Ribavirin enhances myeloid-derived suppressor cell differentiation through CXCL9/10 downregulation

References

• Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009;9:162–174
   PubMed Web of Science ®Google Scholar
• Kong YY, Fuchsberger M, Xiang SD, et al. Myeloid derived suppressor cells and their role in diseases. Curr Med Chem 2013;20:1437–1444
   Google Scholar
• Ostrand-Rosenberg S, Sinha P. Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol 2009;182:4499–4506
   PubMed Web of Science ®Google Scholar
• Peranzoni E, Zilio S, Marigo I, et al. Myeloid-derived suppressor cell heterogeneity and subset definition. Curr Opin Immunol 2010;22:238–244
   PubMed Web of Science ®Google Scholar
• Ribechini E, Greifenberg V, Sandwick S, et al. Subsets, expansion and activation of myeloid-derived suppressor cells. Med Microbiol Immunol 2010;199:273–281
   PubMed Web of Science ®Google Scholar
• De Santo C, Salio M, Masri SH, et al. Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest 2008;118:4036–4048
   PubMed Web of Science ®Google Scholar
• Tacke RS, Lee HC, Goh C, et al. Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species. Hepatology 2012;55:343–353
   PubMed Web of Science ®Google Scholar
• Cai W, Qin A, Guo P, et al. Clinical significance and functional studies of myeloid-derived suppressor cells in chronic hepatitis C patients. J Clin Immunol 2013;33:798–808
   PubMed Web of Science ®Google Scholar
• Chen S, Akbar SM, Abe M, et al. Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus. Clin Exp Immunol 2011;166:134–142
   PubMed Web of Science ®Google Scholar
• Qin A, Cai W, Pan T, et al. Expansion of monocytic myeloid-derived suppressor cells dampens T cell function in HIV-1-seropositive individuals. J Virol 2013;87:1477–1490
   PubMed Web of Science ®Google Scholar
• Vollbrecht T, Stirner R, Tufman A, et al. Chronic progressive HIV-1 infection is associated with elevated levels of myeloid-derived suppressor cells. AIDS 2012;26:F31–F37
   PubMed Web of Science ®Google Scholar
• McHutchinson JG, Gordon SC, Schiff ER, et al. Interferon α2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. N Engl J Med 1998;339:1485–1492
   PubMed Web of Science ®Google Scholar
• Feld JJ, Lutchman GA, Heller T, et al. Ribavirin improves early responses to peginterferon through improved interferon signaling. Gastroenterology 2010;139:154–162
   PubMed Web of Science ®Google Scholar
• Conti F, Vukotic R, Lorenzini S, et al. Increase of ribavirin dose improves sustained virological response in HCV-genotype 1 patients with a partial response to peg-interferon and ribavirin. Ann Hepatol 2014;13:196–203
   Google Scholar
• Mori K, Ikeda M, Ariumi Y, et al. Mechanism of action of Ribavirin in a novel hepatitis C virus replication cell system. Virus Res 2011;157:61–70
   PubMed Web of Science ®Google Scholar
• Shu Q, Nair V. Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery. Med Res Rev 2008;28:219–232
   PubMed Web of Science ®Google Scholar
• Graci JD, Cameron CE. Mechanisms of action of Ribavirin against distinct viruses. Rev Med Virol 2006;16:37–48
   PubMed Web of Science ®Google Scholar
• Fang SH, Hwang LH, Chen DS, et al. Ribavirin enhancement of hepatitis C virus core antigen-specific type 1 T helper cell response correlates with the increased IL-12 level. J Hepatol 2000;33:791–798
   PubMed Web of Science ®Google Scholar
• Boltjes A, Op den Brouw ML, Biesta PJ, et al. Assessment of the effect of ribavirin on myeloid and plasmacytoid dendritic cells during interferon-based therapy of chronic hepatitis B patients. Mol Immunol 2013;53:72–78
   Google Scholar
• Brenndörfer ED, Brass A, Karthe J, et al. Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy. J Immunol 2014;192:1671–1680
