496
Views
70
CrossRef citations to date
0
Altmetric
Research Article

Anti-inflammatory effects of galangin on lipopolysaccharide-activated macrophages via ERK and NF-κB pathway regulation

, , , , , & show all
Pages 426-432 | Received 09 May 2014, Accepted 14 Sep 2014, Published online: 01 Oct 2014

References

  • Park HJ, Jeon BT, Kim HC, et al. Aged red garlic extract reduces lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages and acute pulmonary inflammation through haeme oxygenase-1 induction. Acta Physiol (Oxf) 2012;205:61–70
  • Park SB, Kim MS, Lee HS, et al. 1,2,3,6-tetra-O-galloyl-beta-d-allopyranose gallotannin isolated, from Euphorbia jolkini, attenuates LPS-induced nitric oxide production in macrophages. Phytother Res 2010;24:1329–1333
  • Manzi S, Wasko MC. Inflammation-mediated rheumatic diseases and atherosclerosis. Ann Rheum Dis 2000;59:321–325
  • Kolesov SA, Korkotashvili LV, Yazykova AB, et al. S-nitrosothiols, nitric oxide and proinflammatory cytokines in children with inflammatory bowel disease. Clin Lab 2013;59:953–957
  • Chun J, Choi RJ, Khan S, et al. Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-kappaB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells. Int Immunopharmacol 2012;14:375–383
  • Moncada S. Nitric oxide: discovery and impact on clinical medicine. J R Soc Med 1999;92:164–169
  • Welters ID, Fimiani C, Bilfinger TV, et al. NF-kappaB, nitric oxide and opiate signaling. Med Hypotheses 2000;54:263–268
  • Pearson G, Robinson F, Beers Gibson T, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 2001;22:153–183
  • Kawai T, Akira S. TLR signaling. Cell Death Differ 2006;13:816–825
  • Elicabe RJ, Arias JL, Rabinovich GA, et al. TNFRp55 modulates IL-6 and nitric oxide responses following Yersinia lipopolysaccharide stimulation in peritoneal macrophages. Immunobiology 2011;216:1322–1330
  • Wang L, Lee IM, Zhang SM, et al. Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women. Am J Clin Nutr 2009;89:905–912
  • Leonard E, Yan Y, Koffas MA. Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli. Metab Eng 2006;8:172–181
  • Xie C, Kang J, Li Z, et al. The acai flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-alpha and IL-6 production through inhibiting NF-kappaB activation and MAPK pathway. J Nutr Biochem 2012;23:1184–1191
  • Seelinger G, Merfort I, Wolfle U, et al. Anti-carcinogenic effects of the flavonoid luteolin. Molecules 2008;13:2628–2651
  • Gwak J, Oh J, Cho M, et al. Galangin suppresses the proliferation of beta-catenin response transcription-positive cancer cells by promoting adenomatous polyposis coli/Axin/glycogen synthase kinase-3beta-independent beta-catenin degradation. Mol Pharmacol 2011;79:1014–1022
  • Wen M, Wu J, Luo H, et al. Galangin induces autophagy through upregulation of p53 in HepG2 cells. Pharmacology 2012;89:247–255
  • Kim DA, Jeon YK, Nam MJ. Galangin induces apoptosis in gastric cancer cells via regulation of ubiquitin carboxy-terminal hydrolase isozyme L1 and glutathione S-transferase P. Food Chem Toxicol 2012;50:684–688
  • Zhang HT, Luo H, Wu J, et al. Galangin induces apoptosis of hepatocellular carcinoma cells via the mitochondrial pathway. World J Gastroenterol 2010;16:3377–3384
  • Zhang W, Tang B, Huang Q, et al. Galangin inhibits tumor growth and metastasis of B16F10 melanoma. J Cell Biochem 2013;114:152–161
  • Tolomeo M, Grimaudo S, Di Cristina A, et al. Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells. Cancer Lett 2008;265:289–297
  • Ha TK, Kim ME, Yoon JH, et al. Galangin induces human colon cancer cell death via the mitochondrial dysfunction and caspase-dependent pathway. Exp Biol Med (Maywood) 2013;238:1047–1054
  • Wang X, Gong G, Yang W, et al. Antifibrotic activity of galangin, a novel function evaluated in animal liver fibrosis model. Environ Toxicol Pharmacol 2013;36:288–295
  • Wiklund NP, Iversen HH, Leone AM, et al. Visualization of nitric oxide formation in cell cultures and living tissue. Acta Physiol Scand 1999;167:161–166
  • Wynick C, Petes C, Gee K. Interleukin-27 mediates inflammation during chronic disease. J Interferon Cytokine Res 2014 . [Epub ahead of print]
  • Steinberg GR, Schertzer JD. AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease. Immunol Cell Biol 2014;92:340–345
  • Robinson NM, Zhang HY, Bevan AL, et al. Induction of myocardial nitric oxide synthase by Coxsackie B3 virus in mice. Eur J Clin Invest 1999;29:700–707
  • Evans CH. Nitric oxide: what role does it play in inflammation and tissue destruction? Agents Actions Suppl 1995;47:107–116
  • Zhou HY, Shin EM, Guo LY, et al. Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB, JNK and p38 MAPK inactivation. Eur J Pharmacol 2008;586:340–349
  • Tsatsanis C, Androulidaki A, Venihaki M, et al. Signalling networks regulating cyclooxygenase-2. Int J Biochem Cell Biol 2006;38:1654–1661
  • Li XN, Su J, Zhao L, et al. The p38 MAPK inhibitor JLU1124 inhibits the inflammatory response induced by lipopolysaccharide through the MAPK-NF-kappaB pathway in RAW264.7 macrophages. Int Immunopharmacol 2013;17:785–792
  • Shi Q, Cao J, Fang L, et al. Geniposide suppresses LPS-induced nitric oxide, PGE and inflammatory cytokine by downregulating NF-kappaB, MAPK and AP-1 signaling pathways in macrophages. Int Immunopharmacol 2014;20:298–306
  • Kim KN, Ko YJ, Yang HM, et al. Anti-inflammatory effect of essential oil and its constituents from fingered citron (Citrus medica L. var. sarcodactylis) through blocking JNK, ERK and NF-kappaB signaling pathways in LPS-activated RAW 264.7 cells. Food Chem Toxicol 2013;57:126–131

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.