Methylsulfonylmethane modulates apoptosis of LPS/IFN-γ-activated RAW 264.7 macrophage-like cells by targeting p53, Bax, Bcl-2, cytochrome c and PARP proteins

References

• Mosser DM. The many faces of macrophage activation. J Leukoc Biol 2003;73:209–212
   PubMed Web of Science ®Google Scholar
• Sarih M, Souvannavong V, Adam A. Nitric oxide synthase induces macrophage death by apoptosis. Biochem Biophys Res Commun 1993;191:503–508
   PubMed Web of Science ®Google Scholar
• Lorsbach RB, Murphy WJ, Lowenstein CJ, et al. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. J Biol Chem 1993;25:1908–1913
   Google Scholar
• Albina JE, Cui S, Mateo RB, Reichner JS. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J Immunol 1993;150:5080–5085
   PubMed Web of Science ®Google Scholar
• Ambs S, Hussain SP, Harris CC. Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression. FASEB J 1997;11:443–448
   PubMed Web of Science ®Google Scholar
• Calmels S, Hainaut P, Ohshima H. Nitric oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein. Cancer Res 1997;57:3365–3369
   PubMed Web of Science ®Google Scholar
• Bosca L, Hortelano S. Mechanisms of nitric oxide-dependent apoptosis: involvement of mitochondrial mediators. Cell Signal 1999;11:239–244
   PubMed Web of Science ®Google Scholar
• Barinaga M. Death by dozens of cuts. Science 1998;280:32–34
   PubMed Web of Science ®Google Scholar
• Yang J, Liu X, Bhalla K, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997;275:1129–1132
   PubMed Web of Science ®Google Scholar
• Bossy-Wetzel E, Newmeyer DD, Green DR. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J 1998;17:37–49
   PubMed Web of Science ®Google Scholar
• Yadav UC, Kalariya NM, Srivastava SK, Ramana KV. Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages. Free Radic Biol Med 2010;15:1423–1434
   Google Scholar
• Tsi CJ, Chao Y, Chen CW, Lin WW. Aurintricarboxylic acid protects against cell death caused by lipopolysaccharide in macrophages by decreasing inducible nitric-oxide synthase induction via IkappaB kinase, extracellular signal-regulated kinase, and p38 mitogen-activated protein kinase inhibition. Mol Pharmacol 2002;62:90–101
   PubMed Web of Science ®Google Scholar
• Heras B, Hortelano S, Giron N, et al. Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages. Br J Pharmacol 2007;152:249–255
   Google Scholar
• Pearson TW, Dawson HJ, Lackey HB. Natural occurring levels of dimethyl sulfoxide in selected fruits, vegetables, grains, and beverages. J Agric Food Chem 1981;29:1089–1091
   PubMed Web of Science ®Google Scholar
• Beilke MA, Collins-Lech C, Sohnle PG. Effects of dimethyl sulfoxide on the oxidative function of human neutrophils. J Lab Clin Med 1987;110:91–96
   PubMed Web of Science ®Google Scholar
• Layman DL. Growth inhibitory effects of dimethyl sulfoxide and dimethyl sulfone on vascular smooth muscle and endothelial cells in vitro. In Vitro Cell Dev Biol 1987;23:422–428
   Google Scholar
• O’dwyer PJ, McCabe DP, Sickle-Santanello BJ. Use of polar solvents in chemoprevention of 1,2-dimethylhydrazineinduced colon cancer. Cancer 1988;62:944–948
   PubMedGoogle Scholar
• McCabe D, O’Dwyer P, Sickle-Santanello B. Polar solvents in the chemoprevention of dimethylbenzanthracene-induced rat mammary cancer. Arch Surg 1986;121:1455–1459
   PubMedGoogle Scholar
• Maranon G, Munoz-Escassi B, Manley W, et al. The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise. Acta Veterinaria Scand 2008;50:45
   PubMed Web of Science ®Google Scholar
• Cox WI, Specter S, Friedman H. Susceptibility of Friend erythroleukemia cells to natural cytotoxicity after in vitro treatment with dimethyl sulfoxide. Proc Soc Exp Biol Med 1982;169:337–342
   Google Scholar
• Amirshahrokhi K, Bohlooli S. Effect of Methylsulfonylmethane on Paraquat-Induced Acute Lung and Liver Injury in Mice. Inflammation 2013;36:1111–1121
   Google Scholar
• Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med 2002;8:167–173
   PubMed Web of Science ®Google Scholar
• Mossman T. Rapid colorimetric assay for cellular growth and survivals: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55–63
   PubMed Web of Science ®Google Scholar
• Yang YM, Liu GT. Damaging effect of cigarette smoke extract on primary cultured human umbilical vein endothelial cells and its mechanism. Biomed Environ Sci 2004;17:121–134
   PubMed Web of Science ®Google Scholar
• Chen QQ, Liu WL, Guo X, et al. Biphasic effect of aspirin on apoptosis of bovine vascular endothelial cells and its molecular mechanism. Acta Pharmacol Sin 2007;28:353–358
   PubMedGoogle Scholar
• Suzuki K, Azuma Y, Onishi Y, et al. Biphasic effect of staurosporine on thymocyte apoptosis. Biochem Mol Biol Int 1995;35:1085–1092
   PubMedGoogle Scholar
• Fotakis G, Timbrell JA. In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett 2006;160:171–177
   PubMed Web of Science ®Google Scholar
• Iliya HA, Wallace HM. Cellular growth inhibition and toxic effects of etoposide and acetyl salicylic acid. Nig Journ Pharm Sci 2011;10:57–64