   Google Scholar
• Hultgren C, Milich DR, Weiland O, et al. The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses. J Gen Virol 1998;79:2381–2391
   PubMed Web of Science ®Google Scholar
• Li H, Han Y, Guo Q, et al. Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1. J Immunol 2009;182:240–249
   PubMed Web of Science ®Google Scholar
• Ogbomo H, Michaelis M, Altenbrandt B, et al. A novel immunomodulatory mechanism of ribavirin in suppressing natural killer cell function. Biochem Pharmacol 2010;79:188–197
   Google Scholar
• Atsukawa M, Nakatsuka K, Kobayashi T, et al. Ribavirin downmodulates inducible costimulator on CD4 + T cells and their interleukin-10 secretion to assist in hepatitis C virus clearance. J Gastroenterol Hepatol 2012;27:823–831
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Nakatsuka K, Shimizu M, et al. Ribavirin modulates the conversion of human CD4(+)CD25(−) T cell to CD4(+) CD25(+) FOXP3(+) T cell via suppressing interleukin-10-producing regulatory T cell. Immunology 2012;137:259–270
   Google Scholar
• Lee J, Choi YS, Shin EC. Ribavirin does not impair the suppressive activity of Foxp3+CD4+CD25 + regulatory T cells. Immune Netw 2013;13:25–29
   Google Scholar
• Malvandi AM, Mehrzad J, Saleh-moghaddam M. Biologically relevant doses of mixed aflatoxins B and G up-regulate MyD88, TLR2, TLR4 and CD14 transcripts in human PBMCs. Immunopharmacol Immunotoxicol 2013;35:528–532
   Google Scholar
• Mohammadi A, Mehrzad J, Mahmoudi M, et al. Environmentally relevant level of aflatoxin B1 dysregulates human dendritic cells through signaling on key toll-like receptors. Int J Toxicol 2014;33:175–186
   Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001;25:402–408
   PubMed Web of Science ®Google Scholar
• Thakur A, Schalk D, Sarkar SH, et al. A Th1 cytokine–enriched microenvironment enhances tumor killing by activated T cells armed with bispecific antibodies and inhibits the development of myeloid-derived suppressor cells. Cancer Immunol Immunother 2012;61:497–509
   PubMed Web of Science ®Google Scholar
• Liu M, Guo S, Hibbert JM, et al. CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications. Cytokine Growth Factor Rev 2011;22:121–130
   PubMed Web of Science ®Google Scholar
• Bergamini A, Bolacchi F, Cepparulo M, et al. Treatment with ribavirin and interferon-alpha reduces interferon-gamma expression in patients with chronic hepatitis C. Clin Exp Immunol 2001;123:459–464
   Google Scholar
• Lindau D, Gielen P, Kroesen M, et al. The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells. Immunology 2013;138:105–115
   PubMed Web of Science ®Google Scholar
• Huang B, Pan PY, Li Q, et al. Gr-1+CD115 + immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res 2006;66:1123–1131
   PubMed Web of Science ®Google Scholar
• Claassen MA, de Knegt RJ, Janssen HL, et al. Retention of CD4 + CD25 + FoxP3 + regulatory T cells in the liver after therapy-induced hepatitis C virus eradication in humans. J Virol 2011;85:5323–5330
   PubMed Web of Science ®Google Scholar
• Serafini P, Mgebroff S, Noonan K, Borrello I. Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. Cancer Res 2008;68:5439–5449
   PubMed Web of Science ®Google Scholar
• Loetscher M, Gerber B, Loetscher P, et al. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med 1996;184:963–969
   PubMed Web of Science ®Google Scholar
• Bonacchi A, Romagnani P, Romanelli RG, et al. Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes. J Biol Chem 2001;276:9945–9954
   PubMedGoogle Scholar
• Shahabuddin S, Ji R, Wang P, et al. CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways. Am J Physiol Cell Physiol 2006;291:C34–C39
   Google Scholar