kinase 2-mediated JNK pathway in lipopolysaccharide-activated murine macrophages. Biochem Pharmacol 2005, 70, 1211–1221.
   PubMed Web of Science ®Google Scholar