   Google Scholar
• Kim YH, Kim DH, Lim H, et al. The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages. Biol Pharm Bul 2009;32:651–656
   Google Scholar
• Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 1972;24:239–275
   Google Scholar
• Wyllie AH, Kerr JFR, Currie AR. Cell death: the significance of apoptosis. Int Rev Cytol 1980;68:251–305
   PubMedGoogle Scholar
• Moncada S. The l-arginine: nitric oxide pathway, cellular transduction and immunological roles. Adv Second Messenger Phosphoprotein Res 1993;28:97–99
   PubMedGoogle Scholar
• Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992;6:3051–3064
   PubMed Web of Science ®Google Scholar
• Albina JE, Reichner JS. Role of nitric oxide in mediation of macrophage cytotoxicity and apoptosis. Cancer Metastasis Rev 1998;17:39–53
   PubMed Web of Science ®Google Scholar
• Caron JM, Bannon M, Rosshirt L, et al. Methyl sulfone induces loss of metastatic properties and reemergence of normal phenotypes in a metastatic cloudman S-91 (M3) murine melanoma cell line. PLoS One 2010;5:8:e11788
   Google Scholar
• Jafari N, Bohlooli S, Mohammadi S, Mazani M. Cytotoxicity of methylsulfonylmethane on gastrointestinal (AGS, HepG2, and KEYSE-30) cancer cell lines. J Gastrointest Cancer 2012;43:420–425
   Google Scholar
• Kamel R, El Morsy EM. Hepatoprotective effect of methylsulfonylmethane against carbon tetrachloride-induced acute liver injury in rats. Arch Pharm Res 2013;36:1140–1148
   Google Scholar
• Magnuson BA, Appleton J, Ames GB. Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats. J Agric Food Chem 2007;55:1033–1038
   PubMed Web of Science ®Google Scholar
• Magnuson BA, Appleton J, Ryan B, Matulka RA. Oral developmental toxicity study of methylsulfonylmethane in rats. Food Chem Toxicol 2007;45:977–984
   PubMed Web of Science ®Google Scholar
• Horvath K, Noker PE, Somfai-Relle S. Toxicity of methylsulfonylmethane in rats. Food Chem Toxicol 2002;40:1459–1462
   PubMed Web of Science ®Google Scholar
• Engelke UF, Tangerman A, Willemsen MA, et al. Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one-dimensional (1)H and two-dimensional (1)H-(13)C-NMR. NMR Biomed 2005;18:331–336
   PubMed Web of Science ®Google Scholar
• Cecil KM, Lin A, Ross BD, Egelhoff JC. Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation. J Comput Assist Tomogr 2002;26:818–820
   Google Scholar
• Lin A, Nguy CH, Shic F, Ross BD. Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy. Toxicol Lett 2001;123:169–177
   Google Scholar
• Rose SE, Chalk JB, Galloway GJ, Doddrell DM. Detection of dimethyl sulfone in the human brain by in vivo proton magnetic resonance spectroscopy. Magn Reson Imaging 2000;18:95–98
   Google Scholar
• Methylsulfonylmethane (MSM). Monograph. Altern Med Rev. 2003;8:438–441
   Google Scholar
• Messmer UK, Ankarcrona M, Nicotera P, Brüne B. p53 expression in nitric oxide-induced apoptosis. FEBS Lett 1994;21:23–26
   Google Scholar
• Basu A, Haldar S. The relationship between Bcl 2, Bax and p53: consequences for cell cycle progression and cell death. Mol Hum Reprod 1998;4:1099–1109
   PubMed Web of Science ®Google Scholar
• Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993;74:609–619
   PubMed Web of Science ®Google Scholar
• Messmer UK, Reed UK, Brüne B. Bcl-2 protects macrophages from nitric oxide-induced apoptosis. J. Biol Chem 1996;16:20192–20197
   Google Scholar
• Hortelano S, López-Collazo E, Boscá L. Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages. Br J Pharmacol 1996;126:1139–1146
   Google Scholar
• Hortelano S, Dallaporta B, Zamzami N, et al. Nitric oxide induces apoptosis via triggering mitochondrial permeability transition. FEBS Lett 1997;30:373–377
   Google Scholar
• Wu GJ, Chen TG, Chang HC, et al. Nitric oxide from both exogenous and endogenous sources activates mitochondria-dependent events and induces insults to human chondrocytes. J Cell Biochem 2007;15:1520–1531
   Google Scholar
• Hortelano S, Zeini M, Castrillo A, et al. Induction of apoptosis by nitric oxide in macrophages is independent of apoptotic volume decrease. Cell Death Differ 2002;9:643–650
   PubMed Web of Science ®Google Scholar
• Heler B, Wang ZQ, Wagner EF, et al. Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J Biol Chem 1995;12:11176–11180
   Google Scholar
• Kaufmann SH. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res 1989;49:5870–5878
   PubMed Web of Science ®Google Scholar
• Makin G, Dive C. Apoptosis and cancer chemotherapy. Trends Cell Biol 2001;11:22–26
   PubMed Web of Science ®Google Scholar
• Herbert V. Prooxidant effects of antioxidant vitamins. Introduction J Nutr 1996;126:1197S–1200S
   Google Scholar
• Anderson GP. Resolution of chronic inflammation by therapeutic induction of apoptosis. Trends Pharmacol Sci 1996;17:438–442
   Google Scholar
• Savill J. Apoptosis in resolution of inflammation. J Leukoc Biol 1997;61:375–380
   PubMed Web of Science ®Google Scholar